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Aliases for FAU Gene

Subcategory (RNA class) for FAU Gene

lncRNA

Aliases for FAU Gene

  • FAU, Ubiquitin Like And Ribosomal Protein S30 Fusion 2 3 5
  • Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed (Fox Derived) 2 3
  • Monoclonal Nonspecific Suppressor Factor Beta 2 3
  • Small Ribosomal Subunit Protein ES30 3 4
  • Ribosomal Protein S30 2 3
  • Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed 2
  • Ubiquitin-Like Protein Fubi And Ribosomal Protein S30 3
  • FBR-MuSV-Associated Ubiquitously Expressed 3
  • FAU-Encoded Ubiquitin-Like Protein 3
  • Ubiquitin-Like-S30 Fusion Protein 3
  • 40S Ribosomal Protein S30 3
  • MNSFbeta 3
  • RPS30 3
  • FAU1 3
  • Fub1 3
  • Fubi 3
  • Asr1 3
  • S30 3

External Ids for FAU Gene

ORGUL Members for FAU Gene

Previous GeneCards Identifiers for FAU Gene

  • GC11M067403
  • GC11M066569
  • GC11M065138
  • GC11M064663
  • GC11M064644
  • GC11M064888
  • GC11M061214

Summaries for FAU Gene

Entrez Gene Summary for FAU Gene

  • This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014]

GeneCards Summary for FAU Gene

FAU (FAU, Ubiquitin Like And Ribosomal Protein S30 Fusion) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with FAU include Sarcoma. Among its related pathways are Integrated Breast Cancer Pathway and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for FAU Gene

Additional gene information for FAU Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAU Gene

Genomics for FAU Gene

GeneHancer (GH) Regulatory Elements for FAU Gene

Promoters and enhancers for FAU Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065119 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.8 810 3.9 HDGF FOXA2 PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 MRPL49 FAU LOC728975 SLC22A20P BANF1 ENSG00000278952 SYVN1
GH11J065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 58.8 -367.6 -367611 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 POLA2 PCNX3 ZFPL1 EIF1AD SART1 LOC105369352 MUS81 KAT5
GH11J065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 56.4 -301.7 -301708 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 ENSG00000277599 ENSG00000278050 ENSG00000278144 GC11P065538 SF1 LOC105369352 ZFPL1 POLA2 EIF1AD
GH11J065886 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.1 -773.0 -772985 18.4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 FOSL1 FIBP DRAP1 RBM14 ENSG00000258297 KAT5 MUS81 SART1 SF3B2 RBM4
GH11J065095 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.1 +25.8 25780 2.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC VPS51 ZFPL1 SF1 EIF1AD PCNX3 POLA2 SART1 FAU SF3B2 TRMT112
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAU on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAU gene promoter:
  • ATF6
  • AP-1
  • c-Jun
  • ATF-2
  • ATF
  • GR-beta
  • GR
  • GR-alpha
  • FOXO4

Genomic Locations for FAU Gene

Genomic Locations for FAU Gene
chr11:65,120,627-65,122,473
(GRCh38/hg38)
Size:
1,847 bases
Orientation:
Minus strand
chr11:64,888,099-64,889,945
(GRCh37/hg19)
Size:
1,847 bases
Orientation:
Minus strand

Genomic View for FAU Gene

Genes around FAU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAU Gene

Proteins for FAU Gene

  • Protein details for FAU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35544-UBIM_HUMAN
    Recommended name:
    Ubiquitin-like protein FUBI
    Protein Accession:
    P35544
    Secondary Accessions:
    • Q9H5V4

    Protein attributes for FAU Gene

    Size:
    74 amino acids
    Molecular mass:
    7760 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This protein is synthesized with ribosomal S30 as its C-terminal extension.

    Three dimensional structures from OCA and Proteopedia for FAU Gene

  • Protein details for FAU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62861-RS30_HUMAN
    Recommended name:
    40S ribosomal protein S30
    Protein Accession:
    P62861
    Secondary Accessions:
    • Q05472
    • Q95261
    • Q9H5V4

    Protein attributes for FAU Gene

    Size:
    59 amino acids
    Molecular mass:
    6648 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.
    SequenceCaution:
    • Sequence=AAH33877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ87877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15515.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46714.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46716.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG46772.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FAU Gene

neXtProt entry for FAU Gene

Post-translational modifications for FAU Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAU Gene

Domains & Families for FAU Gene

Gene Families for FAU Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for FAU Gene

Suggested Antigen Peptide Sequences for FAU Gene

Graphical View of Domain Structure for InterPro Entry

P62861

UniProtKB/Swiss-Prot:

RS30_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS30 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS30 family.
  • Belongs to the ubiquitin family.
genes like me logo Genes that share domains with FAU: view

Function for FAU Gene

Molecular function for FAU Gene

GENATLAS Biochemistry:
Finkel-Biskis-Reilly (FBR)-murine sarcoma virus associated,ubiquitously expressed,viral FOX homolog

Phenotypes From GWAS Catalog for FAU Gene

Gene Ontology (GO) - Molecular Function for FAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,HDA 22681889
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI,IEA 15677445
genes like me logo Genes that share ontologies with FAU: view
genes like me logo Genes that share phenotypes with FAU: view

Animal Model Products

miRNA for FAU Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAU Gene

Localization for FAU Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAU gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005615 extracellular space IDA --
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FAU: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAU Gene

Pathways & Interactions for FAU Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with FAU: view

Gene Ontology (GO) - Biological Process for FAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002227 innate immune response in mucosa IDA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with FAU: view

No data available for SIGNOR curated interactions for FAU Gene

Drugs & Compounds for FAU Gene

(1) Additional Compounds for FAU Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FAU: view

Transcripts for FAU Gene

mRNA/cDNA for FAU Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1565) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAU Gene

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAU Gene

No ASD Table

Relevant External Links for FAU Gene

GeneLoc Exon Structure for
FAU
ECgene alternative splicing isoforms for
FAU

Expression for FAU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAU Gene

Protein differential expression in normal tissues from HIPED for FAU Gene

This gene is overexpressed in Bone (8.1), Bone marrow stromal cell (6.1), and Liver (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAU Gene



Protein tissue co-expression partners for FAU Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAU Gene:

FAU

SOURCE GeneReport for Unigene cluster for FAU Gene:

Hs.387208

Evidence on tissue expression from TISSUES for FAU Gene

  • Intestine(4.6)
  • Nervous system(4.6)
  • Lung(4.4)
  • Liver(3.6)
  • Muscle(3.5)
  • Heart(3.4)
  • Blood(3.1)
  • Eye(3.1)
  • Kidney(3)
  • Spleen(2.8)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Skin(2.6)
  • Adrenal gland(2.4)
  • Pancreas(2.4)
  • Gall bladder(2.3)
  • Stomach(2.3)
  • Thyroid gland(2.3)
genes like me logo Genes that share expression patterns with FAU: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAU Gene

Orthologs for FAU Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAU 34 33
  • 99.75 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9843 34
  • 98 (a)
OneToMany
Fau 16 34 33
  • 91.48 (n)
dog
(Canis familiaris)
Mammalia FAU 33
  • 92.23 (n)
-- 34
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC687780 33
  • 91.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAU 34 33
  • 90.98 (n)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 83 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC89853 33
  • 75.69 (n)
Str.17035 33
zebrafish
(Danio rerio)
Actinopterygii faua 34 33
  • 72.93 (n)
ManyToMany
faub 34
  • 72 (a)
ManyToMany
zgc73171 33
fruit fly
(Drosophila melanogaster)
Insecta RpS30 34 33
  • 63.28 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000654 33
  • 60.68 (n)
worm
(Caenorhabditis elegans)
Secernentea rps-30 34 33
  • 58.07 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS30A 36
sea squirt
(Ciona savignyi)
Ascidiacea Cin.6329 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6329 33
Species where no ortholog for FAU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAU Gene

ENSEMBL:
Gene Tree for FAU (if available)
TreeFam:
Gene Tree for FAU (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAU: view image

Paralogs for FAU Gene

(8) SIMAP similar genes for FAU Gene using alignment to 6 proteins:

  • RS30_HUMAN
  • UBIM_HUMAN
  • E9PM49_HUMAN
  • E9PMS9_HUMAN
  • E9PR30_HUMAN
  • J3KN89_HUMAN
genes like me logo Genes that share paralogs with FAU: view

No data available for Paralogs for FAU Gene

Variants for FAU Gene

Sequence variations from dbSNP and Humsavar for FAU Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000188824 -- 65,122,657(-) T/C upstream_transcript_variant
rs1001216092 -- 65,122,399(-) A/C upstream_transcript_variant
rs1001628612 -- 65,123,613(-) A/C upstream_transcript_variant
rs1002071969 -- 65,123,203(-) T/C upstream_transcript_variant
rs1003542760 -- 65,123,903(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAU Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680

Variation tolerance for FAU Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAU Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAU

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAU Gene

Disorders for FAU Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAU Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search FAU in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with FAU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAU Gene

Publications for FAU Gene

  1. Assignment of the human FAU gene to a subregion of chromosome 11q13. (PMID: 8406491) Kas K … Larsson C (Genomics 1993) 2 3 22 58
  2. fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus. (PMID: 8395683) Michiels L … Merregaert J (Oncogene 1993) 3 4 22 58
  3. Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein. (PMID: 1326960) Kas K … Merregaert J (Biochemical and biophysical research communications 1992) 3 4 22 58
  4. Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer. (PMID: 19671159) Pickard MR … Williams GT (Breast cancer research : BCR 2009) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for FAU Gene