Aliases for FBXL19 Gene
External Ids for FBXL19 Gene
Previous GeneCards Identifiers for FBXL19 Gene
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for FBXL19 Gene
FBXL19 (F-Box And Leucine Rich Repeat Protein 19) is a Protein Coding gene. Diseases associated with FBXL19 include Psoriasis 6 and Psoriasis 2. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXL13.
UniProtKB/Swiss-Prot Summary for FBXL19 Gene
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:29276034).