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Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction ... See more...
Aliases for FBXL20 Gene
Aliases for FBXL20 Gene
External Ids for FBXL20 Gene
- HGNC: 24679
- Entrez Gene: 84961
- Ensembl: ENSG00000108306
- OMIM: 609086
- UniProtKB: Q96IG2
Previous GeneCards Identifiers for FBXL20 Gene
- GC17M037792
- GC17M034670
- GC17M037416
- GC17M033204
- GC17M037409
Summaries for FBXL20 Gene
-
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXL20 Gene
FBXL20 (F-Box And Leucine Rich Repeat Protein 20) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXL2.
UniProtKB/Swiss-Prot Summary for FBXL20 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
Additional gene information for FBXL20 Gene
- HGNC(24679)
- Entrez Gene(84961)
- Ensembl(ENSG00000108306)
- OMIM(609086)
- UniProtKB(Q96IG2)
- Open Targets Platform(ENSG00000108306)
- Monarch Initiative
- Search for FBXL20 at DataMed
- Search for FBXL20 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXL20 Gene
Genomics for FBXL20 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FBXL20 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FBXL20 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBXL20
- Top Transcription factor binding sites by QIAGEN in the FBXL20 gene promoter:
-
- AP-1
- AREB6
- Arnt
- ATF-2
- c-Jun
- C/EBPalpha
- Cdc5
- SRY
- STAT3
Genomic Locations for FBXL20 Gene
Genomic Locations for FBXL20 Gene
- chr17:39,252,663-39,402,556
- (GRCh38/hg38)
- Size:
- 149,894 bases
- Orientation:
- Minus strand
- chr17:37,408,897-37,558,776
- (GRCh37/hg19)
- Size:
- 149,880 bases
- Orientation:
- Minus strand
Genomic View for FBXL20 Gene
Genes around FBXL20 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by HGNC
- 17q12 by Entrez Gene
- 17q12 by Ensembl
FBXL20 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXL20 Gene
Proteins for FBXL20 Gene
-
Protein details for FBXL20 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96IG2-FXL20_HUMAN
- Recommended name:
- F-box/LRR-repeat protein 20
- Protein Accession:
- Q96IG2
- A8K729
- Q38J52
Protein attributes for FBXL20 Gene
- Size:
- 436 amino acids
- Molecular mass:
- 48423 Da
- Quaternary structure:
-
- Interacts with SKP1 and CUL1.
Protein Expression for FBXL20 Gene
Post-translational modifications for FBXL20 Gene
Other Protein References for FBXL20 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXL20
- Invitrogen Antibodies for FBXL20 (AFLGC-FBXL20)
-
Boster Bio Antibodies for FBXL20
-
Custom Antibody ServicesProSci Antibodies for FBXL20
-
Santa Cruz Biotechnology (SCBT) Antibodies for FBXL20
Protein Products
-
OriGene Purified Proteins for FBXL20
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXL20
- Origene Custom Protein Services for FBXL20
- antibodies-online: Show 5 available FBXL20 Proteins ranked by validation data
- Compare Top FBXL20 Proteins
-
Quality Products:
-
Abcam proteins for FBXL20
Assay Products
No data available for DME Specific Peptides for FBXL20 Gene
Domains & Families for FBXL20 Gene
Gene Families for FBXL20 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FBXL20 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXL20 Gene
- GenScript: Design optimal peptide antigens:
-
- F-box/LRR-repeat protein 2-like (FXL20_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBXL20 Gene
Function for FBXL20 Gene
Molecular function for FBXL20 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
Phenotypes From GWAS Catalog for FBXL20 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IBA | -- |
| GO:0005515 | protein binding | IEA,IPI | 27705803 |
Phenotypes for FBXL20 Gene
- MGI mutant phenotypes for FBXL20:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FBXL20:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Increased cell death HMECs cells
- Decreased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Increased G1 DNA content
- Increased shRNA abundance (Z-score > 2)
- Decreased cell number
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased shRNA abundance (Z-score < -2)
- G0/1 arrest
Animal Models for FBXL20 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FBXL20 - Select products 50% OFF >
- * FBXL20 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FBXL20
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FBXL20
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL20
miRNA for FBXL20 Gene
- miRTarBase miRNAs that target FBXL20
-
- mmu-miR-223-3p (MIRT009594)
- mmu-miR-24-3p (MIRT013733)
- mmu-miR-181a-5p (MIRT014064)
- hsa-miR-125b-5p (MIRT046059)
- hsa-miR-7703 (MIRT076968)
- hsa-miR-767-3p (MIRT196905)
- hsa-miR-1178-3p (MIRT196906)
- hsa-miR-181b-3p (MIRT196920)
- hsa-miR-181b-2-3p (MIRT196921)
- hsa-miR-4420 (MIRT196933)
- hsa-miR-6760-3p (MIRT196936)
- hsa-miR-4768-5p (MIRT234310)
- hsa-miR-6817-3p (MIRT234311)
- hsa-miR-6833-3p (MIRT234312)
- hsa-miR-6873-3p (MIRT234313)
- hsa-miR-7110-3p (MIRT234314)
- hsa-miR-6818-5p (MIRT548257)
- hsa-miR-202-3p (MIRT548258)
- hsa-miR-98-5p (MIRT548259)
- hsa-miR-4500 (MIRT548260)
- hsa-miR-4458 (MIRT548261)
- hsa-let-7i-5p (MIRT548262)
- hsa-let-7g-5p (MIRT548263)
- hsa-let-7e-5p (MIRT548264)
- hsa-let-7f-5p (MIRT548265)
- hsa-let-7d-5p (MIRT548266)
- hsa-let-7c-5p (MIRT548267)
- hsa-let-7b-5p (MIRT548268)
- hsa-miR-4468 (MIRT548269)
- hsa-let-7a-5p (MIRT548270)
- hsa-miR-3908 (MIRT548271)
- hsa-miR-511-3p (MIRT548272)
- hsa-miR-424-5p (MIRT548273)
- hsa-miR-15b-5p (MIRT548274)
- hsa-miR-15a-5p (MIRT548275)
- hsa-miR-16-5p (MIRT548276)
- hsa-miR-195-5p (MIRT548277)
- hsa-miR-497-5p (MIRT548278)
- hsa-miR-6838-5p (MIRT548279)
- mmu-miR-410-3p (MIRT583544)
- mmu-miR-344d-3p (MIRT583545)
- mmu-miR-344e-3p (MIRT583546)
- hsa-miR-26b-3p (MIRT628224)
- hsa-miR-6793-3p (MIRT628225)
- hsa-miR-1208 (MIRT628226)
- hsa-miR-4762-5p (MIRT628227)
- hsa-miR-216b-5p (MIRT628228)
- hsa-miR-378g (MIRT635254)
- hsa-miR-4486 (MIRT635255)
- hsa-miR-6860 (MIRT635256)
- hsa-miR-612 (MIRT635257)
- hsa-miR-5189-5p (MIRT635258)
- hsa-miR-3187-5p (MIRT635259)
- hsa-miR-1285-3p (MIRT635260)
- hsa-miR-4793-3p (MIRT635261)
- hsa-miR-3925-3p (MIRT635262)
- hsa-miR-1273g-3p (MIRT635263)
- hsa-miR-622 (MIRT635264)
- hsa-miR-508-5p (MIRT635265)
- hsa-miR-586 (MIRT658216)
- hsa-miR-6805-3p (MIRT709407)
- hsa-miR-5691 (MIRT709408)
- hsa-miR-3678-3p (MIRT709409)
- hsa-miR-3194-3p (MIRT709410)
- hsa-miR-2467-3p (MIRT709411)
- hsa-miR-17-3p (MIRT709412)
- hsa-miR-1205 (MIRT709413)
- hsa-miR-1184 (MIRT709414)
- hsa-miR-3158-5p (MIRT709415)
- hsa-miR-4684-5p (MIRT709416)
- hsa-miR-7975 (MIRT709417)
- hsa-miR-4540 (MIRT709418)
- hsa-miR-942-5p (MIRT709419)
- hsa-miR-1251-5p (MIRT709420)
- hsa-miR-517-5p (MIRT709421)
- hsa-miR-554 (MIRT709422)
- hsa-miR-6838-3p (MIRT709423)
- hsa-miR-624-5p (MIRT709424)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FBXL20
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXL20
Clone Products
- Applied Biological Materials (abm): Clones for FBXL20 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for FBXL20
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FBXL20
Cell Line Products
-
Horizon Cell Lines for FBXL20
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL20 Gene
Localization for FBXL20 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXL20 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Microtubules (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0019005 | SCF ubiquitin ligase complex | IBA | 21873635 |
| GO:0045202 | synapse | IEA | -- |
| GO:0098685 | Schaffer collateral - CA1 synapse | IEA | -- |
Pathways & Interactions for FBXL20 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXL20 Gene
4 Reactome pathways for FBXL20 Gene
Interacting Proteins for FBXL20 Gene
Selected Interacting proteins:
Q96IG2-FXL20_HUMAN
ENSP00000264658
for FBXL20 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FBXL20
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0001662 | behavioral fear response | IEA | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IBA | 21873635 |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IBA | 21873635 |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXL20 Gene
Transcripts for FBXL20 Gene
mRNA/cDNA for FBXL20 Gene
- 4 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000264658 10332 nts (view in UCSC)
- ENST00000394294 2309 nts (view in UCSC)
- ENST00000577399 1620 nts (view in UCSC)
- ENST00000581781 629 nts (view in UCSC)
- ENST00000583610 1739 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FBXL20 - Select products 50% OFF >
- * FBXL20 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FBXL20
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FBXL20
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL20
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FBXL20
- Browse OriGene Inhibitory RNA Products For FBXL20
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXL20
Clone Products
- Applied Biological Materials (abm): Clones for FBXL20 - Select products 50% OFF >
- * FBXL20 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FBXL20
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FBXL20
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||
| SP3: |
Relevant External Links for FBXL20 Gene
- GeneLoc Exon Structure for
- FBXL20
Expression for FBXL20 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (29.9), Testis (7.8), Fetal Brain (7.8), and Placenta (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXL20 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBXL20
SOURCE GeneReport for Unigene cluster for FBXL20 Gene:
Hs.462946Evidence on tissue expression from TISSUES for FBXL20 Gene
- Liver(4.4)
- Intestine(4.4)
- Blood(4.3)
- Nervous system(2.8)
Primer Products
-
OriGene qPCR primer pairs for FBXL20
-
OriGene qPCR primer pairs and template standards for FBXL20
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL20 Gene
Orthologs for FBXL20 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FBXL20 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FBXL20 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FBXL20 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FBXL20 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FBXL20 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fbxl20 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FBXL20 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FBXL20 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fbxl20 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.32529 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fbxl20 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007807 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG9003 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | C02F5.7 30 31 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E06051g 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GRR1 30 33 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER398W 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU01216 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pof2 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2004 30 |
|
- Species where no ortholog for FBXL20 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for FBXL20 Gene
- ENSEMBL:
- Gene Tree for FBXL20 (if available)
- TreeFam:
- Gene Tree for FBXL20 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FBXL20: view image
Paralogs for FBXL20 Gene
Paralogs for FBXL20 Gene
(2) SIMAP similar genes for FBXL20 Gene using alignment to 3 proteins:
- FXL20_HUMAN
- J3KTA1_HUMAN
- J3QKL3_HUMAN
Variants for FBXL20 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2132100 | CNV | deletion | 18987734 |
| esv24997 | CNV | loss | 19812545 |
| esv2506125 | CNV | deletion | 19546169 |
| esv2661698 | CNV | deletion | 23128226 |
| esv2671262 | CNV | deletion | 23128226 |
| esv2715900 | CNV | deletion | 23290073 |
| esv3157123 | CNV | deletion | 24192839 |
| esv3554401 | CNV | deletion | 23714750 |
| esv3640544 | CNV | loss | 21293372 |
| nsv1055612 | CNV | gain | 25217958 |
| nsv1072734 | CNV | deletion | 25765185 |
| nsv1109073 | CNV | deletion | 24896259 |
| nsv1138537 | CNV | deletion | 24896259 |
| nsv1138538 | CNV | deletion | 24896259 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv510709 | CNV | deletion | 20534489 |
| nsv833441 | CNV | loss | 17160897 |
| nsv955409 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.50;
10.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FBXL20 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBXL20 Gene
Disorders for FBXL20 Gene
Additional Disease Information for FBXL20
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for FBXL20 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL20 Gene
Publications for FBXL20 Gene
- FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. (PMID: 25593308) Xiao J … Yuan J (Genes & development 2015) 2 3
- Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells GF … Anderson CA (Nature genetics 2011) 3 41
- Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PMID: 19124506) Mavaddat N … Pharoah PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 41
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
Products for FBXL20 Gene
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- Invitrogen Antibodies for FBXL20 (AFLGC-FBXL20)
- VectorBuilder Custom and pre-made DNA vectors for FBXL20 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FBXL20 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FBXL20 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FBXL20 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FBXL20
- antibodies-online: Show 22 available FBXL20 Antibodies ranked by validation data
- Compare Top FBXL20 Antibodies
- antibodies-online: Show 12 available FBXL20 Elisa Kits ranked by validation data
- Compare Top FBXL20 Elisa Kits
- antibodies-online: Show 5 available FBXL20 Proteins ranked by validation data
- Compare Top FBXL20 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for FBXL20
- Search Santa Cruz Biotechnology (SCBT) for FBXL20 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FBXL20
- Horizon Cell Lines for FBXL20
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FBXL20
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FBXL20
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FBXL20
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBXL20
- Boster Bio Antibodies for FBXL20
- Browse Boster Bio ELISA Kits
Sources for FBXL20 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB