Aliases for FBXO43 Gene
External Ids for FBXO43 Gene
Previous GeneCards Identifiers for FBXO43 Gene
Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXO43 Gene
FBXO43 (F-Box Protein 43) is a Protein Coding gene. Diseases associated with FBXO43 include Myeloproliferative Syndrome, Transient. Among its related pathways are Oocyte meiosis. An important paralog of this gene is FBXO5.
UniProtKB/Swiss-Prot for FBXO43 Gene
Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).