Aliases for FBP1 Gene
External Ids for FBP1 Gene
Previous HGNC Symbols for FBP1 Gene
Previous GeneCards Identifiers for FBP1 Gene
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBP1 Gene
FBP1 (Fructose-Bisphosphatase 1) is a Protein Coding gene. Diseases associated with FBP1 include Fructose-1,6-Bisphosphatase Deficiency and Hypoglycemia. Among its related pathways are AMP-activated Protein Kinase (AMPK) Signaling and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include identical protein binding and phosphoric ester hydrolase activity. An important paralog of this gene is FBP2.
UniProtKB/Swiss-Prot for FBP1 Gene
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.