Aliases for FBXO25 Gene
External Ids for FBXO25 Gene
Previous GeneCards Identifiers for FBXO25 Gene
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBXO25 Gene
FBXO25 (F-Box Protein 25) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway. Gene Ontology (GO) annotations related to this gene include actin binding and ubiquitin-protein transferase activity. An important paralog of this gene is FBXO32.
UniProtKB/Swiss-Prot for FBXO25 Gene
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).