Aliases for FASTK Gene
External Ids for FASTK Gene
Previous GeneCards Identifiers for FASTK Gene
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for FASTK Gene
FASTK (Fas Activated Serine/Threonine Kinase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase activity and Fas-activated serine/threonine kinase activity. An important paralog of this gene is FASTKD3.
UniProtKB/Swiss-Prot for FASTK Gene
Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.
Isoform 4: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.