This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-... See more...

Aliases for FBXO21 Gene

Aliases for FBXO21 Gene

  • F-Box Protein 21 2 3 5
  • F-Box Only Protein 21 2 3 4
  • FBX21 3 4
  • KIAA0875 4

External Ids for FBXO21 Gene

Previous GeneCards Identifiers for FBXO21 Gene

  • GC12P116427
  • GC12M117102
  • GC12M117364
  • GC12M115994
  • GC12M115995
  • GC12M116044
  • GC12M117581
  • GC12M114590

Summaries for FBXO21 Gene

Entrez Gene Summary for FBXO21 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO21 Gene

FBXO21 (F-Box Protein 21) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot Summary for FBXO21 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXO21 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXO21 Gene

Genomics for FBXO21 Gene

GeneHancer (GH) Regulatory Elements for FBXO21 Gene

Promoters and enhancers for FBXO21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J117188 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 519.9 +0.5 531 2.8 HNRNPK EP300 NRF1 POLR2G PHF8 ZFX REST POLR2A RBM34 ZBTB26 FBXO21 FBXW8 HE856172
GH12J117191 Enhancer 0.5 Ensembl 500.7 -1.6 -1570 0.2 WT1 ZNF263 ZNF324 ZBTB20 HMBOX1 KDM1A FBXO21 piR-46585
GH12J116817 Promoter/Enhancer 1.7 ENCODE CraniofacialAtlas dbSUPER 20 +371.9 371887 3.2 EP300 SIN3A MYC POLR2G GTF2E2 JUND PHF8 FOS ZFX ZNF10 FBXO21 ENSG00000275467 piR-38051-078 RNFT2
GH12J116405 Enhancer 1.3 Ensembl ENCODE dbSUPER 20.9 +783.9 783931 3.2 ZNF217 CTCF ZSCAN5C TCF12 RBAK ZNF639 ZNF10 ZIC2 ZBTB10 ZNF423 FBXO21 MAP1LC3B2 MED13L piR-33614-069 lnc-MED13L-6
GH12J117140 Enhancer 1.1 Ensembl ENCODE 20.7 +48.1 48130 4.4 ZNF217 TCF12 SP1 NCOR1 FOS ZNF639 EP300 ZIC2 TCF7 NR3C1 FBXO21 piR-35672-014 TESC-AS1 HE856172
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXO21 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBXO21

Top Transcription factor binding sites by QIAGEN in the FBXO21 gene promoter:
  • AREB6
  • Elk-1
  • GR
  • GR-alpha
  • LUN-1
  • Sox5
  • STAT1
  • STAT1alpha
  • STAT1beta
  • ZID

Genomic Locations for FBXO21 Gene

Genomic Locations for FBXO21 Gene
chr12:117,141,988-117,190,531
(GRCh38/hg38)
Size:
48,544 bases
Orientation:
Minus strand
chr12:117,581,146-117,628,336
(GRCh37/hg19)
Size:
47,191 bases
Orientation:
Minus strand

Genomic View for FBXO21 Gene

Genes around FBXO21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO21 Gene

Proteins for FBXO21 Gene

  • Protein details for FBXO21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94952-FBX21_HUMAN
    Recommended name:
    F-box only protein 21
    Protein Accession:
    O94952
    Secondary Accessions:
    • B3KMF0
    • Q5BJG0
    • Q9H087

    Protein attributes for FBXO21 Gene

    Size:
    628 amino acids
    Molecular mass:
    72270 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    Miscellaneous:
    • [Isoform 1]: May be due to a competing acceptor splice site.
    SequenceCaution:
    • Sequence=CAB66833.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO21 Gene

Post-translational modifications for FBXO21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXO21 Gene

Domains & Families for FBXO21 Gene

Gene Families for FBXO21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO21 Gene

Suggested Antigen Peptide Sequences for FBXO21 Gene

GenScript: Design optimal peptide antigens:
  • F-box only protein 21 (FBX21_HUMAN)
genes like me logo Genes that share domains with FBXO21: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBXO21 Gene

Function for FBXO21 Gene

Molecular function for FBXO21 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXO21 Gene

Gene Ontology (GO) - Molecular Function for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FBXO21: view
genes like me logo Genes that share phenotypes with FBXO21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO21

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO21 Gene

Localization for FBXO21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO21 gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXO21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO21 Gene

Pathways & Interactions for FBXO21 Gene

genes like me logo Genes that share pathways with FBXO21: view

Gene Ontology (GO) - Biological Process for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006511 ubiquitin-dependent protein catabolic process NAS 10531035
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXO21: view

No data available for SIGNOR curated interactions for FBXO21 Gene

Drugs & Compounds for FBXO21 Gene

No Compound Related Data Available

Transcripts for FBXO21 Gene

mRNA/cDNA for FBXO21 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO21

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13
SP1: - -
SP2: - - -
SP3:
SP4:
SP5:

Relevant External Links for FBXO21 Gene

GeneLoc Exon Structure for
FBXO21

Expression for FBXO21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXO21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXO21 Gene

This gene is overexpressed in Testis (17.0), Ovary (10.4), Frontal cortex (8.2), and Lung (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXO21 Gene



Protein tissue co-expression partners for FBXO21 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBXO21

SOURCE GeneReport for Unigene cluster for FBXO21 Gene:

Hs.740376

Evidence on tissue expression from TISSUES for FBXO21 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with FBXO21: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO21 Gene

Orthologs for FBXO21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO21 31 30
  • 99.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO21 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO21 31 30
  • 92.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo21 30
  • 87.9 (n)
mouse
(Mus musculus)
Mammalia Fbxo21 17 31 30
  • 87.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO21 31
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO21 31
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO21 31 30
  • 75.88 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO21 31
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo21 30
  • 63.29 (n)
zebrafish
(Danio rerio)
Actinopterygii fbxo21 31 30
  • 63.32 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
OneToOne
Species where no ortholog for FBXO21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO21 Gene

ENSEMBL:
Gene Tree for FBXO21 (if available)
TreeFam:
Gene Tree for FBXO21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXO21: view image

Paralogs for FBXO21 Gene

No data available for Paralogs for FBXO21 Gene

Variants for FBXO21 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBXO21 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs11556202 - p.Asn180Thr

Additional dbSNP identifiers (rs#s) for FBXO21 Gene

Structural Variations from Database of Genomic Variants (DGV) for FBXO21 Gene

Variant ID Type Subtype PubMed ID
dgv2899n54 CNV loss 21841781
dgv520e212 CNV loss 25503493
dgv521e212 CNV loss 25503493
esv2746433 CNV deletion 23290073
esv3630863 CNV gain 21293372
nsv1145628 CNV deletion 24896259
nsv510592 CNV deletion 20534489
nsv832526 CNV loss 17160897

Variation tolerance for FBXO21 Gene

Residual Variation Intolerance Score: 9.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO21 Gene

Disorders for FBXO21 Gene

Additional Disease Information for FBXO21

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FBXO21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO21 Gene

Publications for FBXO21 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 54
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 54

Products for FBXO21 Gene

Sources for FBXO21 Gene