This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several ... See more...

Aliases for FCAR Gene

Aliases for FCAR Gene

  • Fc Fragment Of IgA Receptor 2 3 5
  • CD89 2 3 4
  • Fc Fragment Of IgA, Receptor For 2 3
  • Immunoglobulin Alpha Fc Receptor 3 4
  • Fc Alpha Receptor 3
  • FCAR Variant 14 3
  • IgA Fc Receptor 4
  • CD89 Antigen 4
  • CTB-61M7.2 3
  • FcalphaRI 3
  • FCAR 5

External Ids for FCAR Gene

Previous GeneCards Identifiers for FCAR Gene

  • GC19P056248
  • GC19P055810
  • GC19P060006
  • GC19P060077
  • GC19P055386
  • GC19P051708
  • GC19P054893
  • GC19P054902
  • GC19P055106
  • GC19P055134
  • GC19P055170
  • GC19P055298
  • GC19P054919
  • GC19P054938
  • GC19P054963
  • GC19P054983
  • GC19P054999
  • GC19P055026
  • GC19P055054
  • GC19P055080
  • GC19P055445
  • GC19P055640

Summaries for FCAR Gene

Entrez Gene Summary for FCAR Gene

  • This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCAR Gene

FCAR (Fc Fragment Of IgA Receptor) is a Protein Coding gene. Diseases associated with FCAR include Iga Glomerulonephritis and Hypersensitivity Vasculitis. Among its related pathways are Phagosome and Innate Immune System. Gene Ontology (GO) annotations related to this gene include IgA binding. An important paralog of this gene is LILRA2.

UniProtKB/Swiss-Prot Summary for FCAR Gene

  • Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

Gene Wiki entry for FCAR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FCAR Gene

Genomics for FCAR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FCAR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054876 Promoter/Enhancer 0.9 FANTOM5 Ensembl ENCODE 276 +1.7 1670 1 SPI1 FCAR LILRA2 LILRA1 NLRP2 NLRP7 ENSG00000243494 KIR2DL3 EPS8L1 RDH13 TNNT1
GH19J054873 Promoter 0.8 EPDnew Ensembl 256.6 +0.4 370 1.2 POLR2A FCAR KIR2DS4 KIR3DL2 ENSG00000268734 HSALNG0127575 NCR1
GH19J055319 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 20.1 +447.4 447420 4.1 IKZF1 SIX5 ZNF592 CEBPA CEBPB ETS1 MBD2 ZNF217 SIN3A THAP11 TMEM150B FCAR FAM71E2 IL11 TMEM190 BRSK1 HSPBP1 PPP6R1 RPL28 TMEM238
GH19J054373 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 25.8 -499.3 -499314 2.7 YY1 TRIM22 MAFF ZNF316 CBFB SMARCA5 NFE2 MAFK BHLHE40 SPI1 HSALNG0127520 HSALNG0127521 FCAR LAIR1 LILRB2 OSCAR LILRA5 VSTM1 LILRB3 LILRB4
GH19J054661 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 14.5 -211.7 -211650 3.6 SP1 BCL11A IRF4 EBF1 IKZF1 NFATC1 JUNB ARID3A TARDBP SPI1 LILRB4 FCAR LAIR1 KIR3DX1 LILRB2 KIR2DL3 LILRB1 LILRA5 LILRB3 LILRA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCAR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FCAR

Top Transcription factor binding sites by QIAGEN in the FCAR gene promoter:
  • C/EBPalpha
  • CREB
  • deltaCREB
  • NF-kappaB1
  • RORalpha1

Genomic Locations for FCAR Gene

Latest Assembly
chr19:54,874,231-54,891,420
(GRCh38/hg38)
Size:
17,190 bases
Orientation:
Plus strand

Previous Assembly
chr19:55,385,691-55,402,786
(GRCh37/hg19 by Entrez Gene)
Size:
17,096 bases
Orientation:
Plus strand

chr19:55,385,704-55,401,838
(GRCh37/hg19 by Ensembl)
Size:
16,135 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr19(ALT_REF_LOCI_15):10-7,021 (-)
  • chr19(ALT_REF_LOCI_2):519,503-536,649 (+)
  • chr19(ALT_REF_LOCI_23):153,182-170,367 (+)
  • chr19(ALT_REF_LOCI_26):160,255-177,440 (+)
  • chr19(ALT_REF_LOCI_27):244,474-261,659 (+)
  • chr19(ALT_REF_LOCI_28):150,185-167,370 (+)
  • chr19(ALT_REF_LOCI_29):151,602-168,787 (+)
  • chr19(ALT_REF_LOCI_30):148,453-165,638 (+)
  • chr19(ALT_REF_LOCI_7):778,610-795,785 (+)
  • chr19(ALT_REF_LOCI_9):856,805-873,900 (+)
  • chr19(PATCHES):203,308-220,493 (+)

Genomic View for FCAR Gene

Genes around FCAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for FCAR Gene

  • Protein details for FCAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24071-FCAR_HUMAN
    Recommended name:
    Immunoglobulin alpha Fc receptor
    Protein Accession:
    P24071
    Secondary Accessions:
    • Q13603
    • Q13604
    • Q15727
    • Q15728
    • Q1AJL7
    • Q1AJL8
    • Q1AJL9
    • Q53X38
    • Q53X39
    • Q92587
    • Q92588
    • Q92590
    • Q92592
    • Q92593
    • Q9UEK0

    Protein attributes for FCAR Gene

    Size:
    287 amino acids
    Molecular mass:
    32265 Da
    Quaternary structure:
    • Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.
    • (Microbial infection) Interacts with Staphylococcus aureus protein SSL11.
    Miscellaneous:
    • [Isoform B-delta-S2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for FCAR Gene

    Alternative splice isoforms for FCAR Gene

neXtProt entry for FCAR Gene

Post-translational modifications for FCAR Gene

  • Glycosylation at Asn141, Asn65, Asn79, Asn177, and Asn186
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for FCAR

No data available for DME Specific Peptides for FCAR Gene

Domains & Families for FCAR Gene

Gene Families for FCAR Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FCAR Gene

InterPro:
Blocks:
  • Immunoglobulin subtype

Suggested Antigen Peptide Sequences for FCAR Gene

GenScript: Design optimal peptide antigens:
  • FCAR (A5Y2E9_HUMAN)
  • FCAR (A5Y2F0_HUMAN)
  • Immunoglobulin alpha Fc receptor (FCAR_HUMAN)
genes like me logo Genes that share domains with FCAR: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FCAR Gene

Function for FCAR Gene

Molecular function for FCAR Gene

UniProtKB/Swiss-Prot Function:
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
GENATLAS Biochemistry:
immunoglobulin A,Fc receptor expressed on granulocyte,monocyte,macrophage,T cell,B cell,complexing with a cytoplasmic homodimer gamma subunit with the immunoreceptor based inhibitory motif (ITIM),natural killer inhibitory receptor family

Phenotypes From GWAS Catalog for FCAR Gene

Gene Ontology (GO) - Molecular Function for FCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019766 IgA receptor activity IDA --
GO:0019862 IgA binding IEA --
genes like me logo Genes that share ontologies with FCAR: view
genes like me logo Genes that share phenotypes with FCAR: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCAR

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCAR Gene

Localization for FCAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCAR Gene

[Isoform A. 1]: Cell membrane. Single-pass type I membrane protein.
[Isoform A. 2]: Cell membrane. Single-pass type I membrane protein.
[Isoform A. 3]: Cell membrane. Single-pass type I membrane protein.
[Isoform B]: Secreted.
[Isoform B-delta-S2]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCAR gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2258698
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCAR: view

Pathways & Interactions for FCAR Gene

genes like me logo Genes that share pathways with FCAR: view

Pathways by source for FCAR Gene

3 Reactome pathways for FCAR Gene
2 KEGG pathways for FCAR Gene

Gene Ontology (GO) - Biological Process for FCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002446 neutrophil mediated immunity IDA --
GO:0006955 immune response TAS 10835685
GO:0033031 positive regulation of neutrophil apoptotic process IDA --
GO:0035457 cellular response to interferon-alpha IDA --
GO:0038093 Fc receptor signaling pathway IDA --
genes like me logo Genes that share ontologies with FCAR: view

No data available for SIGNOR curated interactions for FCAR Gene

Drugs & Compounds for FCAR Gene

(4) Drugs for FCAR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for FCAR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCAR: view

Transcripts for FCAR Gene

mRNA/cDNA for FCAR Gene

10 REFSEQ mRNAs :
32 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCAR

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for FCAR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
SP1: - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - -
SP8:
SP9: - - - -

Relevant External Links for FCAR Gene

GeneLoc Exon Structure for
FCAR

Expression for FCAR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FCAR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCAR Gene

This gene is overexpressed in Whole Blood (x46.8).

Protein differential expression in normal tissues from HIPED for FCAR Gene

This gene is overexpressed in Monocytes (44.2) and Neutrophil (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCAR Gene



Protein tissue co-expression partners for FCAR Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FCAR

SOURCE GeneReport for Unigene cluster for FCAR Gene:

Hs.659872

mRNA Expression by UniProt/SwissProt for FCAR Gene:

P24071-FCAR_HUMAN
Tissue specificity: Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.

Evidence on tissue expression from TISSUES for FCAR Gene

  • Bone marrow(4.6)
  • Blood(4.5)
  • Spleen(2.6)
  • Intestine(2.4)
  • Lung(2.2)
  • Lymph node(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with FCAR: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCAR Gene

Orthologs for FCAR Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCAR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FCAR 29
  • 98.21 (n)
PT-FCAR 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia FCAR 29 30
  • 72.84 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fcar 29
  • 68.01 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 29 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 4 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 9 (a)
OneToMany
Species where no ortholog for FCAR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FCAR Gene

ENSEMBL:
Gene Tree for FCAR (if available)
TreeFam:
Gene Tree for FCAR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCAR: view image
Alliance of Genome Resources:
Additional Orthologs for FCAR

Paralogs for FCAR Gene

(4) SIMAP similar genes for FCAR Gene using alignment to 3 proteins:

  • FCAR_HUMAN
  • A5Y2E9_HUMAN
  • A5Y2F0_HUMAN
genes like me logo Genes that share paralogs with FCAR: view

Variants for FCAR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FCAR Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11666735 -- p.Asp113Asn
rs16986050 -- p.Ser269Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FCAR Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FCAR Gene

Variant ID Type Subtype PubMed ID
dgv438n27 CNV gain 19166990
dgv6580n54 CNV gain 21841781
esv2667609 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv3644820 CNV loss 21293372
nsv428372 CNV gain+loss 18775914
nsv469656 CNV loss 16826518
nsv471706 CNV loss 15918152
nsv520644 CNV loss 19592680
nsv833880 CNV loss 17160897

Variation tolerance for FCAR Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCAR Gene

Human Gene Mutation Database (HGMD)
FCAR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCAR
Leiden Open Variation Database (LOVD)
FCAR

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCAR Gene

Disorders for FCAR Gene

MalaCards: The human disease database

(6) MalaCards diseases for FCAR Gene - From: COP

Disorder Aliases PubMed IDs
iga glomerulonephritis
  • berger's iga or igg nephropathy
hypersensitivity vasculitis
  • vasculitis hypersensitivity
henoch-schoenlein purpura
  • allergic purpura
hypersensitivity reaction type iii disease
  • immune complex disease
spondyloarthropathy 1
  • spondyloarthropathy, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search FCAR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FCAR

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FCAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCAR Gene

Publications for FCAR Gene

  1. Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients. (PMID: 17033823) Watanabe A … Ra C (Immunogenetics 2006) 3 22 40
  2. Are single nucleotide polymorphisms of the immunoglobulin A Fc receptor gene associated with allergic asthma? (PMID: 15564774) Jasek M … Kuśnierczyk P (International archives of allergy and immunology 2004) 3 22 40
  3. Crystal structure of the ectodomain of human FcalphaRI. (PMID: 12783876) Ding Y … Rao Z (The Journal of biological chemistry 2003) 3 4 22
  4. IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells. (PMID: 9367406) Toyabe S … Abo T (Clinical and experimental immunology 1997) 3 4 22
  5. Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages. (PMID: 8666819) Patry C … Monteiro RC (Journal of immunology (Baltimore, Md. : 1950) 1996) 3 4 22

Products for FCAR Gene

Sources for FCAR Gene