Aliases for FBXL15 Gene

Aliases for FBXL15 Gene

  • F-Box And Leucine Rich Repeat Protein 15 2 3 5
  • F-Box Only Protein 37 2 3 4
  • F-Box/LRR-Repeat Protein 15 3 4
  • FBXO37 3 4
  • Pleckstrin And Sec7 Domain Protein 3
  • Fbl15 3
  • JET 3
  • PSD 3

External Ids for FBXL15 Gene

Previous HGNC Symbols for FBXL15 Gene

  • FBXO37

Previous GeneCards Identifiers for FBXL15 Gene

  • GC10P103843
  • GC10P104169
  • GC10P097813
  • GC10P104178

Summaries for FBXL15 Gene

GeneCards Summary for FBXL15 Gene

FBXL15 (F-Box And Leucine Rich Repeat Protein 15) is a Protein Coding gene. Diseases associated with FBXL15 include Occlusion Precerebral Artery. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL7.

UniProtKB/Swiss-Prot Summary for FBXL15 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.

Additional gene information for FBXL15 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBXL15 Gene

Genomics for FBXL15 Gene

GeneHancer (GH) Regulatory Elements for FBXL15 Gene

Promoters and enhancers for FBXL15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J102418 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 505.9 +1.9 1885 5.1 EP300 ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 MYC POLR2G USF1 FBXL15 PSD lnc-PSD-1 PPRC1 PDCD11 PCGF6 SFXN2 LDB1 HPS6 PITX3
GH10J102501 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11 +84.3 84340 5.2 FOXK2 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C SIN3A NRF1 POLR2G USF1 ACTR1A SUFU MFSD13A PDCD11 PPRC1 PCGF6 RNU6-43P C10orf95 FBXL15 PSD
GH10J102309 Enhancer 1.1 Ensembl ENCODE dbSUPER 15 -107.6 -107560 5 JUND TEAD1 TBX3 FOXA2 MAFF SAP130 NR3C1 MAFK PBX2 GATA3 PITX3 FBXL15 GBF1 ELOVL3 PSD POLL piR-42700-020 RF00017-785 L13705-001
GH10J102592 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +180.5 180468 14.1 FOXK2 CTCF TCF12 POLR2G NCOR1 JUND FOS ZIC2 KDM6A ZBTB11 MFSD13A SFXN2 ACTR1A SUFU C10orf95 PSD FBXL15 MIR146B CUEDC2 ARL3
GH10J102462 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 11.5 +44.4 44446 1.7 FOXK2 USF1 NCOR1 ZIC2 TOE1 MYC CTBP1 SKI RAD51 SIN3A MFSD13A MIR146B CUEDC2 PSD FBXL15 SUFU RNU6-43P NFKB2 ELOVL3 lnc-SUFU-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXL15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBXL15

Top Transcription factor binding sites by QIAGEN in the FBXL15 gene promoter:
  • HOXA5
  • Ik-2
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • p53
  • PPAR-alpha
  • Zic3

Genomic Locations for FBXL15 Gene

Genomic Locations for FBXL15 Gene
chr10:102,419,061-102,423,138
(GRCh38/hg38)
Size:
4,078 bases
Orientation:
Plus strand
chr10:104,178,946-104,182,893
(GRCh37/hg19)
Size:
3,948 bases
Orientation:
Plus strand

Genomic View for FBXL15 Gene

Genes around FBXL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL15 Gene

Proteins for FBXL15 Gene

  • Protein details for FBXL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H469-FXL15_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 15
    Protein Accession:
    Q9H469
    Secondary Accessions:
    • A1L4J8
    • B1AKX8
    • B1AKX9
    • B1AKY0
    • B1AKY1
    • C9JWA4
    • Q0D2Q3
    • Q49AL7
    • Q5JWA5

    Protein attributes for FBXL15 Gene

    Size:
    300 amino acids
    Molecular mass:
    32998 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.
    SequenceCaution:
    • Sequence=AAH02912.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH36120.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for FBXL15 Gene

Post-translational modifications for FBXL15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL15 Gene

Domains & Families for FBXL15 Gene

Gene Families for FBXL15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXL15 Gene

Suggested Antigen Peptide Sequences for FBXL15 Gene

GenScript: Design optimal peptide antigens:
  • F-box only protein 37 (FXL15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H469

UniProtKB/Swiss-Prot:

FXL15_HUMAN :
  • Belongs to the FBXL15 family.
Family:
  • Belongs to the FBXL15 family.
genes like me logo Genes that share domains with FBXL15: view

Function for FBXL15 Gene

Molecular function for FBXL15 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.

Phenotypes From GWAS Catalog for FBXL15 Gene

Gene Ontology (GO) - Molecular Function for FBXL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA,IBA 21572392
GO:0005515 protein binding IPI,IEA 21572392
genes like me logo Genes that share ontologies with FBXL15: view
genes like me logo Genes that share phenotypes with FBXL15: view

Animal Model Products

CRISPR Products

miRNA for FBXL15 Gene

miRTarBase miRNAs that target FBXL15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL15 Gene

Localization for FBXL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL15 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL15 gene
Compartment Confidence
cytosol 4
extracellular 3
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FBXL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 21572392
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IDA 21572392
genes like me logo Genes that share ontologies with FBXL15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FBXL15 Gene

Pathways & Interactions for FBXL15 Gene

genes like me logo Genes that share pathways with FBXL15: view

UniProtKB/Swiss-Prot Q9H469-FXL15_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IMP 21572392
GO:0000209 protein polyubiquitination TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IBA 21873635
GO:0009953 dorsal/ventral pattern formation ISS --
GO:0016567 protein ubiquitination IDA,IEA 21572392
genes like me logo Genes that share ontologies with FBXL15: view

No data available for SIGNOR curated interactions for FBXL15 Gene

Drugs & Compounds for FBXL15 Gene

No Compound Related Data Available

Transcripts for FBXL15 Gene

mRNA/cDNA for FBXL15 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL15 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b
SP1: - - - - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - - -
SP6:
SP7: - -

Relevant External Links for FBXL15 Gene

GeneLoc Exon Structure for
FBXL15

Expression for FBXL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXL15 Gene

Protein differential expression in normal tissues from HIPED for FBXL15 Gene

This gene is overexpressed in Spinal cord (18.3), Frontal cortex (16.1), Retina (12.8), and Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXL15 Gene



Protein tissue co-expression partners for FBXL15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBXL15

SOURCE GeneReport for Unigene cluster for FBXL15 Gene:

Hs.380081

Evidence on tissue expression from TISSUES for FBXL15 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with FBXL15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL15 Gene

Orthologs for FBXL15 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL15 31 30
  • 99.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FBXL15 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL15 31 30
  • 91.78 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl15 30
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Fbxl15 17 31 30
  • 88.78 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXL15 31
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL15 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXL15 31 30
  • 67.5 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL15 31
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl15 30
  • 59.56 (n)
Str.20389 30
zebrafish
(Danio rerio)
Actinopterygii fbxl15 31 30
  • 64.77 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009335 30
  • 47.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta jet 31 30
  • 45.32 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 32 (a)
OneToOne
Species where no ortholog for FBXL15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL15 Gene

ENSEMBL:
Gene Tree for FBXL15 (if available)
TreeFam:
Gene Tree for FBXL15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXL15: view image

Paralogs for FBXL15 Gene

genes like me logo Genes that share paralogs with FBXL15: view

Variants for FBXL15 Gene

Additional dbSNP identifiers (rs#s) for FBXL15 Gene

Structural Variations from Database of Genomic Variants (DGV) for FBXL15 Gene

Variant ID Type Subtype PubMed ID
nsv1159761 CNV deletion 26073780
nsv951006 CNV deletion 24416366

Variation tolerance for FBXL15 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXL15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBXL15 Gene

Disorders for FBXL15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXL15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
occlusion precerebral artery
  • occlusion and stenosis of multiple and bilateral precerebral arteries
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FBXL15

genes like me logo Genes that share disorders with FBXL15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXL15 Gene

Publications for FBXL15 Gene

  1. SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PMID: 21572392) Cui Y … Zhang L (The EMBO journal 2011) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  4. Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2. (PMID: 29695787) Choi J … Busino L (Nature cell biology 2018) 3 54
  5. The ULK1-FBXW5-SEC23B nexus controls autophagy. (PMID: 30596474) Jeong YT … Pagano M (eLife 2018) 3 54

Products for FBXL15 Gene

Sources for FBXL15 Gene