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Aliases for FBXO34 Gene

Aliases for FBXO34 Gene

  • F-Box Protein 34 2 3 5
  • F-Box Only Protein 34 2 3
  • Fbx34 3 4
  • Protein CGI-301 3
  • CGI-301 3

External Ids for FBXO34 Gene

Previous GeneCards Identifiers for FBXO34 Gene

  • GC14P049534
  • GC14P053728
  • GC14P054807
  • GC14P055738
  • GC14P035900

Summaries for FBXO34 Gene

Entrez Gene Summary for FBXO34 Gene

  • Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO34 Gene

FBXO34 (F-Box Protein 34) is a Protein Coding gene. An important paralog of this gene is FBXO46.

UniProtKB/Swiss-Prot for FBXO34 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXO34 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO34 Gene

Genomics for FBXO34 Gene

GeneHancer (GH) Regulatory Elements for FBXO34 Gene

Promoters and enhancers for FBXO34 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I055270 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.8 1830 4.9 HDGF FOXA2 PKNOX1 ARNT ARID4B NEUROD1 SIN3A FEZF1 ZNF2 ZBTB7B LOC105370509 FBXO34 LGALS3 ENSG00000259318 RPL34P28 GC14M054989
GH14I055113 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 -147.3 -147320 21.7 PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF766 FOS LGALS3 LOC105370509 GCH1 FBXO34 DLGAP5 ATG14 ENSG00000259318 MAPK1IP1L GC14M055058 GC14M055059
GH14I055301 Enhancer 1.2 FANTOM5 Ensembl ENCODE 12.7 +32.0 31998 4.2 CEBPG BATF FOSL1 PRDM10 FOSL2 NFE2 ZNF600 FOS RUNX3 SMARCE1 LOC105370509 FBXO34 ENSG00000259318 GCH1 LGALS3 MAPK1IP1L CHMP4BP1 ENSG00000258455 GC14M054989
GH14I055097 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.1 -167.9 -167899 12.7 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A LGALS3 LOC105370509 MAPK1IP1L ATG14 SOCS4 GCH1 DLGAP5 FBXO34 ENSG00000259318 GC14M055058
GH14I055297 Enhancer 0.8 Ensembl ENCODE 12 +27.0 26997 1 CTCF CHD1 JUNB BATF SREBF1 NFIC FOXK2 PRDM10 RUNX3 CHMP4BP1 LOC105370509 FBXO34 DLGAP5 ENSG00000259318 ENSG00000278818 GC14M054989
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXO34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO34 gene promoter:

Genomic Locations for FBXO34 Gene

Genomic Locations for FBXO34 Gene
90,616 bases
Plus strand

Genomic View for FBXO34 Gene

Genes around FBXO34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO34 Gene

Proteins for FBXO34 Gene

  • Protein details for FBXO34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 34
    Protein Accession:
    Secondary Accessions:
    • Q2VPB5
    • Q4VBP5
    • Q86TY4

    Protein attributes for FBXO34 Gene

    711 amino acids
    Molecular mass:
    78711 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    • Sequence=BAA91346.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD62596.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FBXO34 Gene

Post-translational modifications for FBXO34 Gene

No Post-translational modifications

No data available for DME Specific Peptides for FBXO34 Gene

Domains & Families for FBXO34 Gene

Gene Families for FBXO34 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO34 Gene

Suggested Antigen Peptide Sequences for FBXO34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO34: view

No data available for UniProtKB/Swiss-Prot for FBXO34 Gene

Function for FBXO34 Gene

Molecular function for FBXO34 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXO34 Gene

Gene Ontology (GO) - Molecular Function for FBXO34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FBXO34: view
genes like me logo Genes that share phenotypes with FBXO34: view

Animal Model Products

CRISPR Products

miRNA for FBXO34 Gene

miRTarBase miRNAs that target FBXO34

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO34 Gene

Localization for FBXO34 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO34 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO34 Gene

Pathways & Interactions for FBXO34 Gene

SuperPathways for FBXO34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO34 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXO34 Gene

Drugs & Compounds for FBXO34 Gene

No Compound Related Data Available

Transcripts for FBXO34 Gene

Unigene Clusters for FBXO34 Gene

F-box protein 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO34 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: -
SP5: - -

Relevant External Links for FBXO34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO34 Gene

Protein differential expression in normal tissues from HIPED for FBXO34 Gene

This gene is overexpressed in Islet of Langerhans (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO34 Gene

Protein tissue co-expression partners for FBXO34 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO34 Gene:


SOURCE GeneReport for Unigene cluster for FBXO34 Gene:


Evidence on tissue expression from TISSUES for FBXO34 Gene

  • Nervous system(3)
genes like me logo Genes that share expression patterns with FBXO34: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO34 Gene

Orthologs for FBXO34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO34 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO34 33 34
  • 99.58 (n)
(Canis familiaris)
Mammalia FBXO34 33 34
  • 87.92 (n)
(Bos Taurus)
Mammalia FBXO34 33 34
  • 87.62 (n)
(Rattus norvegicus)
Mammalia Fbxo34 33
  • 79.3 (n)
(Mus musculus)
Mammalia Fbxo34 33 16 34
  • 78.56 (n)
(Gallus gallus)
Aves FBXO34 33 34
  • 65.89 (n)
(Anolis carolinensis)
Reptilia FBXO34 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo34 33
  • 60.32 (n)
Str.14993 33
(Danio rerio)
Actinopterygii si:ch73-132g21.5 33
  • 50.29 (n)
FBXO34 34
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10603 34
  • 15 (a)
Species where no ortholog for FBXO34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO34 Gene

Gene Tree for FBXO34 (if available)
Gene Tree for FBXO34 (if available)

Paralogs for FBXO34 Gene

Paralogs for FBXO34 Gene

genes like me logo Genes that share paralogs with FBXO34: view

Variants for FBXO34 Gene

Sequence variations from dbSNP and Humsavar for FBXO34 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000028849 -- 55,280,247(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000078009 -- 55,324,354(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000125222 -- 55,285,874(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000139506 -- 55,324,612(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000150287 -- 55,270,779(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO34 Gene

Variant ID Type Subtype PubMed ID
nsv84773 CNV deletion 16902084
nsv512361 CNV loss 21212237
esv3634576 CNV loss 21293372
esv3551588 CNV deletion 23714750
esv3551587 CNV deletion 23714750
esv2748726 CNV deletion 23290073
esv2657865 CNV deletion 23128226
esv2657596 CNV deletion 23128226
esv1218411 CNV insertion 17803354

Variation tolerance for FBXO34 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO34 Gene

Disorders for FBXO34 Gene

Additional Disease Information for FBXO34

No disorders were found for FBXO34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO34 Gene

Publications for FBXO34 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression. (PMID: 26087183) Tian X … Jiang Y (Oncotarget 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for FBXO34 Gene

Sources for FBXO34 Gene

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