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Aliases for FBXL3 Gene

Aliases for FBXL3 Gene

  • F-Box And Leucine Rich Repeat Protein 3 2 3 5
  • F-Box And Leucine-Rich Repeat Protein 3A 2 3 4
  • F-Box/LRR-Repeat Protein 3A 3 4
  • FBXL3A 3 4
  • FBL3A 3 4
  • F-Box/LRR-Repeat Protein 3 3
  • F-Box Protein Fbl3a 3
  • FBL3 3

External Ids for FBXL3 Gene

Previous HGNC Symbols for FBXL3 Gene

  • FBXL3A

Previous GeneCards Identifiers for FBXL3 Gene

  • GC13M076477
  • GC13M077566
  • GC13M058277

Summaries for FBXL3 Gene

Entrez Gene Summary for FBXL3 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXL3 Gene

FBXL3 (F-Box And Leucine Rich Repeat Protein 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXL3 Gene

  • Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).

Gene Wiki entry for FBXL3 Gene

Additional gene information for FBXL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL3 Gene

Genomics for FBXL3 Gene

GeneHancer (GH) Regulatory Elements for FBXL3 Gene

Promoters and enhancers for FBXL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I077025 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 565 +0.4 355 3.5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 YY1 POLR2B ZNF766 FBXL3 MYCBP2-AS1 ENSG00000274898 MYCBP2-AS2 CLN5 ENSG00000283208
GH13I076990 Promoter/Enhancer 1.5 Ensembl ENCODE 14.5 +34.5 34454 3.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 POLR2B ENSG00000283208 FBXL3 CLN5 MYCBP2-AS1
GH13I076980 Enhancer 1 Ensembl ENCODE 10.3 +46.9 46895 0.6 ARNT ARID4B SIN3A ZNF48 RAD21 GLIS2 ZNF143 RCOR1 BCLAF1 RUNX3 GC13M076982 RPL7P44 FBXL3 ACOD1
GH13I077324 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.1 -299.1 -299108 3.1 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 MYCBP2 CLN5 FBXL3 KCTD12 GC13P077273
GH13I077022 Enhancer 0.5 Ensembl 11 +4.7 4695 0.6 MYNN PRDM10 ZNF600 ZBTB17 MYCBP2-AS2 FBXL3 MYCBP2 MYCBP2-AS1 ENSG00000283208
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXL3 gene promoter:

Genomic Locations for FBXL3 Gene

Genomic Locations for FBXL3 Gene
chr13:76,992,598-77,027,196
(GRCh38/hg38)
Size:
34,599 bases
Orientation:
Minus strand
chr13:77,566,740-77,601,331
(GRCh37/hg19)

Genomic View for FBXL3 Gene

Genes around FBXL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL3 Gene

Proteins for FBXL3 Gene

  • Protein details for FBXL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT7-FBXL3_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 3
    Protein Accession:
    Q9UKT7
    Secondary Accessions:
    • B2RB04
    • Q9P122

    Protein attributes for FBXL3 Gene

    Size:
    428 amino acids
    Molecular mass:
    48707 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL3) composed of CUL1, SKP1, RBX1 and FBXL3. Interacts with CRY1 and CRY2 (phosphorylated).

    Three dimensional structures from OCA and Proteopedia for FBXL3 Gene

neXtProt entry for FBXL3 Gene

Post-translational modifications for FBXL3 Gene

  • Ubiquitination at Lys201 and Lys321
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXL3 Gene

No data available for DME Specific Peptides for FBXL3 Gene

Domains & Families for FBXL3 Gene

Gene Families for FBXL3 Gene

Protein Domains for FBXL3 Gene

Suggested Antigen Peptide Sequences for FBXL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL3: view

No data available for UniProtKB/Swiss-Prot for FBXL3 Gene

Function for FBXL3 Gene

Molecular function for FBXL3 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).

Phenotypes From GWAS Catalog for FBXL3 Gene

Gene Ontology (GO) - Molecular Function for FBXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA,TAS --
GO:0005515 protein binding IPI 17463251
genes like me logo Genes that share ontologies with FBXL3: view
genes like me logo Genes that share phenotypes with FBXL3: view

Animal Models for FBXL3 Gene

MGI Knock Outs for FBXL3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL3 Gene

Localization for FBXL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL3 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL3 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FBXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IEA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with FBXL3: view

Pathways & Interactions for FBXL3 Gene

genes like me logo Genes that share pathways with FBXL3: view

UniProtKB/Swiss-Prot Q9UKT7-FBXL3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0016567 protein ubiquitination NAS 10531035
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA,IDA 17463251
GO:0031648 protein destabilization IEA,ISS --
GO:0042752 regulation of circadian rhythm IMP,IEA 17463251
genes like me logo Genes that share ontologies with FBXL3: view

No data available for SIGNOR curated interactions for FBXL3 Gene

Drugs & Compounds for FBXL3 Gene

No Compound Related Data Available

Transcripts for FBXL3 Gene

Unigene Clusters for FBXL3 Gene

F-box and leucine-rich repeat protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for FBXL3 Gene

GeneLoc Exon Structure for
FBXL3
ECgene alternative splicing isoforms for
FBXL3

Expression for FBXL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL3 Gene

This gene is overexpressed in Testis (24.6), Ovary (20.1), Gallbladder (15.0), and Blymphocyte (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL3 Gene



Protein tissue co-expression partners for FBXL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXL3 Gene:

FBXL3

SOURCE GeneReport for Unigene cluster for FBXL3 Gene:

Hs.508284

mRNA Expression by UniProt/SwissProt for FBXL3 Gene:

Q9UKT7-FBXL3_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for FBXL3 Gene

  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FBXL3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL3 Gene

Orthologs for FBXL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL3 33 34
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia FBXL3 34
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXL3 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL3 33 34
  • 94.55 (n)
mouse
(Mus musculus)
Mammalia Fbxl3 33 16 34
  • 89.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL3 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl3 33
  • 88.94 (n)
chicken
(Gallus gallus)
Aves FBXL3 33
  • 81.93 (n)
lizard
(Anolis carolinensis)
Reptilia FBXL3 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl3 33
  • 78.89 (n)
Str.9980 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10201 33
zebrafish
(Danio rerio)
Actinopterygii fbxl3a 34
  • 84 (a)
OneToMany
LOC504112 33
  • 73.35 (n)
fbxl3b 34
  • 56 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14083 33
Species where no ortholog for FBXL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL3 Gene

ENSEMBL:
Gene Tree for FBXL3 (if available)
TreeFam:
Gene Tree for FBXL3 (if available)

Paralogs for FBXL3 Gene

(1) SIMAP similar genes for FBXL3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FBXL3 Gene

genes like me logo Genes that share paralogs with FBXL3: view

No data available for Paralogs for FBXL3 Gene

Variants for FBXL3 Gene

Sequence variations from dbSNP and Humsavar for FBXL3 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs104894385 pathogenic, Ceroid lipofuscinosis neuronal 5 76,992,176(-) G/A/T downstream_transcript_variant
rs104894386 pathogenic, likely-pathogenic, Ceroid lipofuscinosis neuronal 5 76,995,077(-) G/A/C genic_downstream_transcript_variant, intron_variant
rs1057516390 likely-pathogenic, Ceroid lipofuscinosis neuronal 5 76,995,901(-) G/ genic_downstream_transcript_variant, intron_variant
rs1057516814 likely-pathogenic, Ceroid lipofuscinosis neuronal 5 76,992,171(-) TC/G downstream_transcript_variant
rs1057517134 likely-pathogenic, Ceroid lipofuscinosis neuronal 5 76,992,250(-) GCCACTGGCCGGTGCC/GCC downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL3 Gene

Variant ID Type Subtype PubMed ID
esv3550733 CNV deletion 23714750
nsv477135 CNV novel sequence insertion 20440878
nsv832652 CNV gain 17160897
nsv832653 CNV loss 17160897

Variation tolerance for FBXL3 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL3 Gene

Disorders for FBXL3 Gene

Additional Disease Information for FBXL3

No disorders were found for FBXL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL3 Gene

Publications for FBXL3 Gene

  1. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PMID: 10828603) Chiaur DS … Pagano M (Cytogenetics and cell genetics 2000) 2 3 22 58
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 58
  3. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. (PMID: 17463251) Busino L … Pagano M (Science (New York, N.Y.) 2007) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FBXL3 Gene

Sources for FBXL3 Gene

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