Aliases for FBXL5 Gene
External Ids for FBXL5 Gene
Previous GeneCards Identifiers for FBXL5 Gene
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]
GeneCards Summary for FBXL5 Gene
FBXL5 (F-Box And Leucine Rich Repeat Protein 5) is a Protein Coding gene. Diseases associated with FBXL5 include Spastic Paraplegia 38, Autosomal Dominant and Familial Expansile Osteolysis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and iron ion binding. An important paralog of this gene is SKP2.
UniProtKB/Swiss-Prot Summary for FBXL5 Gene
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.