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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]
FBXO9 (F-Box Protein 9) is a Protein Coding gene. Diseases associated with FBXO9 include Epilepsy, Myoclonic Juvenile. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | NAS | 10531035 |
GO:0005515 | protein binding | IPI | 22632967 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000151 | ubiquitin ligase complex | NAS | 10531035 |
GO:0005737 | cytoplasm | IBA,IDA | 23263282 |
GO:0005829 | cytosol | TAS | -- |
GO:0019005 | SCF ubiquitin ligase complex | IDA | 23263282 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Innate Immune System |
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|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0016567 | protein ubiquitination | NAS | 10531035 |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IDA | 23263282 |
GO:0032006 | regulation of TOR signaling | IMP | 23263282 |
GO:0043687 | post-translational protein modification | TAS | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FBXO9 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FBXO9 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FBXO9 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fbxo9 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Fbxo9 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FBXO9 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | FBXO9 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FBXO9 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fbxo9 30 |
|
||
MGC75727 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | fbxo9-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fbxo9 30 31 |
|
OneToOne | |
wufc79g12 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.856 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006784 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5961 30 31 32 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HRT3 31 33 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
epilepsy, myoclonic juvenile |
|
|