This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF (SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing results in multiple transcript variants. [provided by ... See more...

Aliases for FBXL6 Gene

Aliases for FBXL6 Gene

  • F-Box And Leucine Rich Repeat Protein 6 2 3 5
  • FBL6 2 3 4
  • F-Box/LRR-Repeat Protein 6 3 4
  • FBL6A 3 4
  • F-Box And Leucine-Rich Repeat Protein 6 4
  • F-Box Protein Fbl6 3
  • F-Box Protein FBL6 4
  • PP14630 3
  • FBXL6 5

External Ids for FBXL6 Gene

Previous GeneCards Identifiers for FBXL6 Gene

  • GC08P143145
  • GC08U900020
  • GC08M145183
  • GC08M145583
  • GC08M145549
  • GC08M140694
  • GC08M145579

Summaries for FBXL6 Gene

Entrez Gene Summary for FBXL6 Gene

  • This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF (SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for FBXL6 Gene

FBXL6 (F-Box And Leucine Rich Repeat Protein 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL13.

UniProtKB/Swiss-Prot Summary for FBXL6 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXL6 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXL6 Gene

Genomics for FBXL6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FBXL6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXL6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBXL6

Top Transcription factor binding sites by QIAGEN in the FBXL6 gene promoter:
  • AML1a
  • c-Myc
  • Max
  • NRSF form 1
  • NRSF form 2
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for FBXL6 Gene

Genomic Locations for FBXL6 Gene
chr8:144,355,431-144,359,376
(GRCh38/hg38)
Size:
3,946 bases
Orientation:
Minus strand
chr8:145,579,091-145,583,036
(GRCh37/hg19)
Size:
3,946 bases
Orientation:
Minus strand

Genomic View for FBXL6 Gene

Genes around FBXL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL6 Gene

Proteins for FBXL6 Gene

  • Protein details for FBXL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N531-FBXL6_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 6
    Protein Accession:
    Q8N531
    Secondary Accessions:
    • Q53G43
    • Q9H5W9
    • Q9UKC7

    Protein attributes for FBXL6 Gene

    Size:
    539 amino acids
    Molecular mass:
    58588 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL6 Gene

Post-translational modifications for FBXL6 Gene

  • Ubiquitination at Lys428
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL6 Gene

Domains & Families for FBXL6 Gene

Gene Families for FBXL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXL6 Gene

InterPro:
Blocks:
  • Leucine-rich repeat 2
ProtoNet:

Suggested Antigen Peptide Sequences for FBXL6 Gene

GenScript: Design optimal peptide antigens:
  • FBL6A (FBXL6_HUMAN)
  • PP14630 (Q71RB6_HUMAN)
genes like me logo Genes that share domains with FBXL6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBXL6 Gene

Function for FBXL6 Gene

Molecular function for FBXL6 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXL6 Gene

Gene Ontology (GO) - Molecular Function for FBXL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 10531035
GO:0005515 protein binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with FBXL6: view
genes like me logo Genes that share phenotypes with FBXL6: view

Animal Model Products

CRISPR Products

miRNA for FBXL6 Gene

miRTarBase miRNAs that target FBXL6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXL6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL6 Gene

Localization for FBXL6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL6 gene
Compartment Confidence
nucleus 3
mitochondrion 2
plasma membrane 1
cytoskeleton 1
cytosol 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FBXL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005829 cytosol IBA 21873635
GO:0019005 SCF ubiquitin ligase complex IBA 21873635
genes like me logo Genes that share ontologies with FBXL6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXL6 Gene

Pathways & Interactions for FBXL6 Gene

PathCards logo

SuperPathways for FBXL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IBA 21873635
GO:0006508 proteolysis TAS 10531035
GO:0016567 protein ubiquitination IEA --
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA 21873635
GO:0043153 entrainment of circadian clock by photoperiod IBA 21873635
genes like me logo Genes that share ontologies with FBXL6: view

No data available for Pathways by source and SIGNOR curated interactions for FBXL6 Gene

Drugs & Compounds for FBXL6 Gene

No Compound Related Data Available

Transcripts for FBXL6 Gene

mRNA/cDNA for FBXL6 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXL6

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - -
SP5:
SP6:
SP7: - -
SP8:

Relevant External Links for FBXL6 Gene

GeneLoc Exon Structure for
FBXL6

Expression for FBXL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL6 Gene

This gene is overexpressed in Nasal epithelium (51.8), Lung (9.2), and Plasma (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXL6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBXL6

SOURCE GeneReport for Unigene cluster for FBXL6 Gene:

Hs.12271

Evidence on tissue expression from TISSUES for FBXL6 Gene

  • Skin(4.3)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with FBXL6: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL6 Gene

Orthologs for FBXL6 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FBXL6 30 31
  • 98.82 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FBXL6 30 31
  • 85.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FBXL6 30 31
  • 84.64 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fbxl6 30 17 31
  • 81.08 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fbxl6 30
  • 80.33 (n)
Oppossum
(Monodelphis domestica)
Mammalia FBXL6 31
  • 51 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FBXL6 31
  • 46 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FBXL6 31
  • 42 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii FBXL6 31
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006431 30
  • 48.47 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta fbl6 30 31
  • 46.12 (n)
OneToOne
CG13213 32
  • 33 (a)
Species where no ortholog for FBXL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FBXL6 Gene

ENSEMBL:
Gene Tree for FBXL6 (if available)
TreeFam:
Gene Tree for FBXL6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXL6: view image

Paralogs for FBXL6 Gene

genes like me logo Genes that share paralogs with FBXL6: view

Variants for FBXL6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBXL6 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs782526479 Uncertain Significance: not provided 144,358,291(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for FBXL6 Gene

Structural Variations from Database of Genomic Variants (DGV) for FBXL6 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
dgv12437n54 CNV loss 21841781
esv2664345 CNV deletion 23128226
esv2759652 CNV gain+loss 17122850
esv3310508 CNV novel sequence insertion 20981092
esv3382509 CNV insertion 20981092
esv3399198 CNV insertion 20981092
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612931 CNV loss 21841781
nsv831489 CNV loss 17160897

Variation tolerance for FBXL6 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXL6 Gene

Human Gene Mutation Database (HGMD)
FBXL6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL6 Gene

Disorders for FBXL6 Gene

No disorders were found for FBXL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL6 Gene

Publications for FBXL6 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. A family of mammalian F-box proteins. (PMID: 10531037) Winston JT … Harper JW (Current biology : CB 1999) 2 3
  5. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3

Products for FBXL6 Gene

Sources for FBXL6 Gene