Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction ... See more...

Aliases for FBXW10 Gene

Aliases for FBXW10 Gene

  • F-Box And WD Repeat Domain Containing 10 2 3 5
  • F-Box/WD Repeat-Containing Protein 10 3 4
  • F-Box And WD-40 Domain Protein 10 2 3
  • SM2SH2 2 3
  • Fbw10 2 3
  • HREP 2 3
  • F-Box And WD-40 Domain-Containing Protein 10 4
  • Chromosome 17 Open Reading Frame 1A 2
  • Ubiquitin Ligase Specificity Factor 3
  • Ubiquitin Ligase-Specificity Factor 4
  • Testicular Tissue Protein Li 69 3
  • SM25H2 3
  • FBXW10 5

External Ids for FBXW10 Gene

Previous HGNC Symbols for FBXW10 Gene

  • C17orf1
  • C17orf1A

Previous GeneCards Identifiers for FBXW10 Gene

  • GC17P018589
  • GC17P018647
  • GC17P018230
  • GC17P018747
  • GC17P018740
  • GC17P018832

Summaries for FBXW10 Gene

Entrez Gene Summary for FBXW10 Gene

  • Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXW10 Gene

FBXW10 (F-Box And WD Repeat Domain Containing 10) is a Protein Coding gene. Diseases associated with FBXW10 include Hereditary Neuropathies and Failure Of Tooth Eruption, Primary. Among its related pathways are Innate Immune System and Metabolism of proteins. An important paralog of this gene is CDRT1.

UniProtKB/Swiss-Prot Summary for FBXW10 Gene

  • Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.

Gene Wiki entry for FBXW10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXW10 Gene

Genomics for FBXW10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FBXW10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J018744 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 258.9 +1.7 1678 3.4 ZFP64 KDM6A THAP11 RAD51 FOXA2 SAP130 RARA RXRB NR2F6 GATAD2A FBXW10 TVP23B SHMT1 SMCR8 piR-55985-077
GH17J018697 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 8.7 -45.9 -45923 1.4 ZBTB10 SIX5 ZNF217 ELF1 THAP11 GABPA HCFC1 SAP130 KMT2B GABPB1 TRIM16L lnc-FBXW10-3 FBXW10 piR-55985-076
GH17J018699 Promoter 0.3 EPDnew 8.7 -44.8 -44843 0.1 TRIM16L lnc-FBXW10-3 FBXW10 piR-55985-076
GH17J018740 Enhancer 0.2 dbSUPER 11.6 -2.6 -2566 1 TVP23B FBXW10 MK280144-257 TRIM16L
GH17J018721 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 0.3 -21.6 -21623 1.2 ZNF316 NFE2 SMARCE1 DPF2 ZBTB8A MAFK PRDM10 EMSY TRIM16L MK280144-257 ENSG00000265693 FBXW10 lnc-FBXW10-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXW10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBXW10

Top Transcription factor binding sites by QIAGEN in the FBXW10 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • FOXO1
  • FOXO1a
  • HNF-4alpha1
  • HNF-4alpha2
  • MyoD

Genomic Locations for FBXW10 Gene

Latest Assembly
chr17:18,744,024-18,779,349
(GRCh38/hg38)
Size:
35,326 bases
Orientation:
Plus strand

Previous Assembly
chr17:18,647,367-18,682,662
(GRCh37/hg19 by Entrez Gene)
Size:
35,296 bases
Orientation:
Plus strand

chr17:18,647,326-18,682,662
(GRCh37/hg19 by Ensembl)
Size:
35,337 bases
Orientation:
Plus strand

Genomic View for FBXW10 Gene

Genes around FBXW10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXW10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXW10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXW10 Gene

Proteins for FBXW10 Gene

  • Protein details for FBXW10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XX13-FBW10_HUMAN
    Recommended name:
    F-box/WD repeat-containing protein 10
    Protein Accession:
    Q5XX13
    Secondary Accessions:
    • C9JRY8
    • C9JZD7
    • Q8TC00
    • Q9H0F0

    Protein attributes for FBXW10 Gene

    Size:
    1052 amino acids
    Molecular mass:
    119846 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FBXW10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXW10 Gene

Post-translational modifications for FBXW10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXW10 Gene

Domains & Families for FBXW10 Gene

Gene Families for FBXW10 Gene

Suggested Antigen Peptide Sequences for FBXW10 Gene

GenScript: Design optimal peptide antigens:
  • Ubiquitin ligase-specificity factor (FBW10_HUMAN)
genes like me logo Genes that share domains with FBXW10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBXW10 Gene

Function for FBXW10 Gene

Molecular function for FBXW10 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.
UniProtKB/Swiss-Prot Induction:
By disease-causing laminin A mutants also inducing CBX5 and CBX1 proteasomal degradation.

Phenotypes From GWAS Catalog for FBXW10 Gene

Gene Ontology (GO) - Molecular Function for FBXW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FBXW10: view
genes like me logo Genes that share phenotypes with FBXW10: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXW10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXW10 Gene

Localization for FBXW10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXW10 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBXW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXW10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXW10 Gene

Pathways & Interactions for FBXW10 Gene

genes like me logo Genes that share pathways with FBXW10: view

Gene Ontology (GO) - Biological Process for FBXW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXW10: view

No data available for SIGNOR curated interactions for FBXW10 Gene

Drugs & Compounds for FBXW10 Gene

No Compound Related Data Available

Transcripts for FBXW10 Gene

mRNA/cDNA for FBXW10 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXW10

Alternative Splicing Database (ASD) splice patterns (SP) for FBXW10 Gene

No ASD Table

Relevant External Links for FBXW10 Gene

GeneLoc Exon Structure for
FBXW10

Expression for FBXW10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXW10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXW10 Gene

This gene is overexpressed in Testis (x19.8).

Protein differential expression in normal tissues from HIPED for FBXW10 Gene

This gene is overexpressed in NK cells (43.8), Breast (15.1), and Spinal cord (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXW10 Gene



Protein tissue co-expression partners for FBXW10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBXW10

SOURCE GeneReport for Unigene cluster for FBXW10 Gene:

Hs.592128
genes like me logo Genes that share expression patterns with FBXW10: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXW10 Gene

Orthologs for FBXW10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXW10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FBXW10 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FBXW10 30
  • 83.35 (n)
-- 31
  • 76 (a)
OneToMany
-- 31
  • 11 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Fbxw10 30 17 31
  • 79.1 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fbxw10 30
  • 78.7 (n)
Cow
(Bos Taurus)
Mammalia FBXW10 30
  • 78.66 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 42 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 32 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 36 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fbxw10 30
  • 55.41 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC563998 30
  • 52.79 (n)
fbxw10 31
  • 26 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP46 31
  • 17 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2090 31
  • 8 (a)
OneToMany
Species where no ortholog for FBXW10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FBXW10 Gene

ENSEMBL:
Gene Tree for FBXW10 (if available)
TreeFam:
Gene Tree for FBXW10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXW10: view image

Paralogs for FBXW10 Gene

Paralogs for FBXW10 Gene

(2) SIMAP similar genes for FBXW10 Gene using alignment to 2 proteins:

  • FBW10_HUMAN
  • J3QLH9_HUMAN
genes like me logo Genes that share paralogs with FBXW10: view

Variants for FBXW10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBXW10 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs17852531 Benign: not provided 18,749,875(+) G/T
NM_001267585.2(FBXW10):c.824G>T (p.Arg275Leu)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs1026259 - p.Ala821Thr
rs11544711 - p.Ile23Asn
rs7209610 - p.Arg372Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FBXW10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FBXW10 Gene

Variant ID Type Subtype PubMed ID
dgv564e214 CNV gain 21293372
nsv1055999 CNV gain 25217958
nsv1057803 CNV loss 25217958
nsv1063354 CNV gain 25217958
nsv1123098 CNV deletion 24896259
nsv1131302 CNV deletion 24896259
nsv499818 OTHER inversion 21111241
nsv523721 CNV gain 19592680
nsv833389 CNV gain 17160897
nsv9504 CNV gain+loss 18304495
nsv960431 CNV duplication 23825009
nsv962279 CNV duplication 23825009

Variation tolerance for FBXW10 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.06; 97.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXW10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXW10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXW10 Gene

Disorders for FBXW10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FBXW10 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hereditary neuropathies
  • neuropathy - hereditary
failure of tooth eruption, primary
  • pfe
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FBXW10

genes like me logo Genes that share disorders with FBXW10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXW10 Gene

Publications for FBXW10 Gene

  1. Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. (PMID: 20498703) Chaturvedi P … Parnaik VK (PloS one 2010) 3 4
  2. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J … Harper JW (Genes & development 2004) 3 4
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4
  4. FBXW10 promotes hepatocarcinogenesis in male patients and mice. (PMID: 31400758) Luo YD … Xie CM (Carcinogenesis 2020) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3

Products for FBXW10 Gene

Sources for FBXW10 Gene