This locus represents a transcribed pseudogene that is related to genes encoding members of the F-box family of proteins. [provided by RefSeq, Nov 2017] See more...

Aliases for FBXL21P Gene

Aliases for FBXL21P Gene

  • F-Box And Leucine Rich Repeat Protein 21, Pseudogene 2 3 5
  • F-Box And Leucine-Rich Repeat Protein 21 2 3 4
  • F-Box And Leucine-Rich Repeat Protein 3 Pseudogene 2 3
  • F-Box And Leucine-Rich Repeat Protein 3B 3 4
  • F-Box/LRR-Repeat Protein 3B 3 4
  • FBXL21 3 4
  • FBXL3B 3 4
  • FBXL3P 3 4
  • F-Box And Leucine Rich Repeat Protein 21 (Gene/Pseudogene) 2
  • F-Box And Leucine Rich Repeat Protein 21 3
  • Putative F-Box/LRR-Repeat Protein 21 4
  • F-Box/LRR-Repeat Protein 21 3
  • F-Box Protein Fbl3b 3
  • FBL3B 3
  • Fbl21 3
  • FBL21 4
  • FBL3 4

External Ids for FBXL21P Gene

Previous HGNC Symbols for FBXL21P Gene

  • FBXL3B
  • FBXL3P
  • FBXL21

Summaries for FBXL21P Gene

Entrez Gene Summary for FBXL21P Gene

  • This locus represents a transcribed pseudogene that is related to genes encoding members of the F-box family of proteins. [provided by RefSeq, Nov 2017]

GeneCards Summary for FBXL21P Gene

FBXL21P (F-Box And Leucine Rich Repeat Protein 21, Pseudogene) is a Pseudogene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System.

UniProtKB/Swiss-Prot Summary for FBXL21P Gene

  • Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).

Additional gene information for FBXL21P Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXL21P Gene

Genomics for FBXL21P Gene

GeneHancer (GH) Regulatory Elements for FBXL21P Gene

Promoters and enhancers for FBXL21P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J135929 Promoter/Enhancer 1.2 Ensembl ENCODE 500.7 +0.3 283 1.2 ZSCAN5C POLR2G PHF8 ZIC2 ZBTB10 ZBTB26 ZBTB7A SKI ZNF341 POLR2A FBXL21P lnc-SLC25A48-4 LECT2 ENSG00000254239 IL9 C5orf66 lnc-IL9-1
GH05J135977 Enhancer 1.1 Ensembl ENCODE dbSUPER 6 +49.0 48983 4.2 CTCF TCF12 REST RAD21 EP300 TRIM22 ATF2 SMC3 FOXA2 ZNF266 LECT2 C5orf66 FBXL21P HSALNG0045068 lnc-LECT2-2
GH05J135945 Enhancer 0.8 ENCODE 6.2 +14.8 14840 0.1 CTCF NCOR1 REST ZBTB25 RAD21 TRIM22 TEAD1 ZKSCAN8 SMC3 ZSCAN9 piR-39904-019 ENSG00000254239 IL9 FBXL21P LECT2 lnc-IL9-1
GH05J136004 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.5 +84.3 84349 21.1 ZSCAN5C TCF12 JUND FOS CTCF ZIC2 REST ZNF623 NR3C1 EP300 TGFBI LECT2 SMAD5 SMAD5-AS1 SMIM32 FBXL21P lnc-LECT2-2 HSALNG0045073 LOC105379189 HSALNG0045068
GH05J135942 Enhancer 0.3 Ensembl 0.4 +12.2 12184 0.2 NFIC NFIB SMAD5 ENSG00000254239 IL9 SMAD5-AS1 piR-39904-019 lnc-IL9-1 LECT2 FBXL21P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXL21P on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBXL21P

Genomic Locations for FBXL21P Gene

Genomic Locations for FBXL21P Gene
chr5:135,930,317-135,951,591
(GRCh38/hg38)
Size:
21,275 bases
Orientation:
Plus strand
chr5:135,266,006-135,287,280
(GRCh37/hg19)
Size:
21,275 bases
Orientation:
Plus strand

Genomic View for FBXL21P Gene

Genes around FBXL21P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL21P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL21P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL21P Gene

Proteins for FBXL21P Gene

  • Protein details for FBXL21P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT6-FXL21_HUMAN
    Recommended name:
    Putative F-box/LRR-repeat protein 21
    Protein Accession:
    Q9UKT6

    Protein attributes for FBXL21P Gene

    Size:
    434 amino acids
    Molecular mass:
    49152 Da
    Quaternary structure:
    • Interacts with CRY1 and CRY2 (By similarity). Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL21) composed of CUL1, SKP1, RBX1 and FBXL21.

neXtProt entry for FBXL21P Gene

Post-translational modifications for FBXL21P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL21P Gene

Domains & Families for FBXL21P Gene

Gene Families for FBXL21P Gene

Protein Domains for FBXL21P Gene

Suggested Antigen Peptide Sequences for FBXL21P Gene

GenScript: Design optimal peptide antigens:
  • F-box/LRR-repeat protein 3B (FXL21_HUMAN)
  • FBXL21 protein (Q3KPF8_HUMAN)
genes like me logo Genes that share domains with FBXL21P: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBXL21P Gene

Function for FBXL21P Gene

Molecular function for FBXL21P Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).

Gene Ontology (GO) - Molecular Function for FBXL21P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0061630 contributes_to ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with FBXL21P: view
genes like me logo Genes that share phenotypes with FBXL21P: view

Animal Models for FBXL21P Gene

MGI Knock Outs for FBXL21P:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXL21P

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXL21P Gene

Localization for FBXL21P Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL21P Gene

Cytoplasm, cytosol. Nucleus. Note=Mainly localizes in the cytosol. Present at low level in the nucleus (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for FBXL21P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus ISS --
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex ISS --
genes like me logo Genes that share ontologies with FBXL21P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for FBXL21P Gene

Pathways & Interactions for FBXL21P Gene

genes like me logo Genes that share pathways with FBXL21P: view

UniProtKB/Swiss-Prot Q9UKT6-FXL21_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for FBXL21P Gene

Selected Interacting proteins: Q9UKT6-FXL21_HUMAN for FBXL21P Gene via IID

;

Gene Ontology (GO) - Biological Process for FBXL21P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IBA 21873635
GO:0000209 protein polyubiquitination TAS --
GO:0016567 protein ubiquitination NAS 10531035
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA 21873635
GO:0043153 entrainment of circadian clock by photoperiod ISS --
genes like me logo Genes that share ontologies with FBXL21P: view

No data available for SIGNOR curated interactions for FBXL21P Gene

Drugs & Compounds for FBXL21P Gene

No Compound Related Data Available

Transcripts for FBXL21P Gene

mRNA/cDNA for FBXL21P Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXL21P

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL21P Gene

No ASD Table

Relevant External Links for FBXL21P Gene

GeneLoc Exon Structure for
FBXL21P

Expression for FBXL21P Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBXL21P

SOURCE GeneReport for Unigene cluster for FBXL21P Gene:

Hs.591275
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL21P Gene

Orthologs for FBXL21P Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL21P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL21 30
  • 97.47 (n)
dog
(Canis familiaris)
Mammalia FBXL21 31 30
  • 88.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FBXL21 31 30
  • 88.17 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl21 17 31 30
  • 80.95 (n)
chicken
(Gallus gallus)
Aves FBXL21 31 30
  • 74.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL21 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489356 30
  • 72.58 (n)
zebrafish
(Danio rerio)
Actinopterygii FBXL21 31
  • 72 (a)
OneToOne
fbxl3 30
  • 69.3 (n)
Species where no ortholog for FBXL21P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL21P Gene

ENSEMBL:
Gene Tree for FBXL21P (if available)
TreeFam:
Gene Tree for FBXL21P (if available)

Paralogs for FBXL21P Gene

No data available for Paralogs for FBXL21P Gene

Variants for FBXL21P Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBXL21P Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs40986 - p.Pro209Leu
rs7705168 - p.Phe76Leu

Structural Variations from Database of Genomic Variants (DGV) for FBXL21P Gene

Variant ID Type Subtype PubMed ID
esv2759380 CNV loss 17122850
nsv471050 CNV loss 18288195
nsv477858 CNV novel sequence insertion 20440878

Additional Variant Information for FBXL21P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL21P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Additional dbSNP identifiers (rs#s) and Variation tolerance for FBXL21P Gene

Disorders for FBXL21P Gene

No disorders were found for FBXL21P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for FBXL21P Gene

Publications for FBXL21P Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway. (PMID: 25225294) Zhu X … Liu S (The Journal of biological chemistry 2014) 3 54
  4. Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. (PMID: 24085301) Yumimoto K … Nakayama KI (The Journal of biological chemistry 2013) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for FBXL21P Gene

  • Biorbyt antibodies for FBXL21P

Sources for FBXL21P Gene