F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conju... See more...

Aliases for FBXW2 Gene

Aliases for FBXW2 Gene

  • F-Box And WD Repeat Domain Containing 2 2 3 5
  • FBW2 2 3 4
  • F-Box And WD-40 Domain-Containing Protein 2 3 4
  • F-Box/WD Repeat-Containing Protein 2 3 4
  • F-Box And WD-40 Domain Protein 2 2 3
  • Fwd2 2 3
  • Md6 2 3
  • Protein MD6 4
  • FBXW2 5
  • FWD2 4

External Ids for FBXW2 Gene

Previous GeneCards Identifiers for FBXW2 Gene

  • GC09M114631
  • GC09M115160
  • GC09M116980
  • GC09M118902
  • GC09M120606
  • GC09M122566
  • GC09M123514
  • GC09M093137

Summaries for FBXW2 Gene

Entrez Gene Summary for FBXW2 Gene

  • F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXW2 Gene

FBXW2 (F-Box And WD Repeat Domain Containing 2) is a Protein Coding gene. Diseases associated with FBXW2 include Intestinal Botulism and Wound Botulism. Among its related pathways are Chaperonin-mediated protein folding and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot Summary for FBXW2 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Wiki entry for FBXW2 Gene

Additional gene information for FBXW2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXW2 Gene

Genomics for FBXW2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FBXW2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXW2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBXW2

Top Transcription factor binding sites by QIAGEN in the FBXW2 gene promoter:
  • AP-2gamma
  • Max1
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • Sox5
  • Sox9
  • SRY

Genomic Locations for FBXW2 Gene

Genomic Locations for FBXW2 Gene
chr9:120,751,978-120,793,440
(GRCh38/hg38)
Size:
41,463 bases
Orientation:
Minus strand
chr9:123,514,256-123,555,740
(GRCh37/hg19)
Size:
41,485 bases
Orientation:
Minus strand

Genomic View for FBXW2 Gene

Genes around FBXW2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW2 Gene

Proteins for FBXW2 Gene

  • Protein details for FBXW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT8-FBXW2_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 2
    Protein Accession:
    Q9UKT8
    Secondary Accessions:
    • B3KRL8
    • Q4VXH2
    • Q7Z4V6
    • Q8WV51
    • Q9HA09
    • Q9UKA3

    Protein attributes for FBXW2 Gene

    Size:
    454 amino acids
    Molecular mass:
    51512 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=AAF04465.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF13226.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAP97276.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAP97280.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXW2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW2 Gene

Post-translational modifications for FBXW2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXW2 Gene

Domains & Families for FBXW2 Gene

Gene Families for FBXW2 Gene

Suggested Antigen Peptide Sequences for FBXW2 Gene

GenScript: Design optimal peptide antigens:
  • Protein MD6 (FBXW2_HUMAN)
genes like me logo Genes that share domains with FBXW2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBXW2 Gene

Function for FBXW2 Gene

Molecular function for FBXW2 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXW2 Gene

Gene Ontology (GO) - Molecular Function for FBXW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 10531035
GO:0005515 protein binding IEA,IPI 11238952
genes like me logo Genes that share ontologies with FBXW2: view
genes like me logo Genes that share phenotypes with FBXW2: view

Animal Models for FBXW2 Gene

MGI Knock Outs for FBXW2:
  • Fbxw2 Fbxw2<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for FBXW2 Gene

miRTarBase miRNAs that target FBXW2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXW2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXW2 Gene

Localization for FBXW2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXW2 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBXW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXW2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXW2 Gene

Pathways & Interactions for FBXW2 Gene

genes like me logo Genes that share pathways with FBXW2: view

Gene Ontology (GO) - Biological Process for FBXW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006464 cellular protein modification process TAS 10531035
GO:0006508 proteolysis TAS 10531035
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXW2: view

No data available for SIGNOR curated interactions for FBXW2 Gene

Drugs & Compounds for FBXW2 Gene

No Compound Related Data Available

Transcripts for FBXW2 Gene

mRNA/cDNA for FBXW2 Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXW2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: - -
SP10:
SP11: -
SP12:

Relevant External Links for FBXW2 Gene

GeneLoc Exon Structure for
FBXW2

Expression for FBXW2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXW2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXW2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.2), Testis (10.1), Breast (8.3), Salivary gland (8.1), Blymphocyte (7.0), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXW2 Gene



Protein tissue co-expression partners for FBXW2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBXW2

SOURCE GeneReport for Unigene cluster for FBXW2 Gene:

Hs.494985

Evidence on tissue expression from TISSUES for FBXW2 Gene

  • Nervous system(4.8)
  • Lung(4.5)
  • Skin(2.8)
  • Muscle(2.4)
  • Heart(2.3)
  • Intestine(2.2)
  • Blood(2.2)
  • Kidney(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with FBXW2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXW2 Gene

Orthologs for FBXW2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXW2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FBXW2 30 31
  • 99.71 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FBXW2 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FBXW2 30 31
  • 96.55 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 96 (a)
OneToMany
-- 31
  • 92 (a)
OneToMany
-- 31
  • 9 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Fbxw2 30 17 31
  • 95.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fbxw2 30
  • 95.23 (n)
Cow
(Bos Taurus)
Mammalia FBXW2 30 31
  • 95.15 (n)
OneToOne
Chicken
(Gallus gallus)
Aves FBXW2 30 31
  • 84.65 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FBXW2 31
  • 92 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fbxw2 30
  • 78.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia fbxw2-prov 30
Zebrafish
(Danio rerio)
Actinopterygii fbxw2 30 31
  • 71.81 (n)
OneToOne
Dr.7935 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2865 30
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET30 31
  • 18 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7775 31
  • 19 (a)
ManyToMany
Species where no ortholog for FBXW2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FBXW2 Gene

ENSEMBL:
Gene Tree for FBXW2 (if available)
TreeFam:
Gene Tree for FBXW2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXW2: view image

Paralogs for FBXW2 Gene

(3) SIMAP similar genes for FBXW2 Gene using alignment to 3 proteins:

  • FBXW2_HUMAN
  • L8EAL9_HUMAN
  • Q4VXH1_HUMAN

Pseudogenes.org Pseudogenes for FBXW2 Gene

genes like me logo Genes that share paralogs with FBXW2: view

No data available for Paralogs for FBXW2 Gene

Variants for FBXW2 Gene

Additional dbSNP identifiers (rs#s) for FBXW2 Gene

Structural Variations from Database of Genomic Variants (DGV) for FBXW2 Gene

Variant ID Type Subtype PubMed ID
nsv517321 CNV loss 19592680
nsv526071 CNV loss 19592680
nsv7434 OTHER inversion 18451855
nsv950935 CNV duplication 24416366

Variation tolerance for FBXW2 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXW2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXW2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBXW2 Gene

Disorders for FBXW2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for FBXW2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intestinal botulism
  • intestinal colonization botulism
wound botulism
  • cutaneous infectious botulism
acute laryngopharyngitis
frontometaphyseal dysplasia 2
  • fmd2
neurotic disorder
  • depressive neurosis
- elite association - COSMIC cancer census association via MalaCards
Search FBXW2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with FBXW2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXW2 Gene

Publications for FBXW2 Gene

  1. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PMID: 10828603) Chiaur DS … Pagano M (Cytogenetics and cell genetics 2000) 2 3 23
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4
  3. Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. (PMID: 18703417) Chiang MH … Chen H (Biology of reproduction 2008) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. A family of mammalian F-box proteins. (PMID: 10531037) Winston JT … Harper JW (Current biology : CB 1999) 3 4

Products for FBXW2 Gene

Sources for FBXW2 Gene