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Aliases for FBXL15 Gene

Aliases for FBXL15 Gene

  • F-Box And Leucine Rich Repeat Protein 15 2 3 5
  • F-Box Only Protein 37 2 3 4
  • FBXO37 3 4
  • Pleckstrin And Sec7 Domain Protein 3
  • F-Box/LRR-Repeat Protein 15 3
  • Fbl15 3
  • JET 3
  • PSD 3

External Ids for FBXL15 Gene

Previous HGNC Symbols for FBXL15 Gene

  • FBXO37

Previous GeneCards Identifiers for FBXL15 Gene

  • GC10P103843
  • GC10P104169
  • GC10P097813
  • GC10P104178

Summaries for FBXL15 Gene

GeneCards Summary for FBXL15 Gene

FBXL15 (F-Box And Leucine Rich Repeat Protein 15) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL13.

UniProtKB/Swiss-Prot for FBXL15 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.

Additional gene information for FBXL15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL15 Gene

Genomics for FBXL15 Gene

GeneHancer (GH) Regulatory Elements for FBXL15 Gene

Promoters and enhancers for FBXL15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J102418 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 656 +1.9 1885 5.1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 FBXL15 PSD PPRC1 PDCD11 LDB1 PCGF6 GBF1 SFXN2 OGA NOLC1
GH10J102501 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11 +84.3 84328 4.6 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ACTR1A SUFU MFSD13A PDCD11 TAF5 PPRC1 PCGF6 RNU6-43P C10orf95 PSD
GH10J102595 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +181.6 181610 11.2 FOXA2 MLX ARID4B DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOS SP5 MFSD13A SFXN2 ACTR1A SUFU C10orf95 PSD FBXL15 CUEDC2 MIR146B ARL3
GH10J102169 Enhancer 1.1 Ensembl ENCODE 10.3 -249.4 -249364 1 ATF1 ARID4B SIN3A ZNF2 ZNF121 ZNF143 ATF7 RUNX3 DEK REST GBF1 NOLC1 ELOVL3 HPS6 PITX3 PPRC1 NFKB2 PSD FBXL15
GH10J102333 Enhancer 0.7 ENCODE dbSUPER 14.9 -84.3 -84315 1.5 RCOR1 PRDM1 EZH2 NR2F2 FBXL15 ELOVL3 GBF1 PITX3 NFKB2 NOLC1 PSD GC10P102289
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBXL15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXL15 gene promoter:
  • p53
  • NRSF form 2
  • NRSF form 1
  • PPAR-alpha
  • HOXA5
  • Ik-2
  • Nkx2-5
  • Zic3

Genomic Locations for FBXL15 Gene

Genomic Locations for FBXL15 Gene
chr10:102,419,061-102,423,138
(GRCh38/hg38)
Size:
4,078 bases
Orientation:
Plus strand
chr10:104,178,946-104,182,893
(GRCh37/hg19)
Size:
3,948 bases
Orientation:
Plus strand

Genomic View for FBXL15 Gene

Genes around FBXL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL15 Gene

Proteins for FBXL15 Gene

  • Protein details for FBXL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H469-FXL15_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 15
    Protein Accession:
    Q9H469
    Secondary Accessions:
    • A1L4J8
    • B1AKX8
    • B1AKX9
    • B1AKY0
    • B1AKY1
    • C9JWA4
    • Q0D2Q3
    • Q49AL7
    • Q5JWA5

    Protein attributes for FBXL15 Gene

    Size:
    300 amino acids
    Molecular mass:
    32998 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.
    SequenceCaution:
    • Sequence=AAH02912.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH36120.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12518.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12519.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12520.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12522.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FBXL15 Gene

Post-translational modifications for FBXL15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL15 Gene

Domains & Families for FBXL15 Gene

Gene Families for FBXL15 Gene

Protein Domains for FBXL15 Gene

Suggested Antigen Peptide Sequences for FBXL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H469

UniProtKB/Swiss-Prot:

FXL15_HUMAN :
  • Belongs to the FBXL15 family.
Family:
  • Belongs to the FBXL15 family.
genes like me logo Genes that share domains with FBXL15: view

Function for FBXL15 Gene

Molecular function for FBXL15 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.

Phenotypes From GWAS Catalog for FBXL15 Gene

Gene Ontology (GO) - Molecular Function for FBXL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 21572392
genes like me logo Genes that share ontologies with FBXL15: view
genes like me logo Genes that share phenotypes with FBXL15: view

Animal Model Products

miRNA for FBXL15 Gene

miRTarBase miRNAs that target FBXL15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL15 Gene

Localization for FBXL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL15 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL15 gene
Compartment Confidence
cytosol 5
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FBXL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 21572392
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IDA 21572392
genes like me logo Genes that share ontologies with FBXL15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FBXL15 Gene

Pathways & Interactions for FBXL15 Gene

genes like me logo Genes that share pathways with FBXL15: view

UniProtKB/Swiss-Prot Q9H469-FXL15_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IMP 21572392
GO:0000209 protein polyubiquitination TAS --
GO:0009953 dorsal/ventral pattern formation ISS --
GO:0016567 protein ubiquitination IEA,IDA 21572392
GO:0030282 bone mineralization ISS,IEA --
genes like me logo Genes that share ontologies with FBXL15: view

No data available for SIGNOR curated interactions for FBXL15 Gene

Drugs & Compounds for FBXL15 Gene

No Compound Related Data Available

Transcripts for FBXL15 Gene

Unigene Clusters for FBXL15 Gene

F-box and leucine-rich repeat protein 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL15 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b
SP1: - - - - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - - -
SP6:
SP7: - -

Relevant External Links for FBXL15 Gene

GeneLoc Exon Structure for
FBXL15
ECgene alternative splicing isoforms for
FBXL15

Expression for FBXL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL15 Gene

Protein differential expression in normal tissues from HIPED for FBXL15 Gene

This gene is overexpressed in Spinal cord (18.3), Frontal cortex (16.1), Retina (12.8), and Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXL15 Gene



Protein tissue co-expression partners for FBXL15 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXL15 Gene:

FBXL15

SOURCE GeneReport for Unigene cluster for FBXL15 Gene:

Hs.380081

Evidence on tissue expression from TISSUES for FBXL15 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with FBXL15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL15 Gene

Orthologs for FBXL15 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL15 34 33
  • 99.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FBXL15 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL15 34 33
  • 91.78 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl15 33
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Fbxl15 16 34 33
  • 88.78 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXL15 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL15 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXL15 34 33
  • 67.5 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL15 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl15 33
  • 59.56 (n)
Str.20389 33
zebrafish
(Danio rerio)
Actinopterygii fbxl15 34 33
  • 64.77 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009335 33
  • 47.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta jet 34 33
  • 45.32 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToOne
Species where no ortholog for FBXL15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL15 Gene

ENSEMBL:
Gene Tree for FBXL15 (if available)
TreeFam:
Gene Tree for FBXL15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBXL15: view image

Paralogs for FBXL15 Gene

Paralogs for FBXL15 Gene

genes like me logo Genes that share paralogs with FBXL15: view

Variants for FBXL15 Gene

Sequence variations from dbSNP and Humsavar for FBXL15 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000325831 -- 102,418,414(+) T/C upstream_transcript_variant
rs1000872443 -- 102,422,498(+) T/G intron_variant
rs1001330523 -- 102,423,001(+) G/A 3_prime_UTR_variant
rs1002159288 -- 102,421,576(+) G/A/T intron_variant
rs1002206188 -- 102,421,920(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL15 Gene

Variant ID Type Subtype PubMed ID
nsv1159761 CNV deletion 26073780
nsv951006 CNV deletion 24416366

Variation tolerance for FBXL15 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXL15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL15 Gene

Disorders for FBXL15 Gene

Additional Disease Information for FBXL15

No disorders were found for FBXL15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL15 Gene

Publications for FBXL15 Gene

  1. SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PMID: 21572392) Cui Y … Zhang L (The EMBO journal 2011) 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FBXL15 Gene

  • Biorbyt antibodies for FBXL15

Sources for FBXL15 Gene

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