Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction ... See more...

Aliases for FBXO15 Gene

Aliases for FBXO15 Gene

  • F-Box Protein 15 2 3 5
  • F-Box Only Protein 15 2 3 4
  • FBX15 2 3 4
  • MGC39671 2
  • FBXO15 5

External Ids for FBXO15 Gene

Previous GeneCards Identifiers for FBXO15 Gene

  • GC18M069889
  • GC18M069891
  • GC18M071740
  • GC18M068474

Summaries for FBXO15 Gene

Entrez Gene Summary for FBXO15 Gene

  • Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO15 Gene

FBXO15 (F-Box Protein 15) is a Protein Coding gene. Diseases associated with FBXO15 include Goldberg-Shprintzen Syndrome and Germ Cell And Embryonal Cancer. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXW5.

UniProtKB/Swiss-Prot Summary for FBXO15 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXO15 Gene

Genomics for FBXO15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FBXO15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J074146 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 259.4 -0.5 -543 4.4 ZSCAN16 CHD2 TBP ZBTB10 MXD4 SIX5 NR2C1 MNT IKZF1 SMAD5 TIMM21 FBXO15 MF281439 NONHSAG024161.2 ZNF407 CYB5A CNDP1
GH18J074082 Enhancer 1.1 FANTOM5 Ensembl ENCODE 7.1 +64.2 64220 3.1 CTCF ELF1 THAP11 SMAD4 MIER3 GABPB1 TEAD3 SMC3 RAD21 ZNF48 TIMM21 FBXO15 CYB5A piR-38872-002 lnc-CYB5A-3 ENSG00000263655
GH18J074342 Enhancer 0.7 Ensembl ENCODE 10 -194.8 -194799 0.5 CTCF REST TRIM22 SMC3 RAD21 ZNF384 ARID3A PRDM1 ZNF654 CNDP1 CYB5A FBXO15 TIMM21 piR-59907-012 C18orf63 RF00017-2704 HSALNG0122433 DIPK1C
GH18J074060 Enhancer 0.9 FANTOM5 Ensembl ENCODE 7.5 +84.4 84442 6.8 CEBPA SPI1 RFX1 CEBPG HNF4A TCF12 CTCF CHD2 TIMM21 FBXO15 CYB5A ZNF407-AS1 ENSG00000263655 piR-38872-002
GH18J074337 Enhancer 0.7 Ensembl 9.3 -190.0 -189958 0.4 IKZF1 TAL1 HDAC2 TCF12 MTA2 TEAD4 MEIS2 ARID1B CREM DPF2 CYB5A FBXO15 TIMM21 piR-59907-012 C18orf63 RF00017-2704 HSALNG0122433 DIPK1C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXO15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBXO15

Top Transcription factor binding sites by QIAGEN in the FBXO15 gene promoter:
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2C

Genomic Locations for FBXO15 Gene

Latest Assembly
chr18:74,073,343-74,147,843
(GRCh38/hg38)
Size:
74,501 bases
Orientation:
Minus strand

Previous Assembly
chr18:71,740,603-71,815,069
(GRCh37/hg19 by Entrez Gene)
Size:
74,467 bases
Orientation:
Minus strand

chr18:71,740,588-71,815,100
(GRCh37/hg19 by Ensembl)
Size:
74,513 bases
Orientation:
Minus strand

Genomic View for FBXO15 Gene

Genes around FBXO15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO15 Gene

Proteins for FBXO15 Gene

  • Protein details for FBXO15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCQ5-FBX15_HUMAN
    Recommended name:
    F-box only protein 15
    Protein Accession:
    Q8NCQ5
    Secondary Accessions:
    • B3KST3

    Protein attributes for FBXO15 Gene

    Size:
    510 amino acids
    Molecular mass:
    57258 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXO15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO15 Gene

Post-translational modifications for FBXO15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXO15 Gene

Domains & Families for FBXO15 Gene

Gene Families for FBXO15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO15 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ36896 fis, clone BRACE2001107, highly similar to F-box only protein 15 (B3KST3_HUMAN)
  • F-box only protein 15 (FBX15_HUMAN)
genes like me logo Genes that share domains with FBXO15: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBXO15 Gene

Function for FBXO15 Gene

Molecular function for FBXO15 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXO15 Gene

Gene Ontology (GO) - Molecular Function for FBXO15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 32814053
genes like me logo Genes that share ontologies with FBXO15: view
genes like me logo Genes that share phenotypes with FBXO15: view

Animal Models for FBXO15 Gene

MGI Knock Outs for FBXO15:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXO15 Gene

Localization for FBXO15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO15 gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
lysosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for FBXO15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXO15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FBXO15 Gene

Pathways & Interactions for FBXO15 Gene

genes like me logo Genes that share pathways with FBXO15: view

Pathways by source for FBXO15 Gene

1 Qiagen pathway for FBXO15 Gene
  • Oct4 in Mammalian ESC Pluripotency

Gene Ontology (GO) - Biological Process for FBXO15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXO15: view

No data available for SIGNOR curated interactions for FBXO15 Gene

Drugs & Compounds for FBXO15 Gene

No Compound Related Data Available

Transcripts for FBXO15 Gene

mRNA/cDNA for FBXO15 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXO15

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4:
SP5:

Relevant External Links for FBXO15 Gene

GeneLoc Exon Structure for
FBXO15

Expression for FBXO15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXO15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO15 Gene

This gene is overexpressed in Testis (x11.0).

Protein differential expression in normal tissues from HIPED for FBXO15 Gene

This gene is overexpressed in Heart (52.2) and Testis (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXO15 Gene



Protein tissue co-expression partners for FBXO15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBXO15

SOURCE GeneReport for Unigene cluster for FBXO15 Gene:

Hs.664011

Evidence on tissue expression from TISSUES for FBXO15 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with FBXO15: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO15 Gene

Orthologs for FBXO15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FBXO15 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FBXO15 30 31
  • 80.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fbxo15 30
  • 77.9 (n)
Cow
(Bos Taurus)
Mammalia FBXO15 30 31
  • 73.69 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fbxo15 30 17 31
  • 70.93 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FBXO15 31
  • 63 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FBXO15 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FBXO15 30 31
  • 63.69 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FBXO15 31
  • 47 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fbxo15 30
  • 57.23 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:161973 30
  • 47.81 (n)
FBXO15 (2 of 2) 31
  • 31 (a)
OneToMany
fbxo15 31
  • 30 (a)
OneToMany
Species where no ortholog for FBXO15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FBXO15 Gene

ENSEMBL:
Gene Tree for FBXO15 (if available)
TreeFam:
Gene Tree for FBXO15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXO15: view image

Paralogs for FBXO15 Gene

Paralogs for FBXO15 Gene

(1) SIMAP similar genes for FBXO15 Gene using alignment to 9 proteins:

  • FBX15_HUMAN
  • J3KRQ6_HUMAN
  • J3KRS5_HUMAN
  • J3KRT3_HUMAN
  • J3KS84_HUMAN
  • J3QKV0_HUMAN
  • J3QL50_HUMAN
  • J3QLF9_HUMAN
  • J3QRE7_HUMAN
genes like me logo Genes that share paralogs with FBXO15: view

Variants for FBXO15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBXO15 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs114044705 Benign: not provided 74,073,539(-) G/A
NM_001142958.2(FBXO15):c.1455C>T (p.Thr485=)
SYNONYMOUS
rs35815390 - p.Tyr496His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FBXO15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FBXO15 Gene

Variant ID Type Subtype PubMed ID
dgv3400n100 CNV gain 25217958
esv27743 CNV loss 19812545
esv3643105 CNV loss 21293372
esv3643108 CNV loss 21293372
nsv1058079 CNV gain 25217958
nsv2355 CNV deletion 18451855
nsv577650 CNV loss 21841781

Variation tolerance for FBXO15 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO15 Gene

Human Gene Mutation Database (HGMD)
FBXO15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO15 Gene

Disorders for FBXO15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FBXO15 Gene - From: COP

Disorder Aliases PubMed IDs
goldberg-shprintzen syndrome
  • goshs
germ cell and embryonal cancer
  • germ cell and embryonal neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FBXO15

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FBXO15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO15 Gene

Publications for FBXO15 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. (PMID: 12665572) Tokuzawa Y … Yamanaka S (Molecular and cellular biology 2003) 2 3
  4. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
  5. Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs. (PMID: 31130363) Clijsters L … Pagano M (Molecular cell 2019) 3

Products for FBXO15 Gene

Sources for FBXO15 Gene