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Aliases for FATE1 Gene

Aliases for FATE1 Gene

  • Fetal And Adult Testis Expressed 1 2 3 5
  • Cancer/Testis Antigen 43 2 3 4
  • Tumor Antigen BJ-HCC-2 3 4
  • CT43 3 4
  • FATE 3 4
  • Fetal And Adult Testis-Expressed Transcript Protein 3
  • BJ-HCC-2 Antigen 3

External Ids for FATE1 Gene

Previous GeneCards Identifiers for FATE1 Gene

  • GC0XP150555
  • GC0XP150884
  • GC0XP139741

Summaries for FATE1 Gene

Entrez Gene Summary for FATE1 Gene

  • This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010]

GeneCards Summary for FATE1 Gene

FATE1 (Fetal And Adult Testis Expressed 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FATE1 Gene

  • Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).

Gene Wiki entry for FATE1 Gene

Additional gene information for FATE1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FATE1 Gene

Genomics for FATE1 Gene

GeneHancer (GH) Regulatory Elements for FATE1 Gene

Promoters and enhancers for FATE1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI151715 Promoter 0.5 EPDnew 550.8 -0.1 -95 0.1 FATE1 PRRG3
GH0XI151718 Enhancer 0.3 FANTOM5 7.5 +2.5 2477 0 ZNF512 CNGA2 FATE1 GC0XM151722
GH0XI151702 Enhancer 0.2 ENCODE 8.2 -12.2 -12196 3.1 PRRG3 FATE1
GH0XI151694 Promoter 1.1 EPDnew Ensembl 0.3 -20.9 -20934 0.6 EZH2 PRRG3 FATE1
GH0XI151695 Enhancer 0.5 ENCODE 0.4 -19.2 -19152 2.6 RFX1 ZNF366 ZNF512 FOS BMI1 PRRG3 FATE1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FATE1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FATE1 gene promoter:

Genomic Locations for FATE1 Gene

Genomic Locations for FATE1 Gene
7,160 bases
Plus strand

Genomic View for FATE1 Gene

Genes around FATE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FATE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FATE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FATE1 Gene

Proteins for FATE1 Gene

  • Protein details for FATE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fetal and adult testis-expressed transcript protein
    Protein Accession:

    Protein attributes for FATE1 Gene

    183 amino acids
    Molecular mass:
    20712 Da
    Quaternary structure:
    • Interacts with BIK and RNF183 (PubMed:26567849). Interacts with IMMT/MIC60and EMD (PubMed:27402544).

neXtProt entry for FATE1 Gene

Post-translational modifications for FATE1 Gene

No Post-translational modifications

Other Protein References for FATE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FATE1 Gene

Domains & Families for FATE1 Gene

Gene Families for FATE1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FATE1 Gene


Suggested Antigen Peptide Sequences for FATE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FATE1: view

No data available for UniProtKB/Swiss-Prot for FATE1 Gene

Function for FATE1 Gene

Molecular function for FATE1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).

Gene Ontology (GO) - Molecular Function for FATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0031625 ubiquitin protein ligase binding IDA 26567849
genes like me logo Genes that share ontologies with FATE1: view
genes like me logo Genes that share phenotypes with FATE1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FATE1 Gene

Localization for FATE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FATE1 Gene

Mitochondrion. Mitochondrion outer membrane. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER. {ECO:0000269 PubMed:27402544}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FATE1 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 4
plasma membrane 2
extracellular 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IDA,IEA 12865919
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FATE1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FATE1 Gene

Pathways & Interactions for FATE1 Gene

SuperPathways for FATE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process IDA 12865919
GO:0051562 negative regulation of mitochondrial calcium ion concentration IDA 12865919
genes like me logo Genes that share ontologies with FATE1: view

No data available for Pathways by source and SIGNOR curated interactions for FATE1 Gene

Drugs & Compounds for FATE1 Gene

No Compound Related Data Available

Transcripts for FATE1 Gene

mRNA/cDNA for FATE1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FATE1 Gene

Fetal and adult testis expressed 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FATE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for FATE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FATE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FATE1 Gene

mRNA differential expression in normal tissues according to GTEx for FATE1 Gene

This gene is overexpressed in Testis (x51.0).

Protein differential expression in normal tissues from HIPED for FATE1 Gene

This gene is overexpressed in Ovary (55.2) and Fetal ovary (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FATE1 Gene

Protein tissue co-expression partners for FATE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FATE1 Gene:


SOURCE GeneReport for Unigene cluster for FATE1 Gene:


mRNA Expression by UniProt/SwissProt for FATE1 Gene:

Tissue specificity: Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919).
genes like me logo Genes that share expression patterns with FATE1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FATE1 Gene

Orthologs for FATE1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FATE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FATE1 33 34
  • 99.45 (n)
(Canis familiaris)
Mammalia FATE1 33 34
  • 78.87 (n)
(Bos Taurus)
Mammalia FATE1 34
  • 49 (a)
(Mus musculus)
Mammalia Fate1 34
  • 48 (a)
Species where no ortholog for FATE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FATE1 Gene

Gene Tree for FATE1 (if available)
Gene Tree for FATE1 (if available)

Paralogs for FATE1 Gene

No data available for Paralogs for FATE1 Gene

Variants for FATE1 Gene

Sequence variations from dbSNP and Humsavar for FATE1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000098596 -- 151,719,180(+) G/A intron_variant
rs1000566062 -- 151,716,767(+) C/T intron_variant
rs1001411260 -- 151,720,117(+) G/A intron_variant
rs1002080607 -- 151,717,494(+) C/T intron_variant
rs1002290591 -- 151,718,413(+) A/G intron_variant

Variation tolerance for FATE1 Gene

Residual Variation Intolerance Score: 54.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.87; 67.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FATE1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FATE1 Gene

Disorders for FATE1 Gene

Additional Disease Information for FATE1

No disorders were found for FATE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FATE1 Gene

Publications for FATE1 Gene

  1. Human FATE is a novel X-linked gene expressed in fetal and adult testis. (PMID: 11694338) Olesen C … Tommerup N (Molecular and cellular endocrinology 2001) 2 3 4 58
  2. FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria. (PMID: 27402544) Doghman-Bouguerra M … Lalli E (EMBO reports 2016) 3 4 58
  3. Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. (PMID: 26567849) Maxfield KE … Whitehurst AW (Nature communications 2015) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FATE1 Gene

Sources for FATE1 Gene

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