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Aliases for FBXL7 Gene

Aliases for FBXL7 Gene

  • F-Box And Leucine Rich Repeat Protein 7 2 3 5
  • FBL6 3 4
  • FBL7 3 4
  • F-Box And Leucine-Rich Repeat Protein 7 4
  • F-Box/LRR-Repeat Protein 7 3
  • F-Box Protein FBL6/FBL7 4
  • F-Box Protein Fbl7 3
  • KIAA0840 4

External Ids for FBXL7 Gene

Previous GeneCards Identifiers for FBXL7 Gene

  • GC05P015490
  • GC05P015777

Summaries for FBXL7 Gene

Entrez Gene Summary for FBXL7 Gene

  • This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for FBXL7 Gene

FBXL7 (F-Box And Leucine Rich Repeat Protein 7) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL20.

UniProtKB/Swiss-Prot for FBXL7 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.

Gene Wiki entry for FBXL7 Gene

Additional gene information for FBXL7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL7 Gene

Genomics for FBXL7 Gene

GeneHancer (GH) Regulatory Elements for FBXL7 Gene

Promoters and enhancers for FBXL7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I015499 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 +1.0 1048 3.3 CTCF PKNOX1 USF1 SIN3A ZIC2 RAD21 E2F1 POLR2A SCRT2 RCOR1 FBXL7 PIR59856
GH05I015612 Promoter 0.5 EPDnew 550.1 +112.6 112624 0.1 FBXL7 CTD-2350J17.1 PIR59856
GH05I016460 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.7 +964.3 964304 7.8 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B GC05P016465 ZNF622 LINC02150 FBXL7 GC05P016453
GH05I015693 Enhancer 0.6 Ensembl ENCODE 10.6 +194.5 194495 3 POLR2A EZH2 FBXL7 GC05P015701 GC05P015675
GH05I015719 Enhancer 0.4 ENCODE 10 +219.2 219226 1.4 RCOR1 CHD2 FBXL7 GC05M015718 GC05P015701
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXL7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXL7 gene promoter:

Genomic Locations for FBXL7 Gene

Genomic Locations for FBXL7 Gene
439,632 bases
Plus strand

Genomic View for FBXL7 Gene

Genes around FBXL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL7 Gene

Proteins for FBXL7 Gene

  • Protein details for FBXL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 7
    Protein Accession:
    Secondary Accessions:
    • B9EGF1
    • D6RDY7
    • O94926

    Protein attributes for FBXL7 Gene

    491 amino acids
    Molecular mass:
    54575 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase (By similarity).
    • Sequence=BAA74863.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL7 Gene


neXtProt entry for FBXL7 Gene

Post-translational modifications for FBXL7 Gene

No Post-translational modifications

Other Protein References for FBXL7 Gene

No data available for DME Specific Peptides for FBXL7 Gene

Domains & Families for FBXL7 Gene

Gene Families for FBXL7 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FBXL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FBXL7 family.
  • Belongs to the FBXL7 family.
genes like me logo Genes that share domains with FBXL7: view

Function for FBXL7 Gene

Molecular function for FBXL7 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.

Phenotypes From GWAS Catalog for FBXL7 Gene

Gene Ontology (GO) - Molecular Function for FBXL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with FBXL7: view
genes like me logo Genes that share phenotypes with FBXL7: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL7 Gene

Localization for FBXL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosome during spindle formation. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL7 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FBXL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome ISS --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXL7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FBXL7 Gene

Pathways & Interactions for FBXL7 Gene

genes like me logo Genes that share pathways with FBXL7: view

UniProtKB/Swiss-Prot Q9UJT9-FBXL7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle ISS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle ISS --
GO:0006511 ubiquitin-dependent protein catabolic process NAS 10531035
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with FBXL7: view

No data available for SIGNOR curated interactions for FBXL7 Gene

Drugs & Compounds for FBXL7 Gene

No Compound Related Data Available

Transcripts for FBXL7 Gene

Unigene Clusters for FBXL7 Gene

F-box and leucine-rich repeat protein 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL7 Gene

No ASD Table

Relevant External Links for FBXL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL7 Gene

This gene is overexpressed in Platelet (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXL7 Gene

Protein tissue co-expression partners for FBXL7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXL7 Gene:


SOURCE GeneReport for Unigene cluster for FBXL7 Gene:


Evidence on tissue expression from TISSUES for FBXL7 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with FBXL7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL7 Gene

Orthologs for FBXL7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXL7 33 34
  • 99.8 (n)
(Monodelphis domestica)
Mammalia FBXL7 34
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia FBXL7 34
  • 95 (a)
(Bos Taurus)
Mammalia FBXL7 33 34
  • 93.41 (n)
(Mus musculus)
Mammalia Fbxl7 33 16 34
  • 89.61 (n)
(Rattus norvegicus)
Mammalia Fbxl7 33
  • 89.07 (n)
(Canis familiaris)
Mammalia FBXL7 33 34
  • 85.7 (n)
(Gallus gallus)
Aves FBXL7 33 34
  • 85.41 (n)
(Anolis carolinensis)
Reptilia FBXL7 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl7 33
  • 78.5 (n)
(Danio rerio)
Actinopterygii FBXL7 34
  • 82 (a)
zgc:158346 33
  • 75.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4221 35 33 34
  • 58.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003285 33
  • 56.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRR1 34
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
Species where no ortholog for FBXL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL7 Gene

Gene Tree for FBXL7 (if available)
Gene Tree for FBXL7 (if available)

Paralogs for FBXL7 Gene

Paralogs for FBXL7 Gene

(2) SIMAP similar genes for FBXL7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXL7: view

Variants for FBXL7 Gene

Sequence variations from dbSNP and Humsavar for FBXL7 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000007770 -- 15,918,588(+) A/C intron_variant
rs1000008388 -- 15,817,322(+) A/G intron_variant
rs1000025863 -- 15,678,740(+) C/T intron_variant
rs1000026724 -- 15,649,845(+) C/T intron_variant
rs1000033765 -- 15,731,516(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL7 Gene

Variant ID Type Subtype PubMed ID
nsv830216 CNV loss 17160897
nsv830214 CNV gain 17160897
nsv823014 CNV loss 20364138
nsv818320 CNV loss 17921354
nsv818319 CNV loss 17921354
nsv597292 CNV gain 21841781
nsv597270 CNV loss 21841781
nsv597265 CNV loss 21841781
nsv516929 CNV gain+loss 19592680
nsv514291 CNV loss 21397061
nsv475636 CNV novel sequence insertion 20440878
nsv4735 CNV deletion 18451855
nsv4734 CNV insertion 18451855
nsv4733 CNV insertion 18451855
nsv4732 CNV deletion 18451855
nsv4730 CNV insertion 18451855
nsv471736 CNV loss 16327809
nsv461985 CNV loss 19166990
nsv461983 CNV loss 19166990
nsv442939 CNV loss 18776908
nsv1161215 CNV deletion 26073780
nsv1161214 CNV deletion 26073780
nsv1161213 CNV deletion 26073780
nsv1161212 CNV deletion 26073780
nsv1144102 CNV deletion 24896259
nsv1121642 CNV deletion 24896259
nsv1074816 CNV deletion 25765185
nsv1072537 CNV deletion 25765185
nsv10671 CNV loss 18304495
nsv1031483 CNV gain 25217958
esv3894140 CNV loss 25118596
esv3894139 CNV loss 25118596
esv3604118 CNV loss 21293372
esv3604117 CNV loss 21293372
esv3604116 CNV loss 21293372
esv3604115 CNV loss 21293372
esv3604114 CNV loss 21293372
esv3604112 CNV loss 21293372
esv3570006 CNV loss 25503493
esv3570003 CNV loss 25503493
esv3565569 CNV deletion 23714750
esv3343086 CNV insertion 20981092
esv2763894 CNV loss 21179565
esv2760924 CNV loss 21179565
esv2759327 CNV gain+loss 17122850
esv2729827 CNV deletion 23290073
esv2729826 CNV deletion 23290073
esv2729825 CNV deletion 23290073
esv2729824 CNV deletion 23290073
esv2672541 CNV deletion 23128226
esv2671030 CNV deletion 23128226
esv2656471 CNV deletion 23128226
esv2517640 CNV deletion 19546169
esv2421516 CNV deletion 20811451
esv2395102 CNV deletion 18987734
esv23849 CNV loss 19812545
esv2021602 CNV deletion 18987734
dgv9616n54 CNV loss 21841781
dgv9615n54 CNV loss 21841781
dgv9614n54 CNV loss 21841781
dgv9613n54 CNV loss 21841781
dgv9612n54 CNV loss 21841781
dgv9611n54 CNV loss 21841781
dgv9610n54 CNV loss 21841781
dgv55e213 CNV loss 24956385
dgv3047n106 CNV deletion 24896259
dgv1582e212 CNV loss 25503493

Variation tolerance for FBXL7 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL7 Gene

Disorders for FBXL7 Gene

Additional Disease Information for FBXL7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FBXL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL7 Gene

Publications for FBXL7 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PMID: 20418484) Wang X … Couch FJ (Human molecular genetics 2010) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FBXL7 Gene

Sources for FBXL7 Gene

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