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Aliases for FBXO27 Gene

Aliases for FBXO27 Gene

  • F-Box Protein 27 2 3 5
  • F-Box/G-Domain Protein 5 3 4
  • F-Box Only Protein 27 2 3
  • Fbx27 3 4
  • FBG5 3 4
  • F-Box Protein FBG5 3

External Ids for FBXO27 Gene

Previous GeneCards Identifiers for FBXO27 Gene

  • GC19M040127
  • GC19M039905
  • GC19M044190
  • GC19M044206
  • GC19M039516
  • GC19M035961
  • GC19M039483

Summaries for FBXO27 Gene

Entrez Gene Summary for FBXO27 Gene

  • Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO27 Gene

FBXO27 (F-Box Protein 27) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXO17.

UniProtKB/Swiss-Prot for FBXO27 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.

Additional gene information for FBXO27 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO27 Gene

Genomics for FBXO27 Gene

GeneHancer (GH) Regulatory Elements for FBXO27 Gene

Promoters and enhancers for FBXO27 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I039029 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 628.7 +0.7 742 4.4 HDGF PKNOX1 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZNF213 FBXO27 ENSG00000267992 HNRNPL RN7SL566P FBL PAK4 PLEKHG2 ENSG00000269688 PSMC4 RPS16
GH19I039038 Enhancer 0.8 Ensembl ENCODE 77.7 -5.6 -5615 0.4 CTCF ZNF654 SP3 ZNF189 CEBPB REST RAD21 YY1 CC2D1A ZFHX2 GC19M039038 FBXO27
GH19I039045 Enhancer 0.8 ENCODE 74.3 -13.5 -13477 1.4 HDAC1 PKNOX1 BMI1 ZBTB40 ZNF335 GATA2 ATF7 CREM SMARCA5 SP3 FBXO27 GC19M039038 GC19P039085
GH19I038974 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 24.8 +56.2 56224 4.5 FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 FBXO17 HNRNPL FBXO27 EID2B MED29 PAK4 ENSG00000267892 DPF1 ERVK9-11 PSMC4
GH19I039052 Enhancer 0.9 ENCODE 62.8 -20.7 -20708 2.3 MLX ZNF493 ZNF2 ZNF48 ZNF121 ZNF143 SP3 RXRA SP5 YY2 FBXO27 PAK4 NFKBIB SIRT2 FBXO17 GC19M039038 GC19P039085
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXO27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO27 gene promoter:

Genomic Locations for FBXO27 Gene

Genomic Locations for FBXO27 Gene
42,072 bases
Minus strand

Genomic View for FBXO27 Gene

Genes around FBXO27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO27 Gene

Proteins for FBXO27 Gene

  • Protein details for FBXO27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 27
    Protein Accession:
    Secondary Accessions:
    • Q96C87

    Protein attributes for FBXO27 Gene

    283 amino acids
    Molecular mass:
    31623 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.

neXtProt entry for FBXO27 Gene

Post-translational modifications for FBXO27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO27 Gene

No data available for DME Specific Peptides for FBXO27 Gene

Domains & Families for FBXO27 Gene

Gene Families for FBXO27 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO27 Gene

Suggested Antigen Peptide Sequences for FBXO27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO27: view

No data available for UniProtKB/Swiss-Prot for FBXO27 Gene

Function for FBXO27 Gene

Molecular function for FBXO27 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.

Phenotypes From GWAS Catalog for FBXO27 Gene

Gene Ontology (GO) - Molecular Function for FBXO27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 18203720
genes like me logo Genes that share ontologies with FBXO27: view
genes like me logo Genes that share phenotypes with FBXO27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO27 Gene

Localization for FBXO27 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO27 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBXO27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IDA 18203720
genes like me logo Genes that share ontologies with FBXO27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO27 Gene

Pathways & Interactions for FBXO27 Gene

genes like me logo Genes that share pathways with FBXO27: view

Gene Ontology (GO) - Biological Process for FBXO27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXO27: view

No data available for SIGNOR curated interactions for FBXO27 Gene

Drugs & Compounds for FBXO27 Gene

No Compound Related Data Available

Transcripts for FBXO27 Gene

Unigene Clusters for FBXO27 Gene

F-box protein 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO27 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2: -
SP3: -

Relevant External Links for FBXO27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO27 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO27 Gene:


SOURCE GeneReport for Unigene cluster for FBXO27 Gene:


mRNA Expression by UniProt/SwissProt for FBXO27 Gene:

Tissue specificity: Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung.

Evidence on tissue expression from TISSUES for FBXO27 Gene

  • Pancreas(4.3)
genes like me logo Genes that share expression patterns with FBXO27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO27 Gene

Orthologs for FBXO27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO27 34
  • 100 (a)
(Canis familiaris)
Mammalia FBXO27 33 34
  • 89.37 (n)
(Mus musculus)
Mammalia Fbxo27 33 16 34
  • 82 (n)
(Rattus norvegicus)
Mammalia Fbxo27 33
  • 81.11 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 56 (a)
-- 34
  • 55 (a)
(Bos Taurus)
Mammalia -- 34
  • 49 (a)
-- 34
  • 45 (a)
-- 34
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo27 33
  • 53.08 (n)
Species where no ortholog for FBXO27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO27 Gene

Gene Tree for FBXO27 (if available)
Gene Tree for FBXO27 (if available)

Paralogs for FBXO27 Gene

Paralogs for FBXO27 Gene

(5) SIMAP similar genes for FBXO27 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXO27: view

Variants for FBXO27 Gene

Sequence variations from dbSNP and Humsavar for FBXO27 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000031369 -- 39,021,937(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000050828 -- 39,021,684(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000057116 -- 39,020,968(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000065194 -- 39,033,062(-) TG/ upstream_transcript_variant
rs1000111855 -- 39,027,346(-) C/T intron_variant

Variation tolerance for FBXO27 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FBXO27 Gene

Disorders for FBXO27 Gene

Additional Disease Information for FBXO27

No disorders were found for FBXO27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO27 Gene

Publications for FBXO27 Gene

  1. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn KA … Paulson HL (The Journal of biological chemistry 2008) 3 4 22 58
  2. A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin GP … Guguen-Guillouzo C (Gene 2002) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. [Clinical conference: Thrombocythemic introduction to chronic myeloid leukemia]. (PMID: 126433) Bauters F … Goudemand M (Nouvelle revue francaise d'hematologie 1975) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FBXO27 Gene

Sources for FBXO27 Gene

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