Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction ... See more...

Aliases for FBXO46 Gene

Aliases for FBXO46 Gene

  • F-Box Protein 46 2 3 5
  • F-Box Only Protein 34-Like 2 4
  • F-Box Only Protein 46 3 4
  • FBXO34L 3 4
  • 20D7-FC4 3
  • Fbx46 3
  • FBX46 4

External Ids for FBXO46 Gene

Previous HGNC Symbols for FBXO46 Gene

  • FBXO34L

Previous GeneCards Identifiers for FBXO46 Gene

  • GC19M050906
  • GC19M046213
  • GC19M042642

Summaries for FBXO46 Gene

Entrez Gene Summary for FBXO46 Gene

  • Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO46 Gene

FBXO46 (F-Box Protein 46) is a Protein Coding gene. An important paralog of this gene is FBXO34.

UniProtKB/Swiss-Prot Summary for FBXO46 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXO46 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXO46 Gene

Genomics for FBXO46 Gene

GeneHancer (GH) Regulatory Elements for FBXO46 Gene

Promoters and enhancers for FBXO46 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXO46 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO46 gene promoter:
  • AML1a
  • Arnt
  • c-Myb
  • CUTL1
  • GATA-1
  • Pax-5
  • RREB-1
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for FBXO46 Gene

Genomic Locations for FBXO46 Gene
chr19:45,710,629-45,730,896
(GRCh38/hg38)
Size:
20,268 bases
Orientation:
Minus strand
chr19:46,213,887-46,234,162
(GRCh37/hg19)
Size:
20,276 bases
Orientation:
Minus strand

Genomic View for FBXO46 Gene

Genes around FBXO46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO46 Gene

Proteins for FBXO46 Gene

  • Protein details for FBXO46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJ61-FBX46_HUMAN
    Recommended name:
    F-box only protein 46
    Protein Accession:
    Q6PJ61

    Protein attributes for FBXO46 Gene

    Size:
    603 amino acids
    Molecular mass:
    64631 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=AAH21978.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH21978.1; Type=Erroneous termination; Positions=604; Note=Translated as stop.; Evidence={ECO:0000305};

neXtProt entry for FBXO46 Gene

Post-translational modifications for FBXO46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO46 Gene

No data available for DME Specific Peptides for FBXO46 Gene

Domains & Families for FBXO46 Gene

Gene Families for FBXO46 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO46 Gene

Suggested Antigen Peptide Sequences for FBXO46 Gene

GenScript: Design optimal peptide antigens:
  • F-box only protein 34-like (FBX46_HUMAN)
genes like me logo Genes that share domains with FBXO46: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBXO46 Gene

Function for FBXO46 Gene

Molecular function for FBXO46 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXO46 Gene

Gene Ontology (GO) - Molecular Function for FBXO46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19159283
genes like me logo Genes that share ontologies with FBXO46: view
genes like me logo Genes that share phenotypes with FBXO46: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO46

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO46 Gene

Localization for FBXO46 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO46 gene
Compartment Confidence
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO46 Gene

Pathways & Interactions for FBXO46 Gene

PathCards logo

SuperPathways for FBXO46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXO46 Gene

Drugs & Compounds for FBXO46 Gene

No Compound Related Data Available

Transcripts for FBXO46 Gene

mRNA/cDNA for FBXO46 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO46

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO46 Gene

No ASD Table

Relevant External Links for FBXO46 Gene

GeneLoc Exon Structure for
FBXO46
ECgene alternative splicing isoforms for
FBXO46

Expression for FBXO46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO46 Gene

Protein differential expression in normal tissues from HIPED for FBXO46 Gene

This gene is overexpressed in Fetal Liver (31.9) and Blymphocyte (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXO46 Gene



Protein tissue co-expression partners for FBXO46 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO46 Gene:

FBXO46

SOURCE GeneReport for Unigene cluster for FBXO46 Gene:

Hs.128702
genes like me logo Genes that share expression patterns with FBXO46: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO46 Gene

Orthologs for FBXO46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO46 33 32
  • 98.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO46 33 32
  • 88.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO46 32
  • 88.68 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo46 32
  • 84.26 (n)
mouse
(Mus musculus)
Mammalia Fbxo46 17 33 32
  • 83.59 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXO46 33
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO46 33
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12966 32
zebrafish
(Danio rerio)
Actinopterygii si:dkey-114g7.4 32
  • 59.18 (n)
FBXO46 33
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10603 33
  • 17 (a)
OneToMany
Species where no ortholog for FBXO46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO46 Gene

ENSEMBL:
Gene Tree for FBXO46 (if available)
TreeFam:
Gene Tree for FBXO46 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXO46: view image

Paralogs for FBXO46 Gene

Paralogs for FBXO46 Gene

genes like me logo Genes that share paralogs with FBXO46: view

Variants for FBXO46 Gene

Sequence variations from dbSNP and Humsavar for FBXO46 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000000521 -- 45,731,355(-) CACCCAGGC/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000011890 -- 45,730,054(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000033077 -- 45,731,034(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000079599 -- 45,723,978(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000569308 -- 45,725,768(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO46 Gene

Variant ID Type Subtype PubMed ID
esv22434 CNV loss 19812545
esv3556466 CNV deletion 23714750
nsv579870 CNV loss 21841781

Variation tolerance for FBXO46 Gene

Residual Variation Intolerance Score: 9.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO46 Gene

Disorders for FBXO46 Gene

Additional Disease Information for FBXO46

No disorders were found for FBXO46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO46 Gene

Publications for FBXO46 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  2. Six transcripts map within 200 kilobases of the myotonic dystrophy expanded repeat. (PMID: 9585442) Alwazzan M … Brook JD (Mammalian genome : official journal of the International Mammalian Genome Society 1998) 2 3 56
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56
  4. The SCFFBXO46 ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. (PMID: 30171069) Choppara S … Santra MK (The Journal of biological chemistry 2018) 3 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for FBXO46 Gene

Sources for FBXO46 Gene