Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction ... See more...

Aliases for FBXL20 Gene

Aliases for FBXL20 Gene

  • F-Box And Leucine Rich Repeat Protein 20 2 3 5
  • F-Box/LRR-Repeat Protein 20 3 4
  • F-Box And Leucine-Rich Repeat Protein 20 4
  • F-Box/LRR-Repeat Protein 2-Like 4
  • F-Box Protein FBL2 3
  • Fbl20 3
  • Fbl2 3
  • FBL2 4

External Ids for FBXL20 Gene

Previous GeneCards Identifiers for FBXL20 Gene

  • GC17M037792
  • GC17M034670
  • GC17M037416
  • GC17M033204
  • GC17M037409

Summaries for FBXL20 Gene

Entrez Gene Summary for FBXL20 Gene

  • Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL20 Gene

FBXL20 (F-Box And Leucine Rich Repeat Protein 20) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is FBXL2.

UniProtKB/Swiss-Prot Summary for FBXL20 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).

Additional gene information for FBXL20 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXL20 Gene

Genomics for FBXL20 Gene

GeneHancer (GH) Regulatory Elements for FBXL20 Gene

Promoters and enhancers for FBXL20 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXL20 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBXL20

Top Transcription factor binding sites by QIAGEN in the FBXL20 gene promoter:
  • AP-1
  • AREB6
  • Arnt
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • Cdc5
  • SRY
  • STAT3

Genomic Locations for FBXL20 Gene

Genomic Locations for FBXL20 Gene
chr17:39,252,644-39,402,661
(GRCh38/hg38)
Size:
150,018 bases
Orientation:
Minus strand
chr17:37,408,897-37,558,776
(GRCh37/hg19)
Size:
149,880 bases
Orientation:
Minus strand

Genomic View for FBXL20 Gene

Genes around FBXL20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL20 Gene

Proteins for FBXL20 Gene

  • Protein details for FBXL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IG2-FXL20_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 20
    Protein Accession:
    Q96IG2
    Secondary Accessions:
    • A8K729
    • Q38J52

    Protein attributes for FBXL20 Gene

    Size:
    436 amino acids
    Molecular mass:
    48423 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL20 Gene

Post-translational modifications for FBXL20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL20 Gene

Domains & Families for FBXL20 Gene

Gene Families for FBXL20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FBXL20 Gene

Suggested Antigen Peptide Sequences for FBXL20 Gene

GenScript: Design optimal peptide antigens:
  • F-box/LRR-repeat protein 2-like (FXL20_HUMAN)
genes like me logo Genes that share domains with FBXL20: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBXL20 Gene

Function for FBXL20 Gene

Molecular function for FBXL20 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).

Phenotypes From GWAS Catalog for FBXL20 Gene

Gene Ontology (GO) - Molecular Function for FBXL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA 21873635
GO:0005515 protein binding IEA,IPI 27705803
genes like me logo Genes that share ontologies with FBXL20: view
genes like me logo Genes that share phenotypes with FBXL20: view

Animal Models for FBXL20 Gene

MGI Knock Outs for FBXL20:

Animal Model Products

CRISPR Products

miRNA for FBXL20 Gene

miRTarBase miRNAs that target FBXL20

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL20 Gene

Localization for FBXL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL20 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL20 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBXL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IBA 21873635
GO:0045202 synapse IEA --
GO:0098685 Schaffer collateral - CA1 synapse IEA --
genes like me logo Genes that share ontologies with FBXL20: view

Pathways & Interactions for FBXL20 Gene

genes like me logo Genes that share pathways with FBXL20: view

Gene Ontology (GO) - Biological Process for FBXL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0001662 behavioral fear response IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IBA 21873635
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA 21873635
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXL20: view

No data available for SIGNOR curated interactions for FBXL20 Gene

Drugs & Compounds for FBXL20 Gene

No Compound Related Data Available

Transcripts for FBXL20 Gene

mRNA/cDNA for FBXL20 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL20 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: -
SP2: - -
SP3:

Relevant External Links for FBXL20 Gene

GeneLoc Exon Structure for
FBXL20

Expression for FBXL20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXL20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL20 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.9), Testis (7.8), Fetal Brain (7.8), and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXL20 Gene



Protein tissue co-expression partners for FBXL20 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBXL20

SOURCE GeneReport for Unigene cluster for FBXL20 Gene:

Hs.462946

Evidence on tissue expression from TISSUES for FBXL20 Gene

  • Intestine(4.2)
  • Liver(4.2)
  • Blood(4.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with FBXL20: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL20 Gene

Orthologs for FBXL20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL20 31 30
  • 99.92 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXL20 31
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL20 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL20 31 30
  • 96.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FBXL20 31 30
  • 95.97 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl20 17 31 30
  • 93.12 (n)
chicken
(Gallus gallus)
Aves FBXL20 31 30
  • 82.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL20 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl20 30
  • 77.91 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32529 30
zebrafish
(Danio rerio)
Actinopterygii fbxl20 31 30
  • 77.52 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007807 30
  • 57.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9003 31 30
  • 57.05 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C02F5.7 31 30
  • 51.41 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06051g 30
  • 40.98 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRR1 33 30
  • 39.19 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER398W 30
  • 37.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 53 (a)
OneToMany
Cin.2004 30
bread mold
(Neurospora crassa)
Ascomycetes NCU01216 30
  • 41.07 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pof2 30
  • 41.01 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2004 30
Species where no ortholog for FBXL20 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXL20 Gene

ENSEMBL:
Gene Tree for FBXL20 (if available)
TreeFam:
Gene Tree for FBXL20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXL20: view image

Paralogs for FBXL20 Gene

(2) SIMAP similar genes for FBXL20 Gene using alignment to 3 proteins:

  • FXL20_HUMAN
  • J3KTA1_HUMAN
  • J3QKL3_HUMAN
genes like me logo Genes that share paralogs with FBXL20: view

Variants for FBXL20 Gene

Additional dbSNP identifiers (rs#s) for FBXL20 Gene

Structural Variations from Database of Genomic Variants (DGV) for FBXL20 Gene

Variant ID Type Subtype PubMed ID
esv2132100 CNV deletion 18987734
esv24997 CNV loss 19812545
esv2506125 CNV deletion 19546169
esv2661698 CNV deletion 23128226
esv2671262 CNV deletion 23128226
esv2715900 CNV deletion 23290073
esv3157123 CNV deletion 24192839
esv3554401 CNV deletion 23714750
esv3640544 CNV loss 21293372
nsv1055612 CNV gain 25217958
nsv1072734 CNV deletion 25765185
nsv1109073 CNV deletion 24896259
nsv1138537 CNV deletion 24896259
nsv1138538 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv510709 CNV deletion 20534489
nsv833441 CNV loss 17160897
nsv955409 CNV deletion 24416366

Variation tolerance for FBXL20 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXL20 Gene

Human Gene Mutation Database (HGMD)
FBXL20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBXL20 Gene

Disorders for FBXL20 Gene

Additional Disease Information for FBXL20

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FBXL20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL20 Gene

Publications for FBXL20 Gene

  1. FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. (PMID: 25593308) Xiao J … Yuan J (Genes & development 2015) 2 3 54
  2. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells GF … Anderson CA (Nature genetics 2011) 3 41 54
  3. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PMID: 19124506) Mavaddat N … Pharoah PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for FBXL20 Gene

Sources for FBXL20 Gene