Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008] See more...

Aliases for FBRS Gene

Aliases for FBRS Gene

  • Fibrosin 2 3 5
  • FBS 2 3 4
  • Probable Fibrosin-1 3 4
  • Fibrosin 1 2 3
  • FBS1 3 4
  • Probable Fibrosin-1 Long Transcript Protein 3
  • Fibrogenic Lymphokine 3
  • FLJ11618 2
  • FBRS 5

External Ids for FBRS Gene

Previous HGNC Symbols for FBRS Gene

  • FBS1

Previous GeneCards Identifiers for FBRS Gene

  • GC16P030579
  • GC16P030670
  • GC16P028238
  • GC16P030663
  • GC16P030664

Summaries for FBRS Gene

Entrez Gene Summary for FBRS Gene

  • Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBRS Gene

FBRS (Fibrosin) is a Protein Coding gene. Diseases associated with FBRS include Neuroschistosomiasis. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is AUTS2.

Gene Wiki entry for FBRS Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FBRS Gene

Genomics for FBRS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FBRS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBRS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FBRS

Top Transcription factor binding sites by QIAGEN in the FBRS gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Pax-4a
  • Pax-5
  • PPAR-alpha

Genomic Locations for FBRS Gene

Genomic Locations for FBRS Gene
chr16:30,658,431-30,670,810
(GRCh38/hg38)
Size:
12,380 bases
Orientation:
Plus strand
chr16:30,669,752-30,682,135
(GRCh37/hg19)
Size:
12,384 bases
Orientation:
Plus strand

Genomic View for FBRS Gene

Genes around FBRS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBRS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBRS Gene

Proteins for FBRS Gene

  • Protein details for FBRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAH7-FBRS_HUMAN
    Recommended name:
    Probable fibrosin-1
    Protein Accession:
    Q9HAH7
    Secondary Accessions:
    • B4DP86
    • Q96CI9
    • Q9H9X4

    Protein attributes for FBRS Gene

    Size:
    460 amino acids
    Molecular mass:
    48388 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13872.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14094.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBRS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBRS Gene

Post-translational modifications for FBRS Gene

  • Ubiquitination at Lys8 and Lys68
  • Modification sites at PhosphoSitePlus

Other Protein References for FBRS Gene

No data available for DME Specific Peptides for FBRS Gene

Domains & Families for FBRS Gene

Gene Families for FBRS Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBRS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBRS Gene

GenScript: Design optimal peptide antigens:
  • Probable fibrosin-1 (FBRS_HUMAN)
genes like me logo Genes that share domains with FBRS: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FBRS Gene

Function for FBRS Gene

Phenotypes From GWAS Catalog for FBRS Gene

genes like me logo Genes that share phenotypes with FBRS: view

Animal Model Products

CRISPR Products

miRNA for FBRS Gene

miRTarBase miRNAs that target FBRS

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBRS

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBRS Gene

Localization for FBRS Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBRS gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBRS Gene

Pathways & Interactions for FBRS Gene

PathCards logo

SuperPathways for FBRS Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBRS Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBRS Gene

Drugs & Compounds for FBRS Gene

No Compound Related Data Available

Transcripts for FBRS Gene

mRNA/cDNA for FBRS Gene

2 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBRS

Alternative Splicing Database (ASD) splice patterns (SP) for FBRS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17
SP1: -
SP2: - - - - - - - - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for FBRS Gene

GeneLoc Exon Structure for
FBRS

Expression for FBRS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBRS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBRS Gene

This gene is overexpressed in Placenta (46.8) and CD8 Tcells (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBRS Gene



Protein tissue co-expression partners for FBRS Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FBRS

SOURCE GeneReport for Unigene cluster for FBRS Gene:

Hs.247186

Evidence on tissue expression from TISSUES for FBRS Gene

  • Skin(2.5)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with FBRS: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBRS Gene

Orthologs for FBRS Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBRS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FBRS 30 31
  • 99.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FBRS 30 31
  • 93.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FBRS 30 31
  • 93.55 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fbrs 30
  • 90.65 (n)
Mouse
(Mus musculus)
Mammalia Fbrs 30 17 31
  • 90.51 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FBRS 31
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FBRS 31
  • 86 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FBRS 31
  • 40 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii fbrs 31
  • 22 (a)
OneToOne
Species where no ortholog for FBRS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FBRS Gene

ENSEMBL:
Gene Tree for FBRS (if available)
TreeFam:
Gene Tree for FBRS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBRS: view image

Paralogs for FBRS Gene

Paralogs for FBRS Gene

genes like me logo Genes that share paralogs with FBRS: view

Variants for FBRS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FBRS Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
774719 Likely Benign: not provided 30,669,198(+) C/A SYNONYMOUS_VARIANT
rs1259852690 Likely Pathogenic: Short stature 30,669,598(+) C/G MISSENSE_VARIANT
rs1567547614 Likely Pathogenic: Short stature 30,668,622(+) G/A MISSENSE_VARIANT
rs751526547 Uncertain Significance: Short stature 30,669,296(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for FBRS Gene

Structural Variations from Database of Genomic Variants (DGV) for FBRS Gene

Variant ID Type Subtype PubMed ID
nsv469724 CNV loss 16826518
nsv833188 CNV loss 17160897

Variation tolerance for FBRS Gene

Gene Damage Index Score: 3.07; 50.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBRS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBRS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBRS Gene

Disorders for FBRS Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBRS Gene - From: DISEASES

Disorder Aliases PubMed IDs
neuroschistosomiasis
- elite association - COSMIC cancer census association via MalaCards
Search FBRS in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with FBRS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBRS Gene

Publications for FBRS Gene

  1. Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic lymphokine. (PMID: 9809749) Prakash S … Robbins PW (DNA and cell biology 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin. (PMID: 7892239) Prakash S … Wyler DJ (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3
  4. MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. (PMID: 30415952) Kalkat M … Penn LZ (Molecular cell 2018) 3
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3

Products for FBRS Gene

  • Signalway ELISA kits for FBRS

Sources for FBRS Gene