Aliases for FASN Gene
External Ids for FASN Gene
Previous GeneCards Identifiers for FASN Gene
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
GeneCards Summary for FASN Gene
FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with FASN include Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Regulation of cholesterol biosynthesis by SREBP (SREBF). Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is OXSM.
UniProtKB/Swiss-Prot Summary for FASN Gene
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.
Fatty acid synthase (FASN), EC 220.127.116.11, is a multienzyme that catalyzes the conversion of acetyl-CoA and malonyl-CoA to the 16-carbon fatty acid palmitate. FASN overexpression and hyperactivity is commonly associated with malignant cells.