This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-... See more...

Aliases for FBXW11 Gene

Aliases for FBXW11 Gene

  • F-Box And WD Repeat Domain Containing 11 2 3 5
  • F-Box And WD Repeats Protein Beta-TrCP2 3 4
  • F-Box/WD Repeat-Containing Protein 11 3 4
  • F-Box/WD Repeat-Containing Protein 1B 3 4
  • F-Box And WD-40 Domain Protein 11 2 3
  • F-Box And WD-40 Domain Protein 1B 2 3
  • Homologous To Slimb Protein 3 4
  • FBXW1B 3 4
  • BTRCP2 3 4
  • FBW1B 3 4
  • Beta-Transducin Repeat-Containing Protein 2 3
  • F-Box Protein Fbw1b 3
  • KIAA0696 4
  • BTRC2 3
  • Fbw11 3
  • Hos 3
  • HOS 4

External Ids for FBXW11 Gene

Previous HGNC Symbols for FBXW11 Gene

  • FBXW1B

Previous GeneCards Identifiers for FBXW11 Gene

  • GC05M171270
  • GC05M171221
  • GC05M166384
  • GC05M171288

Summaries for FBXW11 Gene

Entrez Gene Summary for FBXW11 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXW11 Gene

FBXW11 (F-Box And WD Repeat Domain Containing 11) is a Protein Coding gene. Diseases associated with FBXW11 include Human Immunodeficiency Virus Type 1 and Holoprosencephaly 11. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and Human cytomegalovirus infection. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and protein dimerization activity. An important paralog of this gene is BTRC.

UniProtKB/Swiss-Prot Summary for FBXW11 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262).
  • (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

Gene Wiki entry for FBXW11 Gene

Additional gene information for FBXW11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXW11 Gene

Genomics for FBXW11 Gene

GeneHancer (GH) Regulatory Elements for FBXW11 Gene

Promoters and enhancers for FBXW11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXW11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBXW11

Top Transcription factor binding sites by QIAGEN in the FBXW11 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • En-1
  • FOXL1
  • FOXO1
  • FOXO1a
  • HFH-3
  • YY1

Genomic Locations for FBXW11 Gene

Genomic Locations for FBXW11 Gene
chr5:171,861,549-172,006,873
(GRCh38/hg38)
Size:
145,325 bases
Orientation:
Minus strand
chr5:171,288,553-171,433,877
(GRCh37/hg19)
Size:
145,325 bases
Orientation:
Minus strand

Genomic View for FBXW11 Gene

Genes around FBXW11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW11 Gene

Proteins for FBXW11 Gene

  • Protein details for FBXW11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKB1-FBW1B_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 11
    Protein Accession:
    Q9UKB1
    Secondary Accessions:
    • B2RC98
    • Q9P2S8
    • Q9P2S9
    • Q9Y4C6

    Protein attributes for FBXW11 Gene

    Size:
    542 amino acids
    Molecular mass:
    62091 Da
    Quaternary structure:
    • Self-associates. Component of the SCF(FBXW11) complex formed of CUL1, SKP1, RBX1 and a FBXW11 dimer. Interacts with BTRC, BST2, PER1, RCAN1 and USP47. Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1, PER1 and PER2; the interaction requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. Interacts with TRIM21. Interacts with PER3. Interacts with phosphorylated ubiquitination substrate CEP68 (PubMed:25503564). Interacts with INAVA (PubMed:29420262). Interacts with REST (PubMed:18354482).
    SequenceCaution:
    • Sequence=BAA31671.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXW11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW11 Gene

Post-translational modifications for FBXW11 Gene

  • Ubiquitination at Lys179
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FBXW11 Gene

Domains & Families for FBXW11 Gene

Gene Families for FBXW11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FBXW11 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54601, highly similar to F-box/WD repeat protein 11 (B4DH70_HUMAN)
  • Homologous to Slimb protein (FBW1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UKB1

UniProtKB/Swiss-Prot:

FBW1B_HUMAN :
  • The N-terminal D domain mediates homodimerization.
Domain:
  • The N-terminal D domain mediates homodimerization.
genes like me logo Genes that share domains with FBXW11: view

Function for FBXW11 Gene

Molecular function for FBXW11 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.
UniProtKB/Swiss-Prot Induction:
Expression is negatively regulated by Wnt/beta-catenin pathway.

Phenotypes From GWAS Catalog for FBXW11 Gene

Gene Ontology (GO) - Molecular Function for FBXW11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA,NAS 10531035
GO:0005515 protein binding IEA,IPI 12482991
GO:0046983 protein dimerization activity IEA --
GO:0061630 contributes_to ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with FBXW11: view
genes like me logo Genes that share phenotypes with FBXW11: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXW11 Gene

Localization for FBXW11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXW11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXW11 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FBXW11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXW11: view

Pathways & Interactions for FBXW11 Gene

PathCards logo

SuperPathways for FBXW11 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 CDK-mediated phosphorylation and removal of Cdc6
3 Cell cycle Role of SCF complex in cell cycle regulation
.40
.40
.34
.33
4 Class I MHC mediated antigen processing and presentation
5 Regulation of PLK1 Activity at G2/M Transition
genes like me logo Genes that share pathways with FBXW11: view

Pathways by source for FBXW11 Gene

5 GeneGo (Thomson Reuters) pathways for FBXW11 Gene
  • Cell cycle ESR1 regulation of G1/S transition
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Immune response MIF-JAB1 signaling
  • Proteolysis_Putative ubiquitin pathway

SIGNOR curated interactions for FBXW11 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for FBXW11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination IDA,TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006470 protein dephosphorylation ISS --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with FBXW11: view

Drugs & Compounds for FBXW11 Gene

No Compound Related Data Available

Transcripts for FBXW11 Gene

mRNA/cDNA for FBXW11 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6: - -
SP7: - - -

Relevant External Links for FBXW11 Gene

GeneLoc Exon Structure for
FBXW11

Expression for FBXW11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXW11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXW11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.6), Retina (21.0), and Testis (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXW11 Gene



Protein tissue co-expression partners for FBXW11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBXW11

SOURCE GeneReport for Unigene cluster for FBXW11 Gene:

Hs.484138

Evidence on tissue expression from TISSUES for FBXW11 Gene

  • Nervous system(4.8)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with FBXW11: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXW11 Gene

Orthologs for FBXW11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXW11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXW11 31 30
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FBXW11 31 30
  • 96.49 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXW11 31
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXW11 31
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXW11 31 30
  • 93.23 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxw11 17 31 30
  • 92.31 (n)
chicken
(Gallus gallus)
Aves FBXW11 31 30
  • 84.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXW11 31
  • 99 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fbxw11a 31
  • 87 (a)
OneToMany
fbxw11b 31 30
  • 75.98 (n)
OneToMany
fbxw1b 30
fruit fly
(Drosophila melanogaster)
Insecta slmb 31
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-23 31 30
  • 61.57 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET30 31
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8954 31
  • 63 (a)
OneToMany
Species where no ortholog for FBXW11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FBXW11 Gene

ENSEMBL:
Gene Tree for FBXW11 (if available)
TreeFam:
Gene Tree for FBXW11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXW11: view image

Paralogs for FBXW11 Gene

(6) SIMAP similar genes for FBXW11 Gene using alignment to 5 proteins:

  • FBW1B_HUMAN
  • B4DH70_HUMAN
  • E5RG78_HUMAN
  • E5RGC1_HUMAN
  • E5RH92_HUMAN

Pseudogenes.org Pseudogenes for FBXW11 Gene

genes like me logo Genes that share paralogs with FBXW11: view

Variants for FBXW11 Gene

Additional dbSNP identifiers (rs#s) for FBXW11 Gene

Structural Variations from Database of Genomic Variants (DGV) for FBXW11 Gene

Variant ID Type Subtype PubMed ID
esv2762568 CNV loss 21179565
esv3326841 CNV insertion 20981092
esv3607585 CNV loss 21293372
nsv1020999 CNV gain 25217958
nsv328032 CNV deletion 16902084

Variation tolerance for FBXW11 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXW11 Gene

Human Gene Mutation Database (HGMD)
FBXW11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXW11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBXW11 Gene

Disorders for FBXW11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FBXW11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
holoprosencephaly 11
  • hpe11
holoprosencephaly
  • holoprosencephaly sequence
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FBXW11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FBXW11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXW11 Gene

Publications for FBXW11 Gene

  1. Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1. (PMID: 10694485) Koike J … Katoh M (Biochemical and biophysical research communications 2000) 2 3 4 54
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 54
  3. HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. (PMID: 10321728) Fuchs SY … Ronai Z (Oncogene 1999) 3 4 23 54
  4. C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. (PMID: 29420262) Mohanan V … Xavier RJ (Science (New York, N.Y.) 2018) 3 4 54
  5. The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival. (PMID: 19966869) Peschiaroli A … Melino G (Oncogene 2010) 3 4 54

Products for FBXW11 Gene