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This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF (SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
FBXL6 (F-Box And Leucine Rich Repeat Protein 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL13.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | TAS | 10531035 |
GO:0005515 | protein binding | IEA | -- |
GO:0061630 | ubiquitin protein ligase activity | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005829 | cytosol | IBA | 21873635 |
GO:0019005 | SCF ubiquitin ligase complex | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000086 | G2/M transition of mitotic cell cycle | IBA | 21873635 |
GO:0006508 | proteolysis | TAS | 10531035 |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IBA | 21873635 |
GO:0043153 | entrainment of circadian clock by photoperiod | IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FBXL6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FBXL6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FBXL6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fbxl6 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fbxl6 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | FBXL6 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FBXL6 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FBXL6 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | FBXL6 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006431 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | fbl6 30 31 |
|
OneToOne | |
CG13213 32 |
|
|
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs782526479 | Uncertain Significance: not provided | 144,358,291(-) | C/T | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv12434n54 | CNV | loss | 21841781 |
dgv12437n54 | CNV | loss | 21841781 |
esv2664345 | CNV | deletion | 23128226 |
esv2759652 | CNV | gain+loss | 17122850 |
esv3310508 | CNV | novel sequence insertion | 20981092 |
esv3382509 | CNV | insertion | 20981092 |
esv3399198 | CNV | insertion | 20981092 |
nsv428208 | CNV | gain | 18775914 |
nsv470249 | CNV | loss | 18288195 |
nsv515809 | CNV | gain+loss | 19592680 |
nsv612931 | CNV | loss | 21841781 |
nsv831489 | CNV | loss | 17160897 |
No disorders were found for FBXL6 Gene.