This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing... See more...

Aliases for FBXO5 Gene

Aliases for FBXO5 Gene

  • F-Box Protein 5 2 3 5
  • F-Box Only Protein 5 2 3 4
  • EMI1 2 3 4
  • FBX5 2 3 4
  • Early Mitotic Inhibitor 1 3 4
  • Fbxo31 2 3
  • F-Box Protein Fbx5 3
  • FBXO5 5

External Ids for FBXO5 Gene

Previous GeneCards Identifiers for FBXO5 Gene

  • GC06M152852
  • GC06M153186
  • GC06M153322
  • GC06M153383
  • GC06M153333
  • GC06M153291
  • GC06M150854

Summaries for FBXO5 Gene

Entrez Gene Summary for FBXO5 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

GeneCards Summary for FBXO5 Gene

FBXO5 (F-Box Protein 5) is a Protein Coding gene. Diseases associated with FBXO5 include Ovarian Clear Cell Carcinoma. Among its related pathways are Cell cycle_Role of APC in cell cycle regulation and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is FBXO43.

UniProtKB/Swiss-Prot Summary for FBXO5 Gene

  • Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:29875408, PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase (PubMed:29875408). Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment (PubMed:29875408). As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities (PubMed:23708605, PubMed:23708001, PubMed:16921029). Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence (PubMed:17234884, PubMed:17485488, PubMed:17875940). During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (By similarity). Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (By similarity). Promotes migration and osteogenic differentiation of mesenchymal stem cells (PubMed:29850565).

Gene Wiki entry for FBXO5 Gene

Additional gene information for FBXO5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXO5 Gene

Genomics for FBXO5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FBXO5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J152978 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 648.1 +1.1 1119 6.9 SP1 HNRNPL CREB1 PRDM10 ZNF629 TFE3 LEF1 IKZF1 KDM1A POLR2A FBXO5 ENSG00000227627 piR-40310 MTRF1L lnc-MTRF1L-3 VIP
GH06J153786 Enhancer 0.8 Ensembl ENCODE 41.9 -803.8 -803757 1.5 ZNF140 JUND ZBTB26 ZNF266 ZNF623 ZBTB11 ZNF213 ZNF202 ZC3H11A JUN FBXO5 SCAF8 RGS17 RPL27AP6 piR-57461-220 RF00026-981 RNU6-896P OPRM1
GH06J152559 Enhancer 0.6 Ensembl 29.2 +424.4 424378 0.4 ZNF341 ZNF140 ZNF266 ZNF623 ZBTB11 AEBP2 ZNF213 ZC3H11A ZFP64 ZNF433 FBXO5 SYNE1 RGS17 RPL27AP6 VIP NANOGP11 lnc-MYCT1-2 ESR1
GH06J152093 Enhancer 0.9 ENCODE 19.4 +887.5 887504 4.5 CREB1 PRDM10 ZNF629 ZNF692 JUND PRDM1 ZIC2 ZSCAN4 PATZ1 ZNF501 FBXO5 HSPA8P15 ZBTB2 ENSG00000287914 ENSG00000284615 NONHSAG045166.2 ESR1 SYNE1
GH06J152306 Enhancer 0.9 Ensembl ENCODE 16.2 +677.6 677578 1.6 GATAD2A RCOR2 RXRB IRF2 SP1 FOXK2 SOX13 ZNF140 FOXA1 FOXA2 FBXO5 HSPA8P15 RGS17 SYNE1 RF00001-292 RF00017-5880 ESR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXO5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBXO5

Top Transcription factor binding sites by QIAGEN in the FBXO5 gene promoter:
  • COUP
  • E47
  • HNF-3beta
  • HNF-4alpha1
  • p53
  • Tal-1

Genomic Locations for FBXO5 Gene

Genomic Locations for FBXO5 Gene
chr6:152,970,519-152,983,579
(GRCh38/hg38)
Size:
13,061 bases
Orientation:
Minus strand
chr6:153,291,658-153,304,740
(GRCh37/hg19)
Size:
13,083 bases
Orientation:
Minus strand

Genomic View for FBXO5 Gene

Genes around FBXO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO5 Gene

Proteins for FBXO5 Gene

  • Protein details for FBXO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT4-FBX5_HUMAN
    Recommended name:
    F-box only protein 5
    Protein Accession:
    Q9UKT4
    Secondary Accessions:
    • B3KNX5
    • Q5TF47
    • Q8WV29
    • Q9UGC8

    Protein attributes for FBXO5 Gene

    Size:
    447 amino acids
    Molecular mass:
    50146 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with BTRC; mediates proteolysis by the SCF ubiquitin ligase complex leading to activation of APC in late mitosis and subsequent mitotic progression (PubMed:12791267). Interacts with FZR1/CDH1 and the N-terminal substrate-binding domain of CDC20; prevents APC activation (PubMed:11988738). Also interacts with EVI5 which blocks its phosphorylation by PLK1 and prevents its subsequent binding to BTRC and degradation (PubMed:16439210). Interacts simultaneously with anaphase promoting complex (APC), through at least ANAPC2, CDC23, CDC27, the APC substrate GMNN and the APC activator FZR1 (PubMed:23708001, PubMed:26083744). Interacts with UBE2S; interferes with the activity of UBE2S mainly by disrupting the dynamic electrostatic association between the C-terminal tail of UBE2S and ANAPC2 (PubMed:23708001). Interacts with RPS6KA2; cooperates to induce the metaphase arrest of early blastomeres; increases and stabilizes interaction of FBXO5 with CDC20 (By similarity).

    Three dimensional structures from OCA and Proteopedia for FBXO5 Gene

    Alternative splice isoforms for FBXO5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO5 Gene

Post-translational modifications for FBXO5 Gene

  • Phosphorylation by CDK2 and subsequently by PLK1 triggers degradation during early mitosis through ubiquitin-mediated proteolysis by the SCF ubiquitin ligase complex containing the F-box protein BTRC. This degradation is necessary for the activation of APC in late mitosis and subsequent mitotic progression (PubMed:12791267, PubMed:15469984). Phosphorylated by RPS6KA2; increases and stabilizes interaction with CDC20 (By similarity).
  • Ubiquitinated by the SCF(BTRC) complex following phosphorylation by PLK1 (PubMed:15469984). Undergoes both 'Lys-11' and 'Lys-48'-linked polyubiquitination by APC-FZR1 complex leading to degradation by proteasome during G1 phase (PubMed:29875408). Degraded through the SCF(BTRC) complex; degradation occurs during oocyte maturation, between germinal vesicle breakdown (GVBD) and meiosis I, and is required for the meiosis I-meiosis II transition (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO5 Gene

Domains & Families for FBXO5 Gene

Gene Families for FBXO5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO5 Gene

GenScript: Design optimal peptide antigens:
  • Early mitotic inhibitor 1 (FBX5_HUMAN)
  • F-box protein 5, isoform CRA_b (Q5TF47_HUMAN)
genes like me logo Genes that share domains with FBXO5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBXO5 Gene

Function for FBXO5 Gene

Molecular function for FBXO5 Gene

UniProtKB/Swiss-Prot Function:
Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:29875408, PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase (PubMed:29875408). Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment (PubMed:29875408). As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities (PubMed:23708605, PubMed:23708001, PubMed:16921029). Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence (PubMed:17234884, PubMed:17485488, PubMed:17875940). During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (By similarity). Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (By similarity). Promotes migration and osteogenic differentiation of mesenchymal stem cells (PubMed:29850565).
UniProtKB/Swiss-Prot Induction:
Up-regulated at 7 days after osteogenic induction (PubMed:29850565). Down-regulated in late G2 phase or mitosis (PubMed:17485488). Down-regulated in G2 phase after DNA damage in a CDKN1A-dependent manner (PubMed:19211842). Down-regulated in G1 phase when APC-FZR1 complex is active and accumulates at the G1-S transition, coincident with the inactivation of APC-FZR1 complex (PubMed:29875408). At the G1-S transition, transcriptionally induced by the E2F transcription factor (PubMed:11988738).

Phenotypes From GWAS Catalog for FBXO5 Gene

Gene Ontology (GO) - Molecular Function for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11988738
GO:0010997 anaphase-promoting complex binding IDA 16921029
GO:0019901 protein kinase binding IPI 15148369
GO:0046872 metal ion binding IEA --
GO:1990948 ubiquitin ligase inhibitor activity IDA 15148369
genes like me logo Genes that share ontologies with FBXO5: view
genes like me logo Genes that share phenotypes with FBXO5: view

Animal Models for FBXO5 Gene

MGI Knock Outs for FBXO5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO5 Gene

Localization for FBXO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO5 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration (PubMed:11988738). In mitotic cells, localizes throughout the cell, particularly at the spindle (PubMed:15469984). {ECO:0000269 PubMed:11988738, ECO:0000269 PubMed:15469984}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
mitochondrion 3
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 11988738
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 11988738
GO:0005819 spindle IEA,IDA 15469984
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXO5: view

Pathways & Interactions for FBXO5 Gene

genes like me logo Genes that share pathways with FBXO5: view

Pathways by source for FBXO5 Gene

1 KEGG pathway for FBXO5 Gene
2 GeneGo (Thomson Reuters) pathways for FBXO5 Gene
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Cell cycle_Role of APC in cell cycle regulation

UniProtKB/Swiss-Prot Q9UKT4-FBX5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for FBXO5 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FBXO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0001556 oocyte maturation IEA --
GO:0006275 regulation of DNA replication IMP 17234884
GO:0007049 cell cycle IEA --
GO:0007057 spindle assembly involved in female meiosis I IEA --
genes like me logo Genes that share ontologies with FBXO5: view

Drugs & Compounds for FBXO5 Gene

No Compound Related Data Available

Transcripts for FBXO5 Gene

mRNA/cDNA for FBXO5 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO5

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO5 Gene

No ASD Table

Relevant External Links for FBXO5 Gene

GeneLoc Exon Structure for
FBXO5

Expression for FBXO5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXO5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXO5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBXO5

SOURCE GeneReport for Unigene cluster for FBXO5 Gene:

Hs.520506

Evidence on tissue expression from TISSUES for FBXO5 Gene

  • Nervous system(2.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with FBXO5: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO5 Gene

Orthologs for FBXO5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FBXO5 30 31
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FBXO5 30 31
  • 86.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FBXO5 31
  • 81 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Fbxo5 30 17 31
  • 75.69 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fbxo5 30
  • 73.78 (n)
Oppossum
(Monodelphis domestica)
Mammalia FBXO5 31
  • 64 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 55 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
Chicken
(Gallus gallus)
Aves FBXO5 30 31
  • 62.17 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FBXO5 31
  • 46 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fbxo5 30
  • 56.31 (n)
Zebrafish
(Danio rerio)
Actinopterygii fbxo5 30 31
  • 46.37 (n)
OneToOne
Species where no ortholog for FBXO5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FBXO5 Gene

ENSEMBL:
Gene Tree for FBXO5 (if available)
TreeFam:
Gene Tree for FBXO5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXO5: view image

Paralogs for FBXO5 Gene

Paralogs for FBXO5 Gene

genes like me logo Genes that share paralogs with FBXO5: view

Variants for FBXO5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBXO5 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs2073260 - p.Gln107Glu
rs7763565 - p.Leu164Phe

Additional dbSNP identifiers (rs#s) for FBXO5 Gene

Structural Variations from Database of Genomic Variants (DGV) for FBXO5 Gene

Variant ID Type Subtype PubMed ID
esv24301 CNV gain 19812545
nsv1150330 CNV insertion 26484159

Variation tolerance for FBXO5 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO5 Gene

Disorders for FBXO5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXO5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian clear cell carcinoma
  • clear-cell ovarian carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search FBXO5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FBXO5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FBXO5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO5 Gene

Publications for FBXO5 Gene

  1. Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. (PMID: 15148369) Moshe Y … Hershko A (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 23
  2. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). (PMID: 11988738) Hsu JY … Jackson PK (Nature cell biology 2002) 3 4 23
  3. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4
  4. Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells. (PMID: 29850565) Liu L … Tang C (BioMed research international 2018) 3 4
  5. EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle. (PMID: 29875408) Cappell SD … Meyer T (Nature 2018) 3 4

Products for FBXO5 Gene

Sources for FBXO5 Gene