Aliases for FBXO22 Gene
Aliases for FBXO22 Gene
External Ids for FBXO22 Gene
- HGNC: 13593
- Entrez Gene: 26263
- Ensembl: ENSG00000167196
- OMIM: 609096
- UniProtKB: Q8NEZ5
Previous GeneCards Identifiers for FBXO22 Gene
- GC15P072072
- GC15P069285
- GC15P073772
- GC15P073912
- GC15P073983
- GC15P076196
Summaries for FBXO22 Gene
-
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for FBXO22 Gene
FBXO22 (F-Box Protein 22) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot for FBXO22 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.
Additional gene information for FBXO22 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO22 Gene
Genomics for FBXO22 Gene
GeneHancer (GH) Regulatory Elements for FBXO22 Gene
Promoters and enhancers for FBXO22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FBXO22 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for FBXO22 Gene
Genomic Locations for FBXO22 Gene
- chr15:75,903,859-75,942,510
- (GRCh38/hg38)
- Size:
- 38,652 bases
- Orientation:
- Plus strand
- chr15:76,196,200-76,227,609
- (GRCh37/hg19)
Genomic View for FBXO22 Gene
Genes around FBXO22 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.2 by Ensembl
- 15q24.2 by Entrez Gene
- 15q24.2 by HGNC
FBXO22 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO22 Gene
Proteins for FBXO22 Gene
-
Protein details for FBXO22 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NEZ5-FBX22_HUMAN
- Recommended name:
- F-box only protein 22
- Protein Accession:
- Q8NEZ5
- Q0D2P8
- Q6PIL5
- Q8IXW3
- Q9H824
- Q9UKC0
Protein attributes for FBXO22 Gene
- Size:
- 403 amino acids
- Molecular mass:
- 44508 Da
- Quaternary structure:
-
- Directly interacts with SKP1 and CUL1.
- SequenceCaution:
-
- Sequence=AAH39024.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Protein Expression for FBXO22 Gene
Post-translational modifications for FBXO22 Gene
Other Protein References for FBXO22 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXO22
-
Abcam antibodies for FBXO22
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-
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Protein Products
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-
Abcam proteins for FBXO22
Assay Products
No data available for DME Specific Peptides for FBXO22 Gene
Domains & Families for FBXO22 Gene
Gene Families for FBXO22 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FBXO22 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXO22 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO22 Gene
Function for FBXO22 Gene
Molecular function for FBXO22 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.
Phenotypes From GWAS Catalog for FBXO22 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | EXP,TAS | -- |
| GO:0005515 | protein binding | IPI | 26496610 |
| GO:0005549 | odorant binding | IEA | -- |
Phenotypes for FBXO22 Gene
- MGI mutant phenotypes for FBXO22:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FBXO22:
Animal Models for FBXO22 Gene
- MGI Knock Outs for FBXO22:
-
- Fbxo22 tm1b(EUCOMM)Wtsi
Animal Model Products
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-
-
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-
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CRISPR Products
-
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO22
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miRNA for FBXO22 Gene
- miRTarBase miRNAs that target FBXO22
miRNA Products
- Search ViGene Biosciences for FBXO22
Inhibitory RNA Products
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ViGene Biosciences ready-to-package AAV shRNAs for FBXO22 gene
Clone Products
- Sino Biological Human cDNA Clone for FBXO22
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available FBXO22 gene related products
- orf clones - Search results for available FBXO22 gene related products
- Applied Biological Materials Clones for FBXO22
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FBXO22
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXO22 gene
-
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO22 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO22 Gene
Localization for FBXO22 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXO22 Gene
- Cytoplasm, myofibril, sarcomere, Z line.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0030018 | Z disc | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FBXO22 Gene
Pathways & Interactions for FBXO22 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXO22 Gene
4 Reactome pathways for FBXO22 Gene
Interacting Proteins for FBXO22 Gene
Selected Interacting proteins:
Q8NEZ5-FBX22_HUMAN
ENSP00000307833
for FBXO22 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0006464 | cellular protein modification process | TAS | 10531035 |
| GO:0006511 | ubiquitin-dependent protein catabolic process | TAS | 10531035 |
| GO:0006913 | nucleocytoplasmic transport | IEA | -- |
| GO:0009267 | cellular response to starvation | IEA | -- |
No data available for SIGNOR curated interactions for FBXO22 Gene
Transcripts for FBXO22 Gene
mRNA/cDNA for FBXO22 Gene
- (3) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (421) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO22
- genomics-online: gRNA clones - Search results for available FBXO22 gene related products
- Applied Biological Materials CRISPR for FBXO22
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO22
- GenScript: Design CRISPR guide RNA sequences for FBXO22
miRNA Products
- Search ViGene Biosciences for FBXO22
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available FBXO22 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO22 gene
Clone Products
- Sino Biological Human cDNA Clone for FBXO22
- VectorBuilder custom plasmid, inducible vectors for FBXO22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBXO22
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available FBXO22 gene related products
- orf clones - Search results for available FBXO22 gene related products
- Applied Biological Materials Clones for FBXO22
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||
| SP2: | |||||||||||||||||
| SP3: | - |
Expression for FBXO22 Gene
This gene is overexpressed in Breast (11.4), Stomach (9.7), and Retina (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO22 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FBXO22 Gene:
FBXO22SOURCE GeneReport for Unigene cluster for FBXO22 Gene:
Hs.591115mRNA Expression by UniProt/SwissProt for FBXO22 Gene:
Q8NEZ5-FBX22_HUMAN
Tissue specificity:
Predominantly expressed in liver, also enriched in cardiac muscle.
Evidence on tissue expression from TISSUES for FBXO22 Gene
- Nervous system(4.6)
- Intestine(4.2)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs for FBXO22
-
OriGene qPCR primer pairs and template standards for FBXO22
- genomics-online: primer clones - Search results for available FBXO22 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO22 Gene
Orthologs for FBXO22 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO22 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXO22 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXO22 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo22 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxo22 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXO22 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXO22 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXO22 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXO22 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo22 33 |
|
||
| Str.10458 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | fbxo22 33 34 |
|
||
| -- 33 |
|
- Species where no ortholog for FBXO22 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXO22 Gene
No data available for Paralogs for FBXO22 Gene
Variants for FBXO22 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000167999 | -- | 75,916,678(+) | T/A | intron_variant | |
| rs1000223241 | -- | 75,924,539(+) | G/A | intron_variant | |
| rs1000224456 | -- | 75,907,112(+) | T/C | intron_variant | |
| rs1000277525 | -- | 75,937,138(+) | ATA/A | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000362232 | -- | 75,909,473(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2622n100 | CNV | gain | 25217958 |
| esv2749895 | CNV | deletion | 23290073 |
| esv2749898 | CNV | deletion | 23290073 |
| esv3636933 | CNV | gain | 21293372 |
| nsv1044733 | CNV | loss | 25217958 |
| nsv1116463 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.98;
20.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FBXO22 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO22
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO22 Gene
Disorders for FBXO22 Gene
Additional Disease Information for FBXO22
No disorders were found for FBXO22 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO22 Gene
Publications for FBXO22 Gene
- Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 58
- FIST: a sensory domain for diverse signal transduction pathways in prokaryotes and ubiquitin signaling in eukaryotes. (PMID: 17855421) Borziak K … Zhulin IB (Bioinformatics (Oxford, England) 2007) 2 3 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- A family of mammalian F-box proteins. (PMID: 10531037) Winston JT … Harper JW (Current biology : CB 1999) 2 3 58
Products for FBXO22 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for FBXO22
- VectorBuilder custom plasmid, inducible vectors for FBXO22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBXO22
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 48 available FBXO22 Antibodies ranked by validation data
- Compare Top FBXO22 Antibodies
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- GeneTex FBXO22 antibody for FBXO22
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- ViGene Biosciences adenoviral particle packaged cDNA for FBXO22 gene
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- genomics-online: cdna clones - Search results for available FBXO22 gene related products
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- genomics-online: primer clones - Search results for available FBXO22 gene related products
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Sources for FBXO22 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
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