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Aliases for FBXO15 Gene

Aliases for FBXO15 Gene

  • F-Box Protein 15 2 3 5
  • F-Box Only Protein 15 2 3
  • FBX15 3 4

External Ids for FBXO15 Gene

Previous GeneCards Identifiers for FBXO15 Gene

  • GC18M069889
  • GC18M069891
  • GC18M071740
  • GC18M068474

Summaries for FBXO15 Gene

Entrez Gene Summary for FBXO15 Gene

  • Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO15 Gene

FBXO15 (F-Box Protein 15) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for FBXO15 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXO15 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO15 Gene

Genomics for FBXO15 Gene

GeneHancer (GH) Regulatory Elements for FBXO15 Gene

Promoters and enhancers for FBXO15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I074146 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 559.5 -0.2 -213 3.8 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B TIMM21 FBXO15 ZNF407 CYB5A
GH18I074082 Enhancer 1.1 FANTOM5 Ensembl ENCODE 7.1 +64.2 64242 3.1 ELF3 CTCF KLF11 RNF2 ZNF792 ELF1 ZNF48 RAD21 KAT8 ZNF143 TIMM21 FBXO15 CYB5A ENSG00000263655
GH18I074342 Enhancer 0.6 ENCODE 10 -194.7 -194736 0.2 CTCF ZNF654 TRIM22 ZNF384 REST RAD21 SMC3 PRDM1 CNDP1 TIMM21 FBXO15 C18orf63 FAUP1
GH18I074141 Enhancer 0.7 Ensembl 7.3 +7.5 7464 0.4 HDGF ZNF639 PKNOX1 NR4A1 JUNB DPF2 ZBTB40 ZNF395 ZNF592 MEF2D TIMM21 FBXO15 ENSG00000263655
GH18I074062 Enhancer 0.5 FANTOM5 ENCODE 7.5 +83.1 83062 3.7 CTCF TIMM21 FBXO15 ENSG00000263655
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXO15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO15 gene promoter:

Genomic Locations for FBXO15 Gene

Genomic Locations for FBXO15 Gene
chr18:74,073,343-74,147,865
(GRCh38/hg38)
Size:
74,523 bases
Orientation:
Minus strand
chr18:71,740,588-71,815,100
(GRCh37/hg19)

Genomic View for FBXO15 Gene

Genes around FBXO15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO15 Gene

Proteins for FBXO15 Gene

  • Protein details for FBXO15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCQ5-FBX15_HUMAN
    Recommended name:
    F-box only protein 15
    Protein Accession:
    Q8NCQ5
    Secondary Accessions:
    • B3KST3

    Protein attributes for FBXO15 Gene

    Size:
    510 amino acids
    Molecular mass:
    57258 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXO15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO15 Gene

Post-translational modifications for FBXO15 Gene

No Post-translational modifications

No data available for DME Specific Peptides for FBXO15 Gene

Domains & Families for FBXO15 Gene

Gene Families for FBXO15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO15 Gene

Suggested Antigen Peptide Sequences for FBXO15 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO15: view

No data available for UniProtKB/Swiss-Prot for FBXO15 Gene

Function for FBXO15 Gene

Molecular function for FBXO15 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXO15 Gene

Gene Ontology (GO) - Molecular Function for FBXO15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with FBXO15: view
genes like me logo Genes that share phenotypes with FBXO15: view

Animal Models for FBXO15 Gene

MGI Knock Outs for FBXO15:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXO15 Gene

Localization for FBXO15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO15 gene
Compartment Confidence
cytosol 5
mitochondrion 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FBXO15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXO15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FBXO15 Gene

Pathways & Interactions for FBXO15 Gene

genes like me logo Genes that share pathways with FBXO15: view

Gene Ontology (GO) - Biological Process for FBXO15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXO15: view

No data available for SIGNOR curated interactions for FBXO15 Gene

Drugs & Compounds for FBXO15 Gene

No Compound Related Data Available

Transcripts for FBXO15 Gene

Unigene Clusters for FBXO15 Gene

F-box protein 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4:
SP5:

Relevant External Links for FBXO15 Gene

GeneLoc Exon Structure for
FBXO15
ECgene alternative splicing isoforms for
FBXO15

Expression for FBXO15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO15 Gene

This gene is overexpressed in Testis (x11.0).

Protein differential expression in normal tissues from HIPED for FBXO15 Gene

This gene is overexpressed in Heart (52.2) and Testis (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO15 Gene



Protein tissue co-expression partners for FBXO15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO15 Gene:

FBXO15

SOURCE GeneReport for Unigene cluster for FBXO15 Gene:

Hs.664011

Evidence on tissue expression from TISSUES for FBXO15 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FBXO15: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO15 Gene

Orthologs for FBXO15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO15 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO15 33 34
  • 80.91 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo15 33
  • 77.9 (n)
cow
(Bos Taurus)
Mammalia FBXO15 33 34
  • 73.69 (n)
mouse
(Mus musculus)
Mammalia Fbxo15 16 34 33
  • 70.93 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXO15 34
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO15 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO15 33 34
  • 63.69 (n)
lizard
(Anolis carolinensis)
Reptilia FBXO15 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo15 33
  • 57.23 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:161973 33
  • 47.81 (n)
FBXO15 (2 of 2) 34
  • 31 (a)
OneToMany
fbxo15 34
  • 30 (a)
OneToMany
Species where no ortholog for FBXO15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO15 Gene

ENSEMBL:
Gene Tree for FBXO15 (if available)
TreeFam:
Gene Tree for FBXO15 (if available)

Paralogs for FBXO15 Gene

(1) SIMAP similar genes for FBXO15 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with FBXO15: view

No data available for Paralogs for FBXO15 Gene

Variants for FBXO15 Gene

Sequence variations from dbSNP and Humsavar for FBXO15 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000085878 -- 74,075,014(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000093293 -- 74,116,499(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000194548 -- 74,147,177(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000227084 -- 74,147,932(-) C/T upstream_transcript_variant
rs1000229859 -- 74,136,177(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO15 Gene

Variant ID Type Subtype PubMed ID
nsv577650 CNV loss 21841781
nsv2355 CNV deletion 18451855
nsv1058079 CNV gain 25217958
esv3643108 CNV loss 21293372
esv3643105 CNV loss 21293372
esv27743 CNV loss 19812545
dgv3400n100 CNV gain 25217958

Variation tolerance for FBXO15 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO15 Gene

Human Gene Mutation Database (HGMD)
FBXO15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO15 Gene

Disorders for FBXO15 Gene

Additional Disease Information for FBXO15

No disorders were found for FBXO15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO15 Gene

Publications for FBXO15 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. (PMID: 12665572) Tokuzawa Y … Yamanaka S (Molecular and cellular biology 2003) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for FBXO15 Gene

Sources for FBXO15 Gene

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