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Aliases for FBXO36 Gene

Aliases for FBXO36 Gene

  • F-Box Protein 36 2 3 5
  • F-Box Only Protein 36 2 3 4
  • Fbx36 3
  • FBX36 4

External Ids for FBXO36 Gene

Previous GeneCards Identifiers for FBXO36 Gene

  • GC02P230989
  • GC02P230612
  • GC02P230495
  • GC02P230787
  • GC02P222626

Summaries for FBXO36 Gene

Entrez Gene Summary for FBXO36 Gene

  • Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO36 Gene

FBXO36 (F-Box Protein 36) is a Protein Coding gene. An important paralog of this gene is EFCAB8.

UniProtKB/Swiss-Prot for FBXO36 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXO36 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO36 Gene

Genomics for FBXO36 Gene

GeneHancer (GH) Regulatory Elements for FBXO36 Gene

Promoters and enhancers for FBXO36 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J229919 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 609.3 -0.6 -621 4.6 SP1 ZFX CC2D1A ELF3 MNT ZNF148 NKRF MLLT1 CEBPG RERE FBXO36 TRIP12 RNU6-613P
GH02J230755 Promoter/Enhancer 1.3 Ensembl ENCODE 13.1 +835.3 835262 4.5 MLLT1 CEBPG ZNF680 ZNF547 IKZF1 ZBTB8A PRDM10 IKZF2 PRDM12 CEBPA NCL FBXO36 SLC16A14 CAB39 ENSG00000235419 RNU6-451P RNU6-268P GC02P230779
GH02J229872 Enhancer 0.7 Ensembl 15.8 -49.0 -49001 1.8 IKZF1 BACH1 IKZF2 TRIM22 PKNOX1 DPF2 ELF1 BMI1 HDGF NBN FBXO36 RNU6-613P TRIP12 PIR44053
GH02J230222 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 4.3 +303.4 303371 6.3 NKRF POLR2A ZNF687 RELA CREM MLLT1 ZNF384 ZNF644 IKZF1 CREB1 SP140 SP110 RNU6-451P ENSG00000225963 FBXO36
GH02J229715 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 4.6 -207.5 -207501 2 ELF3 PRDM1 GLIS2 HMG20B RXRA ZNF600 PRDM10 REST RXRB CTCF DNER TRIP12 ENSG00000235419 FBXO36 PIR44053
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXO36 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO36 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Nkx2-5
  • PPAR-gamma1
  • PPAR-gamma2
  • Sox5

Genomic Locations for FBXO36 Gene

Genomic Locations for FBXO36 Gene
90,818 bases
Plus strand
90,808 bases
Plus strand

Genomic View for FBXO36 Gene

Genes around FBXO36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO36 Gene

Proteins for FBXO36 Gene

  • Protein details for FBXO36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 36
    Protein Accession:
    Secondary Accessions:
    • B3KVQ6
    • Q53TE6
    • Q8WWD4

    Protein attributes for FBXO36 Gene

    188 amino acids
    Molecular mass:
    22105 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXO36 Gene


neXtProt entry for FBXO36 Gene

Post-translational modifications for FBXO36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO36 Gene

No data available for DME Specific Peptides for FBXO36 Gene

Domains & Families for FBXO36 Gene

Gene Families for FBXO36 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO36 Gene


Suggested Antigen Peptide Sequences for FBXO36 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ41090 fis, clone ASTRO2003960, highly similar to F-box only protein 36 (B3KVQ6_HUMAN)
  • F-box only protein 36 (FBX36_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO36: view

No data available for UniProtKB/Swiss-Prot for FBXO36 Gene

Function for FBXO36 Gene

Molecular function for FBXO36 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXO36 Gene

genes like me logo Genes that share phenotypes with FBXO36: view

Animal Models for FBXO36 Gene

MGI Knock Outs for FBXO36:
  • Fbxo36 Fbxo36<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO36

Clone Products

  • Applied Biological Materials (abm): Clones for FBXO36 - Now 50% OFF >
  • * FBXO36 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FBXO36 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO36 Gene

Localization for FBXO36 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO36 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO36 Gene

Pathways & Interactions for FBXO36 Gene

PathCards logo

SuperPathways for FBXO36 Gene

No Data Available

Interacting Proteins for FBXO36 Gene

Gene Ontology (GO) - Biological Process for FBXO36 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXO36 Gene

Drugs & Compounds for FBXO36 Gene

No Compound Related Data Available

Transcripts for FBXO36 Gene

mRNA/cDNA for FBXO36 Gene

Unigene Clusters for FBXO36 Gene

F-box protein 36:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO36

Clone Products

  • Applied Biological Materials (abm): Clones for FBXO36 - Now 50% OFF >
  • * FBXO36 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FBXO36 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - -

Relevant External Links for FBXO36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXO36 Gene

Protein tissue co-expression partners for FBXO36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO36 Gene:


SOURCE GeneReport for Unigene cluster for FBXO36 Gene:

genes like me logo Genes that share expression patterns with FBXO36: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO36 Gene

Orthologs for FBXO36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO36 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO36 35 34
  • 99.29 (n)
(Bos Taurus)
Mammalia FBXO36 35 34
  • 86.63 (n)
(Canis familiaris)
Mammalia FBXO36 35
  • 84 (a)
(Rattus norvegicus)
Mammalia Fbxo36 34
  • 82.23 (n)
(Mus musculus)
Mammalia Fbxo36 17 35 34
  • 82.08 (n)
(Monodelphis domestica)
Mammalia FBXO36 35
  • 67 (a)
(Anolis carolinensis)
Reptilia FBXO36 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo36 34
  • 64.46 (n)
Str.16790 34
(Danio rerio)
Actinopterygii fbxo36a 35 34
  • 58.9 (n)
fbxo36b 35
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
Species where no ortholog for FBXO36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO36 Gene

Gene Tree for FBXO36 (if available)
Gene Tree for FBXO36 (if available)
Evolutionary constrained regions (ECRs) for FBXO36: view image

Paralogs for FBXO36 Gene Pseudogenes for FBXO36 Gene

genes like me logo Genes that share paralogs with FBXO36: view

Variants for FBXO36 Gene

Sequence variations from dbSNP and Humsavar for FBXO36 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000003438 -- 229,962,896(+) C/G intron_variant
rs1000017238 -- 229,922,449(+) C/T upstream_transcript_variant
rs1000018466 -- 229,930,884(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000053425 -- 229,971,179(+) C/G intron_variant
rs1000082030 -- 230,007,270(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO36 Gene

Variant ID Type Subtype PubMed ID
dgv164e55 CNV gain 17911159
dgv4179n100 CNV gain 25217958
dgv7330n54 CNV gain 21841781
dgv7331n54 CNV loss 21841781
dgv7332n54 CNV loss 21841781
dgv7333n54 CNV loss 21841781
esv21790 CNV loss 19812545
esv2660647 CNV deletion 23128226
esv2675475 CNV deletion 23128226
esv2721590 CNV deletion 23290073
esv2751841 CNV gain 17911159
esv32933 CNV loss 17666407
esv3561128 CNV deletion 23714750
esv3575337 CNV gain 25503493
esv3584368 CNV loss 25503493
esv3594584 CNV loss 21293372
esv3594585 CNV gain 21293372
esv3594586 CNV loss 21293372
esv3594587 CNV loss 21293372
esv3594588 CNV loss 21293372
esv3594589 CNV gain 21293372
esv3594590 CNV loss 21293372
esv3594591 CNV loss 21293372
esv3594592 CNV gain 21293372
esv3594593 CNV loss 21293372
esv987544 CNV deletion 20482838
nsv1008431 CNV gain 25217958
nsv1138899 CNV deletion 24896259
nsv3201 CNV deletion 18451855
nsv460118 CNV gain 19166990
nsv584650 CNV gain 21841781

Variation tolerance for FBXO36 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.93; 83.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO36 Gene

Disorders for FBXO36 Gene

Additional Disease Information for FBXO36

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FBXO36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO36 Gene

Publications for FBXO36 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression. (PMID: 26087183) Tian X … Jiang Y (Oncotarget 2015) 3 58

Products for FBXO36 Gene

Sources for FBXO36 Gene

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