Aliases for FBXO15 Gene
External Ids for FBXO15 Gene
- HGNC: 13617
- Entrez Gene: 201456
- Ensembl: ENSG00000141665
- OMIM: 609093
- UniProtKB: Q8NCQ5
Previous GeneCards Identifiers for FBXO15 Gene
- GC18M069889
- GC18M069891
- GC18M071740
- GC18M068474
Summaries for FBXO15 Gene
-
Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXO15 Gene
FBXO15 (F-Box Protein 15) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
UniProtKB/Swiss-Prot for FBXO15 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Additional gene information for FBXO15 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO15 Gene
Genomics for FBXO15 Gene
GeneHancer (GH) Regulatory Elements for FBXO15 Gene
Promoters and enhancers for FBXO15 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH18I074146 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 559.5 | -0.2 | -213 | 3.8 | PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B | TIMM21 FBXO15 ZNF407 CYB5A | |
| GH18I074082 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE | 7.1 | +64.2 | 64242 | 3.1 | ELF3 CTCF KLF11 RNF2 ZNF792 ELF1 ZNF48 RAD21 KAT8 ZNF143 | TIMM21 FBXO15 CYB5A ENSG00000263655 | |
| GH18I074342 | Enhancer | 0.6 | ENCODE | 10 | -194.7 | -194736 | 0.2 | CTCF ZNF654 TRIM22 ZNF384 REST RAD21 SMC3 PRDM1 | CNDP1 TIMM21 FBXO15 C18orf63 FAUP1 | |
| GH18I074141 | Enhancer | 0.7 | Ensembl | 7.3 | +7.5 | 7464 | 0.4 | HDGF ZNF639 PKNOX1 NR4A1 JUNB DPF2 ZBTB40 ZNF395 ZNF592 MEF2D | TIMM21 FBXO15 ENSG00000263655 | |
| GH18I074062 | Enhancer | 0.5 | FANTOM5 ENCODE | 7.5 | +83.1 | 83062 | 3.7 | CTCF | TIMM21 FBXO15 ENSG00000263655 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FBXO15 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for FBXO15 Gene
Genomic Locations for FBXO15 Gene
- chr18:74,073,343-74,147,865
- (GRCh38/hg38)
- Size:
- 74,523 bases
- Orientation:
- Minus strand
- chr18:71,740,588-71,815,100
- (GRCh37/hg19)
Genomic View for FBXO15 Gene
Genes around FBXO15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q22.3 by Ensembl
- 18q22.3 by Entrez Gene
- 18q22.3 by HGNC
FBXO15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO15 Gene
Proteins for FBXO15 Gene
-
Protein details for FBXO15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NCQ5-FBX15_HUMAN
- Recommended name:
- F-box only protein 15
- Protein Accession:
- Q8NCQ5
- B3KST3
Protein attributes for FBXO15 Gene
- Size:
- 510 amino acids
- Molecular mass:
- 57258 Da
- Quaternary structure:
-
- Directly interacts with SKP1 and CUL1.
Protein Expression for FBXO15 Gene
Post-translational modifications for FBXO15 Gene
No Post-translational modifications
Other Protein References for FBXO15 Gene
Antibody Products
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-
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Protein Products
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-
Quality Products:
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-
Abcam proteins for FBXO15
Assay Products
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No data available for DME Specific Peptides for FBXO15 Gene
Domains & Families for FBXO15 Gene
Gene Families for FBXO15 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FBXO15 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXO15 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO15 Gene
Function for FBXO15 Gene
Molecular function for FBXO15 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Phenotypes From GWAS Catalog for FBXO15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
Phenotypes for FBXO15 Gene
- MGI mutant phenotypes for FBXO15:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FBXO15:
Animal Models for FBXO15 Gene
- MGI Knock Outs for FBXO15:
-
- Fbxo15 tm1Yam
Animal Model Products
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-
-
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-
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- Search ViGene Biosciences for FBXO15
CRISPR Products
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Vectors and viruses for KO, Activation, Repression, and more
-
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-
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FBXO15
- genomics-online: cdna clones - Search results for available FBXO15 gene related products
- orf clones - Search results for available FBXO15 gene related products
- Applied Biological Materials Clones for FBXO15
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
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-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXO15 Gene
Localization for FBXO15 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FBXO15 Gene
Pathways & Interactions for FBXO15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Oct4 in Mammalian ESC Pluripotency | ||
| 3 | Innate Immune System |
.61
|
|
Pathways by source for FBXO15 Gene
4 Reactome pathways for FBXO15 Gene
1 Qiagen pathway for FBXO15 Gene
Interacting Proteins for FBXO15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IBA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXO15 Gene
Transcripts for FBXO15 Gene
mRNA/cDNA for FBXO15 Gene
- (8) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (46) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO15
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO15
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miRNA Products
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Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for FBXO15
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO15 gene
Clone Products
- Sino Biological Human cDNA Clone for FBXO15
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FBXO15
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FBXO15
- genomics-online: cdna clones - Search results for available FBXO15 gene related products
- orf clones - Search results for available FBXO15 gene related products
- Applied Biological Materials Clones for FBXO15
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||
| SP5: |
Expression for FBXO15 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Inner Cell Mass (Early Embryonic Tissues)
- 20D17
- 440A-3
- 492B4
- Inner Cell Mass Cells Inner Cell Mass
-
Gonad
- XY Germ Cells Testis Cord
- XX Germ Cells Ovigerous Cord
- Primordial Germ Cells Primitive Gonad
-
Testis (Reproductive System)
- XY Germ Cells Testis Cord
-
Ovary (Reproductive System)
- XX Germ Cells Ovigerous Cord
mRNA differential expression in normal tissues according to GTEx for FBXO15 Gene
This gene is overexpressed in Testis (x11.0).
This gene is overexpressed in Heart (52.2) and Testis (16.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO15 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FBXO15 Gene:
FBXO15SOURCE GeneReport for Unigene cluster for FBXO15 Gene:
Hs.664011Evidence on tissue expression from TISSUES for FBXO15 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for FBXO15
-
OriGene qPCR primer pairs and template standards for FBXO15
- genomics-online: primer clones - Search results for available FBXO15 gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO15 Gene
Orthologs for FBXO15 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO15 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXO15 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxo15 33 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXO15 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo15 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXO15 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXO15 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXO15 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXO15 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo15 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:161973 33 |
|
||
| FBXO15 (2 of 2) 34 |
|
OneToMany | |||
| fbxo15 34 |
|
OneToMany |
- Species where no ortholog for FBXO15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXO15 Gene
(1) SIMAP similar genes for FBXO15 Gene using alignment to 9 proteins:
No data available for Paralogs for FBXO15 Gene
Variants for FBXO15 Gene
| SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000085878 | -- | 74,075,014(-) | G/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000093293 | -- | 74,116,499(-) | A/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000194548 | -- | 74,147,177(-) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000227084 | -- | 74,147,932(-) | C/T | upstream_transcript_variant | |
| rs1000229859 | -- | 74,136,177(-) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv577650 | CNV | loss | 21841781 |
| nsv2355 | CNV | deletion | 18451855 |
| nsv1058079 | CNV | gain | 25217958 |
| esv3643108 | CNV | loss | 21293372 |
| esv3643105 | CNV | loss | 21293372 |
| esv27743 | CNV | loss | 19812545 |
| dgv3400n100 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.51;
55.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FBXO15 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO15 Gene
Disorders for FBXO15 Gene
Additional Disease Information for FBXO15
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for FBXO15 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO15 Gene
Publications for FBXO15 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. (PMID: 12665572) Tokuzawa Y … Yamanaka S (Molecular and cellular biology 2003) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
Products for FBXO15 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FBXO15
- antibodies-online: Search results for 66 available FBXO15 Antibodies ranked by validation data
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- genomics-online: cdna clones - Search results for available FBXO15 gene related products
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Sources for FBXO15 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (114) diseasecard
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- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew