Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008] See more...
Aliases for FASTKD2 Gene
Aliases for FASTKD2 Gene
External Ids for FASTKD2 Gene
- HGNC: 29160
- Entrez Gene: 22868
- Ensembl: ENSG00000118246
- OMIM: 612322
- UniProtKB: Q9NYY8
Previous HGNC Symbols for FASTKD2 Gene
- KIAA0971
Previous GeneCards Identifiers for FASTKD2 Gene
- GC02P207338
- GC02P207630
- GC02P199479
Summaries for FASTKD2 Gene
-
This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008]
GeneCards Summary for FASTKD2 Gene
FASTKD2 (FAST Kinase Domains 2) is a Protein Coding gene. Diseases associated with FASTKD2 include Combined Oxidative Phosphorylation Deficiency 44 and Fastkd2-Related Infantile Mitochondrial Encephalomyopathy. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is FASTKD1.
UniProtKB/Swiss-Prot Summary for FASTKD2 Gene
-
Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).
Additional gene information for FASTKD2 Gene
- HGNC(29160)
- Entrez Gene(22868)
- Ensembl(ENSG00000118246)
- OMIM(612322)
- UniProtKB(Q9NYY8)
- Open Targets Platform(ENSG00000118246)
- Monarch Initiative
- Search for FASTKD2 at DataMed
- Search for FASTKD2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FASTKD2 Gene
Genomics for FASTKD2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FASTKD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FASTKD2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FASTKD2
- Top Transcription factor binding sites by QIAGEN in the FASTKD2 gene promoter:
-
- AREB6
- C/EBPalpha
- Cdc5
- CUTL1
- HFH-1
- Ik-1
- POU2F1
- POU2F1a
Genomic Locations for FASTKD2 Gene
Genomic Locations for FASTKD2 Gene
- chr2:206,765,357-206,796,189
- (GRCh38/hg38)
- Size:
- 30,833 bases
- Orientation:
- Plus strand
- chr2:207,630,081-207,660,913
- (GRCh37/hg19)
- Size:
- 30,833 bases
- Orientation:
- Plus strand
Genomic View for FASTKD2 Gene
Genes around FASTKD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q33.3 by HGNC
- 2q33.3 by Entrez Gene
- 2q33.3 by Ensembl
FASTKD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FASTKD2 Gene
Proteins for FASTKD2 Gene
-
Protein details for FASTKD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NYY8-FAKD2_HUMAN
- Recommended name:
- FAST kinase domain-containing protein 2, mitochondrial
- Protein Accession:
- Q9NYY8
- Q9NVX6
- Q9Y2H7
Protein attributes for FASTKD2 Gene
- Size:
- 710 amino acids
- Molecular mass:
- 81463 Da
- Quaternary structure:
-
- Monomer. Found in a complex with GRSF1, DDX28, DHX30 and FASTKD5. Associates with the 16S mitochondrial rRNA (16S mt-rRNA) (PubMed:25683715). Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA (PubMed:27667664).
- SequenceCaution:
-
- Sequence=BAA76815.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91617.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for FASTKD2 Gene
Post-translational modifications for FASTKD2 Gene
Other Protein References for FASTKD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ FAKD2 Antibody
- Creative Diagnostics Anti-FASTKD2 monoclonal antibody
- Novus Biologicals Antibodies for FASTKD2
- Invitrogen Antibodies for FASTKD2 (AFLGC-Fastkd2)
-
Boster Bio Antibodies for FASTKD2
Protein Products
-
OriGene Purified Proteins for FASTKD2
- Search Origene for MassSpec and Protein Over-expression Lysates for FASTKD2
- Origene Custom Protein Services for FASTKD2
-
Signalway Proteins for FASTKD2
-
Abcam proteins for FASTKD2
No data available for DME Specific Peptides for FASTKD2 Gene
Domains & Families for FASTKD2 Gene
Gene Families for FASTKD2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FASTKD2 Gene
- InterPro:
- Blocks:
-
- FAST kinase-like protein, subdomain 2
- RAP domain
- ProtoNet:
Suggested Antigen Peptide Sequences for FASTKD2 Gene
- GenScript: Design optimal peptide antigens:
-
- FAST kinase domain-containing protein 2 (FAKD2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NYY8- Family:
-
- Belongs to the FAST kinase family.
Function for FASTKD2 Gene
Molecular function for FASTKD2 Gene
- UniProtKB/Swiss-Prot Function:
- Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).
Phenotypes From GWAS Catalog for FASTKD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA,HDA | 22658674 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0019843 | rRNA binding | IEA,IDA | 25683715 |
Phenotypes for FASTKD2 Gene
- MGI mutant phenotypes for FASTKD2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FASTKD2:
Animal Models for FASTKD2 Gene
- MGI Knock Outs for FASTKD2:
-
- Fastkd2 Fastkd2<tm1b(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FASTKD2 - Select products 50% OFF >
- * FASTKD2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FASTKD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FASTKD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FASTKD2
miRNA for FASTKD2 Gene
- miRTarBase miRNAs that target FASTKD2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FASTKD2
- Browse OriGene Inhibitory RNA Products For FASTKD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FASTKD2
Clone Products
- Applied Biological Materials (abm): Clones for FASTKD2 - Select products 50% OFF >
- * FASTKD2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210057
- MR210057
- MR210057L3
- MR210057L4
- RC201476
- RC201476L3
- RC201476L4
- RC227338
- RC227338L3
- RC227338L4
- RC227579
- RC227579L3
- RC227579L4
- RG201476
- RG227338
- RG227579
- RR212090
- RR212090L3
- RR212090L4
- MR210057L3V
- MR210057L4V
- RC201476L3V
- RC201476L4V
- RC227338L3V
- RC227338L4V
- RC227579L3V
- RC227579L4V
- RR212090L3V
- RR212090L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FASTKD2
- Addgene plasmids for FASTKD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FASTKD2
Cell Line Products
-
Horizon Cell Lines for FASTKD2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FASTKD2 Gene
Localization for FASTKD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FASTKD2 Gene
- Mitochondrion matrix, mitochondrion nucleoid. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269 PubMed:25683715}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| extracellular | 4 |
| nucleus | 4 |
| cytosol | 2 |
| peroxisome | 0 |
| golgi apparatus | 0 |
- Mitochondria (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005739 | mitochondrion | IEA,IDA | 20869947 |
| GO:0035770 | ribonucleoprotein granule | IDA | 25683715 |
| GO:0042645 | mitochondrial nucleoid | IEA,IDA | 25683715 |
| GO:0045171 | intercellular bridge | IDA | -- |
Pathways & Interactions for FASTKD2 Gene
Interacting Proteins for FASTKD2 Gene
Selected Interacting proteins:
Q9NYY8-FAKD2_HUMAN
ENSP00000236980
for FASTKD2 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for FASTKD2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0042254 | ribosome biogenesis | IEA | -- |
| GO:0070131 | positive regulation of mitochondrial translation | IMP | 27667664 |
| GO:1902775 | mitochondrial large ribosomal subunit assembly | IMP | 25683715 |
No data available for Pathways by source for FASTKD2 Gene
Transcripts for FASTKD2 Gene
mRNA/cDNA for FASTKD2 Gene
- 3 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000236980 3188 nts (view in UCSC)
- ENST00000402774 6712 nts (view in UCSC)
- ENST00000403094 2344 nts (view in UCSC)
- ENST00000418289 576 nts (view in UCSC)
- ENST00000471788 842 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FASTKD2 - Select products 50% OFF >
- * FASTKD2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FASTKD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FASTKD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FASTKD2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FASTKD2
- Browse OriGene Inhibitory RNA Products For FASTKD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FASTKD2
Clone Products
- Applied Biological Materials (abm): Clones for FASTKD2 - Select products 50% OFF >
- * FASTKD2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210057
- MR210057
- MR210057L3
- MR210057L4
- RC201476
- RC201476L3
- RC201476L4
- RC227338
- RC227338L3
- RC227338L4
- RC227579
- RC227579L3
- RC227579L4
- RG201476
- RG227338
- RG227579
- RR212090
- RR212090L3
- RR212090L4
- MR210057L3V
- MR210057L4V
- RC201476L3V
- RC201476L4V
- RC227338L3V
- RC227338L4V
- RC227579L3V
- RC227579L4V
- RR212090L3V
- RR212090L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FASTKD2
- Addgene plasmids for FASTKD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FASTKD2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Relevant External Links for FASTKD2 Gene
- GeneLoc Exon Structure for
- FASTKD2
Expression for FASTKD2 Gene
This gene is overexpressed in Bone (23.7) and Lung (18.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FASTKD2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FASTKD2
SOURCE GeneReport for Unigene cluster for FASTKD2 Gene:
Hs.5930mRNA Expression by UniProt/SwissProt for FASTKD2 Gene:
Q9NYY8-FAKD2_HUMAN
Tissue specificity:
Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle and thyroid.
Evidence on tissue expression from TISSUES for FASTKD2 Gene
- Nervous system(4.8)
- Liver(4.4)
- Adrenal gland(4.2)
- Muscle(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FASTKD2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- urinary
Regions:
Head and neck:
- brain
- cerebrospinal fluid
- cranial nerve
- ear
- eye
- eyelid
- face
- head
- meninges
- neck
Thorax:
- bronchus
- heart
- heart valve
- lung
- trachea
Abdomen:
- kidney
- liver
General:
- blood
- blood vessel
- coagulation system
- peripheral nervous system
- red blood cell
- skin
Primer Products
-
OriGene qPCR primer pairs for FASTKD2
-
OriGene qPCR primer pairs and template standards for FASTKD2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FASTKD2 Gene
Orthologs for FASTKD2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FASTKD2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FASTKD2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FASTKD2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fastkd2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fastkd2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | FASTKD2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FASTKD2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FASTKD2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FASTKD2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fastkd2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fastkd2 30 31 |
|
OneToOne |
- Species where no ortholog for FASTKD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FASTKD2 Gene
- ENSEMBL:
- Gene Tree for FASTKD2 (if available)
- TreeFam:
- Gene Tree for FASTKD2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FASTKD2: view image
Paralogs for FASTKD2 Gene
Variants for FASTKD2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FASTKD2 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 669738 | Benign: not provided | 206,787,058(+) | G/A | INTRON_VARIANT | |
| 671648 | Benign: not provided | 206,770,870(+) | G/T | INTRON_VARIANT | |
| 671649 | Benign: not provided | 206,771,057(+) | G/A | INTRON_VARIANT | |
| 671650 | Likely Benign: not provided | 206,771,826(+) | A/G | INTRON_VARIANT | |
| 671651 | Benign: not provided | 206,774,170(+) | A/C | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1011347 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.98;
74.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FASTKD2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTKD2 Gene
Disorders for FASTKD2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| combined oxidative phosphorylation deficiency 44 |
|
|
| fastkd2-related infantile mitochondrial encephalomyopathy |
|
|
| mitochondrial complex iv deficiency |
|
|
| leigh syndrome |
|
|
| mitochondrial encephalomyopathy |
|
|
Search FASTKD2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FASTKD2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FASTKD2 Gene
Publications for FASTKD2 Gene
- A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. (PMID: 27667664) Arroyo JD … Mootha VK (Cell metabolism 2016) 3 4
- Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. (PMID: 25683715) Antonicka H … Shoubridge EA (Cell reports 2015) 3 4
- Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka DC … Mohlke KL (Obesity (Silver Spring, Md.) 2011) 3 41
- Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. (PMID: 20869947) Simarro M … Anderson P (Biochemical and biophysical research communications 2010) 3 4
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
ExternalLinks
Products for FASTKD2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FASTKD2
- Search Origene for MassSpec and Protein Over-expression Lysates for FASTKD2
- Origene Custom Protein Services for FASTKD2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FASTKD2
- Browse OriGene Inhibitory RNA Products For FASTKD2
- OriGene qPCR primer pairs for FASTKD2
- OriGene qPCR primer pairs and template standards for FASTKD2
- OriGene CRISPR knockouts for FASTKD2
- MG210057
- MR210057
- MR210057L3
- MR210057L4
- RC201476
- RC201476L3
- RC201476L4
- RC227338
- RC227338L3
- RC227338L4
- RC227579
- RC227579L3
- RC227579L4
- RG201476
- RG227338
- RG227579
- RR212090
- RR212090L3
- RR212090L4
- MR210057L3V
- MR210057L4V
- RC201476L3V
- RC201476L4V
- RC227338L3V
- RC227338L4V
- RC227579L3V
- RC227579L4V
- RR212090L3V
- RR212090L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FASTKD2
- Sino Biological Human cDNA Clone for FASTKD2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FASTKD2
- Novus Biologicals proteins and lysates for FASTKD2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for FASTKD2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for FASTKD2 (AFLGC-Fastkd2)
- VectorBuilder Custom and pre-made DNA vectors for FASTKD2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FASTKD2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FASTKD2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FASTKD2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FASTKD2
- Addgene plasmids for FASTKD2
- antibodies-online: Show 18 available FASTKD2 Antibodies ranked by validation data
- Compare Top FASTKD2 Antibodies
- antibodies-online: Search results for available FASTKD2 related products ranked by validation data
- antibodies-online: Search results for available FASTKD2 related products ranked by validation data
- Horizon Cell Lines for FASTKD2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FASTKD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FASTKD2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FASTKD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FASTKD2
- Boster Bio Antibodies for FASTKD2
- Browse Boster Bio ELISA Kits
- Signalway Proteins for FASTKD2
Sources for FASTKD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB