Aliases for FBXO32 Gene
External Ids for FBXO32 Gene
Previous GeneCards Identifiers for FBXO32 Gene
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
GeneCards Summary for FBXO32 Gene
FBXO32 (F-Box Protein 32) is a Protein Coding gene. Diseases associated with FBXO32 include Muscle Hypertrophy and Uremia. Among its related pathways are Class I MHC mediated antigen processing and presentation and FoxO signaling pathway. An important paralog of this gene is FBXO25.
UniProtKB/Swiss-Prot Summary for FBXO32 Gene
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.