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Aliases for FBXL6 Gene

Aliases for FBXL6 Gene

  • F-Box And Leucine Rich Repeat Protein 6 2 3 5
  • FBL6A 3 4
  • FBL6 3 4
  • F-Box And Leucine-Rich Repeat Protein 6 4
  • F-Box/LRR-Repeat Protein 6 3
  • F-Box Protein Fbl6 3
  • F-Box Protein FBL6 4
  • PP14630 3

External Ids for FBXL6 Gene

Previous GeneCards Identifiers for FBXL6 Gene

  • GC08P143145
  • GC08U900020
  • GC08M145183
  • GC08M145583
  • GC08M145549
  • GC08M140694
  • GC08M145579

Summaries for FBXL6 Gene

Entrez Gene Summary for FBXL6 Gene

  • This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF (SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for FBXL6 Gene

FBXL6 (F-Box And Leucine Rich Repeat Protein 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000271698.

UniProtKB/Swiss-Prot for FBXL6 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXL6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL6 Gene

Genomics for FBXL6 Gene

GeneHancer (GH) Regulatory Elements for FBXL6 Gene

Promoters and enhancers for FBXL6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I144353 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.8 +2.9 2864 6.7 PKNOX1 ARID4B SIN3A DMAP1 POLR2B E2F8 ZNF207 ZNF143 SP3 NFYC ENSG00000271698 FBXL6 SLC52A2 TMEM249 CPSF1 VPS28 SHARPIN HSF1 ZNF7 ZNF707
GH08I144290 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.8 +66.0 65974 6 PKNOX1 CLOCK ATF1 ARNT ARID4B NEUROD1 SIN3A YY1 GATA2 ELK1 BOP1 HSF1 ZNF7 CPSF1 VPS28 ZNF623 SLC52A2 DGAT1 ENSG00000254690 COMMD5
GH08I144785 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 -430.4 -430355 9 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 NFYC SSRP1 ZNF610 RPL8 ZNF34 PIR52884 VPS28 ZNF7 CPSF1 ZNF250 PARP10 COMMD5 LOC105375803
GH08I143540 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.6 +818.0 817967 2.2 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B ZNF766 ZC3H3 ENSG00000254144 GC08P143575 RN7SKP175 ENSG00000254859 GSDMD CPSF1 VPS28 ZNF623 SLC52A2
GH08I143595 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.9 +761.4 761444 5.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 EEF1D TIGD5 PIR45575 NAPRT CPSF1 ZNF623 VPS28 JRK LOC105375803 GPAA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXL6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXL6 gene promoter:

Genomic Locations for FBXL6 Gene

Genomic Locations for FBXL6 Gene
3,949 bases
Minus strand

Genomic View for FBXL6 Gene

Genes around FBXL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL6 Gene

Proteins for FBXL6 Gene

  • Protein details for FBXL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 6
    Protein Accession:
    Secondary Accessions:
    • Q53G43
    • Q9H5W9
    • Q9UKC7

    Protein attributes for FBXL6 Gene

    539 amino acids
    Molecular mass:
    58588 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL6 Gene


neXtProt entry for FBXL6 Gene

Post-translational modifications for FBXL6 Gene

Other Protein References for FBXL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL6 Gene

Domains & Families for FBXL6 Gene

Gene Families for FBXL6 Gene

Suggested Antigen Peptide Sequences for FBXL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL6: view

No data available for UniProtKB/Swiss-Prot for FBXL6 Gene

Function for FBXL6 Gene

Molecular function for FBXL6 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 10531035
genes like me logo Genes that share ontologies with FBXL6: view
genes like me logo Genes that share phenotypes with FBXL6: view

miRNA for FBXL6 Gene

miRTarBase miRNAs that target FBXL6

Clone Products

  • Addgene plasmids for FBXL6

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL6 Gene

Localization for FBXL6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL6 gene
Compartment Confidence
nucleus 3
mitochondrion 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL6 Gene

Pathways & Interactions for FBXL6 Gene

SuperPathways for FBXL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 10531035
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with FBXL6: view

No data available for Pathways by source and SIGNOR curated interactions for FBXL6 Gene

Drugs & Compounds for FBXL6 Gene

No Compound Related Data Available

Transcripts for FBXL6 Gene

Unigene Clusters for FBXL6 Gene

F-box and leucine-rich repeat protein 6:
Representative Sequences:

Clone Products

  • Addgene plasmids for FBXL6

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - -
SP7: - -

Relevant External Links for FBXL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL6 Gene

This gene is overexpressed in Nasal epithelium (51.8), Lung (9.2), and Plasma (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL6 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXL6 Gene:


SOURCE GeneReport for Unigene cluster for FBXL6 Gene:


Evidence on tissue expression from TISSUES for FBXL6 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with FBXL6: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL6 Gene

Orthologs for FBXL6 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXL6 33 34
  • 98.82 (n)
(Canis familiaris)
Mammalia FBXL6 33 34
  • 85.08 (n)
(Bos Taurus)
Mammalia FBXL6 33 34
  • 84.64 (n)
(Mus musculus)
Mammalia Fbxl6 33 16 34
  • 81.08 (n)
(Rattus norvegicus)
Mammalia Fbxl6 33
  • 80.33 (n)
(Monodelphis domestica)
Mammalia FBXL6 34
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia FBXL6 34
  • 46 (a)
(Anolis carolinensis)
Reptilia FBXL6 34
  • 42 (a)
(Danio rerio)
Actinopterygii FBXL6 34
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006431 33
  • 48.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta fbl6 33 34
  • 46.12 (n)
CG13213 35
  • 33 (a)
Species where no ortholog for FBXL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL6 Gene

Gene Tree for FBXL6 (if available)
Gene Tree for FBXL6 (if available)

Paralogs for FBXL6 Gene

Paralogs for FBXL6 Gene

genes like me logo Genes that share paralogs with FBXL6: view

Variants for FBXL6 Gene

Sequence variations from dbSNP and Humsavar for FBXL6 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs111588500 likely-benign, not specified, Brown-Vialetto-Van Laere syndrome 2 144,359,720(-) C/T upstream_transcript_variant
rs117500243 uncertain-significance, benign, not specified, Brown-Vialetto-Van Laere syndrome 2 144,359,845(-) C/A/G/T upstream_transcript_variant
rs144912258 uncertain-significance, Brown-Vialetto-Van Laere syndrome 2 144,360,316(-) G/A/T upstream_transcript_variant
rs147954962 likely-benign, benign, not specified, Brown-Vialetto-Van Laere syndrome 2 144,360,135(-) C/T upstream_transcript_variant
rs151081625 uncertain-significance, Brown-Vialetto-Van Laere syndrome 2 144,360,027(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL6 Gene

Variant ID Type Subtype PubMed ID
nsv831489 CNV loss 17160897
nsv612931 CNV loss 21841781
nsv515809 CNV gain+loss 19592680
nsv470249 CNV loss 18288195
nsv428208 CNV gain 18775914
esv3399198 CNV insertion 20981092
esv3382509 CNV insertion 20981092
esv3310508 CNV novel sequence insertion 20981092
esv2759652 CNV gain+loss 17122850
esv2664345 CNV deletion 23128226
dgv12437n54 CNV loss 21841781
dgv12434n54 CNV loss 21841781

Variation tolerance for FBXL6 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXL6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL6 Gene

Disorders for FBXL6 Gene

Additional Disease Information for FBXL6

No disorders were found for FBXL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL6 Gene

Publications for FBXL6 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A family of mammalian F-box proteins. (PMID: 10531037) Winston JT … Harper JW (Current biology : CB 1999) 2 3 58
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58

Products for FBXL6 Gene

  • Addgene plasmids for FBXL6

Sources for FBXL6 Gene

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