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This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
FBXL19 (F-Box And Leucine Rich Repeat Protein 19) is a Protein Coding gene. Diseases associated with FBXL19 include Psoriasis 6 and Psoriasis 2. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXL6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 22660580 |
GO:0008270 | zinc ion binding | IDA | 29276034 |
GO:0045322 | unmethylated CpG binding | IDA | 29276034 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0019005 | SCF ubiquitin ligase complex | IDA | 22660580 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IEA,IDA | 22660580 |
GO:0043687 | post-translational protein modification | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Tumor necrosis factor alpha (TNF-alpha) inhibitors | Pharma | 0 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FBXL19 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FBXL19 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FBXL19 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fbxl19 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FBXL19 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FBXL19 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FBXL19 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | zgc:158376 30 |
|
||
FBXL19 31 |
|
OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Kdm2 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | jhdm-1 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | JHD1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
740443 | Benign: not provided | 30,925,907(+) | G/A | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
774720 | Benign: not provided | 30,927,867(+) | C/T | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
782961 | Benign: not provided | 30,947,160(+) | G/A | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
psoriasis 6 |
|
|
psoriasis 2 |
|
|
psoriasis |
|
|
corneal abscess |
|
|
psoriasis 3 |
|
|