The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame wit... See more...

Aliases for FASN Gene

Aliases for FASN Gene

  • Fatty Acid Synthase 2 3 4 5
  • FAS 2 3 4
  • Short Chain Dehydrogenase/Reductase Family 27X, Member 1 2 3
  • Type I Fatty Acid Synthase 3 4
  • SDR27X1 2 3
  • EC 2.3.1.85 4
  • EC 6.3.3.1 50
  • EC 2.3.1 50
  • OA-519 3
  • FASN 5

External Ids for FASN Gene

Previous GeneCards Identifiers for FASN Gene

  • GC17M079459
  • GC17M9J0077
  • GC17M080572
  • GC17M077629
  • GC17M080037
  • GC17M075436

Summaries for FASN Gene

Entrez Gene Summary for FASN Gene

  • The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

GeneCards Summary for FASN Gene

FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with FASN include Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Regulation of cholesterol biosynthesis by SREBP (SREBF). Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is OXSM.

UniProtKB/Swiss-Prot Summary for FASN Gene

  • Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

Tocris Summary for FASN Gene

  • Fatty acid synthase (FASN), EC 2.3.1.85, is a multienzyme that catalyzes the conversion of acetyl-CoA and malonyl-CoA to the 16-carbon fatty acid palmitate. FASN overexpression and hyperactivity is commonly associated with malignant cells.

Gene Wiki entry for FASN Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FASN Gene

Genomics for FASN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FASN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FASN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FASN

Top Transcription factor binding sites by QIAGEN in the FASN gene promoter:
  • ATF
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for FASN Gene

Latest Assembly
chr17:82,078,338-82,098,303
(GRCh38/hg38)
Size:
19,966 bases
Orientation:
Minus strand

Previous Assembly
chr17:80,036,214-80,056,112
(GRCh37/hg19 by Entrez Gene)
Size:
19,899 bases
Orientation:
Minus strand

chr17:80,036,214-80,056,208
(GRCh37/hg19 by Ensembl)
Size:
19,995 bases
Orientation:
Minus strand

Genomic View for FASN Gene

Genes around FASN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FASN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FASN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASN Gene

Proteins for FASN Gene

  • Protein details for FASN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49327-FAS_HUMAN
    Recommended name:
    Fatty acid synthase
    Protein Accession:
    P49327
    Secondary Accessions:
    • Q13479
    • Q16702
    • Q4LE83
    • Q6P4U5
    • Q6SS02
    • Q969R1
    • Q96C68
    • Q96IT0

    Protein attributes for FASN Gene

    Size:
    2511 amino acids
    Molecular mass:
    273427 Da
    Quaternary structure:
    • Homodimer which is arranged in a head to tail fashion (PubMed:17618296, PubMed:18022563, Ref.33). Interacts with CEACAM1; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity.
    SequenceCaution:
    • Sequence=AAB35516.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAC50259.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305}; Sequence=BAE06070.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • The relatively low beta-ketoacyl synthase activity may be attributable to the low 4'-phosphopantetheine content of the protein.

    Three dimensional structures from OCA and Proteopedia for FASN Gene

neXtProt entry for FASN Gene

Selected DME Specific Peptides for FASN Gene

P49327:
  • GGLGGFG
  • YIEAHGTGT
  • DTACSSS
  • NSFGFGG

Post-translational modifications for FASN Gene

  • S-nitrosylation of Fatty acid synthase at cysteine residues Cys-1471 or Cys-2091 is important for the enzyme dimerization. In adipocytes, S-nitrosylation of Fatty acid synthase occurs under physiological conditions and gradually increases during adipogenesis.
  • Ubiquitination at Lys41, Lys70, Lys213, Lys257, Lys298, Lys326, Lys436, Lys528, Lys631, Lys992, Lys1072, Lys1116, Lys1142, Lys1151, Lys1158, Lys1239, Lys1393, Lys1429, Lys1495, Lys1591, Lys1704, Lys1739, Lys1851, Lys1866, Lys1878, Lys1911, Lys1927, Lys2391, Lys2438, and Lys2449
  • Modification sites at PhosphoSitePlus

Antibodies for research

Domains & Families for FASN Gene

Gene Families for FASN Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FASN Gene

GenScript: Design optimal peptide antigens:
  • Fatty acid synthase (FAS_HUMAN)
  • FASN protein (Q6PJJ3_HUMAN)
genes like me logo Genes that share domains with FASN: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FASN Gene

Function for FASN Gene

Molecular function for FASN Gene

UniProtKB/Swiss-Prot Function:
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+); Xref=Rhea:RHEA:14993, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:57560, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=2.3.1.85; Evidence={ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA; Xref=Rhea:RHEA:41788, Rhea:RHEA-COMP:9621, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64479, ChEBI:CHEBI:78446; EC=2.3.1.38; Evidence={ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]; Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449; EC=2.3.1.39; Evidence={ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:22836, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9916, Rhea:RHEA-COMP:14125, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78776, ChEBI:CHEBI:138651; EC=2.3.1.41; Evidence={ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH; Xref=Rhea:RHEA:17397, Rhea:RHEA-COMP:9916, Rhea:RHEA-COMP:9945, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78776, ChEBI:CHEBI:78827; EC=1.1.1.100; Evidence={ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O; Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945, ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59; Evidence={ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH; Xref=Rhea:RHEA:22564, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9926, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78784, ChEBI:CHEBI:78785; EC=1.3.1.39; Evidence={ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + hexadecanoyl-[ACP] = H(+) + hexadecanoate + holo-[ACP]; Xref=Rhea:RHEA:41932, Rhea:RHEA-COMP:9652, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64479, ChEBI:CHEBI:78483; EC=3.1.2.14; Evidence={ECO:0000269|PubMed:15507492, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41800, Rhea:RHEA-COMP:9621, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9625, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78446, ChEBI:CHEBI:78449, ChEBI:CHEBI:78450; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-oxobutanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41804, Rhea:RHEA-COMP:9625, Rhea:RHEA-COMP:9626, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78450, ChEBI:CHEBI:78451; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41808, Rhea:RHEA-COMP:9626, Rhea:RHEA-COMP:9627, ChEBI:CHEBI:15377, ChEBI:CHEBI:78451, ChEBI:CHEBI:78453; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(2E)-butenoyl-[ACP] + H(+) + NADPH = butanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41812, Rhea:RHEA-COMP:9627, Rhea:RHEA-COMP:9628, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78453, ChEBI:CHEBI:78454; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41820, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9628, Rhea:RHEA-COMP:9629, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78454, ChEBI:CHEBI:78456; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41824, Rhea:RHEA-COMP:9629, Rhea:RHEA-COMP:9630, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78456, ChEBI:CHEBI:78457; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41828, Rhea:RHEA-COMP:9630, Rhea:RHEA-COMP:9631, ChEBI:CHEBI:15377, ChEBI:CHEBI:78457, ChEBI:CHEBI:78458; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41832, Rhea:RHEA-COMP:9631, Rhea:RHEA-COMP:9632, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78458, ChEBI:CHEBI:78459; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41836, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9632, Rhea:RHEA-COMP:9633, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78459, ChEBI:CHEBI:78460; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-oxooctanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41840, Rhea:RHEA-COMP:9633, Rhea:RHEA-COMP:9634, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78460, ChEBI:CHEBI:78461; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41844, Rhea:RHEA-COMP:9634, Rhea:RHEA-COMP:9635, ChEBI:CHEBI:15377, ChEBI:CHEBI:78461, ChEBI:CHEBI:78462; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(2E)-octenoyl-[ACP] + H(+) + NADPH = NADP(+) + octanoyl-[ACP]; Xref=Rhea:RHEA:41848, Rhea:RHEA-COMP:9635, Rhea:RHEA-COMP:9636, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78462, ChEBI:CHEBI:78463; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41852, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9636, Rhea:RHEA-COMP:9637, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78463, ChEBI:CHEBI:78464; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-oxodecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41856, Rhea:RHEA-COMP:9637, Rhea:RHEA-COMP:9638, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78464, ChEBI:CHEBI:78466; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41860, Rhea:RHEA-COMP:9638, Rhea:RHEA-COMP:9639, ChEBI:CHEBI:15377, ChEBI:CHEBI:78466, ChEBI:CHEBI:78467; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41864, Rhea:RHEA-COMP:9639, Rhea:RHEA-COMP:9640, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78467, ChEBI:CHEBI:78468; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41868, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9640, Rhea:RHEA-COMP:9641, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78468, ChEBI:CHEBI:78469; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-oxododecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41872, Rhea:RHEA-COMP:9641, Rhea:RHEA-COMP:9642, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78469, ChEBI:CHEBI:78470; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41876, Rhea:RHEA-COMP:9642, Rhea:RHEA-COMP:9643, ChEBI:CHEBI:15377, ChEBI:CHEBI:78470, ChEBI:CHEBI:78472; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41880, Rhea:RHEA-COMP:9643, Rhea:RHEA-COMP:9644, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:65264, ChEBI:CHEBI:78472; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41884, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9644, Rhea:RHEA-COMP:9645, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:65264, ChEBI:CHEBI:78449, ChEBI:CHEBI:78473; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-oxotetradecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41888, Rhea:RHEA-COMP:9645, Rhea:RHEA-COMP:9646, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78473, ChEBI:CHEBI:78474; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41892, Rhea:RHEA-COMP:9646, Rhea:RHEA-COMP:9647, ChEBI:CHEBI:15377, ChEBI:CHEBI:78474, ChEBI:CHEBI:78475; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]; Xref=Rhea:RHEA:41896, Rhea:RHEA-COMP:9647, Rhea:RHEA-COMP:9648, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78475, ChEBI:CHEBI:78477; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41900, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9648, Rhea:RHEA-COMP:9649, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78477, ChEBI:CHEBI:78478; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-oxohexadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41904, Rhea:RHEA-COMP:9649, Rhea:RHEA-COMP:9650, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78478, ChEBI:CHEBI:78480; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41908, Rhea:RHEA-COMP:9650, Rhea:RHEA-COMP:9651, ChEBI:CHEBI:15377, ChEBI:CHEBI:78480, ChEBI:CHEBI:78481; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41912, Rhea:RHEA-COMP:9651, Rhea:RHEA-COMP:9652, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78481, ChEBI:CHEBI:78483; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41916, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9652, Rhea:RHEA-COMP:9653, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78483, ChEBI:CHEBI:78487; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-oxooctadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41920, Rhea:RHEA-COMP:9653, Rhea:RHEA-COMP:9654, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78487, ChEBI:CHEBI:78488; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41924, Rhea:RHEA-COMP:9654, Rhea:RHEA-COMP:9655, ChEBI:CHEBI:15377, ChEBI:CHEBI:78488, ChEBI:CHEBI:78489; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(2E)-octadecenoyl-[ACP] + H(+) + NADPH = NADP(+) + octadecanoyl-[ACP]; Xref=Rhea:RHEA:41928, Rhea:RHEA-COMP:9655, Rhea:RHEA-COMP:9656, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78489, ChEBI:CHEBI:78495; Evidence={ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + tetradecanoate; Xref=Rhea:RHEA:30123, Rhea:RHEA-COMP:9648, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:64479, ChEBI:CHEBI:78477; EC=3.1.2.14; Evidence={ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + octadecanoyl-[ACP] = H(+) + holo-[ACP] + octadecanoate; Xref=Rhea:RHEA:63204, Rhea:RHEA-COMP:9656, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:64479, ChEBI:CHEBI:78495; Evidence={ECO:0000269|PubMed:15507492, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=8 uM for acetyl-CoA {ECO:0000269|PubMed:7567999}; KM=20 uM for malonyl-CoA {ECO:0000269|PubMed:7567999}; KM=25 uM for NADPH {ECO:0000269|PubMed:7567999}; KM=4 uM for butanoyl-CoA {ECO:0000269|PubMed:7567999}; KM=7 uM for acetyl-CoA {ECO:0000269|PubMed:16215233}; KM=6 uM for malonyl-CoA {ECO:0000269|PubMed:16215233}; KM=5 uM for NADPH {ECO:0000269|PubMed:16215233}; Vmax=29.6 nmol/min/mg enzyme for the incorporation of acetyl-CoA into fatty acids {ECO:0000269|PubMed:7567999}; Vmax=220.6 nmol/min/mg enzyme for the incorporation of malonyl-CoA into fatty acids {ECO:0000269|PubMed:7567999}; Vmax=462 nmol/min/mg enzyme for the oxidation of NADPH {ECO:0000269|PubMed:7567999}; Vmax=440 nmol/min/mg enzyme for the oxidation of NADPH (at pH 7.0) {ECO:0000269|PubMed:16215233}; pH dependence: Optimum pH is 6.5 to 6.7. {ECO:0000269|PubMed:7567999};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by S-nitrosylation which promotes enzyme dimerization (PubMed:26851298). Cerulenin, a potent non-competitive pharmacological inhibitor of FAS, binds covalently to the active site of the condensing enzyme region, inactivating a key enzyme step in fatty acid synthesis (PubMed:16969344).
GENATLAS Biochemistry:
fatty acid ethyl ester synthase 1,NADPH dependent

Enzyme Numbers (IUBMB) for FASN Gene

Phenotypes From GWAS Catalog for FASN Gene

Gene Ontology (GO) - Molecular Function for FASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003824 catalytic activity IEA --
GO:0004312 fatty acid synthase activity IEA --
GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity IEA --
GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity IEA --
genes like me logo Genes that share ontologies with FASN: view
genes like me logo Genes that share phenotypes with FASN: view

Animal Models for FASN Gene

MGI Knock Outs for FASN:
  • Fasn Fasn<tm1.1Sem>
  • Fasn Fasn<tm1Schi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FASN

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FASN Gene

Localization for FASN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FASN Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FASN gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
golgi apparatus 5
mitochondrion 3
peroxisome 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane HDA 16210410
genes like me logo Genes that share ontologies with FASN: view

Pathways & Interactions for FASN Gene

genes like me logo Genes that share pathways with FASN: view

UniProtKB/Swiss-Prot P49327-FAS_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.

SIGNOR curated interactions for FASN Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation HDA 16210410
GO:0002068 glandular epithelial cell development IEA --
GO:0006084 acetyl-CoA metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA,TAS 7835891
genes like me logo Genes that share ontologies with FASN: view

Drugs & Compounds for FASN Gene

(78) Drugs for FASN Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma Target, Enzyme, inhibitor Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 63
Isoniazid Approved, Investigational Pharma 238
oleic acid Approved, Investigational, Vet_approved Pharma 0
Stearic acid Approved, Experimental Pharma 0
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0

(60) Additional Compounds for FASN Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9
(R)-3-Hydroxydecanoic acid
  • (R)-3-Hydroxydecanoate
  • 3-HDA
  • 3-Hydroxydecanoic acid
  • beta-Hydroxydecanoic acid
  • Myrmicacin, (+-)-isomer
(R)-3-Hydroxydodecanoic acid
  • (3R)-3-Hydroxydodecanoic acid
  • (3R)-3-Hydroxylauric acid
  • (R)-3-OH Dodecanoic acid
  • (R)-3-OH Lauric acid
  • (R)-beta-Hydroxydodecanoic acid
(R)-3-Hydroxy-hexadecanoic acid
  • (R)-beta-Hydroxypalmitic acid
  • (R)-b-Hydroxypalmitate
  • (R)-b-Hydroxypalmitic acid
  • (R)-beta-Hydroxypalmitate
  • (R)-Β-hydroxypalmitate
(R)-3-Hydroxy-Octadecanoic acid
  • (R)-3-Hydroxy-octadecanoate
  • 3R-Hydroxy-octadecanoate

(3) ApexBio Compounds for FASN Gene

Compound Action Cas Number
C 75 Fatty acid synthase (FAS) inhibitor 191282-48-1
GSK2194069 human fatty acid synthase inhibitor 1332331-08-4
Isoniazid 54-85-3
genes like me logo Genes that share compounds with FASN: view

Drug products for research

Transcripts for FASN Gene

mRNA/cDNA for FASN Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FASN

Alternative Splicing Database (ASD) splice patterns (SP) for FASN Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b · 37c ^ 38 ^ 39a · 39b · 39c ^ 40a · 40b · 40c ^ 41 ^ 42 ^
SP1:
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - - - -
SP6:

ExUns: 43a · 43b · 43c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for FASN Gene

GeneLoc Exon Structure for
FASN

Expression for FASN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FASN Gene

mRNA differential expression in normal tissues according to GTEx for FASN Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.9), Adipose - Subcutaneous (x6.9), and Breast - Mammary Tissue (x4.9).

Protein differential expression in normal tissues from HIPED for FASN Gene

This gene is overexpressed in Milk (12.0), Liver (8.2), and Breast (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FASN Gene



Protein tissue co-expression partners for FASN Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FASN

SOURCE GeneReport for Unigene cluster for FASN Gene:

Hs.83190

mRNA Expression by UniProt/SwissProt for FASN Gene:

P49327-FAS_HUMAN
Tissue specificity: Ubiquitous. Prominent expression in brain, lung, liver and mammary gland.

Evidence on tissue expression from TISSUES for FASN Gene

  • Liver(5)
  • Nervous system(4.9)
  • Skin(4.8)
  • Eye(4.8)
  • Blood(4.7)
  • Adrenal gland(4.3)
  • Lung(4.2)
  • Heart(4)
  • Intestine(3.6)
  • Pancreas(3.1)
  • Muscle(2.9)
  • Stomach(2.6)
  • Kidney(2.5)
  • Gall bladder(2.4)
  • Thyroid gland(2.3)
  • Lymph node(2.2)
  • Bone marrow(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with FASN: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FASN Gene

Orthologs for FASN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FASN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FASN 29 30
  • 98.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FASN 29 30
  • 83.25 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FASN 29 30
  • 81.78 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fasn 29 16 30
  • 80.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fasn 29
  • 80.63 (n)
Oppossum
(Monodelphis domestica)
Mammalia FASN 30
  • 75 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FASN 30
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FASN 29 30
  • 64.78 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FASN 30
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fasn 29
  • 62.57 (n)
Zebrafish
(Danio rerio)
Actinopterygii fasn 30 30
  • 64 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta v(2)k05816 29 30 31
  • 54.54 (n)
OneToMany
BcDNA:GH07626 31
  • 48 (a)
CG3523 30
  • 42 (a)
OneToMany
CG17374 30 31
  • 37 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea fasn-1 29 30
  • 49.54 (n)
OneToMany
F32H2.5 31
  • 41 (a)
C41A3.1 31
  • 34 (a)
F32H2.6 30
  • 33 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CEM1 30
  • 21 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 36 (a)
OneToOne
Species where no ortholog for FASN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FASN Gene

ENSEMBL:
Gene Tree for FASN (if available)
TreeFam:
Gene Tree for FASN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FASN: view image
Alliance of Genome Resources:
Additional Orthologs for FASN

Paralogs for FASN Gene

Paralogs for FASN Gene

genes like me logo Genes that share paralogs with FASN: view

Variants for FASN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FASN Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
1000736 Uncertain Significance: Epileptic encephalopathy 82,083,226(-) C/A
NM_004104.5(FASN):c.5541G>T (p.Lys1847Asn)
MISSENSE
1001264 Uncertain Significance: Epileptic encephalopathy 82,095,436(-) T/C
NM_004104.5(FASN):c.164A>G (p.Lys55Arg)
MISSENSE
1004004 Uncertain Significance: Epileptic encephalopathy 82,085,561(-) A/G
NM_004104.5(FASN):c.4043T>C (p.Leu1348Pro)
MISSENSE
1004408 Uncertain Significance: Epileptic encephalopathy 82,080,860(-) G/A
NM_004104.5(FASN):c.6658C>T (p.Arg2220Cys)
MISSENSE
1004825 Uncertain Significance: Epileptic encephalopathy 82,091,287(-) T/C
NM_004104.5(FASN):c.1427A>G (p.Glu476Gly)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FASN Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FASN Gene

Variant ID Type Subtype PubMed ID
dgv5801n54 CNV loss 21841781
esv1000741 CNV deletion 20482838
esv21913 CNV gain+loss 19812545
esv2666752 CNV deletion 23128226
esv2716470 CNV deletion 23290073
esv2716471 CNV deletion 23290073
nsv1055241 CNV loss 25217958
nsv1121945 CNV deletion 24896259
nsv428351 CNV gain 18775914
nsv457975 CNV loss 19166990
nsv457976 CNV gain 19166990
nsv470621 CNV gain 18288195
nsv576183 CNV loss 21841781
nsv576187 CNV gain 21841781
nsv952393 CNV deletion 24416366

Variation tolerance for FASN Gene

Residual Variation Intolerance Score: 1.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.91; 74.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FASN Gene

Human Gene Mutation Database (HGMD)
FASN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FASN
Leiden Open Variation Database (LOVD)
FASN

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASN Gene

Disorders for FASN Gene

MalaCards: The human disease database

(18) MalaCards diseases for FASN Gene - From: COP and GCD

Disorder Aliases PubMed IDs
fatty liver disease
  • alcoholic fatty liver
non-alcoholic fatty liver disease
  • nafld
breast cancer
  • breast cancer, familial
prostate cancer
  • prostate cancer, somatic
glucose intolerance
  • glucose: intolerance
- elite association - COSMIC cancer census association via MalaCards
Search FASN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FASN

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FASN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FASN Gene

Publications for FASN Gene

  1. Human fatty acid synthase: properties and molecular cloning. (PMID: 7567999) Jayakumar A … Wakil SJ (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 22
  2. Effect of genetic variation in the human fatty acid synthase gene (FASN) on obesity and fat depot-specific mRNA expression. (PMID: 19876008) Schleinitz D … Kovacs P (Obesity (Silver Spring, Md.) 2010) 3 22 40
  3. Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk. (PMID: 19252981) Campa D … Kaaks R (Breast cancer research and treatment 2009) 3 22 40
  4. Val1483Ile in FASN gene is linked to central obesity and insulin sensitivity in adult white men. (PMID: 19300427) Moreno-Navarrete JM … Fernández-Real JM (Obesity (Silver Spring, Md.) 2009) 3 22 40
  5. Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. (PMID: 17618296) Pemble CW … Lowther WT (Nature structural & molecular biology 2007) 3 4 22

Products for FASN Gene

  • Addgene plasmids for FASN

Sources for FASN Gene