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Aliases for FBXL8 Gene

Aliases for FBXL8 Gene

  • F-Box And Leucine Rich Repeat Protein 8 2 3 5
  • F-Box Protein FBL8 3 4
  • FBL8 3 4
  • F-Box And Leucine-Rich Repeat Protein 8 4
  • F-Box/LRR-Repeat Protein 8 3

External Ids for FBXL8 Gene

Previous GeneCards Identifiers for FBXL8 Gene

  • GC16U990141
  • GC16P067571
  • GC16P066929
  • GC16P066970
  • GC16P065751
  • GC16P053067

Summaries for FBXL8 Gene

Entrez Gene Summary for FBXL8 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXL8 Gene

FBXL8 (F-Box And Leucine Rich Repeat Protein 8) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ENSG00000265690.

UniProtKB/Swiss-Prot for FBXL8 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXL8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL8 Gene

Genomics for FBXL8 Gene

GeneHancer (GH) Regulatory Elements for FBXL8 Gene

Promoters and enhancers for FBXL8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I067157 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 560.8 -0.5 -491 4.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 FBXL8 TRADD ENSG00000260465 CTCF ZDHHC1 SLC12A4 ELMO3 THAP11 LRRC36 B3GNT9
GH16I067555 Enhancer 1.3 Ensembl ENCODE dbSUPER 40.2 +396.4 396377 2 ZNF493 ZFP64 ZNF121 ZNF213 KLF7 FOS ZNF202 ZC3H11A REST ZNF623 ZDHHC1 EDC4 ENSG00000260465 CENPT CTCF NAE1 E2F4 ENKD1 ENSG00000263276 ENSG00000270165
GH16I066547 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.3 -608.9 -608880 6.6 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF416 ZNF143 SP3 NFYC TK2 ENSG00000261519 PIR54425 PIR51465 ENSG00000275745 CKLF-CMTM1 CKLF NAE1 ZDHHC1 BEAN1
GH16I067987 Enhancer 1 Ensembl ENCODE 40.2 +827.7 827711 1 ELF3 ZNF493 ZFP64 ARID4B RAD21 ZNF48 ZNF213 KLF7 ZNF680 ZBTB11 DUS2 ZDHHC1 EDC4 CENPT CTCF E2F4 ENKD1 ENSG00000263276 FBXL8 ENSG00000270165
GH16I067027 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.1 -130.4 -130440 3 HDGF FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 CBFB ENSG00000260465 E2F4 CTCF FBXL8 ENSG00000270165 C16orf70 EDC4 B3GNT9 RANBP10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXL8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXL8 gene promoter:

Genomic Locations for FBXL8 Gene

Genomic Locations for FBXL8 Gene
4,640 bases
Plus strand

Genomic View for FBXL8 Gene

Genes around FBXL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL8 Gene

Proteins for FBXL8 Gene

  • Protein details for FBXL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 8
    Protein Accession:
    Secondary Accessions:
    • Q9NUM0

    Protein attributes for FBXL8 Gene

    374 amino acids
    Molecular mass:
    40516 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

neXtProt entry for FBXL8 Gene

Post-translational modifications for FBXL8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for FBXL8 Gene

Domains & Families for FBXL8 Gene

Gene Families for FBXL8 Gene

Protein Domains for FBXL8 Gene

Suggested Antigen Peptide Sequences for FBXL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL8: view

No data available for UniProtKB/Swiss-Prot for FBXL8 Gene

Function for FBXL8 Gene

Molecular function for FBXL8 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXL8 Gene

Gene Ontology (GO) - Molecular Function for FBXL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 19159283
genes like me logo Genes that share ontologies with FBXL8: view

Phenotypes for FBXL8 Gene

genes like me logo Genes that share phenotypes with FBXL8: view

miRNA for FBXL8 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL8 Gene

Localization for FBXL8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL8 gene
Compartment Confidence
cytosol 5
extracellular 3
golgi apparatus 2
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FBXL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXL8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXL8 Gene

Pathways & Interactions for FBXL8 Gene

genes like me logo Genes that share pathways with FBXL8: view

Gene Ontology (GO) - Biological Process for FBXL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXL8: view

No data available for SIGNOR curated interactions for FBXL8 Gene

Drugs & Compounds for FBXL8 Gene

No Compound Related Data Available

Transcripts for FBXL8 Gene

Unigene Clusters for FBXL8 Gene

F-box and leucine-rich repeat protein 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1: - - - - - - - - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - - - - -
SP8: - -
SP9: - -

Relevant External Links for FBXL8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL8 Gene

mRNA differential expression in normal tissues according to GTEx for FBXL8 Gene

This gene is overexpressed in Pituitary (x5.4).

Protein differential expression in normal tissues from HIPED for FBXL8 Gene

This gene is overexpressed in Salivary gland (8.5), Stomach (7.1), Peripheral blood mononuclear cells (6.7), Islet of Langerhans (6.6), and Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL8 Gene

Protein tissue co-expression partners for FBXL8 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXL8 Gene:


SOURCE GeneReport for Unigene cluster for FBXL8 Gene:


Evidence on tissue expression from TISSUES for FBXL8 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with FBXL8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL8 Gene

Orthologs for FBXL8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXL8 33 34
  • 99.55 (n)
(Bos Taurus)
Mammalia FBXL8 33 34
  • 85.65 (n)
(Canis familiaris)
Mammalia FBXL8 33
  • 84.49 (n)
-- 34
  • 84 (a)
(Mus musculus)
Mammalia Fbxl8 33 16 34
  • 79.71 (n)
(Rattus norvegicus)
Mammalia Fbxl8 33
  • 77.48 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 57 (a)
(Gallus gallus)
Aves FBXL8 33 34
  • 52.33 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
-- 34
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl8 33
  • 45.86 (n)
(Danio rerio)
Actinopterygii fbxl8 33 34
  • 47.84 (n)
Species where no ortholog for FBXL8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL8 Gene

Gene Tree for FBXL8 (if available)
Gene Tree for FBXL8 (if available)

Paralogs for FBXL8 Gene

Paralogs for FBXL8 Gene

genes like me logo Genes that share paralogs with FBXL8: view

Variants for FBXL8 Gene

Sequence variations from dbSNP and Humsavar for FBXL8 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs140579779 likely-benign, Cataract 67,164,562(+) C/T downstream_transcript_variant
rs147591659 uncertain-significance, Cataract 67,163,785(+) G/A/C/T coding_sequence_variant, missense_variant, stop_gained
rs192479571 likely-benign, Cataract 67,164,589(+) C/T downstream_transcript_variant
rs200404151 likely-benign, Cataract 67,163,728(+) G/C coding_sequence_variant, missense_variant
rs201429195 likely-benign, Cataract 67,163,470(+) G/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL8 Gene

Variant ID Type Subtype PubMed ID
nsv1160429 CNV deletion 26073780
nsv476845 CNV novel sequence insertion 20440878
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv827707 CNV loss 20364138
nsv952044 CNV deletion 24416366

Variation tolerance for FBXL8 Gene

Gene Damage Index Score: 3.27; 52.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXL8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL8 Gene

Disorders for FBXL8 Gene

Additional Disease Information for FBXL8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FBXL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL8 Gene

Publications for FBXL8 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S … Beisel C (Cell reports 2016) 3 58

Products for FBXL8 Gene

Sources for FBXL8 Gene

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