Aliases for FBXO8 Gene
External Ids for FBXO8 Gene
Previous GeneCards Identifiers for FBXO8 Gene
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBXO8 Gene
FBXO8 (F-Box Protein 8) is a Protein Coding gene. Diseases associated with FBXO8 include Arthrogryposis, Distal, Type 10 and Cardiomyopathy, Familial Hypertrophic, 17. Among its related pathways are Arf6 signaling events. Gene Ontology (GO) annotations related to this gene include ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is IQSEC1.
UniProtKB/Swiss-Prot Summary for FBXO8 Gene
May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).