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Aliases for FBXO21 Gene

Aliases for FBXO21 Gene

  • F-Box Protein 21 2 3 5
  • F-Box Only Protein 21 2 3
  • FBX21 3 4
  • KIAA0875 4

External Ids for FBXO21 Gene

Previous GeneCards Identifiers for FBXO21 Gene

  • GC12P116427
  • GC12M117102
  • GC12M117364
  • GC12M115994
  • GC12M115995
  • GC12M116044
  • GC12M117581
  • GC12M114590

Summaries for FBXO21 Gene

Entrez Gene Summary for FBXO21 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO21 Gene

FBXO21 (F-Box Protein 21) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO21 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXO21 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO21 Gene

Genomics for FBXO21 Gene

GeneHancer (GH) Regulatory Elements for FBXO21 Gene

Promoters and enhancers for FBXO21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J117188 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 670 +0.6 584 2.3 SMAD1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 ZNF548 FBXO21 FBXW8 MED13L LOC105370010
GH12J116492 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.9 +695.3 695300 5.4 HDGF PKNOX1 ARNT NEUROD1 SIN3A ZBTB7B ZNF766 CBX5 E2F8 ZNF207 FBXW8 MED13L ENSG00000258034 FBXO21 LINC00173 MAP1LC3B2 LOC105370007 LOC105370008
GH12J118015 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.2 -826.5 -826533 2.2 HDGF PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 RFC5 SUDS3 WSB2 FBXO21 ENSG00000277873
GH12J118101 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.5 -912.8 -912825 2.9 PKNOX1 ZFP64 ARID4B SIN3A ZNF48 YY1 GLIS2 FOS KLF13 ZNF202 VSIG10 SUDS3 RFC5 FBXO21 GC12P118112 ENSG00000274859
GH12J117141 Enhancer 1 ENCODE 20.3 +47.7 47720 2.2 PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B YY1 ELK1 FBXO21 LOC105370010 TESC-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXO21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO21 gene promoter:
  • AREB6
  • STAT1beta
  • STAT1alpha
  • STAT1
  • ZID
  • Sox5
  • Elk-1
  • GR-alpha
  • GR
  • LUN-1

Genomic Locations for FBXO21 Gene

Genomic Locations for FBXO21 Gene
48,544 bases
Minus strand
47,191 bases
Minus strand

Genomic View for FBXO21 Gene

Genes around FBXO21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO21 Gene

Proteins for FBXO21 Gene

  • Protein details for FBXO21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 21
    Protein Accession:
    Secondary Accessions:
    • B3KMF0
    • Q5BJG0
    • Q9H087

    Protein attributes for FBXO21 Gene

    628 amino acids
    Molecular mass:
    72270 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    • Sequence=CAB66833.2; Type=Erroneous termination; Positions=81; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO21 Gene


neXtProt entry for FBXO21 Gene

Post-translational modifications for FBXO21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXO21 Gene

Domains & Families for FBXO21 Gene

Gene Families for FBXO21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO21 Gene

Suggested Antigen Peptide Sequences for FBXO21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO21: view

No data available for UniProtKB/Swiss-Prot for FBXO21 Gene

Function for FBXO21 Gene

Molecular function for FBXO21 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXO21 Gene

Gene Ontology (GO) - Molecular Function for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FBXO21: view
genes like me logo Genes that share phenotypes with FBXO21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO21

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO21 Gene

Localization for FBXO21 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO21 gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXO21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO21 Gene

Pathways & Interactions for FBXO21 Gene

genes like me logo Genes that share pathways with FBXO21: view

Gene Ontology (GO) - Biological Process for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006511 ubiquitin-dependent protein catabolic process NAS 10531035
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXO21: view

No data available for SIGNOR curated interactions for FBXO21 Gene

Drugs & Compounds for FBXO21 Gene

No Compound Related Data Available

Transcripts for FBXO21 Gene

Unigene Clusters for FBXO21 Gene

F-box protein 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO21

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13
SP1: - -
SP2: - - -

Relevant External Links for FBXO21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXO21 Gene

This gene is overexpressed in Testis (17.0), Ovary (10.4), Frontal cortex (8.2), and Lung (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXO21 Gene

Protein tissue co-expression partners for FBXO21 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO21 Gene:


SOURCE GeneReport for Unigene cluster for FBXO21 Gene:


Evidence on tissue expression from TISSUES for FBXO21 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with FBXO21: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO21 Gene

Orthologs for FBXO21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO21 34 33
  • 99.89 (n)
(Bos Taurus)
Mammalia FBXO21 34
  • 95 (a)
(Canis familiaris)
Mammalia FBXO21 34 33
  • 92.82 (n)
(Rattus norvegicus)
Mammalia Fbxo21 33
  • 87.9 (n)
(Mus musculus)
Mammalia Fbxo21 16 34 33
  • 87.67 (n)
(Ornithorhynchus anatinus)
Mammalia FBXO21 34
  • 69 (a)
(Monodelphis domestica)
Mammalia FBXO21 34
  • 61 (a)
(Gallus gallus)
Aves FBXO21 34 33
  • 75.88 (n)
(Anolis carolinensis)
Reptilia FBXO21 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo21 33
  • 63.29 (n)
(Danio rerio)
Actinopterygii fbxo21 34 33
  • 63.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for FBXO21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO21 Gene

Gene Tree for FBXO21 (if available)
Gene Tree for FBXO21 (if available)
Evolutionary constrained regions (ECRs) for FBXO21: view image

Paralogs for FBXO21 Gene

No data available for Paralogs for FBXO21 Gene

Variants for FBXO21 Gene

Sequence variations from dbSNP and Humsavar for FBXO21 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000091136 -- 117,190,355(-) C/G/T coding_sequence_variant, genic_upstream_transcript_variant, synonymous_variant, upstream_transcript_variant
rs1000092165 -- 117,149,542(-) A/G intron_variant
rs1000098367 -- 117,183,788(-) C/T intron_variant
rs1000101860 -- 117,144,313(-) C/T 3_prime_UTR_variant
rs1000152550 -- 117,144,489(-) G/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO21 Gene

Variant ID Type Subtype PubMed ID
dgv2899n54 CNV loss 21841781
dgv520e212 CNV loss 25503493
dgv521e212 CNV loss 25503493
esv2746433 CNV deletion 23290073
esv3630863 CNV gain 21293372
nsv1145628 CNV deletion 24896259
nsv510592 CNV deletion 20534489
nsv832526 CNV loss 17160897

Variation tolerance for FBXO21 Gene

Residual Variation Intolerance Score: 9.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO21 Gene

Disorders for FBXO21 Gene

Additional Disease Information for FBXO21

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FBXO21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO21 Gene

Publications for FBXO21 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58

Products for FBXO21 Gene

Sources for FBXO21 Gene

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