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Aliases for FBXO16 Gene

Aliases for FBXO16 Gene

  • F-Box Protein 16 2 3 5
  • F-Box Only Protein 16 2 3
  • FBX16 3 4

External Ids for FBXO16 Gene

Previous GeneCards Identifiers for FBXO16 Gene

  • GC08M028027
  • GC08M028307
  • GC08M028259
  • GC08M028341
  • GC08M026830
  • GC08M028206

Summaries for FBXO16 Gene

Entrez Gene Summary for FBXO16 Gene

  • This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for FBXO16 Gene

FBXO16 (F-Box Protein 16) is a Protein Coding gene. An important paralog of this gene is ECT2L.

UniProtKB/Swiss-Prot for FBXO16 Gene

  • Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Additional gene information for FBXO16 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO16 Gene

Genomics for FBXO16 Gene

GeneHancer (GH) Regulatory Elements for FBXO16 Gene

Promoters and enhancers for FBXO16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J028489 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.2 -175 1.6 PKNOX1 FOXA2 NEUROD1 SIN3A DMAP1 ZNF2 YY1 ZNF121 ZNF213 ATF7 FBXO16 FZD3
GH08J028363 Enhancer 1.4 Ensembl ENCODE dbSUPER 17.6 +120.4 120418 13.8 HDGF FOXA2 PKNOX1 SMAD1 ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 FZD3 FBXO16 INTS9 ENSG00000259366 ZNF395 ENSG00000253690 PNOC PIR39512
GH08J028346 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.6 +140.2 140182 7.9 HDGF PKNOX1 ZBTB7B ZNF121 HSF1 ZNF143 FOS IKZF2 ZNF362 SMARCC1 ZNF395 FZD3 INTS9 FBXO16 EXTL3 NUGGC PNOC PIR48760 PIR39512
GH08J028378 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 6.2 +106.6 106584 10.1 ATF1 FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF121 GLIS2 FOS ATF7 ZNF395 FBXO16 FZD3 INTS9 PIR39512
GH08J028355 Enhancer 0.8 ENCODE dbSUPER 10.6 +134.6 134579 0.2 SRF CTCF PKNOX1 DACH1 TRIM22 REST RAD21 ZNF143 ZBTB33 PRDM1 ZNF395 FZD3 FBXO16 EXTL3 PNOC NUGGC PIR39512
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXO16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO16 gene promoter:
  • YY1
  • FOXO4
  • Egr-3
  • C/EBPbeta
  • ITF-2
  • Tal-1beta
  • POU2F1
  • POU2F1a
  • C/EBPalpha

Genomic Locations for FBXO16 Gene

Genomic Locations for FBXO16 Gene
142,032 bases
Minus strand
142,032 bases
Minus strand

Genomic View for FBXO16 Gene

Genes around FBXO16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO16 Gene

Proteins for FBXO16 Gene

  • Protein details for FBXO16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 16
    Protein Accession:
    Secondary Accessions:
    • Q3T1B2
    • Q3T1B3
    • Q3T1B4

    Protein attributes for FBXO16 Gene

    292 amino acids
    Molecular mass:
    34588 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

    Alternative splice isoforms for FBXO16 Gene


neXtProt entry for FBXO16 Gene

Post-translational modifications for FBXO16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXO16 Gene

Domains & Families for FBXO16 Gene

Gene Families for FBXO16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO16 Gene


Suggested Antigen Peptide Sequences for FBXO16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO16: view

No data available for UniProtKB/Swiss-Prot for FBXO16 Gene

Function for FBXO16 Gene

Molecular function for FBXO16 Gene

UniProtKB/Swiss-Prot Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Phenotypes From GWAS Catalog for FBXO16 Gene

genes like me logo Genes that share phenotypes with FBXO16: view

Animal Models for FBXO16 Gene

MGI Knock Outs for FBXO16:
  • Fbxo16 Fbxo16<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO16

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXO16 Gene

Localization for FBXO16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO16 gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO16 Gene

Pathways & Interactions for FBXO16 Gene

SuperPathways for FBXO16 Gene

No Data Available

Interacting Proteins for FBXO16 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8IX29-FBX16_HUMAN ENSP00000369604 for FBXO16 Gene via IID STRING

Gene Ontology (GO) - Biological Process for FBXO16 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXO16 Gene

Drugs & Compounds for FBXO16 Gene

No Compound Related Data Available

Transcripts for FBXO16 Gene

mRNA/cDNA for FBXO16 Gene

Unigene Clusters for FBXO16 Gene

F-box protein 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO16

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO16 Gene

No ASD Table

Relevant External Links for FBXO16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO16 Gene

This gene is overexpressed in Pituitary (x6.3).

Protein differential expression in normal tissues from HIPED for FBXO16 Gene

This gene is overexpressed in Colon (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXO16 Gene

Protein tissue co-expression partners for FBXO16 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO16 Gene:


SOURCE GeneReport for Unigene cluster for FBXO16 Gene:


mRNA Expression by UniProt/SwissProt for FBXO16 Gene:

Tissue specificity: Expressed in heart, spleen and colon.
genes like me logo Genes that share expression patterns with FBXO16: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO16 Gene

Orthologs for FBXO16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO16 34 33
  • 99.09 (n)
(Bos Taurus)
Mammalia FBXO16 33
  • 91.96 (n)
-- 34
  • 84 (a)
-- 34
  • 80 (a)
-- 34
  • 79 (a)
(Canis familiaris)
Mammalia -- 34
  • 90 (a)
LOC102155575 33
  • 88.26 (n)
-- 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Fbxo16 33
  • 83.8 (n)
(Mus musculus)
Mammalia Fbxo16 16 34 33
  • 83.1 (n)
(Monodelphis domestica)
Mammalia FBXO16 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia FBXO16 34
  • 64 (a)
(Gallus gallus)
Aves FBXO16 34 33
  • 70.45 (n)
(Anolis carolinensis)
Reptilia FBXO16 34
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo16 33
  • 67.98 (n)
(Danio rerio)
Actinopterygii fbxo16 34 33
  • 59.95 (n)
FBXO16 (2 of 2) 34
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for FBXO16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO16 Gene

Gene Tree for FBXO16 (if available)
Gene Tree for FBXO16 (if available)
Evolutionary constrained regions (ECRs) for FBXO16: view image

Paralogs for FBXO16 Gene

Paralogs for FBXO16 Gene

(2) SIMAP similar genes for FBXO16 Gene using alignment to 6 proteins:

  • G3V0Z8_HUMAN
  • H0YC72_HUMAN
genes like me logo Genes that share paralogs with FBXO16: view

Variants for FBXO16 Gene

Sequence variations from dbSNP and Humsavar for FBXO16 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000003945 -- 28,436,654(-) T/C intron_variant
rs1000010036 -- 28,465,817(-) T/G intron_variant
rs1000128817 -- 28,469,011(-) A/C intron_variant
rs1000159683 -- 28,488,930(-) A/G intron_variant
rs1000161621 -- 28,433,567(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO16 Gene

Variant ID Type Subtype PubMed ID
dgv2063e212 CNV loss 25503493
dgv456n21 CNV gain 19592680
esv2666579 CNV deletion 23128226
esv2678373 CNV deletion 23128226
esv27064 CNV loss 19812545
esv3543276 CNV deletion 23714750
esv3616738 CNV loss 21293372
esv3616739 CNV loss 21293372
nsv1109961 CNV deletion 24896259
nsv1125943 CNV tandem duplication 24896259
nsv527661 CNV loss 19592680

Variation tolerance for FBXO16 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.47; 95.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO16 Gene

Disorders for FBXO16 Gene

Additional Disease Information for FBXO16

No disorders were found for FBXO16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO16 Gene

Publications for FBXO16 Gene

  1. cDNA cloning and expression analysis of a novel human F-box only protein. (PMID: 12243353) Cheng H … Mao Y (Molecules and cells 2002) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang AG … Kim NS (Biochemical and biophysical research communications 2006) 3 58
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58

Products for FBXO16 Gene

Sources for FBXO16 Gene

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