Aliases for FBXL15 Gene
External Ids for FBXL15 Gene
Previous HGNC Symbols for FBXL15 Gene
Previous GeneCards Identifiers for FBXL15 Gene
GeneCards Summary for FBXL15 Gene
FBXL15 (F-Box And Leucine Rich Repeat Protein 15) is a Protein Coding gene. Diseases associated with FBXL15 include Occlusion Precerebral Artery. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL7.
UniProtKB/Swiss-Prot Summary for FBXL15 Gene
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.