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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
FBXO4 (F-Box Protein 4) is a Protein Coding gene. Diseases associated with FBXO4 include Adult Brain Stem Glioma. Among its related pathways are Ubiquitin mediated proteolysis and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ubiquitin-protein transferase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | IDA | 10531035 |
GO:0005515 | protein binding | IEA,IPI | 16278047 |
GO:0042803 | protein homodimerization activity | IPI | 20181953 |
GO:0061630 | ubiquitin protein ligase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000151 | ubiquitin ligase complex | IDA | 10531035 |
GO:0005737 | cytoplasm | IDA | 21378169 |
GO:0005829 | cytosol | TAS | -- |
GO:0019005 | SCF ubiquitin ligase complex | IEA,IDA | 20181953 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Chaperonin-mediated protein folding |
.94
|
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3 | Ubiquitin mediated proteolysis | ||
4 | Innate Immune System |
.61
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|
5 | Metabolism of proteins |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000209 | protein polyubiquitination | IDA,TAS | -- |
GO:0000723 | telomere maintenance | IMP | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IDA | -- |
GO:0007568 | aging | IEA | -- |
GO:0010608 | posttranscriptional regulation of gene expression | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||
SP6: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FBXO4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FBXO4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FBXO4 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fbxo4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Fbxo4 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FBXO4 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FBXO4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FBXO4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FBXO4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fbxo4 30 |
|
||
Str.20453 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.24187 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-46a10.2 30 |
|
||
FBXO4 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2231917 | Esophagus cancer samples |
p.Ser8Arg |
|||
VAR_063501 | Esophagus cancer sample |
p.Ser12Leu |
|||
VAR_063502 | Esophagus cancer sample |
p.Pro13Ser |
|||
VAR_063503 | Esophagus cancer samples |
p.Leu23Gln |
|||
VAR_063504 | Esophagus cancer samples |
p.Pro76Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1096e214 | CNV | gain | 21293372 |
esv2762518 | CNV | loss | 21179565 |
esv3604851 | CNV | gain | 21293372 |
nsv830272 | CNV | gain | 17160897 |
nsv830273 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
adult brain stem glioma |
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