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Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]
FARSA (Phenylalanyl-TRNA Synthetase Subunit Alpha) is a Protein Coding gene. Diseases associated with FARSA include B-Lymphoblastic Leukemia/Lymphoma With Hypodiploidy and B-Lymphoblastic Leukemia/Lymphoma With Hyperdiploidy. Among its related pathways are tRNA Aminoacylation and Gene Expression. Gene Ontology (GO) annotations related to this gene include tRNA binding. An important paralog of this gene is FARS2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000049 | tRNA binding | IEA | -- |
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003723 | RNA binding | HDA | 22681889 |
GO:0004812 | aminoacyl-tRNA ligase activity | IEA | -- |
GO:0004826 | phenylalanine-tRNA ligase activity | IEA,IDA | 20223217 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0009328 | phenylalanine-tRNA ligase complex | IBA,IDA | 20223217 |
GO:0016020 | membrane | HDA | 19946888 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | tRNA Aminoacylation | ||
2 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006412 | translation | IEA | -- |
GO:0006418 | tRNA aminoacylation for protein translation | TAS | -- |
GO:0006432 | phenylalanyl-tRNA aminoacylation | IEA,IDA | 20223217 |
GO:0043039 | tRNA aminoacylation | IEA | -- |
GO:0051290 | protein heterotetramerization | IDA | 20223217 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Phenylalanine | Approved, Investigational | Nutra | Target | 256 | ||
Phosphoric acid | Approved | Pharma | 0 | |||
Adenosine monophosphate | Approved, Investigational | Nutra | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FARSA 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FARSA 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FARSA 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FARSA 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FARSA 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Farsa 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Farsa 30 |
|
||
Chicken (Gallus gallus) |
Aves | FARSA 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FARSA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | farsa 30 |
|
||
Str.3839 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | farsl-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | farsa 30 31 |
|
OneToOne | |
wufj21a11 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10382 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG2263 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002653 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | fars-1 30 31 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR516W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FRS2 30 31 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F25234g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G39280 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.12602 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os10g0400800 30 |
|
||
Os.3191 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.10634 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.1529 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.5623 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1858 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU05095 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | frs2 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.11498 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
871679 | Uncertain Significance: not provided | 12,924,918(-) | G/A | MISSENSE_VARIANT | |
rs35087277 | - | p.Gln341Arg |
Disorder | Aliases | PubMed IDs |
---|---|---|
b-lymphoblastic leukemia/lymphoma with hypodiploidy |
|
|
b-lymphoblastic leukemia/lymphoma with hyperdiploidy |
|
|
autosomal recessive cerebellar ataxia |
|
|
fetal akinesia deformation sequence 1 |
|
|