Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein inter... See more...

Aliases for FBXO42 Gene

Aliases for FBXO42 Gene

  • F-Box Protein 42 2 3 5
  • Just One F-Box And Kelch Domain-Containing Protein 3 4
  • F-Box Only Protein 42 3 4
  • JFK 3 4
  • KIAA1332 4
  • Fbx42 3
  • FBX42 4

External Ids for FBXO42 Gene

Previous GeneCards Identifiers for FBXO42 Gene

  • GC01M015956
  • GC01M016321
  • GC01M016445
  • GC01M016575
  • GC01M016577
  • GC01M015093
  • GC01M016580
  • GC01M016582
  • GC01M016584
  • GC01M016593
  • GC01M016603
  • GC01M016612
  • GC01M016620

Summaries for FBXO42 Gene

Entrez Gene Summary for FBXO42 Gene

  • Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]

GeneCards Summary for FBXO42 Gene

FBXO42 (F-Box Protein 42) is a Protein Coding gene. An important paralog of this gene is HCFC1.

UniProtKB/Swiss-Prot Summary for FBXO42 Gene

  • Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.

Additional gene information for FBXO42 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXO42 Gene

Genomics for FBXO42 Gene

GeneHancer (GH) Regulatory Elements for FBXO42 Gene

Promoters and enhancers for FBXO42 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXO42 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO42 gene promoter:
  • AML1a
  • CREB
  • GATA-1
  • MZF-1
  • POU2F1
  • POU2F1a
  • STAT1
  • STAT1alpha
  • STAT1beta
  • ZIC2

Genomic Locations for FBXO42 Gene

Genomic Locations for FBXO42 Gene
chr1:16,246,840-16,352,491
(GRCh38/hg38)
Size:
105,652 bases
Orientation:
Minus strand
chr1:16,573,334-16,678,949
(GRCh37/hg19)
Size:
105,616 bases
Orientation:
Minus strand

Genomic View for FBXO42 Gene

Genes around FBXO42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO42 Gene

Proteins for FBXO42 Gene

  • Protein details for FBXO42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3S6-FBX42_HUMAN
    Recommended name:
    F-box only protein 42
    Protein Accession:
    Q6P3S6
    Secondary Accessions:
    • B3KP30
    • Q5TEU8
    • Q86XI0
    • Q8N3N4
    • Q8N5F8
    • Q9BRM0
    • Q9P2L4

    Protein attributes for FBXO42 Gene

    Size:
    717 amino acids
    Molecular mass:
    77839 Da
    Quaternary structure:
    • Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct.

neXtProt entry for FBXO42 Gene

Post-translational modifications for FBXO42 Gene

  • Glycosylation at Asn274
  • Ubiquitination at Lys564
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FBX42_HUMAN (2039)

Other Protein References for FBXO42 Gene

Antibody Products

  • Abcam antibodies for FBXO42
  • Santa Cruz Biotechnology (SCBT) Antibodies for FBXO42

No data available for DME Specific Peptides for FBXO42 Gene

Domains & Families for FBXO42 Gene

Gene Families for FBXO42 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO42 Gene

Suggested Antigen Peptide Sequences for FBXO42 Gene

GenScript: Design optimal peptide antigens:
  • Just one F-box and Kelch domain-containing protein (FBX42_HUMAN)
genes like me logo Genes that share domains with FBXO42: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBXO42 Gene

Function for FBXO42 Gene

Molecular function for FBXO42 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.

Phenotypes From GWAS Catalog for FBXO42 Gene

Gene Ontology (GO) - Molecular Function for FBXO42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25609649
genes like me logo Genes that share ontologies with FBXO42: view
genes like me logo Genes that share phenotypes with FBXO42: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO42

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO42 Gene

Localization for FBXO42 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO42 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO42 Gene

Pathways & Interactions for FBXO42 Gene

PathCards logo

SuperPathways for FBXO42 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO42 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXO42 Gene

Drugs & Compounds for FBXO42 Gene

No Compound Related Data Available

Transcripts for FBXO42 Gene

mRNA/cDNA for FBXO42 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO42

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO42 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - -
SP8:
SP9:
SP10: - -
SP11: - - -
SP12: - -
SP13:

ExUns: 11b ^ 12 ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FBXO42 Gene

GeneLoc Exon Structure for
FBXO42
ECgene alternative splicing isoforms for
FBXO42

Expression for FBXO42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO42 Gene

Protein differential expression in normal tissues from HIPED for FBXO42 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.1), Fetal Brain (16.0), and Placenta (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXO42 Gene



Protein tissue co-expression partners for FBXO42 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO42 Gene:

FBXO42

SOURCE GeneReport for Unigene cluster for FBXO42 Gene:

Hs.522384

Evidence on tissue expression from TISSUES for FBXO42 Gene

  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with FBXO42: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO42 Gene

Orthologs for FBXO42 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO42 33 32
  • 99.81 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO42 33 32
  • 93.49 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 93 (a)
OneToMany
-- 33
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fbxo42 32
  • 91.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO42 33
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo42 17 33 32
  • 88.8 (n)
cow
(Bos Taurus)
Mammalia FBXO42 33 32
  • 87.59 (n)
OneToOne
chicken
(Gallus gallus)
Aves FBXO42 33 32
  • 80.35 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO42 33
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo42 32
  • 69.68 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5343 32
zebrafish
(Danio rerio)
Actinopterygii fbxo42 33 32
  • 69.06 (n)
OneToOne
Dr.24223 32
fruit fly
(Drosophila melanogaster)
Insecta CG6758 33
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y50D7A.1 33
  • 21 (a)
OneToOne
Species where no ortholog for FBXO42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO42 Gene

ENSEMBL:
Gene Tree for FBXO42 (if available)
TreeFam:
Gene Tree for FBXO42 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXO42: view image

Paralogs for FBXO42 Gene

Paralogs for FBXO42 Gene

genes like me logo Genes that share paralogs with FBXO42: view

Variants for FBXO42 Gene

Sequence variations from dbSNP and Humsavar for FBXO42 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000008027 -- 16,292,254(-) A/T intron_variant
rs1000042450 -- 16,295,870(-) G/A intron_variant
rs1000048001 -- 16,317,002(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000099011 -- 16,308,115(-) A/C/G intron_variant
rs1000142923 -- 16,260,240(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO42 Gene

Variant ID Type Subtype PubMed ID
dgv18e212 CNV gain 25503493
esv1036042 CNV insertion 17803354
esv2618916 CNV deletion 19546169
esv2667137 CNV deletion 23128226
esv3577750 CNV loss 25503493
esv3585334 CNV gain 21293372
esv3585336 CNV loss 21293372
nsv1113081 CNV deletion 24896259
nsv3520 CNV insertion 18451855
nsv545641 CNV loss 21841781
nsv545642 CNV loss 21841781
nsv833869 CNV loss 17160897
nsv947414 CNV duplication 23825009

Variation tolerance for FBXO42 Gene

Residual Variation Intolerance Score: 5.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.12; 75.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO42 Gene

Disorders for FBXO42 Gene

Additional Disease Information for FBXO42

No disorders were found for FBXO42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO42 Gene

Publications for FBXO42 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 56
  2. JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. (PMID: 19509332) Sun L … Shang Y (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 56
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for FBXO42 Gene

Sources for FBXO42 Gene