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This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]
FBP2 (Fructose-Bisphosphatase 2) is a Protein Coding gene. Diseases associated with FBP2 include Fructose-1,6-Bisphosphatase Deficiency and Glycogen Storage Disease. Among its related pathways are Glucose metabolism and Carbon metabolism. Gene Ontology (GO) annotations related to this gene include phosphoric ester hydrolase activity and fructose 1,6-bisphosphate 1-phosphatase activity. An important paralog of this gene is FBP1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH09J094593 | Promoter/Enhancer | 0.8 | EPDnew Ensembl ENCODE | 257.3 | 0.0 | -9 | 1.7 | FBP2 MFSD14B ZNF169 HSALNG0072927 PCAT7 FBP1 RF00017-7722 | ||
GH09J094595 | Enhancer | 0.3 | Ensembl | 250.7 | -1.7 | -1677 | 0.2 | CEBPG | FBP2 HSALNG0072927 PCAT7 FBP1 RF00017-7722 | |
GH09J094629 | Enhancer | 0.8 | ENCODE | 17.9 | -37.6 | -37565 | 4.4 | ZNF217 ELF1 MBD2 CUX1 RXRA CTBP1 SIN3A ZBTB33 JUND FOXP1 | FBP2 MFSD14B FBP1 HSALNG0072929-001 piR-50444-481 | |
GH09J094662 | Enhancer | 1.1 | Ensembl ENCODE | 10.4 | -72.5 | -72471 | 7.8 | CEBPA IKZF1 HES1 MBD2 CTCF CEBPB ARNT VEZF1 NBN SMAD4 | FBP1 FBP2 hsa-miR-5095-513 lnc-FBP1-2 AOPEP | |
GH09J094636 | Promoter/Enhancer | 1.6 | EPDnew FANTOM5 Ensembl ENCODE | 6.3 | -44.6 | -44577 | 4.4 | ZNF217 ZBTB7B ELF1 ZIC2 MBD2 RXRA CTBP1 SIN3A POLR2A MYC | FBP1 HSALNG0072929-001 HSALNG0072929-002 FBP2 AOPEP ZNF169 lnc-FBP1-1 piR-50444-481 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016791 | phosphatase activity | IEA | -- |
GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | IDA | -- |
GO:0030018 | Z disc | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glucose metabolism |
Glycolysis and gluconeogenesis (short map)
.58
.46
|
.35
|
2 | Metabolism |
.40
|
|
3 | AMP-activated Protein Kinase (AMPK) Signaling | ||
4 | Carbon metabolism | ||
5 | Fructose and mannose metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005975 | carbohydrate metabolic process | IEA | -- |
GO:0005986 | sucrose biosynthetic process | IBA | 21873635 |
GO:0006000 | fructose metabolic process | TAS,IBA | 21873635 |
GO:0006002 | fructose 6-phosphate metabolic process | IBA | 21873635 |
GO:0006094 | gluconeogenesis | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Beta-D-Fructose 6-phosphate |
|
|
||||
Fructose 1,6-bisphosphate |
|
34693-15-7 |
|
Compound | Action | Cas Number |
---|---|---|
MB05032 | GNG inhibitor,special and efficacious | 261365-11-1 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FBP2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FBP2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FBP2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FBP2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fbp2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Fbp2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FBP2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FBP2 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fbp2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fbp2 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8304 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009173 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | fbp 30 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | fbp-1 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FBP1 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G43670 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0866400 30 |
|
||
Os.3408 30 |
|
||||
Wheat (Triticum aestivum) |
Liliopsida | Ta.439 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.13437 30 |
|
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs111617337 | Benign: not provided | 94,567,300(-) |
A/G NM_003837.4(FBP2):c.675T>C (p.Thr225=) |
SYNONYMOUS | |
rs77568573 | Benign: not provided | 94,558,939(-) |
T/C NM_003837.4(FBP2):c.1019A>G (p.Ter340Trp) |
STOP_LOST,NON_CODING_TRANSCRIPT | |
rs573212 | - |
p.Val86Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1493e214 | CNV | gain | 21293372 |
esv25230 | CNV | loss | 19812545 |
esv2761545 | CNV | gain | 21179565 |
esv3576685 | CNV | gain | 25503493 |
esv3621113 | CNV | gain | 21293372 |
nsv1124452 | CNV | deletion | 24896259 |
nsv1147999 | OTHER | inversion | 26484159 |
nsv466436 | CNV | loss | 19166990 |
nsv521698 | CNV | loss | 19592680 |
nsv614917 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
fructose-1,6-bisphosphatase deficiency |
|
|
glycogen storage disease |
|
|