Aliases for FBXL18 Gene
External Ids for FBXL18 Gene
Previous GeneCards Identifiers for FBXL18 Gene
The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]
GeneCards Summary for FBXL18 Gene
FBXL18 (F-Box And Leucine Rich Repeat Protein 18) is a Protein Coding gene. Diseases associated with FBXL18 include Baraitser-Winter Syndrome and Parkinson Disease 15, Autosomal Recessive Early-Onset. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Innate Immune System. An important paralog of this gene is FBXL2.
UniProtKB/Swiss-Prot Summary for FBXL18 Gene
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.