Aliases for FASN Gene
External Ids for FASN Gene
Previous GeneCards Identifiers for FASN Gene
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
GeneCards Summary for FASN Gene
FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with FASN include Hyperinsulinemic Hypoglycemia, Familial, 3 and Partial Fetal Alcohol Syndrome. Among its related pathways are AMP-activated Protein Kinase (AMPK) Signaling and Fatty Acid Biosynthesis (WikiPathways). Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is OXSM.
UniProtKB/Swiss-Prot Summary for FASN Gene
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.
Fatty acid synthase (FASN), EC 188.8.131.52, is a multienzyme that catalyzes the conversion of acetyl-CoA and malonyl-CoA to the 16-carbon fatty acid palmitate. FASN overexpression and hyperactivity is commonly associated with malignant cells.