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Aliases for FBXO22 Gene

Aliases for FBXO22 Gene

  • F-Box Protein 22 2 3 5
  • FIST Domain Containing 1 2 3
  • F-Box Protein FBX22p44 3 4
  • F-Box Only Protein 22 2 3
  • FBX22 3 4
  • FISTC1 3

External Ids for FBXO22 Gene

Previous GeneCards Identifiers for FBXO22 Gene

  • GC15P072072
  • GC15P069285
  • GC15P073772
  • GC15P073912
  • GC15P073983
  • GC15P076196

Summaries for FBXO22 Gene

Entrez Gene Summary for FBXO22 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for FBXO22 Gene

FBXO22 (F-Box Protein 22) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO22 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Additional gene information for FBXO22 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO22 Gene

Genomics for FBXO22 Gene

GeneHancer (GH) Regulatory Elements for FBXO22 Gene

Promoters and enhancers for FBXO22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I075901 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 588.1 -0.7 -741 3.8 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 GLIS1 NBN FBXO22 DNM1P35 NRG4 SIN3A MAN2C1 ENSG00000260274 ENSG00000203392 UBE2Q2 RN7SL510P
GH15I075366 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 44.3 -535.1 -535104 3.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ENSG00000260274 MAN2C1 DNM1P35 SIN3A LOC441728 FBXO22 EDC3 COMMD4 LOC101929333 CLK3
GH15I074936 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 37.1 -966.2 -966188 2.6 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 COX5A SIN3A ENSG00000260274 MAN2C1 FBXO22 DNM1P35 ENSG00000203392 RPP25 EDC3 CLK3
GH15I075346 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 25.4 -554.7 -554746 5 HDGF ARID4B SIN3A ZNF2 ZNF213 ZNF143 KLF13 ZNF263 SP3 SP5 NEIL1 ENSG00000275645 ENSG00000260274 DNM1P35 EDC3 SIN3A MAN2C1 SNUPN FBXO22 LOC441728
GH15I075449 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.6 -450.5 -450503 8.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SIN3A ENSG00000276744 MAN2C1 ENSG00000260274 SNUPN EDC3 CLK3 DNM1P34 LOC101929333 FBXO22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXO22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO22 gene promoter:

Genomic Locations for FBXO22 Gene

Genomic Locations for FBXO22 Gene
chr15:75,903,859-75,942,510
(GRCh38/hg38)
Size:
38,652 bases
Orientation:
Plus strand
chr15:76,196,200-76,227,609
(GRCh37/hg19)

Genomic View for FBXO22 Gene

Genes around FBXO22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO22 Gene

Proteins for FBXO22 Gene

  • Protein details for FBXO22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEZ5-FBX22_HUMAN
    Recommended name:
    F-box only protein 22
    Protein Accession:
    Q8NEZ5
    Secondary Accessions:
    • Q0D2P8
    • Q6PIL5
    • Q8IXW3
    • Q9H824
    • Q9UKC0

    Protein attributes for FBXO22 Gene

    Size:
    403 amino acids
    Molecular mass:
    44508 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=AAH39024.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO22 Gene

Post-translational modifications for FBXO22 Gene

  • Ubiquitination at posLast=4040
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FBXO22 Gene

Domains & Families for FBXO22 Gene

Gene Families for FBXO22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO22 Gene

Suggested Antigen Peptide Sequences for FBXO22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO22: view

No data available for UniProtKB/Swiss-Prot for FBXO22 Gene

Function for FBXO22 Gene

Molecular function for FBXO22 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Phenotypes From GWAS Catalog for FBXO22 Gene

Gene Ontology (GO) - Molecular Function for FBXO22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity EXP,TAS --
GO:0005515 protein binding IPI 26496610
GO:0005549 odorant binding IEA --
genes like me logo Genes that share ontologies with FBXO22: view
genes like me logo Genes that share phenotypes with FBXO22: view

Animal Models for FBXO22 Gene

MGI Knock Outs for FBXO22:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO22 Gene

Localization for FBXO22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO22 Gene

Cytoplasm, myofibril, sarcomere, Z line.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO22 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with FBXO22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FBXO22 Gene

Pathways & Interactions for FBXO22 Gene

genes like me logo Genes that share pathways with FBXO22: view

Gene Ontology (GO) - Biological Process for FBXO22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006464 cellular protein modification process TAS 10531035
GO:0006511 ubiquitin-dependent protein catabolic process TAS 10531035
GO:0006913 nucleocytoplasmic transport IEA --
GO:0009267 cellular response to starvation IEA --
genes like me logo Genes that share ontologies with FBXO22: view

No data available for SIGNOR curated interactions for FBXO22 Gene

Drugs & Compounds for FBXO22 Gene

No Compound Related Data Available

Transcripts for FBXO22 Gene

Unigene Clusters for FBXO22 Gene

F-box protein 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO22 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2:
SP3: -

Relevant External Links for FBXO22 Gene

GeneLoc Exon Structure for
FBXO22
ECgene alternative splicing isoforms for
FBXO22

Expression for FBXO22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO22 Gene

Protein differential expression in normal tissues from HIPED for FBXO22 Gene

This gene is overexpressed in Breast (11.4), Stomach (9.7), and Retina (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO22 Gene



Protein tissue co-expression partners for FBXO22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO22 Gene:

FBXO22

SOURCE GeneReport for Unigene cluster for FBXO22 Gene:

Hs.591115

mRNA Expression by UniProt/SwissProt for FBXO22 Gene:

Q8NEZ5-FBX22_HUMAN
Tissue specificity: Predominantly expressed in liver, also enriched in cardiac muscle.

Evidence on tissue expression from TISSUES for FBXO22 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with FBXO22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO22 Gene

Orthologs for FBXO22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO22 33 34
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia FBXO22 33 34
  • 90.38 (n)
dog
(Canis familiaris)
Mammalia FBXO22 33 34
  • 89.44 (n)
mouse
(Mus musculus)
Mammalia Fbxo22 33 16 34
  • 88.39 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo22 33
  • 87.64 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXO22 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO22 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO22 33 34
  • 70.5 (n)
lizard
(Anolis carolinensis)
Reptilia FBXO22 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo22 33
  • 59.85 (n)
Str.10458 33
zebrafish
(Danio rerio)
Actinopterygii fbxo22 33 34
  • 54.33 (n)
-- 33
Species where no ortholog for FBXO22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO22 Gene

ENSEMBL:
Gene Tree for FBXO22 (if available)
TreeFam:
Gene Tree for FBXO22 (if available)

Paralogs for FBXO22 Gene

No data available for Paralogs for FBXO22 Gene

Variants for FBXO22 Gene

Sequence variations from dbSNP and Humsavar for FBXO22 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000167999 -- 75,916,678(+) T/A intron_variant
rs1000223241 -- 75,924,539(+) G/A intron_variant
rs1000224456 -- 75,907,112(+) T/C intron_variant
rs1000277525 -- 75,937,138(+) ATA/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000362232 -- 75,909,473(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO22 Gene

Variant ID Type Subtype PubMed ID
dgv2622n100 CNV gain 25217958
esv2749895 CNV deletion 23290073
esv2749898 CNV deletion 23290073
esv3636933 CNV gain 21293372
nsv1044733 CNV loss 25217958
nsv1116463 OTHER inversion 24896259

Variation tolerance for FBXO22 Gene

Residual Variation Intolerance Score: 21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO22 Gene

Disorders for FBXO22 Gene

Additional Disease Information for FBXO22

No disorders were found for FBXO22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO22 Gene

Publications for FBXO22 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 58
  2. FIST: a sensory domain for diverse signal transduction pathways in prokaryotes and ubiquitin signaling in eukaryotes. (PMID: 17855421) Borziak K … Zhulin IB (Bioinformatics (Oxford, England) 2007) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A family of mammalian F-box proteins. (PMID: 10531037) Winston JT … Harper JW (Current biology : CB 1999) 2 3 58

Products for FBXO22 Gene

Sources for FBXO22 Gene

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