Aliases for FBXO42 Gene
External Ids for FBXO42 Gene
Previous GeneCards Identifiers for FBXO42 Gene
Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]
GeneCards Summary for FBXO42 Gene
FBXO42 (F-Box Protein 42) is a Protein Coding gene. Diseases associated with FBXO42 include Desmoid Disease, Hereditary and Parkinson Disease 15, Autosomal Recessive Early-Onset. An important paralog of this gene is HCFC1.
UniProtKB/Swiss-Prot Summary for FBXO42 Gene
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.