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Aliases for FBRS Gene

Aliases for FBRS Gene

  • Fibrosin 2 3 5
  • Probable Fibrosin-1 3 4
  • Fibrosin 1 2 3
  • FBS1 3 4
  • FBS 3 4
  • Probable Fibrosin-1 Long Transcript Protein 3
  • Fibrogenic Lymphokine 3

External Ids for FBRS Gene

Previous HGNC Symbols for FBRS Gene

  • FBS1

Previous GeneCards Identifiers for FBRS Gene

  • GC16P030579
  • GC16P028238

Summaries for FBRS Gene

Entrez Gene Summary for FBRS Gene

  • Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBRS Gene

FBRS (Fibrosin) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is AUTS2.

Gene Wiki entry for FBRS Gene

Additional gene information for FBRS Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBRS Gene

Genomics for FBRS Gene

GeneHancer (GH) Regulatory Elements for FBRS Gene

Promoters and enhancers for FBRS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J030656 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 638.2 +1.1 1138 5.8 MTA3 SP1 CTCF ZFX ELF3 MNT ZNF148 NKRF POLR2A CEBPG FBRS PIR57497 SETD1A SRCAP ENSG00000260304 RNF40 ZNF764 INO80E ENSG00000260267 SMG1P5
GH16J030367 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 56.3 -282.6 -282555 17.4 HDGF SP1 CC2D1A ELF3 ZFX MNT ZNF148 NKRF POLR2A MLLT1 MYLPF TBC1D10B SETD1A SRCAP NPIPB12 INO80E SMG1P5 ZNF764 FBRS ZNF747
GH16J030051 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 61 -605.0 -605015 4.6 MTA3 CC2D1A ZFX SP1 ELF3 CTCF MNT NKRF ZNF121 CEBPG LOC112694756 TLCD3B ALDOA SETD1A SRCAP NPIPB12 INO80E ZNF764 NPIPB13 ZNF747
GH16J029803 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 56.2 -847.9 -847889 14.5 MTA3 SP1 ZNF652 ZFX CTCF CC2D1A ELF3 ZKSCAN8 MNT SIX5 PRRT2 ENSG00000280607 MAZ PIR38319 PIR43581 PIR52049 PIR44883 GC16P029809 GC16M029811 ENSG00000280893
GH16J030566 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 46.5 -88.5 -88497 6.1 HDGF CC2D1A SP1 ZFX ELF3 MNT SIX5 ZNF148 NKRF ZNF121 ZNF688 SETD1A SRCAP ENSG00000260267 NPIPB13 ZNF747 INO80E ZNF764 C16orf58 SMG1P5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBRS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBRS gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Pax-4a
  • Pax-5
  • PPAR-alpha

Genomic Locations for FBRS Gene

Genomic Locations for FBRS Gene
12,384 bases
Plus strand
12,384 bases
Plus strand

Genomic View for FBRS Gene

Genes around FBRS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBRS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBRS Gene

Proteins for FBRS Gene

  • Protein details for FBRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable fibrosin-1
    Protein Accession:
    Secondary Accessions:
    • B4DP86
    • Q96CI9
    • Q9H9X4

    Protein attributes for FBRS Gene

    460 amino acids
    Molecular mass:
    48388 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB13872.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14094.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBRS Gene


neXtProt entry for FBRS Gene

Post-translational modifications for FBRS Gene

  • Ubiquitination at isoforms=28 and posLast=6868
  • Modification sites at PhosphoSitePlus

Other Protein References for FBRS Gene

No data available for DME Specific Peptides for FBRS Gene

Domains & Families for FBRS Gene

Gene Families for FBRS Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBRS Gene


Suggested Antigen Peptide Sequences for FBRS Gene

GenScript: Design optimal peptide antigens:
  • Probable fibrosin-1 (FBRS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBRS: view

No data available for UniProtKB/Swiss-Prot for FBRS Gene

Function for FBRS Gene

Phenotypes From GWAS Catalog for FBRS Gene

Gene Ontology (GO) - Molecular Function for FBRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IBA --
genes like me logo Genes that share ontologies with FBRS: view
genes like me logo Genes that share phenotypes with FBRS: view

Animal Model Products

CRISPR Products

miRNA for FBRS Gene

miRTarBase miRNAs that target FBRS

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBRS

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBRS Gene

Localization for FBRS Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBRS gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 1
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBRS Gene

Pathways & Interactions for FBRS Gene

PathCards logo

SuperPathways for FBRS Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010469 regulation of signaling receptor activity IEA --
GO:0048146 positive regulation of fibroblast proliferation IBA --
genes like me logo Genes that share ontologies with FBRS: view

No data available for Pathways by source and SIGNOR curated interactions for FBRS Gene

Drugs & Compounds for FBRS Gene

No Compound Related Data Available

Transcripts for FBRS Gene

mRNA/cDNA for FBRS Gene

Unigene Clusters for FBRS Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FBRS

Alternative Splicing Database (ASD) splice patterns (SP) for FBRS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17
SP1: -
SP2: - - - - - - - - -
SP3: -

Relevant External Links for FBRS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBRS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBRS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBRS Gene

This gene is overexpressed in Placenta (46.8) and CD8 Tcells (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBRS Gene

Protein tissue co-expression partners for FBRS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBRS Gene:


SOURCE GeneReport for Unigene cluster for FBRS Gene:

genes like me logo Genes that share expression patterns with FBRS: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBRS Gene

Orthologs for FBRS Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBRS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBRS 35 34
  • 99.71 (n)
(Canis familiaris)
Mammalia FBRS 35 34
  • 93.7 (n)
(Bos Taurus)
Mammalia FBRS 35 34
  • 93.55 (n)
(Rattus norvegicus)
Mammalia Fbrs 34
  • 90.65 (n)
(Mus musculus)
Mammalia Fbrs 17 35 34
  • 90.51 (n)
(Monodelphis domestica)
Mammalia FBRS 35
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia FBRS 35
  • 86 (a)
(Anolis carolinensis)
Reptilia FBRS 35
  • 40 (a)
(Danio rerio)
Actinopterygii fbrs 35
  • 22 (a)
Species where no ortholog for FBRS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBRS Gene

Gene Tree for FBRS (if available)
Gene Tree for FBRS (if available)
Evolutionary constrained regions (ECRs) for FBRS: view image

Paralogs for FBRS Gene

Paralogs for FBRS Gene

genes like me logo Genes that share paralogs with FBRS: view

Variants for FBRS Gene

Sequence variations from dbSNP and Humsavar for FBRS Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000024822 -- 30,661,844(+) A/G intron_variant
rs1000037008 -- 30,667,556(+) G/A coding_sequence_variant, missense_variant
rs1000119615 -- 30,657,698(+) A/G upstream_transcript_variant
rs1000269889 -- 30,657,300(+) T/C upstream_transcript_variant
rs1000278530 -- 30,657,893(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FBRS Gene

Variant ID Type Subtype PubMed ID
nsv469724 CNV loss 16826518
nsv833188 CNV loss 17160897

Variation tolerance for FBRS Gene

Gene Damage Index Score: 3.07; 50.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBRS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBRS Gene

Disorders for FBRS Gene

Additional Disease Information for FBRS

No disorders were found for FBRS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBRS Gene

Publications for FBRS Gene

  1. Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic lymphokine. (PMID: 9809749) Prakash S … Robbins PW (DNA and cell biology 1998) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin. (PMID: 7892239) Prakash S … Wyler DJ (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 58
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FBRS Gene

Sources for FBRS Gene

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