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Aliases for FASTK Gene

Aliases for FASTK Gene

  • Fas Activated Serine/Threonine Kinase 2 3 5
  • Fas-Activated Serine/Threonine Kinase 2 3
  • FAST Kinase 3 4
  • EC 2.7.11.8 4
  • FAST 3

External Ids for FASTK Gene

Previous GeneCards Identifiers for FASTK Gene

  • GC07M149020
  • GC07M150088
  • GC07M150165
  • GC07M150211
  • GC07M150404
  • GC07M150773
  • GC07M144586

Summaries for FASTK Gene

Entrez Gene Summary for FASTK Gene

  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for FASTK Gene

FASTK (Fas Activated Serine/Threonine Kinase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase activity and Fas-activated serine/threonine kinase activity. An important paralog of this gene is FASTKD3.

UniProtKB/Swiss-Prot for FASTK Gene

  • Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.

  • Isoform 4: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.

Gene Wiki entry for FASTK Gene

Additional gene information for FASTK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTK Gene

Genomics for FASTK Gene

GeneHancer (GH) Regulatory Elements for FASTK Gene

Promoters and enhancers for FASTK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J151076 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 662.4 +0.3 347 8.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 FASTK TMUB1 GC07M151083 GC07M151082 ENSG00000244151 NUB1 AGAP3 GC07M151084 SLC4A2
GH07J151038 Enhancer 1.4 Ensembl ENCODE dbSUPER 21.8 +41.6 41572 2.6 HDGF PKNOX1 SMAD1 ARNT SIN3A POLR2B ZNF766 FOS SP3 REST FASTK ENSG00000244151 TMUB1 AGAP3 ABCB8 ASIC3 ENSG00000243433
GH07J151084 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11.7 -6.9 -6905 5.9 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 AGAP3 GC07M151084 ENSG00000243433 SLC4A2 FASTK CDK5 ASIC3 SMARCD3 GBX1 ASB10
GH07J151245 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -168.5 -168474 9.1 HDGF PKNOX1 FOXA2 ARNT SIN3A ZNF2 YY1 ZNF143 KLF13 ZNF263 SMARCD3 ENSG00000243018 ENSG00000244151 NUB1 ABCF2 ASB10 GBX1 ENSG00000229591 SLC4A2 TMUB1
GH07J151056 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 +20.4 20441 7.6 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SLC4A2 GC07P151061 CDK5 ENSG00000244151 NUB1 ENSG00000243433 ABCB8 TMUB1 AGAP3 ATG9B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FASTK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FASTK gene promoter:

Genomic Locations for FASTK Gene

Genomic Locations for FASTK Gene
chr7:151,076,593-151,080,883
(GRCh38/hg38)
Size:
4,291 bases
Orientation:
Minus strand
chr7:150,773,708-150,777,953
(GRCh37/hg19)

Genomic View for FASTK Gene

Genes around FASTK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FASTK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FASTK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASTK Gene

Proteins for FASTK Gene

  • Protein details for FASTK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14296-FASTK_HUMAN
    Recommended name:
    Fas-activated serine/threonine kinase
    Protein Accession:
    Q14296
    Secondary Accessions:
    • A8K867
    • F8VTW9
    • Q59EM8
    • Q8IVA0

    Protein attributes for FASTK Gene

    Size:
    549 amino acids
    Molecular mass:
    61104 Da
    Quaternary structure:
    • Interacts with TIA-1 and TIAR.
    SequenceCaution:
    • Sequence=BAD93020.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FASTK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FASTK Gene

Post-translational modifications for FASTK Gene

  • Autophosphorylated on serine/threonine residues. Activated by dephosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FASTK Gene

Domains & Families for FASTK Gene

Gene Families for FASTK Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for FASTK Gene

Suggested Antigen Peptide Sequences for FASTK Gene

Graphical View of Domain Structure for InterPro Entry

Q14296

UniProtKB/Swiss-Prot:

FASTK_HUMAN :
  • The RAP domain is essential for RNA-binding.
  • Belongs to the FAST protein kinase family.
Domain:
  • The RAP domain is essential for RNA-binding.
Family:
  • Belongs to the FAST protein kinase family.
genes like me logo Genes that share domains with FASTK: view

Function for FASTK Gene

Molecular function for FASTK Gene

UniProtKB/Swiss-Prot Function:
Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.
UniProtKB/Swiss-Prot Function:
Isoform 4: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein].

Enzyme Numbers (IUBMB) for FASTK Gene

Phenotypes From GWAS Catalog for FASTK Gene

Gene Ontology (GO) - Molecular Function for FASTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 7544399
GO:0005515 protein binding IPI 7544399
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with FASTK: view
genes like me logo Genes that share phenotypes with FASTK: view

Animal Models for FASTK Gene

MGI Knock Outs for FASTK:

Animal Model Products

  • Taconic Biosciences Mouse Models for FASTK

Clone Products

  • Addgene plasmids for FASTK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FASTK Gene

Localization for FASTK Gene

Subcellular locations from UniProtKB/Swiss-Prot for FASTK Gene

Isoform 4: Mitochondrion matrix. Note=Colocalizes with mitochondrial RNA granules. {ECO:0000269 PubMed:25704814}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FASTK gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FASTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with FASTK: view

Pathways & Interactions for FASTK Gene

SuperPathways for FASTK Gene

No Data Available

Gene Ontology (GO) - Biological Process for FASTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA,IEA 7544399
GO:0006915 apoptotic process IEA --
GO:0016310 phosphorylation IEA --
GO:0043484 regulation of RNA splicing IMP 17592127
GO:0097190 apoptotic signaling pathway TAS 7544399
genes like me logo Genes that share ontologies with FASTK: view

No data available for Pathways by source and SIGNOR curated interactions for FASTK Gene

Drugs & Compounds for FASTK Gene

(2) Drugs for FASTK Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FASTK: view

Transcripts for FASTK Gene

Unigene Clusters for FASTK Gene

Fas-activated serine/threonine kinase:
Representative Sequences:

Clone Products

  • Addgene plasmids for FASTK

Alternative Splicing Database (ASD) splice patterns (SP) for FASTK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: -
SP7: -
SP8: - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - -
SP14: - - - - - - -
SP15: - - -
SP16:
SP17: - -
SP18:
SP19:

ExUns: 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for FASTK Gene

GeneLoc Exon Structure for
FASTK
ECgene alternative splicing isoforms for
FASTK

Expression for FASTK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FASTK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FASTK Gene

This gene is overexpressed in Liver (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FASTK Gene



Protein tissue co-expression partners for FASTK Gene

NURSA nuclear receptor signaling pathways regulating expression of FASTK Gene:

FASTK

SOURCE GeneReport for Unigene cluster for FASTK Gene:

Hs.647094

mRNA Expression by UniProt/SwissProt for FASTK Gene:

Q14296-FASTK_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for FASTK Gene

  • Nervous system(4.9)
  • Skin(4.3)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with FASTK: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FASTK Gene

Orthologs for FASTK Gene

This gene was present in the common ancestor of chordates.

Orthologs for FASTK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FASTK 34 33
  • 99.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FASTK 34 33
  • 91.2 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FASTK 34 33
  • 90.34 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fastk 33
  • 87.41 (n)
mouse
(Mus musculus)
Mammalia Fastk 16 34 33
  • 86.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FASTK 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves FASTK 34 33
  • 62.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FASTK 34
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fastk 34 33
  • 54.87 (n)
OneToOne
Dr.13216 33
Species where no ortholog for FASTK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASTK Gene

ENSEMBL:
Gene Tree for FASTK (if available)
TreeFam:
Gene Tree for FASTK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FASTK: view image

Paralogs for FASTK Gene

Paralogs for FASTK Gene

(1) SIMAP similar genes for FASTK Gene using alignment to 3 proteins:

  • FASTK_HUMAN
  • G3V1R6_HUMAN
  • Q9BWD7_HUMAN
genes like me logo Genes that share paralogs with FASTK: view

Variants for FASTK Gene

Sequence variations from dbSNP and Humsavar for FASTK Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs758691941 A lung adenocarcinoma sample 151,077,331(-) C/A/T coding_sequence_variant, missense_variant
rs1000693573 -- 151,080,811(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001244461 -- 151,080,086(-) C/T intron_variant
rs1001512726 -- 151,080,781(-) G/A 5_prime_UTR_variant
rs1001844773 -- 151,079,321(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FASTK Gene

Variant ID Type Subtype PubMed ID
dgv11724n54 CNV loss 21841781
dgv3695n106 OTHER inversion 24896259
dgv6756n100 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv465215 CNV loss 19166990
nsv517508 CNV loss 19592680
nsv526410 CNV loss 19592680
nsv6004 CNV insertion 18451855
nsv831188 CNV loss 17160897
nsv951648 CNV deletion 24416366

Variation tolerance for FASTK Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.67; 65.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FASTK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FASTK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTK Gene

Disorders for FASTK Gene

Additional Disease Information for FASTK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FASTK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FASTK Gene

Publications for FASTK Gene

  1. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. (PMID: 7544399) Tian Q … Anderson P (The Journal of experimental medicine 1995) 2 3 4 22 58
  2. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. (PMID: 15572676) Li W … Anderson P (Molecular and cellular biology 2004) 2 3 22 58
  3. A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function. (PMID: 25704814) Jourdain AA … Martinou JC (Cell reports 2015) 3 4 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 44 58

Products for FASTK Gene

Sources for FASTK Gene

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