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Aliases for FBXL16 Gene

Aliases for FBXL16 Gene

  • F-Box And Leucine Rich Repeat Protein 16 2 3 5
  • C16orf22 3 4
  • Fbl16 3 4
  • F-Box And Leucine-Rich Repeat Protein 16 4
  • Chromosome 16 Open Reading Frame 22 2
  • F-Box/LRR-Repeat Protein 16 3
  • C380A1.1 (Novel Protein) 3
  • C380A1.1 3

External Ids for FBXL16 Gene

Previous HGNC Symbols for FBXL16 Gene

  • C16orf22

Previous GeneCards Identifiers for FBXL16 Gene

  • GC16M000683
  • GC16M000684
  • GC16M000685
  • GC16M000742
  • GC16M000664
  • GC16M000717
  • GC16M000746
  • GC16M000815
  • GC16M000839
  • GC16M000863
  • GC16M000883
  • GC16M000907

Summaries for FBXL16 Gene

Entrez Gene Summary for FBXL16 Gene

  • Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL16 Gene

FBXL16 (F-Box And Leucine Rich Repeat Protein 16) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXL20.

UniProtKB/Swiss-Prot for FBXL16 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXL16 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL16 Gene

Genomics for FBXL16 Gene

GeneHancer (GH) Regulatory Elements for FBXL16 Gene

Promoters and enhancers for FBXL16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I000706 Promoter 0.9 EPDnew 550.8 +0.1 57 0.1 MXI1 SIN3A ZNF644 E2F1 ZNF766 POLR2A VEZF1 ZFX FBXL16 ENSG00000279255 GC16M000946 PIR50671
GH16I000705 Promoter 0.8 EPDnew 550.8 +0.2 241 0.1 MXI1 SIN3A ZFX EZH2 FBXL16 GC16M000946 PIR50671
GH16I000707 Enhancer 0.6 ENCODE 550.8 -0.1 -117 0.1 E2F1 ZNF766 MAZ POLR2A VEZF1 ZNF398 ZNF644 ZBTB26 EZH2 ENSG00000279255 FBXL16
GH16I000709 Enhancer 1.3 Ensembl ENCODE dbSUPER 20.9 -4.7 -4672 3 ARID4B SIN3A ZNF2 GLIS2 ZNF213 ZNF143 FOS KLF13 ZNF263 REST ENSG00000259840 FBXL16 RPUSD1 CHTF18 WFIKKN1 ENSG00000262528 ENSG00000279255
GH16I000713 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 4.8 -9.8 -9785 3.8 ARNT ARID4B SIN3A GLIS2 FOS SP3 RXRA SP5 NFYC MXD4 METRN NARFL ENSG00000262528 FBXL16 RPUSD1 GC16P000997
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXL16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXL16 gene promoter:

Genomic Locations for FBXL16 Gene

Genomic Locations for FBXL16 Gene
13,332 bases
Minus strand

Genomic View for FBXL16 Gene

Genes around FBXL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL16 Gene

Proteins for FBXL16 Gene

  • Protein details for FBXL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 16
    Protein Accession:
    Secondary Accessions:
    • B3KR59
    • D3DU60
    • Q2MHR2
    • Q96S14
    • Q9UJI0

    Protein attributes for FBXL16 Gene

    479 amino acids
    Molecular mass:
    51658 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.
    • Sequence=AAK61245.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL16 Gene


neXtProt entry for FBXL16 Gene

Post-translational modifications for FBXL16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL16 Gene

Domains & Families for FBXL16 Gene

Gene Families for FBXL16 Gene

Protein Domains for FBXL16 Gene

Suggested Antigen Peptide Sequences for FBXL16 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL16: view

No data available for UniProtKB/Swiss-Prot for FBXL16 Gene

Function for FBXL16 Gene

Molecular function for FBXL16 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXL16 Gene

Gene Ontology (GO) - Molecular Function for FBXL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with FBXL16: view
genes like me logo Genes that share phenotypes with FBXL16: view

Animal Models for FBXL16 Gene

MGI Knock Outs for FBXL16:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL16 Gene

Localization for FBXL16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL16 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FBXL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXL16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FBXL16 Gene

Pathways & Interactions for FBXL16 Gene

genes like me logo Genes that share pathways with FBXL16: view

Gene Ontology (GO) - Biological Process for FBXL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXL16: view

No data available for SIGNOR curated interactions for FBXL16 Gene

Drugs & Compounds for FBXL16 Gene

No Compound Related Data Available

Transcripts for FBXL16 Gene

Unigene Clusters for FBXL16 Gene

F-box and leucine-rich repeat protein 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL16 Gene

No ASD Table

Relevant External Links for FBXL16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXL16 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.7), Brain - Caudate (basal ganglia) (x7.1), Brain - Nucleus accumbens (basal ganglia) (x6.6), Brain - Cortex (x5.4), Brain - Amygdala (x4.9), Brain - Anterior cingulate cortex (BA24) (x4.9), Brain - Frontal Cortex (BA9) (x4.4), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for FBXL16 Gene

This gene is overexpressed in Serum (32.5), Frontal cortex (20.0), and Fetal Brain (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL16 Gene

Protein tissue co-expression partners for FBXL16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXL16 Gene:


SOURCE GeneReport for Unigene cluster for FBXL16 Gene:


Evidence on tissue expression from TISSUES for FBXL16 Gene

  • Nervous system(4.8)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with FBXL16: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL16 Gene

Orthologs for FBXL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXL16 33 34
  • 99.83 (n)
(Canis familiaris)
Mammalia FBXL16 33 34
  • 92.35 (n)
(Bos Taurus)
Mammalia FBXL16 33 34
  • 91.49 (n)
(Rattus norvegicus)
Mammalia Fbxl16 33
  • 87.96 (n)
(Mus musculus)
Mammalia Fbxl16 16 34 33
  • 87.96 (n)
(Monodelphis domestica)
Mammalia FBXL16 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia FBXL16 34
  • 77 (a)
(Gallus gallus)
Aves FBXL16 33 34
  • 81.41 (n)
(Anolis carolinensis)
Reptilia FBXL16 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl16 33
  • 73.64 (n)
(Danio rerio)
Actinopterygii fbxl16 33 34
  • 74.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32085 34 33
  • 64.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012123 33
  • 63.27 (n)
Species where no ortholog for FBXL16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL16 Gene

Gene Tree for FBXL16 (if available)
Gene Tree for FBXL16 (if available)

Paralogs for FBXL16 Gene

Paralogs for FBXL16 Gene

(1) SIMAP similar genes for FBXL16 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FBXL16: view

Variants for FBXL16 Gene

Sequence variations from dbSNP and Humsavar for FBXL16 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000003040 -- 693,954(-) G/A 3_prime_UTR_variant
rs1000175819 -- 702,879(-) G/A intron_variant
rs1000480062 -- 697,918(-) T/A/G intron_variant
rs1000607163 -- 692,806(-) C/A 3_prime_UTR_variant
rs1000610108 -- 702,682(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL16 Gene

Variant ID Type Subtype PubMed ID
dgv454n67 CNV gain 20364138
dgv4825n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv33054 CNV gain+loss 17666407
nsv1131101 CNV deletion 24896259
nsv1147718 CNV insertion 26484159
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv457311 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv571021 CNV loss 21841781
nsv827482 CNV loss 20364138
nsv827486 CNV gain 20364138
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for FBXL16 Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXL16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL16 Gene

Disorders for FBXL16 Gene

Additional Disease Information for FBXL16

No disorders were found for FBXL16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL16 Gene

Publications for FBXL16 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FBXL16 Gene

Sources for FBXL16 Gene

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