Aliases for FBXO31 Gene
External Ids for FBXO31 Gene
Previous GeneCards Identifiers for FBXO31 Gene
This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for FBXO31 Gene
FBXO31 (F-Box Protein 31) is a Protein Coding gene. Diseases associated with FBXO31 include Mental Retardation, Autosomal Recessive 45 and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include cyclin binding. An important paralog of this gene is FBXO39.
UniProtKB/Swiss-Prot Summary for FBXO31 Gene
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.