Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FCAR Gene

Aliases for FCAR Gene

  • Fc Fragment Of IgA Receptor 2 3 5
  • Fc Fragment Of IgA, Receptor For 2 3
  • CD89 3 4
  • Immunoglobulin Alpha Fc Receptor 3
  • Fc Alpha Receptor 3
  • FCAR Variant 14 3
  • IgA Fc Receptor 4
  • CD89 Antigen 4
  • CTB-61M7.2 3
  • FcalphaRI 3

External Ids for FCAR Gene

Previous GeneCards Identifiers for FCAR Gene

  • GC19P056248
  • GC19P055810
  • GC19P060006
  • GC19P060077
  • GC19P055386
  • GC19P051708
  • GC19P054893
  • GC19P054902
  • GC19P054919
  • GC19P054938
  • GC19P054963
  • GC19P054983
  • GC19P054999
  • GC19P055026

Summaries for FCAR Gene

Entrez Gene Summary for FCAR Gene

  • This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCAR Gene

FCAR (Fc Fragment Of IgA Receptor) is a Protein Coding gene. Diseases associated with FCAR include Iga Glomerulonephritis. Among its related pathways are Phagosome and Staphylococcus aureus infection. Gene Ontology (GO) annotations related to this gene include IgA binding. An important paralog of this gene is LILRB1.

UniProtKB/Swiss-Prot for FCAR Gene

  • Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

Gene Wiki entry for FCAR Gene

Additional gene information for FCAR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCAR Gene

Genomics for FCAR Gene

GeneHancer (GH) Regulatory Elements for FCAR Gene

Promoters and enhancers for FCAR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054873 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 682.5 +2.1 2091 5.2 GATA3 ZNF157 POLR2A SPI1 FCAR LILRA2 KIR2DS4 LILRA1 NLRP2 NLRP7 ENSG00000243494 KIR2DL3 EPS8L1 RDH13
GH19J054368 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.8 -501.3 -501257 8.9 PKNOX1 YY1 ZNF766 ZNF143 ETV6 ATF7 IKZF2 RUNX3 CREM SMARCA5 LAIR1 FCAR LILRB2 OSCAR LILRA5 VSTM1 LILRB3 LILRB4 LILRB1 LILRA2
GH19J055320 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 20.1 +449.2 449233 5.7 BACH1 CEBPG ZNF384 E4F1 ZNF316 POLR2A SCRT2 NFE2 MAFK CREM TMEM150B FCAR FAM71E2 IL11 TMEM190 HSPBP1 BRSK1 PPP6R1 RPL28 TMEM238
GH19J054660 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 14.5 -211.8 -211796 4.2 EBF1 IRF4 POLR2A NFATC1 EED ATF7 ETV6 IKZF2 RUNX3 CREM LILRB4 FCAR LAIR1 LILRB1 KIR3DX1 LILRB2 KIR2DL3 LILRA5 LILRB3 LILRA1
GH19J054642 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE 14.7 -230.2 -230192 2.6 ZNF316 PRDM10 LILRB4 MIR8061 LILRA1 LAIR1 FCAR LILRB1 LILRB3 LILRA2 LILRB2 LILRA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCAR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FCAR gene promoter:
  • RORalpha1
  • deltaCREB
  • CREB
  • NF-kappaB1
  • C/EBPalpha

Genomic Locations for FCAR Gene

Genomic Locations for FCAR Gene
chr19:54,874,093-54,891,420
(GRCh38/hg38)
Size:
17,328 bases
Orientation:
Plus strand
chr19:55,385,549-55,401,839
(GRCh37/hg19)
Size:
16,291 bases
Orientation:
Plus strand

Genomic View for FCAR Gene

Genes around FCAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for FCAR Gene

  • Protein details for FCAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24071-FCAR_HUMAN
    Recommended name:
    Immunoglobulin alpha Fc receptor
    Protein Accession:
    P24071
    Secondary Accessions:
    • Q13603
    • Q13604
    • Q15727
    • Q15728
    • Q1AJL7
    • Q1AJL8
    • Q1AJL9
    • Q53X38
    • Q53X39
    • Q92587
    • Q92588
    • Q92590
    • Q92592
    • Q92593
    • Q9UEK0

    Protein attributes for FCAR Gene

    Size:
    287 amino acids
    Molecular mass:
    32265 Da
    Quaternary structure:
    • Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.

    Three dimensional structures from OCA and Proteopedia for FCAR Gene

    Alternative splice isoforms for FCAR Gene

neXtProt entry for FCAR Gene

Post-translational modifications for FCAR Gene

  • Glycosylation at Asn198, isoforms=2, 4, 5, 7, 6, 8, 10, 11186, Asn177, Asn141, Asn79, and Asn65
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FCAR Gene

Domains & Families for FCAR Gene

Gene Families for FCAR Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FCAR Gene

Suggested Antigen Peptide Sequences for FCAR Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCAR: view

No data available for UniProtKB/Swiss-Prot for FCAR Gene

Function for FCAR Gene

Molecular function for FCAR Gene

UniProtKB/Swiss-Prot Function:
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
GENATLAS Biochemistry:
immunoglobulin A,Fc receptor expressed on granulocyte,monocyte,macrophage,T cell,B cell,complexing with a cytoplasmic homodimer gamma subunit with the immunoreceptor based inhibitory motif (ITIM),natural killer inhibitory receptor family

Phenotypes From GWAS Catalog for FCAR Gene

Gene Ontology (GO) - Molecular Function for FCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019862 IgA binding IEA --
genes like me logo Genes that share ontologies with FCAR: view
genes like me logo Genes that share phenotypes with FCAR: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCAR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCAR Gene

Localization for FCAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCAR Gene

Isoform A.1: Cell membrane; Single-pass type I membrane protein.
Isoform A.2: Cell membrane; Single-pass type I membrane protein.
Isoform A.3: Cell membrane; Single-pass type I membrane protein.
Isoform B: Secreted.
Isoform B-delta-S2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCAR gene
Compartment Confidence
plasma membrane 5
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2258698
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCAR: view

Pathways & Interactions for FCAR Gene

genes like me logo Genes that share pathways with FCAR: view

Pathways by source for FCAR Gene

3 Reactome pathways for FCAR Gene
2 KEGG pathways for FCAR Gene

Gene Ontology (GO) - Biological Process for FCAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 10835685
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with FCAR: view

No data available for SIGNOR curated interactions for FCAR Gene

Drugs & Compounds for FCAR Gene

(4) Drugs for FCAR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for FCAR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCAR: view

Transcripts for FCAR Gene

mRNA/cDNA for FCAR Gene

Unigene Clusters for FCAR Gene

Fc fragment of IgA, receptor for:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCAR

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCAR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
SP1: - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - -
SP8:
SP9: - - - -

Relevant External Links for FCAR Gene

GeneLoc Exon Structure for
FCAR
ECgene alternative splicing isoforms for
FCAR

Expression for FCAR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCAR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCAR Gene

This gene is overexpressed in Whole Blood (x46.8).

Protein differential expression in normal tissues from HIPED for FCAR Gene

This gene is overexpressed in Monocytes (44.2) and Neutrophil (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCAR Gene



Protein tissue co-expression partners for FCAR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FCAR Gene:

FCAR

SOURCE GeneReport for Unigene cluster for FCAR Gene:

Hs.659872

mRNA Expression by UniProt/SwissProt for FCAR Gene:

P24071-FCAR_HUMAN
Tissue specificity: Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.

Evidence on tissue expression from TISSUES for FCAR Gene

  • Blood(4.5)
  • Bone marrow(4.5)
  • Spleen(2)
genes like me logo Genes that share expression patterns with FCAR: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCAR Gene

Orthologs for FCAR Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCAR 33
  • 98.21 (n)
PT-FCAR 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FCAR 34 33
  • 72.84 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcar 33
  • 68.01 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 29 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 4 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 9 (a)
OneToMany
Species where no ortholog for FCAR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCAR Gene

ENSEMBL:
Gene Tree for FCAR (if available)
TreeFam:
Gene Tree for FCAR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCAR: view image

Paralogs for FCAR Gene

(4) SIMAP similar genes for FCAR Gene using alignment to 3 proteins:

  • FCAR_HUMAN
  • A5Y2E9_HUMAN
  • A5Y2F0_HUMAN
genes like me logo Genes that share paralogs with FCAR: view

Variants for FCAR Gene

Sequence variations from dbSNP and Humsavar for FCAR Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000259878 -- 54,885,844(+) G/C intron_variant
rs1000280412 -- 54,881,770(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000294146 -- 54,876,464(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000319943 -- 54,876,344(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000364978 -- 54,881,369(+) C/A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FCAR Gene

Variant ID Type Subtype PubMed ID
dgv438n27 CNV gain 19166990
dgv6580n54 CNV gain 21841781
esv2667609 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv3644820 CNV loss 21293372
nsv428372 CNV gain+loss 18775914
nsv469656 CNV loss 16826518
nsv471706 CNV loss 15918152
nsv520644 CNV loss 19592680
nsv833880 CNV loss 17160897

Variation tolerance for FCAR Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCAR Gene

Human Gene Mutation Database (HGMD)
FCAR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCAR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCAR Gene

Disorders for FCAR Gene

MalaCards: The human disease database

(1) MalaCards diseases for FCAR Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
iga glomerulonephritis
  • igan
- elite association - COSMIC cancer census association via MalaCards
Search FCAR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FCAR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FCAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCAR Gene

Publications for FCAR Gene

  1. Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients. (PMID: 17033823) Watanabe A … Ra C (Immunogenetics 2006) 3 22 44 58
  2. Are single nucleotide polymorphisms of the immunoglobulin A Fc receptor gene associated with allergic asthma? (PMID: 15564774) Jasek M … Kuśnierczyk P (International archives of allergy and immunology 2004) 3 22 44 58
  3. IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells. (PMID: 9367406) Toyabe S … Abo T (Clinical and experimental immunology 1997) 3 4 22 58
  4. Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages. (PMID: 8666819) Patry C … Monteiro RC (Journal of immunology (Baltimore, Md. : 1950) 1996) 3 4 22 58
  5. Structure of the gene for the human myeloid IgA Fc receptor (CD89). (PMID: 7636188) de Wit TP … van de Winkel JG (Journal of immunology (Baltimore, Md. : 1950) 1995) 3 4 22 58

Products for FCAR Gene

Sources for FCAR Gene

Content
Loading form....