FARSA Gene (Protein Coding)

Phenylalanyl-TRNA Synthetase Subunit Alpha

GC19M012922
GIFtS:
41
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manne... See more...

Aliases for FARSA Gene

Aliases for FARSA Gene

  • Phenylalanyl-TRNA Synthetase Subunit Alpha 2 3 5
  • CML33 2 3 4
  • Phenylalanyl-TRNA Synthetase-Like, Alpha Subunit 2 3
  • Phenylalanine TRNA Ligase 1, Alpha, Cytoplasmic 2 3
  • Phenylalanyl-TRNA Synthetase Alpha Subunit 3 4
  • Phenylalanine--TRNA Ligase Alpha Subunit 3 4
  • EC 6.1.1.20 4 50
  • FARSLA 3 4
  • FARSL 3 4
  • PheRS 3 4
  • Phenylalanine-TRNA Synthetase-Like, Alpha Subunit 3
  • Phenylalanine-TRNA Synthetase Alpha-Subunit 3
  • Phenylalanyl-TRNA Synthetase Alpha Chain 3
  • Phenylalanine--TRNA Ligase Alpha Chain 3
  • Phenylalanine-TRNA Synthetase-Like 2
  • RILDBC2 3
  • PheHA 3
  • FARSA 5
  • FRSA 3
  • FARS 4

External Ids for FARSA Gene

Previous HGNC Symbols for FARSA Gene

  • FARSL
  • FARSLA

Previous GeneCards Identifiers for FARSA Gene

  • GC19M012895
  • GC19M013033
  • GC19M012605

Summaries for FARSA Gene

Entrez Gene Summary for FARSA Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]

GeneCards Summary for FARSA Gene

FARSA (Phenylalanyl-TRNA Synthetase Subunit Alpha) is a Protein Coding gene. Diseases associated with FARSA include Rajab Interstitial Lung Disease With Brain Calcifications 2 and Combined Oxidative Phosphorylation Deficiency 4. Among its related pathways are tRNA Aminoacylation and Gene Expression. Gene Ontology (GO) annotations related to this gene include tRNA binding. An important paralog of this gene is FARS2.

Gene Wiki entry for FARSA Gene

Additional gene information for FARSA Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FARSA Gene

Genomics for FARSA Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for FARSA Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J012932 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.5 549 2.3 SP1 ZNF207 NCOR1 MYC ZNF600 SIX5 ZNF580 ZNF592 ZMYM3 ATF2 FARSA GCDH DNASE2 FARSA-AS1 SYCE2
GH19J012934 Promoter 0.4 Ensembl 250.7 -0.9 -864 0.2 ZBTB33 FARSA GCDH CALR NONHSAG024912.2
GH19J013115 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.2 -184.9 -184899 7.7 BCLAF1 SP1 ZNF207 MYC NCOR1 ZNF600 IKZF1 SIX5 ZNF580 ZMYM3 TRMT1 NACC1 ZNF791 ZNF136 ZNF442 MRI1 YJU2B WDR83OS ZNF44 ZNF564
GH19J012918 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 +14.2 14167 2.2 SP1 ZNF207 MYC ZNF600 ZNF580 ZNF592 POLR2A BRCA1 NONO CTCF HSALNG0124187 MIR5695 SYCE2 ZNF136 YJU2B ZNF564 TRMT1 ZNF44 ZNF20 ZNF791
GH19J012931 Enhancer 0.3 dbSUPER 0.7 +2.2 2196 0.6 POLR2A ATF4 FARSA-AS1 FARSA SYCE2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FARSA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FARSA

Top Transcription factor binding sites by QIAGEN in the FARSA gene promoter:
  • ATF-2
  • c-Jun
  • CUTL1
  • NF-kappaB1
  • Nkx2-5
  • p53

Genomic Locations for FARSA Gene

Latest Assembly
chr19:12,922,479-12,934,037
(GRCh38/hg38)
Size:
11,559 bases
Orientation:
Minus strand

Previous Assembly
chr19:13,033,293-13,044,525
(GRCh37/hg19 by Entrez Gene)
Size:
11,233 bases
Orientation:
Minus strand

chr19:13,033,293-13,044,851
(GRCh37/hg19 by Ensembl)
Size:
11,559 bases
Orientation:
Minus strand

Genomic View for FARSA Gene

Genes around FARSA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FARSA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FARSA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FARSA Gene

Proteins for FARSA Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for FARSA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y285-SYFA_HUMAN
    Recommended name:
    Phenylalanine--tRNA ligase alpha subunit
    Protein Accession:
    Q9Y285
    Secondary Accessions:
    • B4E363
    • Q9NSD8
    • Q9Y4W8

    Protein attributes for FARSA Gene

    Size:
    508 amino acids
    Molecular mass:
    57564 Da
    Quaternary structure:
    • Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB.
    SequenceCaution:
    • Sequence=AAB51175.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FARSA Gene

    Alternative splice isoforms for FARSA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FARSA Gene

Protein Expression for FARSA Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for FARSA Gene

Q9Y285:
  • FWNFDAL
  • IFLEMGF
  • GGYGSQGYKY
  • KWVEVGNSG
  • THLAEFHQ
  • KNLLRTHTT
  • VIAWGLSLERPTMIKYGINNIR
  • MGFTEMP
  • IDRVFRNE
  • NIRELVGHKVNLQMVYDSP
  • YNPYTEPS
  • GSHEARVF
  • VGFSKAM

Post-translational modifications for FARSA Gene

  • Ubiquitination at Lys59, Lys101, Lys106, Lys150, Lys208, Lys177, Lys187, Lys311, Lys315, Lys349, Lys406, Lys468, and Lys481
  • Modification sites at PhosphoSitePlus

Other Protein References for FARSA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for FARSA

Domains & Families for FARSA Gene

Gene Families for FARSA Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for FARSA Gene

InterPro:
Blocks:
  • Phenylalanyl-tRNA synthetase, class IIc
  • Helix-turn-helix, type 11

Suggested Antigen Peptide Sequences for FARSA Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50378, highly similar to Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) (B4E363_HUMAN)
  • cDNA FLJ34774 fis, clone NT2NE2003309, highly similar to Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) (Q6IBR2_HUMAN)
  • Phenylalanine--tRNA ligase alpha chain (SYFA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y285

UniProtKB/Swiss-Prot:

SYFA_HUMAN :
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
genes like me logo Genes that share domains with FARSA: view

Function for FARSA Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for FARSA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe); Xref=Rhea:RHEA:19413, Rhea:RHEA-COMP:9668, Rhea:RHEA-COMP:9699, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58095, ChEBI:CHEBI:78442, ChEBI:CHEBI:78531, ChEBI:CHEBI:456215; EC=6.1.1.20; Evidence={ECO:0000269|PubMed:20223217};.

Enzyme Numbers (IUBMB) for FARSA Gene

Phenotypes From GWAS Catalog for FARSA Gene

Gene Ontology (GO) - Molecular Function for FARSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22681889
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004826 phenylalanine-tRNA ligase activity IEA,IDA 20223217
genes like me logo Genes that share ontologies with FARSA: view
genes like me logo Genes that share phenotypes with FARSA: view

Human Phenotype Ontology for FARSA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FARSA Gene

MGI Knock Outs for FARSA:
  • Farsa Farsa<tm2a(EUCOMM)Wtsi>

Animal Models for research

  • Taconic Biosciences Mouse Models for FARSA

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FARSA

No data available for Transcription Factor Targets and HOMER Transcription for FARSA Gene

Localization for FARSA Gene

Subcellular locations from UniProtKB/Swiss-Prot for FARSA Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FARSA gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FARSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005829 cytosol TAS --
GO:0009328 phenylalanine-tRNA ligase complex IBA,IDA 20223217
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with FARSA: view

Pathways & Interactions for FARSA Gene

PathCards logo

SuperPathways for FARSA Gene

genes like me logo Genes that share pathways with FARSA: view

Pathways by source for FARSA Gene

1 KEGG pathway for FARSA Gene

Gene Ontology (GO) - Biological Process for FARSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006432 phenylalanyl-tRNA aminoacylation IEA,IDA 20223217
GO:0043039 tRNA aminoacylation IEA --
GO:0051290 protein heterotetramerization IDA 20223217
genes like me logo Genes that share ontologies with FARSA: view

No data available for SIGNOR curated interactions for FARSA Gene

Drugs & Compounds for FARSA Gene

Products:

  1. Drug products for research

(4) Drugs for FARSA Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenylalanine Approved, Investigational Nutra Target 268
Adenosine monophosphate Approved, Investigational Nutra 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for FARSA Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
 14000-31-8
genes like me logo Genes that share compounds with FARSA: view

Transcripts for FARSA Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for FARSA Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FARSA

Alternative Splicing Database (ASD) splice patterns (SP) for FARSA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for FARSA Gene

GeneLoc Exon Structure for
FARSA

Expression for FARSA Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FARSA Gene

mRNA expression in normal human tissues for FARSA Gene
mRNA expression by BioGPS for FARSA GenemRNA expression by GTEx for FARSA Gene

Protein differential expression in normal tissues from HIPED for FARSA Gene

This gene is overexpressed in Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FARSA Gene



Protein tissue co-expression partners for FARSA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FARSA

SOURCE GeneReport for Unigene cluster for FARSA Gene:

Hs.23111

Evidence on tissue expression from TISSUES for FARSA Gene

  • Lung(4.5)
  • Nervous system(4.5)
  • Blood(4.3)
  • Skin(3)
  • Intestine(2.5)
  • Muscle(2.3)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with FARSA: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FARSA Gene

Orthologs for FARSA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FARSA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia FARSA 29 30
  • 99.67 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia FARSA 30
  • 90 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia FARSA 29 30
  • 89.96 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia FARSA 29 30
  • 89.63 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia FARSA 30
  • 86 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Farsa 29 16 30
  • 85.83 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Farsa 29
  • 85.5 (n)
Chicken
(Gallus gallus)
 Aves FARSA 29 30
  • 75.95 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia FARSA 30
  • 67 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia farsa 29
  • 72.08 (n)
Str.3839 29
African clawed frog
(Xenopus laevis)
 Amphibia farsl-prov 29
Zebrafish
(Danio rerio)
 Actinopterygii farsa 29 30
  • 74.04 (n)
 OneToOne
wufj21a11 29
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.10382 29
Fruit Fly
(Drosophila melanogaster)
 Insecta CG2263 29 30
  • 66.33 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002653 29
  • 62.39 (n)
Worm
(Caenorhabditis elegans)
 Secernentea fars-1 29 30
  • 58 (n)
 OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AFR516W 29
  • 57.76 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes FRS2 29 30 32
  • 52.04 (n)
 OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F25234g 29
  • 51.63 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT4G39280 29
  • 56.3 (n)
Soybean
(Glycine max)
 eudicotyledons Gma.12602 29
Rice
(Oryza sativa)
 Liliopsida Os10g0400800 29
  • 58.32 (n)
Os.3191 29
Barley
(Hordeum vulgare)
 Liliopsida Hv.10634 29
Wheat
(Triticum aestivum)
 Liliopsida Ta.1529 29
Corn
(Zea mays)
 Liliopsida Zm.5623 29
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.1858 30
  • 63 (a)
 OneToOne
Bread mold
(Neurospora crassa)
 Ascomycetes NCU05095 29
  • 60.47 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes frs2 29
  • 50.51 (n)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.11498 29
Species where no ortholog for FARSA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FARSA Gene

ENSEMBL:
Gene Tree for FARSA (if available)
TreeFam:
Gene Tree for FARSA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FARSA: view image
Alliance of Genome Resources:
Additional Orthologs for FARSA

Paralogs for FARSA Gene

Paralogs for FARSA Gene

(1) SIMAP similar genes for FARSA Gene using alignment to 7 proteins:

  • SYFA_HUMAN
  • B4E363_HUMAN
  • K7EK06_HUMAN
  • K7EPH2_HUMAN
  • K7ER00_HUMAN
  • K7ER16_HUMAN
  • K7ERS0_HUMAN
genes like me logo Genes that share paralogs with FARSA: view

Variants for FARSA Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FARSA Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
871679 Uncertain Significance: not provided 12,924,918(-) G/A
NM_004461.3(FARSA):c.1012C>T (p.Arg338Cys) 		MISSENSE
977639 Pathogenic: Rajab interstitial lung disease with brain calcifications 2 12,928,417(-) A/G
NM_004461.3(FARSA):c.766T>C (p.Phe256Leu) 		MISSENSE
977640 Pathogenic: Rajab interstitial lung disease with brain calcifications 2 12,924,492(-) G/T
NM_004461.3(FARSA):c.1230C>A (p.Asn410Lys) 		MISSENSE
rs35087277 -- p.Gln341Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FARSA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FARSA Gene

Variant ID Type Subtype PubMed ID
nsv1160589 CNV duplication 26073780
nsv833754 CNV loss 17160897
nsv953977 CNV deletion 24416366

Variation tolerance for FARSA Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FARSA Gene

Human Gene Mutation Database (HGMD)
FARSA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FARSA
Leiden Open Variation Database (LOVD)
FARSA

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FARSA Gene

Disorders for FARSA Gene

MalaCards: The human disease database

(2) MalaCards diseases for FARSA Gene - From: OMI, CVR, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search FARSA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FARSA

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FARSA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FARSA Gene

Publications for FARSA Gene

  1. Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent. (PMID: 9177188) Sen S … White RA (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22
  2. FARSA mutations mimic phenylalanyl-tRNA synthetase deficiency caused by FARSB defects. (PMID: 31355908) Krenke K … Płoski R (Clinical genetics 2019) 3 72
  3. Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns. (PMID: 20223217) Finarov I … Safro MG (Structure (London, England : 1993) 2010) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

ExternalLinks

View latest publications for FARSA gene in Mastermind

Products for FARSA Gene

Sources for FARSA Gene