Free for academic non-profit institutions. Other users need a Commercial license
This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein ... See more...
Aliases for FAU Gene
Aliases for FAU Gene
- FAU Ubiquitin Like And Ribosomal Protein S30 Fusion 2 3 5
- Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed (Fox Derived) 2 3
- Monoclonal Nonspecific Suppressor Factor Beta 2 3
- Small Ribosomal Subunit Protein ES30 3 4
- 40S Ribosomal Protein S30 3 4
- Ribosomal Protein S30 2 3
- MNSFbeta 2 3
- RPS30 2 3
- Fub1 2 3
- Fubi 2 3
- Asr1 2 3
- S30 2 3
- Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed 2
- Ubiquitin-Like Protein Fubi And Ribosomal Protein S30 3
- FAU, Ubiquitin Like And Ribosomal Protein S30 Fusion 2
- FBR-MuSV-Associated Ubiquitously Expressed 3
- FAU-Encoded Ubiquitin-Like Protein 3
- Ubiquitin-Like-S30 Fusion Protein 3
- Ubiquitin-Like Protein FUBI 4
- FLJ22986 2
- FAU1 3
- FAU 5
External Ids for FAU Gene
Previous GeneCards Identifiers for FAU Gene
- GC11M067403
- GC11M066569
- GC11M065138
- GC11M064663
- GC11M064644
- GC11M064888
- GC11M061214
Summaries for FAU Gene
-
This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014]
GeneCards Summary for FAU Gene
FAU (FAU Ubiquitin Like And Ribosomal Protein S30 Fusion) is a Protein Coding gene. Diseases associated with FAU include Sarcoma and Exudative Vitreoretinopathy 7. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.
Additional gene information for FAU Gene
- HGNC(3597)
- Entrez Gene(2197)
- Ensembl(ENSG00000149806)
- OMIM(134690)
- UniProtKB(P62861)
- UniProtKB(P35544)
- Open Targets Platform(ENSG00000149806)
- Search for FAU at DataMed
- Search for FAU at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAU Gene
Genomics for FAU Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FAU Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FAU on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAU
- Top Transcription factor binding sites by QIAGEN in the FAU gene promoter:
-
- AP-1
- ATF
- ATF-2
- ATF6
- c-Jun
- FOXO4
- GR
- GR-alpha
- GR-beta
Genomic Locations for FAU Gene
Genomic Locations for FAU Gene
- chr11:65,120,630-65,122,177
- (GRCh38/hg38)
- Size:
- 1,548 bases
- Orientation:
- Minus strand
- chr11:64,888,099-64,889,945
- (GRCh37/hg19)
- Size:
- 1,847 bases
- Orientation:
- Minus strand
Genomic View for FAU Gene
Genes around FAU on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by HGNC
- 11q13.1 by Entrez Gene
- 11q13.1 by Ensembl
FAU Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAU Gene
Proteins for FAU Gene
-
Protein details for FAU Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62861-RS30_HUMAN
- Recommended name:
- 40S ribosomal protein S30
- Protein Accession:
- P62861
- Q05472
- Q95261
- Q9H5V4
Protein attributes for FAU Gene
- Size:
- 59 amino acids
- Molecular mass:
- 6648 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH33877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ87877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15515.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46714.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46716.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG46772.1; Type=Erroneous initiation; Evidence={ECO:0000305};
- Miscellaneous:
-
- This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.
-
Protein details for FAU Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35544-UBIM_HUMAN
- Recommended name:
- Ubiquitin-like protein FUBI
- Protein Accession:
- P35544
- Q9H5V4
Protein attributes for FAU Gene
- Size:
- 74 amino acids
- Molecular mass:
- 7760 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- This protein is synthesized with ribosomal S30 as its C-terminal extension.
Protein Expression for FAU Gene
Post-translational modifications for FAU Gene
Other Protein References for FAU Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-FAU monoclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for FAU
- Novus Biologicals Antibodies for FAU
-
Abcam antibodies for FAU
- Invitrogen Antibodies for FAU (AFLGC-FAU)
- antibodies-online: Show 36 available FAU Antibodies ranked by validation data
- Compare Top FAU Antibodies
-
Quality Products:
-
Boster Bio Antibodies for FAU
- Sino Biological Antibodies for FAU
Protein Products
- Creative Biomart Recombinant Human FAU
-
OriGene Purified Proteins for FAU
- Search Origene for MassSpec and Protein Over-expression Lysates for FAU
- Origene Custom Protein Services for FAU
- antibodies-online: Show 18 available FAU Proteins ranked by validation data
- Compare Top FAU Proteins
-
Signalway Proteins for FAU
-
Abcam proteins for FAU
Assay Products
- antibodies-online: Show 10 available FAU Elisa Kits ranked by validation data
- Compare Top FAU Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for FAU Gene
Domains & Families for FAU Gene
Gene Families for FAU Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Ribosomal proteins
Protein Domains for FAU Gene
- InterPro:
- Blocks:
-
- Ubiquitin domain
- Ribosomal protein S30
- ProtoNet:
Suggested Antigen Peptide Sequences for FAU Gene
- GenScript: Design optimal peptide antigens:
-
- 40S ribosomal protein S30 (RS30_HUMAN)
- Ubiquitin-like protein FUBI (UBIM_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62861- Family:
-
- Belongs to the eukaryotic ribosomal protein eS30 family.
- Belongs to the ubiquitin family.
Function for FAU Gene
Molecular function for FAU Gene
- GENATLAS Biochemistry:
- Finkel-Biskis-Reilly (FBR)-murine sarcoma virus associated,ubiquitously expressed,viral FOX homolog
Phenotypes From GWAS Catalog for FAU Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | TAS,HDA | 22681889 |
| GO:0003735 | structural constituent of ribosome | IEA | -- |
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for FAU Gene
- GenomeRNAi human phenotypes for FAU:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased influenza A/WSN/33 replication
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased lymphocytic choriomeningitis virus (LCMV) infection
- Decreased human parainfluenza virus type 3 (HPIV3) infection
- Decreased cell number
- Inconclusive
- Increased shRNA abundance (Z-score > 2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased G3BP1 protein expression and assembly in stress granules and decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Nucleolar pre-40S maturation defects
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased cell number in G1, small nuclei in G1
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FAU - Select products 50% OFF >
- * FAU CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FAU
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FAU
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAU
miRNA for FAU Gene
- miRTarBase miRNAs that target FAU
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FAU
- Browse OriGene Inhibitory RNA Products For FAU
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAU
Clone Products
- Applied Biological Materials (abm): Clones for FAU - Select products 50% OFF >
- * FAU as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG200780
- MG221995
- MG221996
- MR200780
- MR200780L3
- MR200780L4
- MR221995
- MR221995L3
- MR221995L4
- MR221996
- MR221996L3
- MR221996L4
- RC207711
- RC207711L1
- RC207711L2
- RC207711L3
- RC207711L4
- RG207711
- RR201561
- RR201561L3
- RR201561L4
- RR215875
- RR215876
- MR200780L3V
- MR200780L4V
- MR221995L3V
- MR221995L4V
- MR221996L3V
- MR221996L4V
- RC207711L1V
- RC207711L2V
- RC207711L3V
- RC207711L4V
- RR201561L3V
- RR201561L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FAU
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FAU
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAU Gene
Localization for FAU Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Endoplasmic reticulum (3)
- Nucleoli (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005615 | extracellular space | IDA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005840 | ribosome | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAU Gene
Pathways & Interactions for FAU Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
CFTR translational fidelity (class I mutations)
.79
.77
.53
|
|
| 2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
| 3 | Influenza Viral RNA Transcription and Replication | ||
| 4 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for FAU Gene
2 BioSystems pathways for FAU Gene
1 KEGG pathway for FAU Gene
1 GeneGo (Thomson Reuters) pathway for FAU Gene
- CFTR translational fidelity (class I mutations)
Interacting Proteins for FAU Gene
Selected Interacting proteins:
P35544-UBIM_HUMAN
ENSP00000435370
P62861-RS30_HUMAN
for FAU Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for FAU
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
| GO:0002227 | innate immune response in mucosa | IDA | -- |
| GO:0006412 | translation | IEA | -- |
| GO:0006413 | translational initiation | TAS | -- |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | TAS | -- |
No data available for SIGNOR curated interactions for FAU Gene
Drugs & Compounds for FAU Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Creative Biomart Recombinant Human FAU
Transcripts for FAU Gene
mRNA/cDNA for FAU Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000279259 461 nts (view in UCSC)
- ENST00000434372 533 nts (view in UCSC)
- ENST00000525297 355 nts (view in UCSC)
- ENST00000526555 507 nts (view in UCSC)
- ENST00000527548 538 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FAU - Select products 50% OFF >
- * FAU CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FAU
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FAU
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAU
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FAU
- Browse OriGene Inhibitory RNA Products For FAU
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAU
Clone Products
- Applied Biological Materials (abm): Clones for FAU - Select products 50% OFF >
- * FAU as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG200780
- MG221995
- MG221996
- MR200780
- MR200780L3
- MR200780L4
- MR221995
- MR221995L3
- MR221995L4
- MR221996
- MR221996L3
- MR221996L4
- RC207711
- RC207711L1
- RC207711L2
- RC207711L3
- RC207711L4
- RG207711
- RR201561
- RR201561L3
- RR201561L4
- RR215875
- RR215876
- MR200780L3V
- MR200780L4V
- MR221995L3V
- MR221995L4V
- MR221996L3V
- MR221996L4V
- RC207711L1V
- RC207711L2V
- RC207711L3V
- RC207711L4V
- RR201561L3V
- RR201561L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FAU
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FAU
Relevant External Links for FAU Gene
- GeneLoc Exon Structure for
- FAU
Expression for FAU Gene
This gene is overexpressed in Bone (8.1), Bone marrow stromal cell (6.1), and Liver (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAU Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAU
SOURCE GeneReport for Unigene cluster for FAU Gene:
Hs.387208Evidence on tissue expression from TISSUES for FAU Gene
- Intestine(4.7)
- Nervous system(4.7)
- Lung(4.4)
- Liver(3.9)
- Heart(3.8)
- Muscle(3.8)
- Skin(3.6)
- Kidney(3.6)
- Blood(3.5)
- Eye(3.4)
- Bone marrow(3.1)
- Spleen(3.1)
- Lymph node(3)
- Stomach(2.9)
- Pancreas(2.8)
- Thyroid gland(2.8)
- Adrenal gland(2.6)
- Gall bladder(2.6)
Primer Products
-
OriGene qPCR primer pairs for FAU
-
OriGene qPCR primer pairs and template standards for FAU