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Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
FBXL20 (F-Box And Leucine Rich Repeat Protein 20) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXL2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | IBA | -- |
GO:0005515 | protein binding | IEA,IPI | 27705803 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0019005 | SCF ubiquitin ligase complex | IBA | 21873635 |
GO:0045202 | synapse | IEA | -- |
GO:0098685 | Schaffer collateral - CA1 synapse | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0001662 | behavioral fear response | IEA | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IBA | 21873635 |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IBA | 21873635 |
GO:0043687 | post-translational protein modification | TAS | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FBXL20 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FBXL20 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FBXL20 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FBXL20 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FBXL20 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fbxl20 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FBXL20 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FBXL20 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fbxl20 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.32529 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fbxl20 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007807 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9003 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | C02F5.7 30 31 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E06051g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GRR1 30 33 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER398W 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01216 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pof2 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2004 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2132100 | CNV | deletion | 18987734 |
esv24997 | CNV | loss | 19812545 |
esv2506125 | CNV | deletion | 19546169 |
esv2661698 | CNV | deletion | 23128226 |
esv2671262 | CNV | deletion | 23128226 |
esv2715900 | CNV | deletion | 23290073 |
esv3157123 | CNV | deletion | 24192839 |
esv3554401 | CNV | deletion | 23714750 |
esv3640544 | CNV | loss | 21293372 |
nsv1055612 | CNV | gain | 25217958 |
nsv1072734 | CNV | deletion | 25765185 |
nsv1109073 | CNV | deletion | 24896259 |
nsv1138537 | CNV | deletion | 24896259 |
nsv1138538 | CNV | deletion | 24896259 |
nsv1146669 | OTHER | inversion | 26484159 |
nsv510709 | CNV | deletion | 20534489 |
nsv833441 | CNV | loss | 17160897 |
nsv955409 | CNV | deletion | 24416366 |
No disorders were found for FBXL20 Gene.