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Aliases for FARSA Gene

Aliases for FARSA Gene

  • Phenylalanyl-TRNA Synthetase Subunit Alpha 2 3 5
  • Phenylalanyl-TRNA Synthetase-Like, Alpha Subunit 2 3
  • Phenylalanine TRNA Ligase 1, Alpha, Cytoplasmic 2 3
  • Phenylalanyl-TRNA Synthetase Alpha Subunit 3 4
  • Phenylalanine--TRNA Ligase Alpha Subunit 3 4
  • EC 4 56
  • FARSLA 3 4
  • PheRS 3 4
  • FARSL 3 4
  • CML33 3 4
  • Phenylalanine-TRNA Synthetase-Like, Alpha Subunit 3
  • Phenylalanine-TRNA Synthetase Alpha-Subunit 3
  • Phenylalanyl-TRNA Synthetase Alpha Chain 3
  • Phenylalanine--TRNA Ligase Alpha Chain 3
  • Phenylalanine-TRNA Synthetase-Like 2
  • PheHA 3
  • FRSA 3
  • FARS 4

External Ids for FARSA Gene

Previous HGNC Symbols for FARSA Gene


Previous GeneCards Identifiers for FARSA Gene

  • GC19M012895
  • GC19M013033
  • GC19M012605

Summaries for FARSA Gene

Entrez Gene Summary for FARSA Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]

GeneCards Summary for FARSA Gene

FARSA (Phenylalanyl-TRNA Synthetase Subunit Alpha) is a Protein Coding gene. Diseases associated with FARSA include Myiasis and Parasitic Ectoparasitic Infectious Disease. Among its related pathways are tRNA Aminoacylation and Gene Expression. Gene Ontology (GO) annotations related to this gene include tRNA binding. An important paralog of this gene is FARS2.

Gene Wiki entry for FARSA Gene

Additional gene information for FARSA Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARSA Gene

Genomics for FARSA Gene

GeneHancer (GH) Regulatory Elements for FARSA Gene

Promoters and enhancers for FARSA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J012932 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.0 36 3.6 SP1 ZFX ELF3 MNT SIX5 NKRF POLR2A ZNF121 CEBPG RERE FARSA GCDH DNASE2 FARSA-AS1
GH19J013115 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.2 -184.9 -184899 7.7 MTA3 ZFX SP1 CC2D1A ELF3 ZKSCAN8 MNT SIX5 CBFA2T2 ZNF148 TRMT1 NACC1 ZNF791 ZNF136 CCDC130 MRI1 WDR83OS ZNF44 ZNF442 ZNF564
GH19J012931 Enhancer 0.3 dbSUPER 0.7 +2.2 2196 0.6 POLR2A FARSA-AS1 FARSA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FARSA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FARSA gene promoter:
  • ATF-2
  • c-Jun
  • CUTL1
  • NF-kappaB1
  • Nkx2-5
  • p53

Genomic Locations for FARSA Gene

Genomic Locations for FARSA Gene
11,568 bases
Minus strand
11,568 bases
Minus strand

Genomic View for FARSA Gene

Genes around FARSA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FARSA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FARSA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FARSA Gene

Proteins for FARSA Gene

  • Protein details for FARSA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phenylalanine--tRNA ligase alpha subunit
    Protein Accession:
    Secondary Accessions:
    • B4E363
    • Q9NSD8
    • Q9Y4W8

    Protein attributes for FARSA Gene

    508 amino acids
    Molecular mass:
    57564 Da
    Quaternary structure:
    • Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB.
    • Sequence=AAB51175.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FARSA Gene

    Alternative splice isoforms for FARSA Gene


neXtProt entry for FARSA Gene

Selected DME Specific Peptides for FARSA Gene


Post-translational modifications for FARSA Gene

  • Ubiquitination at isoforms=2315, isoforms=2468, isoforms=2101, posLast=177177, posLast=481481, posLast=5959, isoforms=187, isoforms=2406, isoforms=2208, isoforms=2311, posLast=150150, and posLast=106106
  • Modification sites at PhosphoSitePlus

Domains & Families for FARSA Gene

Gene Families for FARSA Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FARSA Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50378, highly similar to Phenylalanyl-tRNA synthetase alpha chain (EC (B4E363_HUMAN)
  • cDNA FLJ34774 fis, clone NT2NE2003309, highly similar to Phenylalanyl-tRNA synthetase alpha chain (EC (Q6IBR2_HUMAN)
  • Phenylalanine--tRNA ligase alpha chain (SYFA_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
genes like me logo Genes that share domains with FARSA: view

Function for FARSA Gene

Molecular function for FARSA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe); Xref=Rhea:RHEA:19413, Rhea:RHEA-COMP:9668, Rhea:RHEA-COMP:9699, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58095, ChEBI:CHEBI:78442, ChEBI:CHEBI:78531, ChEBI:CHEBI:456215; EC=; Evidence=. ;.

Enzyme Numbers (IUBMB) for FARSA Gene

Phenotypes From GWAS Catalog for FARSA Gene

Gene Ontology (GO) - Molecular Function for FARSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22681889
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004826 phenylalanine-tRNA ligase activity IEA,IDA 20223217
genes like me logo Genes that share ontologies with FARSA: view
genes like me logo Genes that share phenotypes with FARSA: view

Animal Models for FARSA Gene

MGI Knock Outs for FARSA:
  • Farsa Farsa<tm2a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for FARSA

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FARSA

Clone Products

  • Applied Biological Materials (abm): Clones for FARSA - Now 50% OFF >
  • * FARSA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FARSA tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FARSA Gene

Localization for FARSA Gene

Subcellular locations from UniProtKB/Swiss-Prot for FARSA Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FARSA gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FARSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005829 cytosol TAS --
GO:0009328 phenylalanine-tRNA ligase complex IDA,IBA 20223217
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with FARSA: view

Pathways & Interactions for FARSA Gene

PathCards logo

SuperPathways for FARSA Gene

genes like me logo Genes that share pathways with FARSA: view

Pathways by source for FARSA Gene

1 KEGG pathway for FARSA Gene

Gene Ontology (GO) - Biological Process for FARSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006432 phenylalanyl-tRNA aminoacylation IEA,IDA 20223217
GO:0043039 tRNA aminoacylation IEA --
GO:0051290 protein heterotetramerization IDA 20223217
genes like me logo Genes that share ontologies with FARSA: view

No data available for SIGNOR curated interactions for FARSA Gene

Drugs & Compounds for FARSA Gene

(4) Drugs for FARSA Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Phenylalanine Approved, Investigational Nutra Target 0
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for FARSA Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
genes like me logo Genes that share compounds with FARSA: view

Transcripts for FARSA Gene

mRNA/cDNA for FARSA Gene

Unigene Clusters for FARSA Gene

Phenylalanyl-tRNA synthetase, alpha subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FARSA

Clone Products

  • Applied Biological Materials (abm): Clones for FARSA - Now 50% OFF >
  • * FARSA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FARSA tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for FARSA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -

Relevant External Links for FARSA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FARSA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FARSA Gene

Protein differential expression in normal tissues from HIPED for FARSA Gene

This gene is overexpressed in Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FARSA Gene

Protein tissue co-expression partners for FARSA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FARSA Gene:


SOURCE GeneReport for Unigene cluster for FARSA Gene:


Evidence on tissue expression from TISSUES for FARSA Gene

  • Lung(4.5)
  • Nervous system(4.5)
  • Blood(4.4)
  • Intestine(3)
  • Skin(3)
  • Liver(2.4)
  • Stomach(2)
genes like me logo Genes that share expression patterns with FARSA: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FARSA Gene

Orthologs for FARSA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FARSA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FARSA 35 34
  • 99.67 (n)
(Ornithorhynchus anatinus)
Mammalia FARSA 35
  • 90 (a)
(Canis familiaris)
Mammalia FARSA 35 34
  • 89.96 (n)
(Bos Taurus)
Mammalia FARSA 35 34
  • 89.63 (n)
(Monodelphis domestica)
Mammalia FARSA 35
  • 86 (a)
(Mus musculus)
Mammalia Farsa 17 35 34
  • 85.83 (n)
(Rattus norvegicus)
Mammalia Farsa 34
  • 85.5 (n)
(Gallus gallus)
Aves FARSA 35 34
  • 75.95 (n)
(Anolis carolinensis)
Reptilia FARSA 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia farsa 34
  • 72.08 (n)
Str.3839 34
African clawed frog
(Xenopus laevis)
Amphibia farsl-prov 34
(Danio rerio)
Actinopterygii farsa 35 34
  • 74.04 (n)
wufj21a11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10382 34
fruit fly
(Drosophila melanogaster)
Insecta CG2263 35 34
  • 66.33 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002653 34
  • 62.39 (n)
(Caenorhabditis elegans)
Secernentea fars-1 35 34
  • 58 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR516W 34
  • 57.76 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRS2 37 35 34
  • 52.04 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25234g 34
  • 51.63 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G39280 34
  • 56.3 (n)
(Glycine max)
eudicotyledons Gma.12602 34
(Oryza sativa)
Liliopsida Os10g0400800 34
  • 58.32 (n)
Os.3191 34
(Triticum aestivum)
Liliopsida Ta.1529 34
(Hordeum vulgare)
Liliopsida Hv.10634 34
(Zea mays)
Liliopsida Zm.5623 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1858 35
  • 63 (a)
Cin.11498 34
bread mold
(Neurospora crassa)
Ascomycetes NCU05095 34
  • 60.47 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes frs2 34
  • 50.51 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11498 34
Species where no ortholog for FARSA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FARSA Gene

Gene Tree for FARSA (if available)
Gene Tree for FARSA (if available)
Evolutionary constrained regions (ECRs) for FARSA: view image

Paralogs for FARSA Gene

Paralogs for FARSA Gene

(1) SIMAP similar genes for FARSA Gene using alignment to 7 proteins:

  • B4E363_HUMAN
  • K7EK06_HUMAN
  • K7ER00_HUMAN
  • K7ER16_HUMAN
genes like me logo Genes that share paralogs with FARSA: view

Variants for FARSA Gene

Sequence variations from dbSNP and Humsavar for FARSA Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000185743 -- 12,927,963(-) A/G intron_variant
rs1000288063 -- 12,934,041(-) C/T upstream_transcript_variant
rs1000614335 -- 12,931,303(-) G/A intron_variant
rs1000662199 -- 12,927,765(-) G/A/T intron_variant
rs1000687918 -- 12,931,514(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FARSA Gene

Variant ID Type Subtype PubMed ID
nsv1160589 CNV duplication 26073780
nsv833754 CNV loss 17160897
nsv953977 CNV deletion 24416366

Variation tolerance for FARSA Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FARSA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FARSA Gene

Disorders for FARSA Gene

MalaCards: The human disease database

(12) MalaCards diseases for FARSA Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
  • infestation by fly larvae
parasitic ectoparasitic infectious disease
  • ectoparasitism
pediculus humanus capitis infestation
  • head louse infestation
  • sarcosporidiosis
splenic disease
  • dyssplenism
- elite association - COSMIC cancer census association via MalaCards
Search FARSA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FARSA

genes like me logo Genes that share disorders with FARSA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FARSA Gene

Publications for FARSA Gene

  1. Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent. (PMID: 9177188) Sen S … White RA (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 23 58
  2. Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns. (PMID: 20223217) Finarov I … Safro MG (Structure (London, England : 1993) 2010) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FARSA Gene

Sources for FARSA Gene

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