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Aliases for FBP1 Gene

Aliases for FBP1 Gene

  • Fructose-Bisphosphatase 1 2 3 5
  • D-Fructose-1,6-Bisphosphate 1-Phosphohydrolase 1 3 4
  • Fructose-1,6-Bisphosphatase 1 2 3
  • Liver FBPase 3 4
  • FBPase 1 3 4
  • FBP 3 4
  • Growth-Inhibiting Protein 17 3
  • EC 3.1.3.11 4

External Ids for FBP1 Gene

Previous HGNC Symbols for FBP1 Gene

  • FBP

Previous GeneCards Identifiers for FBP1 Gene

  • GC09M088192
  • GC09M089093
  • GC09M090664
  • GC09M092706
  • GC09M094444
  • GC09M096405
  • GC09M097365
  • GC09M066974

Summaries for FBP1 Gene

Entrez Gene Summary for FBP1 Gene

  • Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBP1 Gene

FBP1 (Fructose-Bisphosphatase 1) is a Protein Coding gene. Diseases associated with FBP1 include Fructose-1,6-Bisphosphatase Deficiency and Hypoglycemia. Among its related pathways are AMP-activated Protein Kinase (AMPK) Signaling and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include identical protein binding and phosphoric ester hydrolase activity. An important paralog of this gene is FBP2.

UniProtKB/Swiss-Prot for FBP1 Gene

  • Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

Additional gene information for FBP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBP1 Gene

Genomics for FBP1 Gene

GeneHancer (GH) Regulatory Elements for FBP1 Gene

Promoters and enhancers for FBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J094638 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 660.9 +0.9 889 2.1 CLOCK NEUROD1 SIN3A NFXL1 ZBTB7B YY1 EGR1 HCFC1 RXRA ELF1 FBP1 FBP2 C9orf3 ZNF169
GH09J094726 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.4 -86.6 -86593 1.6 HDGF CLOCK SMAD1 ARID4B SIN3A YY1 POLR2B ZNF766 E2F8 ZNF207 C9orf3 LOC100132077 FBP1 MIR2278
GH09J094970 Enhancer 1.1 Ensembl ENCODE 16 -332.7 -332675 4.3 MLX ARID4B DMAP1 ETS1 YY1 SLC30A9 RXRA MIER2 REST KAT8 FBP1 LOC101928119 ZNF169 MIR6081 C9orf3
GH09J094602 Enhancer 1 Ensembl ENCODE 16.3 +36.2 36193 2.7 ELF3 ATF1 ARID4B SIN3A RAD21 ZEB1 ZNF143 ATF7 RUNX3 CREM FBP1 MFSD14B FBP2 PCAT7
GH09J094606 Enhancer 0.9 ENCODE 17.5 +32.1 32069 3.8 FOXA2 MLX DMAP1 THRB RAD21 RARA YY1 SLC30A9 EGR1 CREM FBP1 FBP2 ZNF169
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBP1 gene promoter:
  • TBP
  • AP-1
  • TFIID

Genomic Locations for FBP1 Gene

Genomic Locations for FBP1 Gene
chr9:94,603,133-94,640,249
(GRCh38/hg38)
Size:
37,117 bases
Orientation:
Minus strand
chr9:97,365,415-97,402,531
(GRCh37/hg19)
Size:
37,117 bases
Orientation:
Minus strand

Genomic View for FBP1 Gene

Genes around FBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBP1 Gene

Proteins for FBP1 Gene

  • Protein details for FBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09467-F16P1_HUMAN
    Recommended name:
    Fructose-1,6-bisphosphatase 1
    Protein Accession:
    P09467
    Secondary Accessions:
    • O75571
    • Q53F94
    • Q96E46

    Protein attributes for FBP1 Gene

    Size:
    338 amino acids
    Molecular mass:
    36842 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homotetramer.
    SequenceCaution:
    • Sequence=AAC50207.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FBP1 Gene

neXtProt entry for FBP1 Gene

Post-translational modifications for FBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBP1 Gene

No data available for DME Specific Peptides for FBP1 Gene

Domains & Families for FBP1 Gene

Gene Families for FBP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P09467

UniProtKB/Swiss-Prot:

F16P1_HUMAN :
  • Belongs to the FBPase class 1 family.
Family:
  • Belongs to the FBPase class 1 family.
genes like me logo Genes that share domains with FBP1: view

Function for FBP1 Gene

Molecular function for FBP1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
UniProtKB/Swiss-Prot CatalyticActivity:
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as allosteric inhibitor. AMP binding affects the turnover of bound substrate and not the affinity for substrate. Fructose 2,6-bisphosphate acts as competitive inhibitor. Fructose 2,6-bisphosphate and AMP have synergistic effects.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.7 uM for fructose 1,6-biphosphate {ECO:0000269 PubMed:17350621}; Note=The kinetic constants are determined for the recombinant enzyme expressed in E.coli.;
UniProtKB/Swiss-Prot Induction:
Up-regulated in pancreatic islets of individuals with type 2 diabetes.
GENATLAS Biochemistry:
fructose 1,6-bisphosphatase,hepatic,expressed in liver,fructose metabolism,neoglucogenesis,energy pathway

Enzyme Numbers (IUBMB) for FBP1 Gene

Phenotypes From GWAS Catalog for FBP1 Gene

Gene Ontology (GO) - Molecular Function for FBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IMP 25043030
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 8387495
GO:0016208 AMP binding IDA 8387495
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with FBP1: view
genes like me logo Genes that share phenotypes with FBP1: view

Human Phenotype Ontology for FBP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for FBP1 Gene

miRTarBase miRNAs that target FBP1

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FBP1 Gene

Localization for FBP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBP1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 25043030
GO:0005737 cytoplasm IDA 20096900
GO:0005829 cytosol IBA,TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with FBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBP1 Gene

Pathways & Interactions for FBP1 Gene

genes like me logo Genes that share pathways with FBP1: view

Pathways by source for FBP1 Gene

UniProtKB/Swiss-Prot P09467-F16P1_HUMAN

  • Pathway: Carbohydrate biosynthesis; gluconeogenesis.

Gene Ontology (GO) - Biological Process for FBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 25043030
GO:0005975 carbohydrate metabolic process IEA --
GO:0005986 sucrose biosynthetic process IBA --
GO:0006000 fructose metabolic process TAS 7558035
GO:0006002 fructose 6-phosphate metabolic process IDA 8387495
genes like me logo Genes that share ontologies with FBP1: view

No data available for SIGNOR curated interactions for FBP1 Gene

Drugs & Compounds for FBP1 Gene

(19) Drugs for FBP1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra Target, antagonist, inhibitory allosteric modulator 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
{4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol Experimental Pharma Target 0
2,5-Anhydroglucitol-1,6-Biphosphate Experimental Pharma Target 0

(5) Additional Compounds for FBP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-D-Fructose 1,6-bisphosphate
  • 1,6-Di-O-phosphono-alpha-D-fructofuranose
  • ALPHA FRUCTOSE 1,6-diphosphATE
  • 1,6-Di-O-phosphono-a-D-fructofuranose
  • 1,6-Di-O-phosphono-α-D-fructofuranose
  • Fructose 1,6-bisphosphoric acid
34693-15-7
Beta-D-Fructose 6-phosphate
  • 6-O-phosphono-beta-D-Fructofuranose
  • FRUCTOSE-6-phosphATE
  • 6-O-phosphono-b-D-Fructofuranose
  • 6-O-phosphono-β-D-fructofuranose
  • b-D-Fructose 6-phosphate
Fructose 6-phosphate
  • D-Fructose 6-phosphate
  • D-Fructose 6-phosphoric acid
  • Fructose-6-phosphate
  • Neuberg ester
  • Fructose 6-phosphoric acid
643-13-0
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2
genes like me logo Genes that share compounds with FBP1: view

Transcripts for FBP1 Gene

mRNA/cDNA for FBP1 Gene

Unigene Clusters for FBP1 Gene

Fructose-1,6-bisphosphatase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBP1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for FBP1 Gene

GeneLoc Exon Structure for
FBP1
ECgene alternative splicing isoforms for
FBP1

Expression for FBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBP1 Gene

This gene is overexpressed in Liver (x22.2) and Kidney - Cortex (x5.7).

Protein differential expression in normal tissues from HIPED for FBP1 Gene

This gene is overexpressed in Liver, secretome (32.0) and Liver (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FBP1 Gene:

FBP1

SOURCE GeneReport for Unigene cluster for FBP1 Gene:

Hs.494496

mRNA Expression by UniProt/SwissProt for FBP1 Gene:

P09467-F16P1_HUMAN
Tissue specificity: Expressed in pancreatic islets.

Evidence on tissue expression from TISSUES for FBP1 Gene

  • Liver(4.7)
  • Lung(4.7)
  • Kidney(4.6)
  • Blood(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FBP1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • ear
  • head
Thorax:
  • diaphragm
  • heart
  • heart valve
  • lung
Abdomen:
  • adrenal gland
  • liver
General:
  • blood
  • peripheral nerve
  • peripheral nervous system
  • skin
  • sweat gland
  • white blood cell
genes like me logo Genes that share expression patterns with FBP1: view

No data available for Protein tissue co-expression partners for FBP1 Gene

Orthologs for FBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBP1 34 33
  • 99.31 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 90 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 89 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
-- 34
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FBP1 34 33
  • 87.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FBP1 34 33
  • 85.11 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbp1 33
  • 83.83 (n)
mouse
(Mus musculus)
Mammalia Fbp1 16 34 33
  • 83.63 (n)
chicken
(Gallus gallus)
Aves FBP1 34 33
  • 74.36 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBP1 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbp1 33
  • 72.78 (n)
MGC75708 33
African clawed frog
(Xenopus laevis)
Amphibia fbp-prov 33
zebrafish
(Danio rerio)
Actinopterygii fbp1b 34
  • 80 (a)
OneToMany
fbp1a 34 33
  • 73.23 (n)
OneToMany
wufk92h02 33
fruit fly
(Drosophila melanogaster)
Insecta fbp 34 35
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fbp-1 34
  • 59 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR593C 33
  • 57.34 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E01211g 33
  • 52.73 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FBP1 36 34 33
  • 52.17 (n)
soybean
(Glycine max)
eudicotyledons Gma.2522 33
rice
(Oryza sativa)
Liliopsida Os.11756 33
barley
(Hordeum vulgare)
Liliopsida Hv.5733 33
bread mold
(Neurospora crassa)
Ascomycetes NCU04797 33
  • 57.23 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fbp1 33
  • 50.21 (n)
Species where no ortholog for FBP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBP1 Gene

ENSEMBL:
Gene Tree for FBP1 (if available)
TreeFam:
Gene Tree for FBP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FBP1: view image

Paralogs for FBP1 Gene

Paralogs for FBP1 Gene

(1) SIMAP similar genes for FBP1 Gene using alignment to 3 proteins:

  • F16P1_HUMAN
  • Q2TU34_HUMAN
  • Q5VZC3_HUMAN
genes like me logo Genes that share paralogs with FBP1: view

Variants for FBP1 Gene

Sequence variations from dbSNP and Humsavar for FBP1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1042144 benign, likely-benign, not specified, Fructose-biphosphatase deficiency 94,606,869(-) G/A/T coding_sequence_variant, synonymous_variant
rs1057515690 uncertain-significance, Fructose-biphosphatase deficiency 94,639,364(-) G/T 5_prime_UTR_variant, intron_variant
rs1057515693 uncertain-significance, Fructose-biphosphatase deficiency 94,639,529(-) G/A 5_prime_UTR_variant, intron_variant
rs1060499726 pathogenic, Fructose-biphosphatase deficiency 94,605,553(-) GGCCCCATAAGG/GG coding_sequence_variant, frameshift
rs111437558 pathogenic, Fructose-biphosphatase deficiency 94,605,456(-) C/G/T splice_donor_variant

Structural Variations from Database of Genomic Variants (DGV) for FBP1 Gene

Variant ID Type Subtype PubMed ID
esv2668617 CNV deletion 23128226
esv2738800 CNV deletion 23290073
esv3545146 CNV deletion 23714750
esv3576685 CNV gain 25503493
esv3621113 CNV gain 21293372
esv3621134 CNV loss 21293372
nsv1147999 OTHER inversion 26484159
nsv415436 CNV deletion 16902084
nsv466436 CNV loss 19166990
nsv614917 CNV loss 21841781
nsv614918 CNV gain 21841781

Variation tolerance for FBP1 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBP1 Gene

Human Gene Mutation Database (HGMD)
FBP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBP1 Gene

Disorders for FBP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FBP1 Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fructose-1,6-bisphosphatase deficiency
  • fbp1d
hypoglycemia
  • hypoglycaemia
metabolic acidosis
- elite association - COSMIC cancer census association via MalaCards
Search FBP1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

F16P1_HUMAN
  • Fructose-1,6-bisphosphatase deficiency (FBP1D) [MIM:229700]: An autosomal recessive metabolic disorder characterized by impaired gluconeogenesis, and episodes of hypoglycemia and metabolic acidosis that can be lethal in newborn infants or young children. {ECO:0000269 PubMed:12126934, ECO:0000269 PubMed:25601412, ECO:0000269 PubMed:9382095}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for FBP1 Gene

episodic spells of hyperventilation,apnea,hypoglycemia,metabolic acidosis and lactic acidosis with a risk of lethal course in the newborn

Additional Disease Information for FBP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FBP1: view

Publications for FBP1 Gene

  1. The estrogen hypothesis of schizophrenia implicates glucose metabolism: association study in three independent samples. (PMID: 18460190) Olsen L … Werge T (BMC medical genetics 2008) 3 22 44 58
  2. Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode. (PMID: 16442285) von Geldern TW … Abad-Zapatero C (Bioorganic & medicinal chemistry letters 2006) 3 4 22 58
  3. Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency. (PMID: 7558035) el-Maghrabi MR … Baker L (Genomics 1995) 3 4 22 58
  4. Isolation of a human liver fructose-1,6-bisphosphatase cDNA and expression of the protein in Escherichia coli. Role of ASP-118 and ASP-121 in catalysis. (PMID: 8387495) el-Maghrabi MR … Pilkis SJ (The Journal of biological chemistry 1993) 2 3 4 58
  5. Fructose 1,6-bisphosphatase deficiency: clinical, biochemical and genetic features in French patients. (PMID: 25601412) Lebigot E … Boutron A (Journal of inherited metabolic disease 2015) 3 4 58

Products for FBP1 Gene

Sources for FBP1 Gene

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