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FBXO8 Gene(Protein Coding)

F-Box Protein 8

GCID:
GC04M174236
GIFtS:
43
Genes Participants
UDN Logo

Aliases for FBXO8 Gene

Aliases for FBXO8 Gene

  • F-Box Protein 8 2 3 5
  • F-Box/SEC7 Protein FBS 3 4
  • F-Box Only Protein 8 2 3
  • FBX8 3 4
  • FBS 3 4
  • F-Box Protein Fbx8 3
  • DC10 3

External Ids for FBXO8 Gene

Previous GeneCards Identifiers for FBXO8 Gene

  • GC04M176077
  • GC04M175695
  • GC04M175742
  • GC04M175853
  • GC04M175532
  • GC04M175394
  • GC04M175157
  • GC04M170904

Summaries for FBXO8 Gene

Entrez Gene Summary for FBXO8 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO8 Gene

FBXO8 (F-Box Protein 8) is a Protein Coding gene. Among its related pathways are Arf6 signaling events. Gene Ontology (GO) annotations related to this gene include ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is IQSEC2.

UniProtKB/Swiss-Prot for FBXO8 Gene

  • May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).

Additional gene information for FBXO8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO8 Gene

Genomics for FBXO8 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for FBXO8 Gene

Promoters and enhancers for FBXO8 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I174281 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.5 500 3.5 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 CEP44 FBXO8
GH04I173369 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.1 +913.2 913163 4.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LOC105377540 SAP30 HMGB2 ENSG00000248774 SCRG1 CEP44 FBXO8 LOC101928383 GC04M173250
GH04I174217 Enhancer 1.1 FANTOM5 Ensembl ENCODE 10.9 +66.2 66170 1.8 PKNOX1 SUZ12 ZNF335 ZFHX2 GLIS2 POLR2A ZNF692 GLIS1 PRDM10 RCOR1 CEP44 FBXO8 LINC02268 ENSG00000251213
GH04I174423 Enhancer 1.1 Ensembl ENCODE 10.5 -139.3 -139321 1.2 PKNOX1 ATF1 SMAD1 ARNT SIN3A NCOA2 TCF12 ZNF766 GATA2 ARID2 MIR4276 CEP44 FBXO8 ENSG00000261646 LINC02268 ENSG00000249875
GH04I173366 Enhancer 0.9 Ensembl ENCODE 9.1 +916.6 916598 1.6 JUN JUNB CBFA2T3 DPF2 BATF ATF2 IRF4 CHAMP1 FOSL1 ZNF217 HMGB2 ENSG00000248774 SCRG1 RNU6-1096P CEP44 FBXO8 LOC105377540 SAP30 GC04P173358 GC04M173250
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXO8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO8 gene promoter:

Genomic Locations for FBXO8 Gene

Genomic Locations for FBXO8 Gene
chr4:174,236,658-174,284,264
(GRCh38/hg38)
Size:
47,607 bases
Orientation:
Minus strand
chr4:175,157,809-175,205,415
(GRCh37/hg19)

Genomic View for FBXO8 Gene

Genes around FBXO8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FBXO8 Gene

Proteins for FBXO8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FBXO8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRD0-FBX8_HUMAN
    Recommended name:
    F-box only protein 8
    Protein Accession:
    Q9NRD0
    Secondary Accessions:
    • B2RB40
    • D3DP41
    • G5E9Z0
    • Q6UWN4
    • Q8IWE1
    • Q9NRP5
    • Q9UKC4

    Protein attributes for FBXO8 Gene

    Size:
    319 amino acids
    Molecular mass:
    37068 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF04517.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO8 Gene

Protein Expression for FBXO8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FBXO8 Gene

No Post-translational modifications

Other Protein References for FBXO8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO8 Gene

Domains & Families for FBXO8 Gene

Gene Families for FBXO8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO8: view

No data available for UniProtKB/Swiss-Prot for FBXO8 Gene

Function for FBXO8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for FBXO8 Gene

UniProtKB/Swiss-Prot Function:
May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).

Phenotypes From GWAS Catalog for FBXO8 Gene

Gene Ontology (GO) - Molecular Function for FBXO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005086 ARF guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with FBXO8: view
genes like me logo Genes that share phenotypes with FBXO8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO8 Gene

Localization for FBXO8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO8 gene
Compartment Confidence
nucleus 3
cytosol 3
peroxisome 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FBXO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10945468
genes like me logo Genes that share ontologies with FBXO8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO8 Gene

Pathways & Interactions for FBXO8 Gene

SuperPathways for FBXO8 Gene

PathCards logo More details on SuperPathways for FBXO8
SuperPathway Contained pathways
1 Arf6 signaling events
Arf6 signaling events
-
genes like me logo Genes that share pathways with FBXO8: view

Pathways by source for FBXO8 Gene

1 BioSystems pathway for FBXO8 Gene

Gene Ontology (GO) - Biological Process for FBXO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process NAS 10945468
GO:0032012 regulation of ARF protein signal transduction IEA --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with FBXO8: view

No data available for SIGNOR curated interactions for FBXO8 Gene

Drugs & Compounds for FBXO8 Gene

Products:

  1. Drug

(1) Drugs for FBXO8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with FBXO8: view

Transcripts for FBXO8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FBXO8 Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(217) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO8 Gene

F-box protein 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2:
SP3: - -
SP4:
SP5: - - -

Relevant External Links for FBXO8 Gene

GeneLoc Exon Structure for
FBXO8
ECgene alternative splicing isoforms for
FBXO8

Expression for FBXO8 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO8 Gene

mRNA expression in normal human tissues for FBXO8 Gene
mRNA expression by GTEx for FBXO8 GenemRNA expression by BioGPS for FBXO8 Gene

Protein differential expression in normal tissues from HIPED for FBXO8 Gene

This gene is overexpressed in Bone (54.8) and Breast (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO8 Gene



Protein tissue co-expression partners for FBXO8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO8 Gene:

FBXO8

SOURCE GeneReport for Unigene cluster for FBXO8 Gene:

Hs.76917

Evidence on tissue expression from TISSUES for FBXO8 Gene

  • Spleen(4.5)
  • Nervous system(4.5)
  • Lymph node(4.4)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with FBXO8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO8 Gene

Orthologs for FBXO8 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FBXO8 33 34
  • 99.58 (n)
dog
(Canis familiaris)
 Mammalia FBXO8 33 34
  • 95.19 (n)
cow
(Bos Taurus)
 Mammalia FBXO8 33 34
  • 93.31 (n)
mouse
(Mus musculus)
 Mammalia Fbxo8 33 16 34
  • 92.16 (n)
rat
(Rattus norvegicus)
 Mammalia Fbxo8 33
  • 91.85 (n)
oppossum
(Monodelphis domestica)
 Mammalia FBXO8 34
  • 77 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia FBXO8 34
  • 74 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FBXO8 33 34
  • 86.42 (n)
lizard
(Anolis carolinensis)
 Reptilia FBXO8 34
  • 94 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fbxo8 33
  • 76.27 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.18650 33
zebrafish
(Danio rerio)
 Actinopterygii fbxo8 33 34
  • 70.55 (n)
worm
(Caenorhabditis elegans)
 Secernentea M02B7.5 34
  • 10 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.8763 34
  • 51 (a)
 OneToOne
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.713 33
Species where no ortholog for FBXO8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO8 Gene

ENSEMBL:
Gene Tree for FBXO8 (if available)
TreeFam:
Gene Tree for FBXO8 (if available)

Paralogs for FBXO8 Gene

Paralogs for FBXO8 Gene

(2) SIMAP similar genes for FBXO8 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FBXO8: view

Variants for FBXO8 Gene

Sequence variations from dbSNP and Humsavar for FBXO8 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
VAR_036157 A breast cancer sample p.Leu269Ile
rs1000010769 -- 174,247,624(-) A/T intron_variant
rs1000102645 -- 174,268,240(-) CT/ genic_upstream_transcript_variant, intron_variant
rs1000133072 -- 174,247,261(-) T/C intron_variant
rs1000200614 -- 174,254,192(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO8 Gene

Variant ID Type Subtype PubMed ID
nsv596234 CNV gain 21841781
nsv480020 CNV novel sequence insertion 20440878
nsv479066 CNV novel sequence insertion 20440878
esv2728766 CNV deletion 23290073
esv2123340 CNV deletion 18987734

Variation tolerance for FBXO8 Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO8 Gene

Disorders for FBXO8 Gene

Additional Disease Information for FBXO8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FBXO8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO8 Gene

Publications for FBXO8 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 58
  2. Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S … Hardiman O (European journal of human genetics : EJHG 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for FBXO8 Gene

Sources for FBXO8 Gene

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