This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein ... See more...

Aliases for FAU Gene

Aliases for FAU Gene

  • FAU Ubiquitin Like And Ribosomal Protein S30 Fusion 2 3 5
  • Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed (Fox Derived) 2 3
  • Monoclonal Nonspecific Suppressor Factor Beta 2 3
  • Small Ribosomal Subunit Protein ES30 3 4
  • 40S Ribosomal Protein S30 3 4
  • Ribosomal Protein S30 2 3
  • MNSFbeta 2 3
  • RPS30 2 3
  • Fub1 2 3
  • Fubi 2 3
  • Asr1 2 3
  • S30 2 3
  • Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed 2
  • Ubiquitin-Like Protein Fubi And Ribosomal Protein S30 3
  • FAU, Ubiquitin Like And Ribosomal Protein S30 Fusion 2
  • FBR-MuSV-Associated Ubiquitously Expressed 3
  • FAU-Encoded Ubiquitin-Like Protein 3
  • Ubiquitin-Like-S30 Fusion Protein 3
  • Ubiquitin-Like Protein FUBI 4
  • FLJ22986 2
  • FAU1 3
  • FAU 5

External Ids for FAU Gene

Previous GeneCards Identifiers for FAU Gene

  • GC11M067403
  • GC11M066569
  • GC11M065138
  • GC11M064663
  • GC11M064644
  • GC11M064888
  • GC11M061214

Summaries for FAU Gene

Entrez Gene Summary for FAU Gene

  • This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014]

GeneCards Summary for FAU Gene

FAU (FAU Ubiquitin Like And Ribosomal Protein S30 Fusion) is a Protein Coding gene. Diseases associated with FAU include Sarcoma and Exudative Vitreoretinopathy 7. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for FAU Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAU Gene

Genomics for FAU Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAU Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAU on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAU

Top Transcription factor binding sites by QIAGEN in the FAU gene promoter:
  • AP-1
  • ATF
  • ATF-2
  • ATF6
  • c-Jun
  • FOXO4
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for FAU Gene

Genomic Locations for FAU Gene
chr11:65,120,630-65,122,177
(GRCh38/hg38)
Size:
1,548 bases
Orientation:
Minus strand
chr11:64,888,099-64,889,945
(GRCh37/hg19)
Size:
1,847 bases
Orientation:
Minus strand

Genomic View for FAU Gene

Genes around FAU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAU Gene

Proteins for FAU Gene

  • Protein details for FAU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62861-RS30_HUMAN
    Recommended name:
    40S ribosomal protein S30
    Protein Accession:
    P62861
    Secondary Accessions:
    • Q05472
    • Q95261
    • Q9H5V4

    Protein attributes for FAU Gene

    Size:
    59 amino acids
    Molecular mass:
    6648 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ87877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15515.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46714.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46716.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG46772.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.

    Three dimensional structures from OCA and Proteopedia for FAU Gene

  • Protein details for FAU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35544-UBIM_HUMAN
    Recommended name:
    Ubiquitin-like protein FUBI
    Protein Accession:
    P35544
    Secondary Accessions:
    • Q9H5V4

    Protein attributes for FAU Gene

    Size:
    74 amino acids
    Molecular mass:
    7760 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This protein is synthesized with ribosomal S30 as its C-terminal extension.

    Three dimensional structures from OCA and Proteopedia for FAU Gene

neXtProt entry for FAU Gene

Post-translational modifications for FAU Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAU Gene

Domains & Families for FAU Gene

Gene Families for FAU Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for FAU Gene

InterPro:
Blocks:
  • Ubiquitin domain
  • Ribosomal protein S30
ProtoNet:

Suggested Antigen Peptide Sequences for FAU Gene

GenScript: Design optimal peptide antigens:
  • 40S ribosomal protein S30 (RS30_HUMAN)
  • Ubiquitin-like protein FUBI (UBIM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62861

UniProtKB/Swiss-Prot:

UBIM_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS30 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS30 family.
  • Belongs to the ubiquitin family.
genes like me logo Genes that share domains with FAU: view

Function for FAU Gene

Molecular function for FAU Gene

GENATLAS Biochemistry:
Finkel-Biskis-Reilly (FBR)-murine sarcoma virus associated,ubiquitously expressed,viral FOX homolog

Phenotypes From GWAS Catalog for FAU Gene

Gene Ontology (GO) - Molecular Function for FAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,HDA 22681889
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FAU: view
genes like me logo Genes that share phenotypes with FAU: view

Animal Model Products

CRISPR Products

miRNA for FAU Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAU

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAU Gene

Localization for FAU Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAU gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005615 extracellular space IDA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with FAU: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAU Gene

Pathways & Interactions for FAU Gene

PathCards logo

SuperPathways for FAU Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.79
.53
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with FAU: view

Pathways by source for FAU Gene

1 KEGG pathway for FAU Gene
1 GeneGo (Thomson Reuters) pathway for FAU Gene
  • CFTR translational fidelity (class I mutations)

Gene Ontology (GO) - Biological Process for FAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002227 innate immune response in mucosa IDA --
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with FAU: view

No data available for SIGNOR curated interactions for FAU Gene

Drugs & Compounds for FAU Gene

(1) Additional Compounds for FAU Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FAU: view

Transcripts for FAU Gene

mRNA/cDNA for FAU Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAU

Alternative Splicing Database (ASD) splice patterns (SP) for FAU Gene

No ASD Table

Relevant External Links for FAU Gene

GeneLoc Exon Structure for
FAU

Expression for FAU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAU Gene

Protein differential expression in normal tissues from HIPED for FAU Gene

This gene is overexpressed in Bone (8.1), Bone marrow stromal cell (6.1), and Liver (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAU Gene



Protein tissue co-expression partners for FAU Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAU

SOURCE GeneReport for Unigene cluster for FAU Gene:

Hs.387208

Evidence on tissue expression from TISSUES for FAU Gene

  • Intestine(4.7)
  • Nervous system(4.7)
  • Lung(4.4)
  • Liver(3.9)
  • Heart(3.8)
  • Muscle(3.8)
  • Skin(3.6)
  • Kidney(3.6)
  • Blood(3.5)
  • Eye(3.4)
  • Bone marrow(3.1)
  • Spleen(3.1)
  • Lymph node(3)
  • Stomach(2.9)
  • Pancreas(2.8)
  • Thyroid gland(2.8)
  • Adrenal gland(2.6)
  • Gall bladder(2.6)
genes like me logo Genes that share expression patterns with FAU: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAU Gene

Orthologs for FAU Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAU Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAU 30 31
  • 99.75 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia