Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction d... See more...

Aliases for FBXW9 Gene

Aliases for FBXW9 Gene

  • F-Box And WD Repeat Domain Containing 9 2 3 5
  • F-Box And WD-40 Domain-Containing Protein 9 3 4
  • F-Box/WD Repeat-Containing Protein 9 3 4
  • F-Box And WD-40 Domain Protein 9 2 3
  • MEC-15 2 3
  • Fbw9 2 3
  • F-Box And WD-40 Repeat Containing Protein 9 3
  • Specificity Factor For SCF Ubiquitin Ligase 3
  • MGC10870 2
  • FBXW9 5
  • FBW9 4

External Ids for FBXW9 Gene

Previous GeneCards Identifiers for FBXW9 Gene

  • GC19M012661
  • GC19M012662
  • GC19M012799
  • GC19M012372

Summaries for FBXW9 Gene

Entrez Gene Summary for FBXW9 Gene

  • Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXW9 Gene

FBXW9 (F-Box And WD Repeat Domain Containing 9) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Innate Immune System. An important paralog of this gene is FBXW7.

UniProtKB/Swiss-Prot Summary for FBXW9 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXW9 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXW9 Gene

Genomics for FBXW9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FBXW9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXW9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBXW9

Top Transcription factor binding sites by QIAGEN in the FBXW9 gene promoter:
  • c-Ets-1
  • C/EBPalpha
  • CHOP-10
  • E47
  • Egr-4
  • Evi-1
  • Nkx5-1
  • p53
  • Pax-3
  • Tal-1

Genomic Locations for FBXW9 Gene

Genomic Locations for FBXW9 Gene
chr19:12,688,053-12,696,900
(GRCh38/hg38)
Size:
8,848 bases
Orientation:
Minus strand
chr19:12,798,867-12,807,457
(GRCh37/hg19)
Size:
8,591 bases
Orientation:
Minus strand

Genomic View for FBXW9 Gene

Genes around FBXW9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW9 Gene

Proteins for FBXW9 Gene

  • Protein details for FBXW9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XUX1-FBXW9_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 9
    Protein Accession:
    Q5XUX1
    Secondary Accessions:
    • B3KVP7
    • Q9BT89

    Protein attributes for FBXW9 Gene

    Size:
    488 amino acids
    Molecular mass:
    54115 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXW9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW9 Gene

Post-translational modifications for FBXW9 Gene

  • Ubiquitination at Lys215
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXW9 Gene

No data available for DME Specific Peptides for FBXW9 Gene

Domains & Families for FBXW9 Gene

Gene Families for FBXW9 Gene

Suggested Antigen Peptide Sequences for FBXW9 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52949, highly similar to F-box/WD repeat protein 9 (B4DZ46_HUMAN)
  • F-box and WD-40 domain-containing protein 9 (FBXW9_HUMAN)
genes like me logo Genes that share domains with FBXW9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBXW9 Gene

Function for FBXW9 Gene

Molecular function for FBXW9 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXW9 Gene

Gene Ontology (GO) - Molecular Function for FBXW9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19159283
genes like me logo Genes that share ontologies with FBXW9: view
genes like me logo Genes that share phenotypes with FBXW9: view

Animal Models for FBXW9 Gene

MGI Knock Outs for FBXW9:
  • Fbxw9 Fbxw9<tm1a(EUCOMM)Wtsi>
  • Fbxw9 Fbxw9<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXW9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXW9 Gene

Localization for FBXW9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXW9 gene
Compartment Confidence
cytosol 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBXW9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0030687 preribosome, large subunit precursor IBA 21873635
GO:0070545 PeBoW complex IBA --
genes like me logo Genes that share ontologies with FBXW9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXW9 Gene

Pathways & Interactions for FBXW9 Gene

genes like me logo Genes that share pathways with FBXW9: view

Gene Ontology (GO) - Biological Process for FBXW9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0000460 maturation of 5.8S rRNA IBA --
GO:0000470 maturation of LSU-rRNA IBA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXW9: view

No data available for SIGNOR curated interactions for FBXW9 Gene

Drugs & Compounds for FBXW9 Gene

No Compound Related Data Available

Transcripts for FBXW9 Gene

mRNA/cDNA for FBXW9 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXW9

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for FBXW9 Gene

GeneLoc Exon Structure for
FBXW9

Expression for FBXW9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXW9 Gene

Protein differential expression in normal tissues from HIPED for FBXW9 Gene

This gene is overexpressed in Fetal Brain (23.9), Ovary (9.9), Tonsil (9.1), Frontal cortex (8.3), and Testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXW9 Gene



Protein tissue co-expression partners for FBXW9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBXW9

SOURCE GeneReport for Unigene cluster for FBXW9 Gene:

Hs.515154

Evidence on tissue expression from TISSUES for FBXW9 Gene

  • Liver(4)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with FBXW9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXW9 Gene

Orthologs for FBXW9 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXW9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FBXW9 30 31
  • 98.84 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FBXW9 30 31
  • 85.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FBXW9 30 31
  • 85.08 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fbxw9 30 17 31
  • 80.2 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fbxw9 30
  • 80.06 (n)
Oppossum
(Monodelphis domestica)
Mammalia FBXW9 31
  • 63 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FBXW9 31
  • 58 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FBXW9 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fbxw9 30
  • 60.29 (n)
Str.10743 30
Zebrafish
(Danio rerio)
Actinopterygii fbxw9 30 31
  • 58.48 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea mec-15 30 31
  • 41.75 (n)
OneToOne
Species where no ortholog for FBXW9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FBXW9 Gene

ENSEMBL:
Gene Tree for FBXW9 (if available)
TreeFam:
Gene Tree for FBXW9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXW9: view image

Paralogs for FBXW9 Gene

genes like me logo Genes that share paralogs with FBXW9: view

Variants for FBXW9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBXW9 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10424623 - p.Thr219Ala
rs6511833 - p.Arg70Lys

Additional dbSNP identifiers (rs#s) for FBXW9 Gene

Structural Variations from Database of Genomic Variants (DGV) for FBXW9 Gene

Variant ID Type Subtype PubMed ID
dgv138n111 CNV deletion 26073780
nsv1160586 CNV duplication 26073780
nsv953977 CNV deletion 24416366

Variation tolerance for FBXW9 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.96; 79.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXW9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXW9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW9 Gene

Disorders for FBXW9 Gene

No disorders were found for FBXW9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXW9 Gene

Publications for FBXW9 Gene

  1. The F-box protein MEC-15 (FBXW9) promotes synaptic transmission in GABAergic motor neurons in C. elegans. (PMID: 23527112) Sun Y … Dreier L (PloS one 2013) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J … Harper JW (Genes & development 2004) 3 4
  4. The ULK1-FBXW5-SEC23B nexus controls autophagy. (PMID: 30596474) Jeong YT … Pagano M (eLife 2018) 3
  5. Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases. (PMID: 29103612) Reitsma JM … Deshaies RJ (Cell 2017) 3

Products for FBXW9 Gene

Sources for FBXW9 Gene