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Aliases for FASTKD5 Gene

Aliases for FASTKD5 Gene

  • FAST Kinase Domains 5 2 3 5
  • FAST Kinase Domain-Containing Protein 5, Mitochondrial 3
  • DJ1187M17.5 3
  • KIAA1792 4

External Ids for FASTKD5 Gene

Previous GeneCards Identifiers for FASTKD5 Gene

  • GC20M003077

Summaries for FASTKD5 Gene

GeneCards Summary for FASTKD5 Gene

FASTKD5 (FAST Kinase Domains 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase activity.

UniProtKB/Swiss-Prot for FASTKD5 Gene

  • Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715).

Additional gene information for FASTKD5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTKD5 Gene

Genomics for FASTKD5 Gene

GeneHancer (GH) Regulatory Elements for FASTKD5 Gene

Promoters and enhancers for FASTKD5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J003156 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +1.4 1355 4.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 UBOX5 FASTKD5 ENSG00000229539 RN7SL555P ZNF343 VPS16 UBOX5-AS1 IDH3B ITPA SNRPB
GH20J003148 Promoter 0.5 EPDnew 650.4 +11.8 11758 0.1 FASTKD5 LZTS3 DDRGK1 UBOX5 GC20P003124 UBOX5-AS1
GH20J003149 Promoter 0.5 EPDnew 650.4 +10.7 10699 0.1 FASTKD5 LZTS3 MRPS26 GNRH2 DDRGK1 PTPRA VPS16 UBOX5 GC20P003124 UBOX5-AS1
GH20J003113 Enhancer 0.3 Ensembl 12.2 +46.7 46696 0.4 EGR2 OXT FASTKD5 UBOX5 MRPS26 GNRH2 DDRGK1 ITPA UBOX5-AS1 GC20P003124
GH20J003092 Enhancer 0.9 FANTOM5 Ensembl ENCODE 2.2 +66.2 66236 2.5 POLR2A BHLHE40 SIN3A NR2F2 AVP RN7SL555P SNRPB PCED1A UBOX5 FASTKD5 PTPRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FASTKD5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FASTKD5 gene promoter:
  • NF-kappaB
  • Ik-2
  • GATA-2
  • CP2
  • NF-kappaB1
  • Pax-2a
  • MZF-1
  • Pax-2
  • c-Myb
  • Zic3

Genomic Locations for FASTKD5 Gene

Genomic Locations for FASTKD5 Gene
13,379 bases
Minus strand
13,379 bases
Minus strand

Genomic View for FASTKD5 Gene

Genes around FASTKD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FASTKD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FASTKD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASTKD5 Gene

Proteins for FASTKD5 Gene

  • Protein details for FASTKD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FAST kinase domain-containing protein 5, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q96JN3
    • Q9H5D1
    • Q9H8Y3

    Protein attributes for FASTKD5 Gene

    764 amino acids
    Molecular mass:
    86574 Da
    Quaternary structure:
    • Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2. Associates with the 12S mitochondrial rRNA (12S mt-rRNA).
    • Sequence=BAB15696.1; Type=Frameshift; Positions=662; Evidence={ECO:0000305}; Sequence=BAB47421.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FASTKD5 Gene

Post-translational modifications for FASTKD5 Gene

  • Ubiquitination at Lys87
  • Modification sites at PhosphoSitePlus

Other Protein References for FASTKD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FASTKD5 Gene

Domains & Families for FASTKD5 Gene

Gene Families for FASTKD5 Gene

Protein Domains for FASTKD5 Gene


Suggested Antigen Peptide Sequences for FASTKD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAST kinase family.
  • Belongs to the FAST kinase family.
genes like me logo Genes that share domains with FASTKD5: view

Function for FASTKD5 Gene

Molecular function for FASTKD5 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715).

Gene Ontology (GO) - Molecular Function for FASTKD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22681889
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0019843 rRNA binding IEA,IDA 25683715
genes like me logo Genes that share ontologies with FASTKD5: view
genes like me logo Genes that share phenotypes with FASTKD5: view

Animal Model Products

CRISPR Products

miRNA for FASTKD5 Gene

miRTarBase miRNAs that target FASTKD5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FASTKD5

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FASTKD5 Gene

Localization for FASTKD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FASTKD5 Gene

Mitochondrion matrix, mitochondrion nucleoid. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269 PubMed:25683715}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FASTKD5 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for FASTKD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 20869947
GO:0035770 ribonucleoprotein granule IDA 25683715
GO:0042645 mitochondrial nucleoid IEA,IDA 25683715
genes like me logo Genes that share ontologies with FASTKD5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FASTKD5 Gene

Pathways & Interactions for FASTKD5 Gene

SuperPathways for FASTKD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FASTKD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000963 mitochondrial RNA processing IMP 25683715
GO:0006397 mRNA processing IEA --
GO:0006468 protein phosphorylation IEA --
GO:0045333 cellular respiration ISS 20869947
genes like me logo Genes that share ontologies with FASTKD5: view

No data available for Pathways by source and SIGNOR curated interactions for FASTKD5 Gene

Drugs & Compounds for FASTKD5 Gene

No Compound Related Data Available

Transcripts for FASTKD5 Gene

mRNA/cDNA for FASTKD5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(218) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FASTKD5 Gene

FAST kinase domains 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FASTKD5

Alternative Splicing Database (ASD) splice patterns (SP) for FASTKD5 Gene

No ASD Table

Relevant External Links for FASTKD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FASTKD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FASTKD5 Gene

mRNA differential expression in normal tissues according to GTEx for FASTKD5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for FASTKD5 Gene

This gene is overexpressed in Lung (19.7), Peripheral blood mononuclear cells (19.0), and Bone (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FASTKD5 Gene

Protein tissue co-expression partners for FASTKD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of FASTKD5 Gene:


SOURCE GeneReport for Unigene cluster for FASTKD5 Gene:


mRNA Expression by UniProt/SwissProt for FASTKD5 Gene:

Tissue specificity: Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle, liver and thyroid.

Evidence on tissue expression from TISSUES for FASTKD5 Gene

  • Nervous system(4.6)
  • Muscle(4.3)
  • Lung(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with FASTKD5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FASTKD5 Gene

Orthologs for FASTKD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FASTKD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FASTKD5 34 33
  • 99.3 (n)
(Bos Taurus)
Mammalia FASTKD5 33
  • 86.16 (n)
(Canis familiaris)
Mammalia FASTKD5 34 33
  • 84.28 (n)
(Rattus norvegicus)
Mammalia Fastkd5 33
  • 81.78 (n)
(Mus musculus)
Mammalia Fastkd5 16 34 33
  • 81.03 (n)
(Ornithorhynchus anatinus)
Mammalia FASTKD5 34
  • 63 (a)
(Gallus gallus)
Aves FASTKD5 34 33
  • 57.7 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fastkd5 33
  • 55.28 (n)
(Danio rerio)
Actinopterygii LOC569940 33
  • 51.1 (n)
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2124 34
  • 19 (a)
Species where no ortholog for FASTKD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASTKD5 Gene

Gene Tree for FASTKD5 (if available)
Gene Tree for FASTKD5 (if available)
Evolutionary constrained regions (ECRs) for FASTKD5: view image

Paralogs for FASTKD5 Gene

No data available for Paralogs for FASTKD5 Gene

Variants for FASTKD5 Gene

Sequence variations from dbSNP and Humsavar for FASTKD5 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000350120 -- 3,160,481(-) A/AA upstream_transcript_variant
rs1000860442 -- 3,157,154(-) G/C intron_variant
rs1001033893 -- 3,151,271(-) T/C intron_variant
rs1001063423 -- 3,151,548(-) G/C intron_variant
rs1001065372 -- 3,150,670(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FASTKD5 Gene

Variant ID Type Subtype PubMed ID
nsv524482 CNV gain 19592680
nsv585276 CNV gain 21841781
nsv833897 CNV loss 17160897
nsv833898 CNV gain+loss 17160897

Variation tolerance for FASTKD5 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.89; 67.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FASTKD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTKD5 Gene

Disorders for FASTKD5 Gene

Additional Disease Information for FASTKD5

No disorders were found for FASTKD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FASTKD5 Gene

Publications for FASTKD5 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. (PMID: 25683715) Antonicka H … Shoubridge EA (Cell reports 2015) 3 4 58
  3. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. (PMID: 20869947) Simarro M … Anderson P (Biochemical and biophysical research communications 2010) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FASTKD5 Gene

Sources for FASTKD5 Gene

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