Aliases for FBXW10 Gene
External Ids for FBXW10 Gene
Previous HGNC Symbols for FBXW10 Gene
Previous GeneCards Identifiers for FBXW10 Gene
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXW10 Gene
FBXW10 (F-Box And WD Repeat Domain Containing 10) is a Protein Coding gene. Diseases associated with FBXW10 include Hereditary Neuropathies and Failure Of Tooth Eruption, Primary. Among its related pathways are Innate Immune System and Metabolism of proteins. An important paralog of this gene is CDRT1.
UniProtKB/Swiss-Prot Summary for FBXW10 Gene
Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.