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Aliases for FBXO25 Gene

Aliases for FBXO25 Gene

  • F-Box Protein 25 2 3 5
  • F-Box Only Protein 25 2 3
  • FBX25 3 4
  • F-Box Protein Fbx25 3

External Ids for FBXO25 Gene

Previous GeneCards Identifiers for FBXO25 Gene

  • GC08P000253
  • GC08P000396
  • GC08P000509
  • GC08P000353
  • GC08P000200

Summaries for FBXO25 Gene

Entrez Gene Summary for FBXO25 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO25 Gene

FBXO25 (F-Box Protein 25) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway. Gene Ontology (GO) annotations related to this gene include actin binding and ubiquitin-protein transferase activity. An important paralog of this gene is FBXO32.

UniProtKB/Swiss-Prot for FBXO25 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).

Additional gene information for FBXO25 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO25 Gene

Genomics for FBXO25 Gene

GeneHancer (GH) Regulatory Elements for FBXO25 Gene

Promoters and enhancers for FBXO25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I000406 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.8 757 1.6 ATF1 ARID4B SIN3A GLI4 ZNF48 ZNF121 GLIS2 ZNF213 ELK1 ZNF143 FBXO25 RPL23AP53 GC08P000416
GH08I000627 Enhancer 1.5 Ensembl ENCODE dbSUPER 10.1 +223.4 223371 4.6 CLOCK MLX FEZF1 ZNF416 ZNF548 SP3 MEF2D SSRP1 GLIS1 NBN ENSG00000273402 ENSG00000272240 ENSG00000272812 ZNF596 ENSG00000272293 RPL23AP53 ERICH1 TDRP LOC105377773 ENSG00000254207
GH08I000460 Enhancer 0.6 Ensembl ENCODE 10.4 +55.6 55646 2.5 JUND FOS HNF4A LOC105377773 FBXO25 GC08M000451 GC08P000470 PIR47185 TDRP
GH08I000399 Enhancer 1 ENCODE dbSUPER 5.5 -5.5 -5456 2.2 ELF3 SOX13 ZNF146 FOXA2 TAF1 SAP130 ARID4B ZNF384 CEBPG RARA TDRP FBXO25 GC08M000366
GH08I000381 Enhancer 0.4 ENCODE 4.7 -23.8 -23753 2.2 ETV1 ZNF48 FAM87A LOC105377773 RPL23AP53 FBXO25 GC08M000366
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXO25 on UCSC Golden Path with GeneCards custom track

Genomic Locations for FBXO25 Gene

Genomic Locations for FBXO25 Gene
71,540 bases
Plus strand

Genomic View for FBXO25 Gene

Genes around FBXO25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO25 Gene

Proteins for FBXO25 Gene

  • Protein details for FBXO25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 25
    Protein Accession:
    Secondary Accessions:
    • Q6PJ83
    • Q7Z4V4
    • Q9UKB8

    Protein attributes for FBXO25 Gene

    367 amino acids
    Molecular mass:
    43313 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly with SKP1 and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus).

    Alternative splice isoforms for FBXO25 Gene


neXtProt entry for FBXO25 Gene

Post-translational modifications for FBXO25 Gene

  • Ubiquitination at posLast=1717 and posLast=146146
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FBXO25 Gene

Domains & Families for FBXO25 Gene

Gene Families for FBXO25 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for FBXO25 Gene


Suggested Antigen Peptide Sequences for FBXO25 Gene

Graphical View of Domain Structure for InterPro Entry



  • The F-box is necessary for the interaction with SKP1.
  • The F-box is necessary for the interaction with SKP1.
genes like me logo Genes that share domains with FBXO25: view

Function for FBXO25 Gene

Molecular function for FBXO25 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).

Gene Ontology (GO) - Molecular Function for FBXO25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
genes like me logo Genes that share ontologies with FBXO25: view

Phenotypes for FBXO25 Gene

GenomeRNAi human phenotypes for FBXO25:
genes like me logo Genes that share phenotypes with FBXO25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO25 Gene

Localization for FBXO25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO25 Gene

Nucleus. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO25 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FBXO25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus ISS,IDA --
GO:0005730 NOT nucleolus IDA 16278047
GO:0019005 SCF ubiquitin ligase complex ISS --
genes like me logo Genes that share ontologies with FBXO25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FBXO25 Gene

Pathways & Interactions for FBXO25 Gene

SuperPathways for FBXO25 Gene

SuperPathway Contained pathways
1 FoxO signaling pathway
genes like me logo Genes that share pathways with FBXO25: view

Pathways by source for FBXO25 Gene

1 KEGG pathway for FBXO25 Gene

UniProtKB/Swiss-Prot Q8TCJ0-FBX25_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXO25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
genes like me logo Genes that share ontologies with FBXO25: view

No data available for SIGNOR curated interactions for FBXO25 Gene

Drugs & Compounds for FBXO25 Gene

No Compound Related Data Available

Transcripts for FBXO25 Gene

Unigene Clusters for FBXO25 Gene

F-box protein 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO25 Gene

No ASD Table

Relevant External Links for FBXO25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO25 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO25 Gene

This gene is overexpressed in Testis (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO25 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO25 Gene:


SOURCE GeneReport for Unigene cluster for FBXO25 Gene:


mRNA Expression by UniProt/SwissProt for FBXO25 Gene:

Tissue specificity: Expressed in all brain tissue observed.

Evidence on tissue expression from TISSUES for FBXO25 Gene

  • Nervous system(4.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with FBXO25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO25 Gene

Orthologs for FBXO25 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO25 33 34
  • 99.73 (n)
(Monodelphis domestica)
Mammalia FBXO25 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia FBXO25 34
  • 86 (a)
(Bos Taurus)
Mammalia FBXO25 33 34
  • 85.43 (n)
(Canis familiaris)
Mammalia FBXO25 33 34
  • 84.47 (n)
(Rattus norvegicus)
Mammalia Fbxo25 33
  • 84.22 (n)
(Mus musculus)
Mammalia Fbxo25 33 16 34
  • 83.29 (n)
(Gallus gallus)
Aves FBXO25 33 34
  • 80.47 (n)
(Anolis carolinensis)
Reptilia FBXO25 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo25 33
  • 70.82 (n)
(Danio rerio)
Actinopterygii fbxo25 33 34
  • 71.35 (n)
Dr.16139 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012127 33
  • 46.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11658 33 34
  • 41.92 (n)
(Caenorhabditis elegans)
Secernentea mfb-1 33 34
  • 42.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for FBXO25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO25 Gene

Gene Tree for FBXO25 (if available)
Gene Tree for FBXO25 (if available)

Paralogs for FBXO25 Gene

Paralogs for FBXO25 Gene

(1) SIMAP similar genes for FBXO25 Gene using alignment to 3 proteins: Pseudogenes for FBXO25 Gene

genes like me logo Genes that share paralogs with FBXO25: view

Variants for FBXO25 Gene

Sequence variations from dbSNP and Humsavar for FBXO25 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000004420 -- 469,836(+) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000019438 -- 454,599(+) C/G intron_variant
rs1000025450 -- 463,405(+) A/C intron_variant
rs1000119633 -- 405,605(+) C/T upstream_transcript_variant
rs1000123442 -- 441,443(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO25 Gene

Variant ID Type Subtype PubMed ID
dgv11809n54 CNV loss 21841781
dgv240e55 CNV gain 17911159
dgv6789n100 CNV gain 25217958
dgv6791n100 CNV gain 25217958
dgv6792n100 CNV gain 25217958
esv1419160 CNV insertion 17803354
esv2759581 CNV gain+loss 17122850
esv2761228 CNV gain+loss 21179565
esv27875 CNV loss 19812545
esv3576501 CNV gain 25503493
esv3576502 CNV gain 25503493
esv3615771 CNV gain 21293372
esv3615785 CNV gain 21293372
esv3615786 CNV gain 21293372
esv3615787 CNV gain 21293372
nsv1020142 CNV loss 25217958
nsv1027283 CNV gain 25217958
nsv1030422 CNV gain 25217958
nsv1032614 CNV gain 25217958
nsv465263 CNV gain 19166990
nsv465264 CNV loss 19166990
nsv470163 CNV loss 18288195
nsv470164 CNV gain 18288195
nsv471483 CNV gain 19718026
nsv524542 CNV gain 19592680
nsv527388 CNV gain 19592680
nsv609450 CNV gain 21841781
nsv609451 CNV loss 21841781
nsv609452 CNV loss 21841781
nsv609454 CNV gain 21841781
nsv8257 CNV gain 18304495
nsv8259 CNV gain 18304495
nsv971270 CNV duplication 23825009
nsv971271 CNV duplication 23825009
nsv971615 CNV duplication 23825009

Variation tolerance for FBXO25 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.87; 79.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO25 Gene

Disorders for FBXO25 Gene


  • Note=A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with SHROOM4.

Additional Disease Information for FBXO25

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FBXO25 Gene.

No data available for MalaCards and Genatlas for FBXO25 Gene

Publications for FBXO25 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 58
  2. Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PMID: 20473970) Teixeira FR … Gomes MD (Proteomics 2010) 3 4 58
  3. FBXO25-associated nuclear domains: a novel subnuclear structure. (PMID: 18287534) Manfiolli AO … Gomes MD (Molecular biology of the cell 2008) 3 4 58
  4. Characterization of FBX25, encoding a novel brain-expressed F-box protein. (PMID: 16278047) Hagens O … Kalscheuer V (Biochimica et biophysica acta 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FBXO25 Gene

Sources for FBXO25 Gene

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